Pediatric tumors of the central nervous system are the most common cause of cancer-related death in children. The five-year survival rate for high-grade gliomas in children is less than 20%. Due to ...their rarity, the diagnosis of these entities is often delayed, their treatment is mainly based on historic treatment concepts, and clinical trials require multi-institutional collaborations. Here we present the CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs challenge, focused on pediatric brain tumors with data acquired across multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. The CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs challenge brings together clinicians and AI/imaging scientists to lead to faster development of automated segmentation techniques that could benefit clinical trials, and ultimately the care of children with brain tumors.
Pediatric tumors of the central nervous system are the most common cause of cancer-related death in children. The five-year survival rate for high-grade gliomas in children is less than 20\%. Due to ...their rarity, the diagnosis of these entities is often delayed, their treatment is mainly based on historic treatment concepts, and clinical trials require multi-institutional collaborations. The MICCAI Brain Tumor Segmentation (BraTS) Challenge is a landmark community benchmark event with a successful history of 12 years of resource creation for the segmentation and analysis of adult glioma. Here we present the CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs 2023 challenge, which represents the first BraTS challenge focused on pediatric brain tumors with data acquired across multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. The BraTS-PEDs 2023 challenge focuses on benchmarking the development of volumentric segmentation algorithms for pediatric brain glioma through standardized quantitative performance evaluation metrics utilized across the BraTS 2023 cluster of challenges. Models gaining knowledge from the BraTS-PEDs multi-parametric structural MRI (mpMRI) training data will be evaluated on separate validation and unseen test mpMRI dataof high-grade pediatric glioma. The CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs 2023 challenge brings together clinicians and AI/imaging scientists to lead to faster development of automated segmentation techniques that could benefit clinical trials, and ultimately the care of children with brain tumors.
Pediatric tumors of the central nervous system are the most common cause of cancer-related death in children. The five-year survival rate for high-grade gliomas in children is less than 20\%. Due to ...their rarity, the diagnosis of these entities is often delayed, their treatment is mainly based on historic treatment concepts, and clinical trials require multi-institutional collaborations. The MICCAI Brain Tumor Segmentation (BraTS) Challenge is a landmark community benchmark event with a successful history of 12 years of resource creation for the segmentation and analysis of adult glioma. Here we present the CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs 2023 challenge, which represents the first BraTS challenge focused on pediatric brain tumors with data acquired across multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. The BraTS-PEDs 2023 challenge focuses on benchmarking the development of volumentric segmentation algorithms for pediatric brain glioma through standardized quantitative performance evaluation metrics utilized across the BraTS 2023 cluster of challenges. Models gaining knowledge from the BraTS-PEDs multi-parametric structural MRI (mpMRI) training data will be evaluated on separate validation and unseen test mpMRI dataof high-grade pediatric glioma. The CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs 2023 challenge brings together clinicians and AI/imaging scientists to lead to faster development of automated segmentation techniques that could benefit clinical trials, and ultimately the care of children with brain tumors.
1. The specific activities for palmitoyl-CoA synthetase and for sn-glycerol 3-phosphate esterification, with palmitoyl-CoA generated either by the endogenous synthetase or from ...palmitoyl-(-)-carnitine, CoA and excess of carnitine palmitoyltransferase, were measured with rat liver mitochondria. 2. The mean specific activity of palmitoyl-CoA synthetase was approximately five- and seven-fold the rates of sn-glycerol 3-phosphate esterification from palmitate and palmitoyl-(-)-carnitine respectively. No significant correlation was found in different rats between the activities of palmitoyl-CoA synthetase and sn-glycerol 3-phosphate esterification from either acyl precursor. However, there was a significant correlation (r=0.83, P<0.001) between the rates of glycerolipid synthesis from palmitate and palmitoyl-(-)-carnitine. 3. The mean molar composition of the glycerolipid synthesized from palmitate was 58% lysophosphatidate, 31% phosphatidate and 11% neutral lipid. With palmitoyl-(-)-carnitine the equivalent values were 70, 23 and 7%, which were significantly different. 4. When palmitoyl-CoA synthetase had been inactivated by 60-70% after preincubation of mitochondria at 37 degrees C, it became rate-limiting in glycerolipid biosynthesis. Additions of 1-5mm-ATP prevented inactivation of palmitoyl-CoA synthetase. 5. Preincubation also inhibited the oxidation of palmitate, palmitoyl-CoA, palmitoyl-(-)-carnitine and malate plus glutamate. These inhibitions could not be prevented by addition of ATP. 6. Diversion of palmitoyl-CoA to form palmitoyl-(-)-carnitine did not inhibit sn-glycerol 3-phosphate esterification. 7. The palmitoyl-CoA pool synthesized by the palmitoyl-CoA synthetase was augmented by adding partially purified synthetase or carnitine palmitoyltransferase and palmitoyl-(-)-carnitine. No stimulation of palmitate incorporation into glycerolipids occurred. 8. At low concentrations of Mg(2+), palmitate, ATP and CoA the velocity with palmitoyl-CoA synthetase decreased more than that of glycerolipid synthesis from palmitate. 9. It is concluded that in the presence of optimum substrate concentrations the activity of sn-glycerol 3-phosphate acyltransferase and not of palmitoyl-CoA synthetase is rate-limiting in the synthesis of phosphatidate and lysophosphatidate in isolated rat liver mitochondria.
Essential oils from aerial parts of six aromatic plants were analysed by GC-MS. The major compounds identified were γ-terpinene (11.5%), cuminaldehyde (26.6%) and γ-terpinen-7-al (40.6%) in Cuminum ...cyminum, trans-anethol (95.2%) in Pimpinella anisum, α-pinene (11.6%), limonene (21.0%), β-caryophyllene (22.3%) and α-humulene (16.7%) in Lippia integrifolia, limonene (40.8%) and artemisia ketone (19.3%) in Lippia junelliana, trans-β-ocimene (15.6%), 4-ethyl-4-methyl-1-hexene (24.5%), trans-tagetone (20.5%) and verbenone (27.2%) in Tagetes minuta, 1,8-cineole (17.9%),elixene (10.3%) and spathulenol (13.8%) in Aloysia gratissima. Oils with strong insecticidal activity on Carpophilus dimidiatus and Oryzaephilus mercator were from P. anisum (LC
50
= 4 µl/L; LC
100
= 10 µl/L) and T. minuta (LC
50
=10.19-12.57 µl/L; LC
100
=20 µl/L). Scents of C. cyminum and L. junelliana were strong insecticides on O. mercator (LC
50
=7.02-7.17 µl/L; LC
100
=10.00-20.00 µl/L). The insecticidal activity was associated to the whole content of C10 molecules and oxygenated constituents. The P. anisum oil is promising as protective agent of nut products.
Os Centros de Referência em Saúde do Trabalhador (Cerest) tem como uma de suas prioridades as ações de vigilância em saúde do trabalhador como articulador das intervenções nas relações entre o ...processo de trabalho e a saúde. Com o crescimento da indústria sucroalcooleira no Estado de São Paulo, o consequente aumento dos postos de trabalho desse setor, e os riscos à saúde existentes nesse ambiente laboral, torna-se absolutamente necessária a intervenção do Sistema Único de Saúde (SUS), em parceria com outras instâncias governamentais, no controle dos riscos e na assistência integral à saúde desses trabalhadores. Este estudo relata a experiência do Cerest de Bauru durante as ações de vigilância em saúde do trabalhador do setor canavieiro, especificamente a usina. Ao todo são 17 usinas de abrangência de Bauru. Até o presente momento foram fiscalizadas sete: entre as irregularidades encontradas, podemos citar: vãos dos guarda-corpos, rodapés, escadas tipo marinheiro sem trava-quedas; ausência de laudo ergonômico; falta de proteção devida aos trabalhadores que ficam confinados, dentre outras. Devemos ressaltar a vontade política da Secretaria Municipal de Bauru como uma das facilidades encontradas para a execução das ações, entretanto a inexperiência, o despreparo, as dificuldades nas relações interinstitucionais intra e extra-SUS e a grande complexidade do setor são grandes obstáculos a serem ultrapassados.The Reference Centers in Workers' Health (Cerest) have, as one of their priorities, actions of occupational health surveillance as an articulator of interventions in the relationships between the work process and health. With the growth of the sugarcane industry in the State of São Paulo, the consequent increase in jobs in this sector, and the health risks that exist in that work environment, the intervention of Sistema Único de Saúde (SUS - National Health System) becomes absolutely necessary, in partnership with other governmental agencies, to control the risks and provide full assistance concerning the health of these workers. This study reports the experience of the Cerest of the city of Bauru during the actions of occupational health surveillance in the sugarcane industry, specifically the processing plant. Seventeen plants are in the catchment area of Bauru, but so far seven have been audited. Among the irregularities found, we can cite: unsafe equipment, lack of an ergonomic report, lack of proper protection to confined workers. We must emphasize the political will of the Municipal Department of Bauru as one element that facilitated the implementation of the actions; however, the inexperience, the lack of knowledge, the difficulties in the relations between institutions within and outside the SUS, and the vast complexity of the sector are major obstacles to be overcome.
Although studies with informal workers have been conducted in Latin America and the Caribbean, there is still scarce evidence on the prevalence of food poisoning among workers with subsistence jobs ...on the streets and sidewalks of cities and on the factors that influence its presentation.
To determine sociodemographic, labor, sanitary, and environmental conditions that influence the prevalence of food poisoning in informal workers in downtown Medellín, Colombia.
This is a cross-sectional study using a workers' survey as the primary source. A total of 686 workers aged ≥18 years who had been working for ≥ 5 years were surveyed. An assisted survey was initially applied as a pilot test for training purposes and to obtain informed consent.
We identified several associations and explanatory factors of food poisoning using chi-square tests and prevalence ratios, with unadjusted and adjusted 95% confidence intervals (95%CI). A higher prevalence of food poisoning (p < 0.05) was observed in workers with lower frequency of waste collection (PR = 2.09; 95%CI = 1.04-4.19), who left cooked food (PR = 6.40; 95%CI = 2.34-17.8), beverages or chopped fruits uncovered at their workplace (PR = 3.92; 95%CI = 1.40-10.48), with inadequate waste management (PR = 4.84; 95%CI = 2.12-11.06), exposure to polluted water (PR = 3.00; 95%CI = 1.20-7.50) and acceptable water supply (PR = 5.40; 95%CI = 1.60-17.8). The factors that explained higher rates of food poisoning were not having a waste collection service (PR
= 5.58; 95%CI = 3.38-13.10), inadequate waste management (PR
= 6.61; 95%CI = 1.25-34.84), and having sanitary services next to worker's stall (PR
= 14.44; 95%CI = 1.26-165.11).
The conditions that are associated with and explain the higher prevalence of food poisoning in this working population can be addressed with health promotion and disease prevention interventions.
La realidad aumentada se define como el sistema que puede enriquecer al mundo real con diferentes tipos de elementos virtuales que son generados mediante un ordenador ayudando así a la coexistencia ...en un mismo espacio de objetos reales y virtuales, entonces sabiendo este concepto se puede decir que la realidad aumentada es una herramienta tecnológica muy avanzada que sería de mucha ayuda para poder proyectar algún lugar que se quiera apreciar e interactuar desde la comodidad del espacio en donde el turista se encuentre. Teniendo en cuenta los antecedentes de la aplicación de la realidad aumentada en los museos y como esta herramienta le da una gran potencialidad a estos, se puede decir que se podría aplicar la realidad aumentada en los museos de la ciudad de Lambayeque, para que así los visitantes no solo observen sin también interactúen con ellos y obtengan un gran experiencia que los motive a regresar otra vez, y así ayudaría en la innovación que la OMT quiere lograr para la reactivación;
del turismo. Para que la investigación sea llevada a cabo el enfoque que se tomó en cuenta fue;
cuantitativo, diseño no experimental de nivel descriptivo simple, en donde se utilizó la técnica de la encuesta de modo virtual que contó con la herramienta del cuestionario la cual fue aplicada teniendo en cuenta el número de visitantes nacionales que llegaron a la ciudad de Lambayeque durante el año 2019.
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