Abstract
General relativistic effects have long been predicted to subtly influence the observed large-scale structure of the universe. The current generation of galaxy redshift surveys has reached a ...size where detection of such effects is becoming feasible. In this paper, we report the first detection of the redshift asymmetry from the cross-correlation function of two galaxy populations that is consistent with relativistic effects. The data set is taken from the Sloan Digital Sky Survey Data Release 12 CMASS galaxy sample, and we detect the asymmetry at the 2.7σ level by applying a shell-averaged estimator to the cross-correlation function. Our measurement dominates at scales around 10 h
−1 Mpc, larger than those over which the gravitational redshift profile has been recently measured in galaxy clusters, but smaller than scales for which linear perturbation theory is likely to be accurate. The detection significance varies by 0.5σ with the details of our measurement and tests for systematic effects. We have also devised two null tests to check for various survey systematics and show that both results are consistent with the null hypothesis. We measure the dipole moment of the cross-correlation function, and from this the asymmetry is also detected, at the 2.8σ level. The amplitude and scale dependence of the clustering asymmetries are approximately consistent with the expectations of general relativity and a biased galaxy population, within large uncertainties. We explore theoretical predictions using numerical simulations in a companion paper.
A
bstract
The pion-pole contribution to hadronic light-by-light scattering in the anomalous magnetic moment of the muon (
g
− 2)
μ
is fully determined by the doubly-virtual pion transition form ...factor. Although this crucial input quantity is, in principle, directly accessible in experiment, a complete measurement covering all kinematic regions relevant for (
g
−2)
μ
is not realistic in the foreseeable future. Here, we report in detail on a reconstruction from available data, both space- and time-like, using a dispersive representation that accounts for all the low-lying singularities, reproduces the correct high- and low-energy limits, and proves convenient for the evaluation of the (
g
− 2)
μ
loop integral. We concentrate on the systematics of the fit to
e
+
e
−
→ 3
π
data, which are key in constraining the isoscalar dependence, as well as the matching to the asymptotic limits. In particular, we provide a detailed account of the pion transition form factor at low energies in the time- and space-like region, including the error estimates underlying our final result for the pion-pole contribution,
a
μ
π
0
−
pole
=
62.6
−
2.5
+
3.0
×
10
−
11
, and demonstrate how forthcoming singly-virtual measurements will further reduce its uncertainty.
Absorption of high-energy radiation in planetary thermospheres is generally believed to lead to the formation of planetary winds. The resulting mass-loss rates can affect the evolution, particularly ...of small gas planets. We present 1D, spherically symmetric hydrodynamic simulations of the escaping atmospheres of 18 hot gas planets in the solar neighborhood. Our sample only includes strongly irradiated planets, whose expanded atmospheres may be detectable via transit spectroscopy using current instrumentation. The simulations were performed with the PLUTO-CLOUDY interface, which couples a detailed photoionization and plasma simulation code with a general MHD code. We study the thermospheric escape and derive improved estimates for the planetary mass-loss rates. Our simulations reproduce the temperature-pressure profile measured via sodium D absorption in HD 189733 b, but show still unexplained differences in the case of HD 209458 b. In contrast to general assumptions, we find that the gravitationally more tightly bound thermospheres of massive and compact planets, such as HAT-P-2 b are hydrodynamically stable. Compact planets dispose of the radiative energy input through hydrogen Lyα and free-free emission. Radiative cooling is also important in HD 189733 b, but it decreases toward smaller planets like GJ 436 b. Computing the planetary Lyα absorption and emission signals from the simulations, we find that the strong and cool winds of smaller planets mainly cause strong Lyα absorption but little emission. Compact and massive planets with hot, stable thermospheres cause small absorption signals but are strong Lyα emitters, possibly detectable with the current instrumentation. The absorption and emission signals provide a possible distinction between these two classes of thermospheres in hot gas planets. According to our results, WASP-80 and GJ 3470 are currently the most promising targets for observational follow-up aimed at detecting atmospheric Lyα absorption signals.
Background For patients with esophageal adenocarcinoma or cancer of the gastroesophageal junction, radical esophagectomy with 2-field lymphadenectomy is the cornerstone of the multimodality treatment ...with curative intent. Both conventional minimally invasive esophagectomy (MIE) and robot assisted minimally invasive esophagectomy (RAMIE) were shown to be superior compared to open transthoracic esophagectomy considering postoperative complications. However, no randomized comparison exists between MIE and RAMIE in the Western World for patients with esophageal adenocarcinoma. Methods This is an investigator-initiated and investigator-driven multicenter randomized controlled parallel-group superiority trial. All adult patients (age greater than or equai to 18 and less than or equai to 90 years) with histologically proven, surgically resectable (cT1-4a, N0-3, M0) esophageal adenocarcinoma of the intrathoracic esophagus or adenocarcinoma of the gastroesophageal junction and with European Clinical Oncology Group performance status 0, 1 or 2 will be assessed for eligibility and included after obtaining informed consent. Patients (n = 218) with resectable esophageal adenocarcinoma of the intrathoracic esophagus or adenocarcinoma of the gastroesophageal junction are randomized to either RAMIE (n = 109) or MIE (n = 109). The primary outcome of this study is the total number of resected abdominal and mediastinal lymph nodes specified per lymph node station. Conclusion This is the first randomized controlled trial designed to compare RAMIE to MIE as surgical treatment for resectable esophageal adenocarcinoma or adenocarcinoma of the gastroesophageal junction in the Western World. The hypothesis of the proposed study is that RAMIE will result in a higher abdominal and mediastinal lymph node yield specified per station compared to conventional MIE. Short-term results and the primary endpoint (total number of resected abdominal and mediastinal lymph nodes per lymph node station) will be analyzed and published after discharge of the last randomized patient within this trial. Trial registration ClinicalTrials.gov Identifier: NCT04306458. Registered 13th March 2020, Keywords: MIE, RAMIE, Ivor-Lewis, Esophageal adenocarcinoma, Lymphadenectomy
Active machine learning puts artificial intelligence in charge of a sequential, feedback-driven discovery process. We present the application of a multi-objective active learning scheme for ...identifying small molecules that inhibit the protein-protein interaction between the anti-cancer target CXC chemokine receptor 4 (CXCR4) and its endogenous ligand CXCL-12 (SDF-1). Experimental design by active learning was used to retrieve informative active compounds that continuously improved the adaptive structure-activity model. The balanced character of the compound selection function rapidly delivered new molecular structures with the desired inhibitory activity and at the same time allowed us to focus on informative compounds for model adjustment. The results of our study validate active learning for prospective ligand finding by adaptive, focused screening of large compound repositories and virtual compound libraries.
The π^{0} pole constitutes the lowest-lying singularity of the hadronic light-by-light (HLBL) tensor, and thus, it provides the leading contribution in a dispersive approach to HLBL scattering in the ...anomalous magnetic moment of the muon (g-2)_{μ}. It is unambiguously defined in terms of the doubly virtual pion transition form factor, which in principle, can be accessed in its entirety by experiment. We demonstrate that, in the absence of a direct measurement, the full spacelike doubly virtual form factor can be reconstructed very accurately based on existing data for e^{+}e^{-}→3π, e^{+}e^{-}→e^{+}e^{-}π^{0}, and the π^{0}→γγ decay width. We derive a representation that incorporates all the low-lying singularities of the form factor, matches correctly onto the asymptotic behavior expected from perturbative QCD, and is suitable for the evaluation of the (g-2)_{μ} loop integral. The resulting value, a_{μ}^{π^{0}-pole}=62.6_{-2.5}^{+3.0}×10^{-11}, for the first time, represents a complete data-driven determination of the pion-pole contribution with fully controlled uncertainty estimates. In particular, we show that already improved singly virtual measurements alone would allow one to further reduce the uncertainty in a_{μ}^{π^{0}-pole}.
We analyze the pion transition form factor using dispersion theory. We calculate the singly-virtual form factor in the time-like region based on data for the
e
+
e
-
→
3
π
cross section, generalizing ...previous studies on
ω
,
ϕ
→
3
π
decays and
γ
π
→
π
π
scattering, and verify our result by comparing to
e
+
e
-
→
π
0
γ
data. We perform the analytic continuation to the space-like region, predicting the poorly-constrained space-like transition form factor below
1
GeV
, and extract the slope of the form factor at vanishing momentum transfer
a
π
=
(
30.7
±
0.6
)
×
10
-
3
. We derive the dispersive formalism necessary for the extension of these results to the doubly-virtual case, as required for the pion-pole contribution to hadronic light-by-light scattering in the anomalous magnetic moment of the muon.
We present cosmological parameter constraints from a tomographic weak gravitational lensing analysis of ~450 deg super( 2) of imaging data from the Kilo Degree Survey (KiDS). For a flat ... cold dark ...matter (...CDM) cosmology with a prior on H sub( 0) that encompasses the most recent direct measurements, we find S sub( 8) ... = 0.745 plus or minus 0.039. This result is in good agreement with other low-redshift probes of large-scale structure, including recent cosmic shear results, along with pre-Planck cosmic microwave background constraints. A 2.3... tension in S sub( 8) and 'substantial discordance' in the full parameter space is found with respect to the Planck 2015 results. We use shear measurements for nearly 15 million galaxies, determined with a new improved 'self-calibrating' version of lensfit validated using an extensive suite of image simulations. Four-band ugri photometric redshifts are calibrated directly with deep spectroscopic surveys. The redshift calibration is confirmed using two independent techniques based on angular cross-correlations and the properties of the photometric redshift probability distributions. Our covariance matrix is determined using an analytical approach, verified numerically with large mock galaxy catalogues. We account for uncertainties in the modelling of intrinsic galaxy alignments and the impact of baryon feedback on the shape of the non-linear matter power spectrum, in addition to the small residual uncertainties in the shear and redshift calibration. The cosmology analysis was performed blind. Our high-level data products, including shear correlation functions, covariance matrices, redshift distributions, and Monte Carlo Markov chains are available at http://kids.strw.leidenuniv.nl. (ProQuest: ... denotes formulae/symbols omitted.)
To update the ASCO guideline on the recommended prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer survivors.
An Expert Panel ...conducted targeted systematic literature reviews to identify new studies.
The search strategy identified 257 new references, which led to a full-text review of 87 manuscripts. A total of 3 systematic reviews, 2 with meta-analyses, and 28 primary trials for prevention of CIPN in addition to 14 primary trials related to treatment of established CIPN, are included in this update.
The identified data reconfirmed that no agents are recommended for the prevention of CIPN. The use of acetyl-l-carnitine for the prevention of CIPN in patients with cancer should be discouraged. Furthermore, clinicians should assess the appropriateness of dose delaying, dose reduction, substitutions, or stopping chemotherapy in patients who develop intolerable neuropathy and/or functional impairment. Duloxetine is the only agent that has appropriate evidence to support its use for patients with established painful CIPN. Nonetheless, the amount of benefit from duloxetine is limited.Additional information is available at www.asco.org/survivorship-guidelines.
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