Neutropenic sepsis is a life-threatening combination of neutropenia and infection. Patients undergoing concurrent chemoradiotherapy are at a high risk of neutropenic sepsis and thus are likely to ...present in a clinical setting. This study aimed to evaluate levels of Therapeutic Radiographers' understanding of sepsis signs and response pathways along with the impact of a training session on this.
A teaching session at the trust was conducted by the Sepsis Lead Nurse and utilised a range of active learning techniques including scenario-based questions and a sepsis game. Pre and post-training questionnaires were completed by participants which comprised of multiple-choice questions related to sepsis identification and response. Respondents were asked to rate their confidence in each answer. This enabled scoring to award penalties for higher levels of confidence in incorrect answers and reward high confidence in correct answers. Lower levels of confidence attracted or lost smaller marks.
There was a statistically significant (p < 0.0002) improvement in questionnaire scores after the training session from 42% to 66%. Lower scores on the pre-test responses mainly related to incorrect selection of responses to scenario questions.
This service evaluation has highlighted a lack of sepsis awareness amongst Therapeutic Radiographers. It also demonstrates that an active learning based training session can significantly improve understanding of sepsis.
Sepsis training utilising scenario and response questions should be provided to Therapeutic Radiographers more frequently who are likely to work with patients undergoing concurrent chemoradiotherapy.
We report on the expected sensitivity of dedicated scintillator-based detectors at the LHC for elementary particles with charges much smaller than the electron charge. The dataset provided by a ...prototype scintillator-based detector is used to characterize the performance of the detector and provide an accurate background projection. Detector designs, including a novel slab detector configuration, are considered for the data taking period of the LHC to start in 2022 (Run 3) and for the high luminosity LHC. With the Run 3 dataset, the existence of new particles with masses between 10 MeV and 45 GeV could be excluded at 95% confidence level for charges between 0.003 e and 0.3 e, depending on their mass. With the high luminosity LHC dataset, the expected limits would reach between 10 MeV and 80 GeV for charges between 0.0018 e and 0.3 e, depending on their mass.
We report on a search for elementary particles with charges much smaller than the electron charge using a data sample of proton-proton collisions provided by the CERN Large Hadron Collider in 2018, ...corresponding to an integrated luminosity of 37.5 fb−1 at a center-of-mass energy of 13 TeV. A prototype scintillator-based detector is deployed to conduct the first search at a hadron collider sensitive to particles with charges ≤ 0.1 e . The existence of new particles with masses between 20 and 4700 MeV is excluded at 95% confidence level for charges between 0.006 e and 0.3 e , depending on their mass. New sensitivity is achieved for masses larger than 700 MeV.
We report on the expected sensitivity of dedicated scintillator-based detectors at the LHC for elementary particles with charges much smaller than the electron charge. The dataset provided by a ...prototype scintillator-based detector is used to characterise the performance of the detector and provide an accurate background projection. Detector designs, including a novel slab detector configuration, are considered for the data taking period of the LHC to start in 2022 (Run 3) and for the high luminosity LHC. With the Run 3 dataset, the existence of new particles with masses between 10 MeV and 45 GeV could be excluded at 95% confidence level for charges between 0.003e and 0.3e, depending on their mass. With the high luminosity LHC dataset, the expected limits would reach between 10 MeV and 80 GeV for charges between 0.0018e and 0.3e, depending on their mass
Phys. Rev. D 102, 032002 (2020) We report on a search for elementary particles with charges much smaller than
the electron charge using a data sample of proton-proton collisions provided by
the CERN ...Large Hadron Collider in 2018, corresponding to an integrated
luminosity of 37.5 fb$^{-1}$ at a center-of-mass energy of 13 TeV. A prototype
scintillator-based detector is deployed to conduct the first search at a hadron
collider sensitive to particles with charges ${\leq}0.1e$. The existence of new
particles with masses between 20 and 4700 MeV is excluded at 95% confidence
level for charges between $0.006e$ and $0.3e$, depending on their mass. New
sensitivity is achieved for masses larger than $700$ MeV.
We report on a search for elementary particles with charges much smaller than the electron charge using a data sample of proton-proton collisions provided by the CERN Large Hadron Collider in 2018, ...corresponding to an integrated luminosity of 37.5 fb\(^{-1}\) at a center-of-mass energy of 13 TeV. A prototype scintillator-based detector is deployed to conduct the first search at a hadron collider sensitive to particles with charges \({\leq}0.1e\). The existence of new particles with masses between 20 and 4700 MeV is excluded at 95% confidence level for charges between \(0.006e\) and \(0.3e\), depending on their mass. New sensitivity is achieved for masses larger than \(700\) MeV.
Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised epilepsy with variable seizure prognosis and sex differences in disease presentation. Here, we investigate the combined ...epidemiology of sex, seizure types and precipitants, and their influence on prognosis in JME, through cross-sectional data collected by The Biology of Juvenile Myoclonic Epilepsy (BIOJUME) consortium. 765 individuals met strict inclusion criteria for JME (female:male, 1.8:1). 59% of females and 50% of males reported triggered seizures, and in females only, this was associated with experiencing absence seizures (OR = 2.0, p < 0.001). Absence seizures significantly predicted drug resistance in both males (OR = 3.0, p = 0.001) and females (OR = 3.0, p < 0.001) in univariate analysis. In multivariable analysis in females, catamenial seizures (OR = 14.7, p = 0.001), absence seizures (OR = 6.0, p < 0.001) and stress-precipitated seizures (OR = 5.3, p = 0.02) were associated with drug resistance, while a photoparoxysmal response predicted seizure freedom (OR = 0.47, p = 0.03). Females with both absence seizures and stress-related precipitants constitute the prognostic subgroup in JME with the highest prevalence of drug resistance (49%) compared to females with neither (15%) and males (29%), highlighting the unmet need for effective, targeted interventions for this subgroup. We propose a new prognostic stratification for JME and suggest a role for circuit-based risk of seizure control as an avenue for further investigation.
► An online questionnaire to examine the incidence of plate-cleaning and meal planning. ► Plate-cleaning occurred at 91% of meals, of which the majority were planned. ► Pre-meal plans were resistant ...to modification over the course of the meal. ► Pre-meal planning was the most important predictor of consumption.
The customary approach to the study of meal size suggests that ‘events’ occurring during a meal lead to its termination. Recent research, however, suggests that a number of decisions are made before eating commences that may affect meal size. The present study sought to address three key research questions around meal size: the extent to which plate-cleaning occurs; prevalence of pre-meal planning and its influence on meal size; and the effect of within-meal experiences, notably the development of satiation. To address these, a large-cohort internet-based questionnaire was developed. Results showed that plate-cleaning occurred at 91% of meals, and was planned from the outset in 92% of these cases. A significant relationship between plate-cleaning and meal planning was observed. Pre-meal plans were resistant to modification over the course of the meal: only 18% of participants reported consumption that deviated from expected. By contrast, 28% reported continuing eating beyond satiation, and 57% stated that they could have eaten more at the end of the meal. Logistic regression confirmed pre-meal planning as the most important predictor of consumption. Together, our findings demonstrate the importance of meal planning as a key determinant of meal size and energy intake.
Intracerebral haemorrhage (ICH) is a life-threatening emergency, the incidence of which has increased in part due to an increase in the use of oral anticoagulants. A blood-fluid level within the ...haematoma, as revealed by computed tomography (CT), has been suggested as a marker for oral anticoagulant-associated ICH (OAC-ICH), but the diagnostic specificity and prognostic value of this finding remains unclear. In 855 patients with CT-confirmed acute ICH scanned within 48 h of symptom onset, we investigated the sensitivity and specificity of the presence of a CT-defined blood-fluid level (rated blinded to anticoagulant status) for identifying concomitant anticoagulant use. We also investigated the association of the presence of a blood-fluid level with six-month case fatality. Eighteen patients (2.1%) had a blood-fluid level identified on CT; of those with a blood-fluid level, 15 (83.3%) were taking anticoagulants. The specificity of blood-fluid level for OAC-ICH was 99.4%; the sensitivity was 4.2%. We could not detect an association between the presence of a blood-fluid level and an increased risk of death at six months (OR = 1.21, 95% CI 0.28-3.88, p = 0.769). The presence of a blood-fluid level should alert clinicians to the possibility of OAC-ICH, but absence of a blood-fluid level is not useful in excluding OAC-ICH.
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