Imbalance in or inadequate intake of micronutrients may impair insulin synthesis, secretion, and it's signaling pathways. This study aimed to investigate the associations between dietary copper (Cu) ...and selenium (Se) with insulin resistance (IR), in overweight/obese adults. We hypothesized that dietary Cu and Se are associated with IR in a non-linear trend. A cross-sectional study was conducted on 128 non-diabetic overweight and obese Malaysian adults aged ≥18 years with a body mass index ≥23 kg/m2. Dietary intake was assessed using food frequency questionnaire. IR was defined as homeostatic model assessment-insulin resistance (HOMA-IR) ≥1.7. Locally weighted scatterplot smoothing regression was performed to detect non-linearity and piecewise regression models were computed to examine the trend of the associations at different cut off points. In this study, 45% (n = 57) of the study participants were found to be insulin resistant. A U-shaped non-linear relation between Se and HOMA-IR was observed. Three-piecewise regression models revealed positive association between Se and HOMA-IR in individuals with relatively low (<0.3 µg/kg/d) and high (≥1.01 µg/kg/d) intake of Se (β coefficient = 3.835, CI = -12.216 to 19.886, P= 0.614; and β coefficient = 0.785, CI = 0.386-1.185, P = 0.014, respectively). Significant positive association was only found between dietary Cu and HOMA-IR with intake of Cu ≥ 13.4 µg/kg/d, 0.276 (CI = 0.025-0.526; P = 0.033). In conclusion, our findings reveal that a critical balance in the dietary intake of copper and Se is crucial for health, more so in insulin resistant and diabetic individuals. In the latter treatment should include measured intake of both copper and Se, personalized according to individual habitual food preferences and intakes.
The aim of this study was to investigate the effectiveness of the Hipcref (high-protein, energy-restricted, high-vitamin E and high-fibre) diet in Malaysian adults on body composition and metabolic ...parameters after an intervention period of 6 months. Overweight/obese Malaysian adults (n 128; BMI≥23 kg/m2) were randomised to the Hipcref (n 65) or control diet (n 63). The intervention group received Hipcref diet charts based on their personal preferences. The control group followed a generalised dietary advice based on Malaysian Dietary Guidelines, 2010. All participants were responsible for preparing their own meals. There was a significant treatment group×time effect on anthropometric parameters (P<0·05) on an intention-to-treat basis. Pairwise comparisons revealed that Hipcref diet participants had significant reduction in weight, BMI, waist circumference, fat mass and percentage body fat at months 3 and 6 compared with baseline (P<0·001). The control group had significant increase in weight and BMI at months 3 and 6 compared with baseline (P<0·05). The Hipcref diet group had higher reduction in fasting insulin, insulin resistance and C-reactive protein levels compared with the control group at month 6 (P<0·05). Post-intervention, compared with the control group, the Hipcref diet group was found to consume significantly higher percentage energy from protein, and PUFA, higher energy-adjusted vitamin E (mg) and fibre (g), and lower total energy, lower percentage energy from fat and carbohydrate (P<0·05). The success of the Hipcref diet on overweight/obese Malaysian adults may be due to the combined effect of the nutrient composition of the Hipcref diet.
Long-term trends in the frequency of thunderstorm days are investigated using fifty years of data recorded by weather observatories throughout India. An attempt has been made to identify whether the ...trends are spatially cohesive and collocated with regions with maximum of thunderstorm days. This analysis of trends is significant, since most of the weather over India is of convective origin and has devastating impact on life and property. There are three thunderstorm maximum regions (a) northwest Indian Himalayas and adjoining Pakistan, (b) east India and (c) extreme southern parts of peninsular India. The results of the study revealed on a monthly scale, the frequency of thunderstorm days has a consistent spatially cohesive decreasing trend over east central and northeast India, collocated with the intra-annually shifting maximum of thunderstorm activity. The trend is more diffused for the thunderstorm maxima over north and south peninsular India. Comparison with rainfall trends from previous studies indicates that this decreasing trend of thunderstorm days is in phase with decreasing trends in rainfall activity over east central and northeast Indian regions. Detailed analysis indicates that frequency of thunderstorm days over these regions decreased during the latter half of the twentieth century followed by gradually increasing trend. This corresponds to a global warming hiatus and matches similar findings around the world. It seems likely that the decreasing moisture inflow from the surrounding oceans into the Indian subcontinent throughout the year due to weakening of the land-sea thermal gradient is causing a decreasing trend in the convection during this period. Over north and south peninsular India, where circum-global planetary waves play an important role in triggering convection, the strengthening of these waves offsets the effect of the generally decreasing moisture.
To promote understanding of and interest in working with data among diverse student populations, we developed and studied a high school mathematics curriculum module that examines income inequality ...in the United States. Designed as a multi-week set of applied data investigations, the module supports student analyses of income inequality using U.S. Census Bureau microdata and the online data analysis tool the Common Online Data Analysis Platform (CODAP). Pre- and post-module data show that use of this module was associated with statistically significant growth in students' understanding of fundamental data concepts and individual interests in statistics and data analysis, with small to moderate effect sizes. Student survey responses and interview data from students and teachers suggest that the topic of income inequality, features within CODAP, the use of person-level data, and opportunities to engage in multivariable thinking helped to support critical data literacy and its foundations among participating students. We describe our definitions of data literacy and critical data literacy and discuss curriculum strategies to develop them.
In recent years, while developed countries are decommissioning hydroelectric projects (HEPs)/dams at a higher rate than constructing new ones, developing economies are doing the opposite. Although ...HEPs are regarded green, renewable and cheap, recent studies reveal that they do more harm than good. The impacts of HEPs are multiple, including socio-economic, environmental and geopolitical. India’s Northeastern (NE) region is a part of the Ganges–Brahmaputra–Meghna river basin, and has immense hydropower potential. A large number of HEPs are planned or under construction in the region, mainly in the hilly states of Arunachal Pradesh, Manipur, Meghalaya, Sikkim and Mizoram. One such mega project is the Tipaimukh multipurpose HEP, to be constructed on the Barak river in the state of Manipur. The project is highly controversial, and is being protested against by the locals, academicians, researchers, social activists, NGOs, as well as Bangladesh. Further, a serious cost–benefit analysis, judicious environmental impact assessment and democratic public hearings have been questioned. The area submergence of the project is disproportionately high compared to other such projects of NE India, and the project site and the adjoining areas form a part of Indo-Burma global biodiversity hotspot. The present study details the impacts of the project from multidisciplinary perspectives, categorized into bio-physical, socio-economic and geopolitical impacts, including impacts on the downstream riparian nation—Bangladesh. Based on the study, we have provided recommendations, if ever the construction of project is actualized. Since there is lack of any such analysis, the present study is of immense significance on the decision making of the project, and paves a guideline for impact analysis of the upcoming large number of projects of the region.
A 36-year-old male patient presented with a firm swelling in the left lacrimal sac region with a history of recurrent episodes of acute dacryocystitis, which partly resolved with systemic ...antibiotics. Computed tomography showed diffuse soft tissue mass without bony erosion in the same area. Incisional biopsy confirmed diffuse large cell lymphoma of non-Hodgkin's type by histopathology and immunohistochemistry. Oncologists did not detect systemic involvement, and the patient received six cycles of cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (CHOP). Epiphora was resolved, and no recurrence of the lesion was seen with subsequent dacryocystorhinostomy with intubation and was in good health for up to 3 years of follow-up. Although primary lacrimal sac lymphoma is a rare entity, high suspicion, and prompt action in atypical cases can save lives from aggressive diffuse large cell lymphoma.
Ocular surface squamous neoplasia (OSSN) is the most common nonpigmented ocular surface neoplasm. Interferon-alpha (IFNα)-2b has been proved to be an effective immunotherapeutic agent to treat OSSN. ...We have used intralesional and topical (36 μg/ml) pegylated (peg) IFNα-2a to treat a recurrent surgically failed case of OSSN instead of IFNα-2b. In this case report, we have shared our initial experience with the novel use of peg-IFNα-2a to treat OSSN. According to our brief clinical experience, peg-IFNα-2a is nontoxic to ocular surface and has a promising role to treat OSSN.
Widespread very heavy to extremely heavy rainfall occurred over Uttarakhand and its neighbouring states during 16–18 June 2013, which caused flash floods, landslides, large-scales loss of lives and ...damage to property. The present study analyses the dynamical and thermodynamical features associated with this torrential rainfall episode. The analysis suggests that due to strong interaction between an oncoming mid-tropospheric trough in the westerlies and the strong lower-tropospheric southeasterly monsoon wind flow in association with a monsoon low-pressure system over the North Indian region, a lower tropospheric wind convergence zone developed over Uttarakhand and its neighbouring regions. A strong Bay of Bengal current of air with wind speed of 40 kts in the northern periphery of the monsoon low, pumped a lot of moisture into the region. Supported by strong orographic effect due to high terrain and strong moisture feeding from both the Arabian Sea and the Bay of Bengal, a large-scale quasistationary regenerative mesoscale convective system (MCS) developed over the zone of convergence. The episode was comparable to the 2010 Leh flash flood episode, in that the synoptic conditions were similar in both cases. However, while the Leh episode resulted from repeated surges of westward travelling MCS across the Tibetan Plateau, the present case was due to quasistationary regenerative MCS over the region.
Background: Computing polygenic risk scores (PRS) to predict the degree of risk for obesity may contribute to weight management programs strategically. Objectives: To investigate the combined effect ...of FTO rs9930501, rs9930506, and rs9932754 and ADRB2 rs1042713 and rs1042714 using PRS on (1) the odds of obesity and (2) post-intervention differences in dietary, anthropometric, and cardiometabolic parameters in response to high-protein calorie-restricted, high-vitamin E, high-fiber (Hipcref) diet intervention in Malaysian adults. Methods: Both a cross-sectional study (n = 178) and a randomized controlled trial (RCT) (n = 128) were conducted to test the aforementioned objectives. PRS was computed as the weighted sum of the risk alleles possessed by each individual participant. Participants were stratified into first (PRS 0–0.64), second (PRS 0.65–3.59), and third (PRS 3.60–8.18) tertiles. Results: The third tertile of PRS was associated with significantly higher odds of obesity: 2.29 (95% CI = 1.11–4.72, adjusted p = 0.025) compared to the first tertile. Indians (3.9 ± 0.3) had significantly higher PRS compared to Chinese (2.1 ± 0.4) (p = 0.010). In the RCT, a greater reduction in high-sensitivity C-reactive protein (hsCRP) levels was found in second and third tertiles after Hipcref diet intervention compared to the control diet (p interaction = 0.048). Conclusion: Higher PRS was significantly associated with increased odds of obesity. Individuals with higher PRS had a significantly greater reduction in hsCRP levels after Hipcref diet compared to the control diet.
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