A coalition of leftist political groups, civic movements, and grassroots organizations led by social activist Ada Colau won the Barcelona municipal elections of 2015 and is now governing the Catalan ...capital. The key to this success may well have been its critical positioning in relation to its tourism. Until recently considered a best practice in urban regeneration and a successful global destination, Barcelona has seen in the last 2 years a radical change in the public perception on tourism: from “manna from heaven” to serious issues that are affecting the quality of life of its citizens.This article looks into the factors that may have determined this political change, from the growth of tourism beyond what could be considered a critical threshold for an urban system, to the development of a critical discourse on tourism by the new coalition—attributed to its peculiar constituency and working methods—and the role of the media in airing this discursive shift. The article follows the thread of the “growth machine” theorizations and questions whether the increasing dimension of tourism in urban societies could be a driver for regime changes.
The prepandemic unbridled growth of tourism has triggered a significant debate regarding the future of cities; several authors suggest that neighbourhood change produced by tourism should be ...conceived as a form of gentrification. Yet research on population shifts—a fundamental dimension of gentrification—in such neighbourhoods is scarce. Our exploration of the Gòtic area in Barcelona, using quantitative and qualitative techniques, reveals a process of population restructuring characterised by a decrease of long‐term residents and inhabited dwellings, and the arrival of young and transnational gentrifiers that are increasingly mobile and form a transient population. We then use some insights from the mobilities literature to make sense of these results. In the gentrification of the Gòtic, the attractiveness of the area for visitors and for a wider palette of transnational dwellers feeds one another, resulting in an uneven negotiation whereby more wealthy and ‘footloose’ individuals gain access and control of space and housing over less mobile and more dependent populations.
Tourism global value chains connect strategically to local operations; in the case of cruise lines, where most part of the experience happens in a 'placeless' environment, cruise ports embody this ...singular but fundamental connection. However, a third stakeholder should be taken into account in cruise product design, and it is the destination region. This article introduces an analytic framework that connects the global structure of cruise value chains to the regional articulation of land-based cruise services, and reflects upon strategies by which local agents can enhance the generation of value at the local level. After discussing the possible strategies of port regionalization, we present a general framework to assess the competitive position of a cruise destination. A case study of Catalonia and its three main ports is used as an illustration.
Temporal Activity Patterns of Theme Park Visitors Birenboim, Amit; Anton-Clavé, Salvador; Russo, Antonio Paolo ...
Tourism geographies,
11/1/2013, 2013-11-00, 20131101, Letnik:
15, Številka:
4
Journal Article
Recenzirano
In this article, we illustrate the importance of time in understanding theme park visitor activity patterns. The study that is described here made use of the GPS (Global Positioning System) ...technology to track and record the time-space trajectories of visitors at the PortAventura theme park in Catalonia, Spain. The findings suggest that visitors to theme parks do demonstrate distinct diurnal and intradiurnal mass behavior patterns or rhythms of activity. The investigation of temporal activity patterns holds two main advantages: the first is that compared with spatial activity patterns, it is more straightforward to aggregate, present, and compare temporal patterns; the second is that the external validity of temporal activity patterns is generally higher than that of spatial activity patterns. That is to say that temporal activity patterns are more likely to repeat themselves in other environments. Practical, theoretical, and methodological insights that can be relevant to both researchers and site managers are discussed.
BackgroundConcomitant medications, such as steroids, proton pump inhibitors (PPI) and antibiotics, might affect clinical outcomes with immune checkpoint inhibitors.MethodsWe conducted a multicenter ...observational retrospective study aimed at evaluating the impact of concomitant medications on clinical outcomes, by weighing their associations with baseline clinical characteristics (including performance status, burden of disease and body mass index) and the underlying causes for their prescription. This analysis included consecutive stage IV patients with cancer, who underwent treatment with single agent antiprogrammed death-1/programmed death ligand-1 (PD-1/PD-L1) with standard doses and schedules at the medical oncology departments of 20 Italian institutions. Each medication taken at the immunotherapy initiation was screened and collected into key categories as follows: corticosteroids, antibiotics, gastric acid suppressants (including proton pump inhibitors - PPIs), statins and other lipid-lowering agents, aspirin, anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDs), ACE inhibitors/Angiotensin II receptor blockers, calcium antagonists, β-blockers, metformin and other oral antidiabetics, opioids.ResultsFrom June 2014 to March 2020, 1012 patients were included in the analysis. Primary tumors were: non-small cell lung cancer (52.2%), melanoma (26%), renal cell carcinoma (18.3%) and others (3.6%). Baseline statins (HR 1.60 (95% CI 1.14 to 2.25), p=0.0064), aspirin (HR 1.47 (95% CI 1.04 to 2.08, p=0.0267) and β-blockers (HR 1.76 (95% CI 1.16 to 2.69), p=0.0080) were confirmed to be independently related to an increased objective response rate. Patients receiving cancer-related steroids (HR 1.72 (95% CI 1.43 to 2.07), p<0.0001), prophylactic systemic antibiotics (HR 1.85 (95% CI 1.23 to 2.78), p=0.0030), prophylactic gastric acid suppressants (HR 1.29 (95% CI 1.09 to 1.53), p=0.0021), PPIs (HR 1.26 (95% CI 1.07 to 1.48), p=0.0050), anticoagulants (HR 1.43 (95% CI: 1.16 to 1.77), p=0.0007) and opioids (HR 1.71 (95% CI 1.28 to 2.28), p=0.0002) were confirmed to have a significantly higher risk of disease progression. Patients receiving cancer-related steroids (HR 2.16 (95% CI 1.76 to 2.65), p<0.0001), prophylactic systemic antibiotics (HR 1.93 (95% CI 1.25 to 2.98), p=0.0030), prophylactic gastric acid suppressants (HR 1.29 (95% CI 1.06 to 1.57), p=0.0091), PPI (HR 1.26 (95% CI 1.04 to 1.52), p=0.0172), anticoagulants (HR 1.45 (95% CI 1.14 to 1.84), p=0.0024) and opioids (HR 1.53 (95% CI 1.11 to 2.11), p=0.0098) were confirmed to have a significantly higher risk of death.ConclusionWe confirmed the association between baseline steroids administered for cancer-related indication, systemic antibiotics, PPIs and worse clinical outcomes with PD-1/PD-L1 checkpoint inhibitors, which can be assumed to have immune-modulating detrimental effects.
The paper introduces the concept of territorial assets and discusses their role for regional development. Focusing on European societies and taking into account different strands of the literature on ...place and territorial capital, we argue that the endowment with – and mobilization of – such territorial assets could be seen as a key aspect of regional policy, producing changes in the attraction (and/or retention) of specific segments of population and, in a longer-term perspective, influencing sustainable development strategies. In this light, ‘territorial attractiveness’ – characterized in this paper in both conceptual and operational terms – is presented as a powerful element in European spatial policy, allowing regional development strategies to be more systematically integrated under an overall objective of territorial cohesion, while taking into account their implications in terms of human mobility.
•Professional travel is a relevant topic in mobilities and place studies.•Intermeshing between professional and leisurely practices is observed in Barcelona.•Congress attendants spend time at tourist ...spaces away from professional venues.•The use of ICT facilitates the convergence of tourist and professional practices.•These results challenge specialisation models in Barcelona’s urban planning.
This study analyses to what extent conventional tourism is part of the experience of professional visitors. Following the literature on mobilities, this paper assumes that leisure and work increasingly intermingle in time and space. Empirical work based on a survey of conference attendants in Barcelona confirms this stance, and invites to reframe professional life ‘in mobility’ as performed as part of a wider package of everyday activities. Public transport and mobile communication are analysed as facilitators of such convergence, highlighting how professional travel is situated in flexible spaces and flows. These findings provide insights for urban (tourism) policy, insofar as they demonstrate that planning for specialised spaces is not sufficient to reduce visitor pressure on the main tourist ‘sights’.
The current therapeutic algorithm for Advanced Stage Melanoma comprises of alternating lines of Targeted and Immuno-therapy, mostly via Immune-Checkpoint blockade. While Comprehensive Genomic ...Profiling of solid tumours has been approved as a companion diagnostic, still no approved predictive biomarkers are available for Melanoma aside from BRAF mutations and the controversial Tumor Mutational Burden. This study presents the results of a Multi-Centre Observational Clinical Trial of Comprehensive Genomic Profiling on Target and Immuno-therapy treated advanced Melanoma.
82 samples, collected from 7 Italian Cancer Centres of FFPE-archived Metastatic Melanoma and matched blood were sequenced via a custom-made 184-gene amplicon-based NGS panel. Sequencing and bioinformatics analysis was performed at a central hub. Primary analysis was carried out via the Ion Reporter framework. Secondary analysis and Machine Learning modelling comprising of uni and multivariate, COX/Lasso combination, and Random Forest, was implemented via custom R/Python scripting.
The genomics landscape of the ACC-mela cohort is comparable at the somatic level for Single Nucleotide Variants and INDELs aside a few gene targets. All the clinically relevant targets such as BRAF and NRAS have a comparable distribution thus suggesting the value of larger scale sequencing in melanoma. No comparability is reached at the CNV level due to biotechnological biases and cohort numerosity. Tumour Mutational Burden is slightly higher in median for Complete Responders but fails to achieve statistical significance in Kaplan-Meier survival analysis via several thresholding strategies. Mutations on PDGFRB, NOTCH3 and RET were shown to have a positive effect on Immune-checkpoint treatment Overall and Disease-Free Survival, while variants in NOTCH4 were found to be detrimental for both endpoints.
The results presented in this study show the value and the challenge of a genomics-driven network trial. The data can be also a valuable resource as a validation cohort for Immunotherapy and Target therapy genomic biomarker research.
Coronavirus disease 2019 (COVID-19) global pandemic has created unique challenges to healthcare systems throughout the world. Ensuring subjects' safety is mandatory especially in oncology, in ...consideration of cancer patients' particular frailty. We examined the proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgM and/or IgG positive subjects in three different groups from Istituto Nazionale Tumori - IRCCS "Fondazione G. Pascale" in Naples (Campania region, Italy): cancer patients treated with Innovative Immunotherapy (Immune Checkpoint Inhibitors, ICIs), cancer patients undergoing standard Chemotherapies (CHTs) and healthcare providers. 9 out of 287 (3.1%) ICIs patients resulted positive, with a significant lower percentage in respect to CHTs patients (39 positive subjects out of 598, 6.5%) (p = 0.04). There was no statistically significant difference between ICIs cohort and healthcare providers, 48 out of 1050 resulting positive (4.6%). Performing a Propensity Score Matching based on gender and tumor stage, the effect of treatment on seropositivity was analyzed through a regression logistic model and the ICIs treatment resulted to be the only protective factor significantly (p = 0.03) associated with positivity (odds ratio-OR: 0.41; 95% confidence interval-CI 0.18-0.91). According to these preliminary data, ICIs would appear to be a protective factor against the onset of COVID-19 infection.
This paper explores how places are culturally constructed through the practices, bodily performances and memories of dwelling in the context of places that stand out as destinations of temporary ...mobilities. To do this, I narrate my own personal experiences of finding my way and respectively make or contest personal roots, in two autoethnographic accounts of my city of origin, Venice, where I return occasionally, and in Barcelona, where I settled in the 2000 decade. In these memoirs, I excavate on the nexa between domestic home spaces and public life in the urban space, focusing especially on my experiences of homing, on the assemblage of domestic spaces as unfolding in a negotiation between my old and new self, my family (past and present), and other place users, including friends and passers-by in the spaces in questions. My own navigation and mooring in those cities is analysed as a collective, relational process that calls in affinity and distancing, serendipitous engagements and purposeful disengagements. In this way I hope to shed more light on the cultural construction of two cities that stand out as ‘touristed’ places, and contribute to debates on translocal urbanism and the need for an embodied, grounded understanding of the social and cultural evolution of cities.
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