We present COOL J1323+0343, an early-type galaxy at \(z = 1.0153 \pm 0.0006\), strongly lensed by a cluster of galaxies at z = \(z = 0.353 \pm 0.001\). This object was originally imaged by DECaLS and ...noted as a gravitational lens by COOL-LAMPS, a collaboration initiated to find strong-lensing systems in recent public optical imaging data, and confirmed with follow-up data. With ground-based grzH imaging and optical spectroscopy from the Las Campanas Observatory and the Nordic Optical Telescope, we derive a stellar mass, metallicity, and star-formation history from stellar-population synthesis modeling. The lens modeling implies a total magnification of \(\mu \sim \)113. The median remnant stellar mass in the source plane is M\(_* \sim 10.63\) \(M_\odot\) and the median star-formation rate in the source plane is SFR \(\sim 1.55 \times 10^{-3}\) M\(_\odot\) yr\(^{-1}\) (log sSFR = -13.4 yr\(^{-1}\)) in the youngest two age bins (0-100 Myr), closest to the epoch of observation. Our measurements place COOL J1323+0343 below the characteristic mass of the stellar mass function, making it an especially compelling target that could help clarify how intermediate mass quiescent galaxies evolve. We reconstruct COOL J1323+0343 in the source plane and fit its light profile. This object is below the expected size-evolution of early-type galaxy at this mass with an effective radius r\(_e \sim\) 0.5 kpc. This extraordinarily magnified and bright lensed early-type galaxy offers an exciting opportunity to study the morphology and star formation history of an intermediate mass early-type galaxy in detail at \(z \sim \)1 .
To measure the prevalence of medically actionable pathogenic variants (PVs) among a population of healthy elderly individuals.
We used targeted sequencing to detect pathogenic or likely pathogenic ...variants in 55 genes associated with autosomal dominant medically actionable conditions, among a population of 13,131 individuals aged 70 or older (mean age 75 years) enrolled in the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Participants had no previous diagnosis or current symptoms of cardiovascular disease, physical disability or dementia, and no current diagnosis of life-threatening cancer. Variant curation followed American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) standards.
One in 75 (1.3%) healthy elderly individuals carried a PV. This was lower than rates reported from population-based studies, which have ranged from 1.8% to 3.4%. We detected 20 PV carriers for Lynch syndrome (MSH6/MLH1/MSH2/PMS2) and 13 for familial hypercholesterolemia (LDLR/APOB/PCSK9). Among 7056 female participants, we detected 15 BRCA1/BRCA2 PV carriers (1 in 470 females). We detected 86 carriers of PVs in lower-penetrance genes associated with inherited cardiac disorders.
Medically actionable PVs are carried in a healthy elderly population. Our findings raise questions about the actionability of lower-penetrance genes, especially when PVs are detected in the absence of symptoms and/or family history of disease.
We report the discovery of COOL J1241+2219, a strongly-lensed galaxy at redshift \(z\)=5.043\(\pm\)0.002 with observed magnitude \(z_{AB}=20.47\), lensed by a moderate-mass galaxy cluster at ...\(z\)=1.001\(\pm\)0.001. COOL J1241+2219 is the brightest lensed galaxy currently known at optical and near-infrared wavelengths at \(z\) \(\gtrsim\) 5; it is \(\sim\)5 times brighter than the prior record-holder lensed galaxy, and several magnitudes brighter than the brightest unlensed galaxies known at these redshifts. It was discovered as part of COOL-LAMPS, a collaboration initiated to find strongly lensed systems in recent public optical imaging data. We characterise the lensed galaxy, as well as the central galaxy of the lensing cluster using ground-based \(griz\)JH imaging and optical spectroscopy. We report model-based magnitudes, and derive stellar masses, dust content, metallicity and star-formation rates via stellar-population synthesis modeling. Our lens mass modeling, based on ground-based imaging, implies a median source magnification of \(\sim\)30, which puts the stellar mass and star formation rate (in the youngest age bin, closest to the epoch of observation) at logM\(_{*}\) = \(10.11^{+0.21}_{-0.26}\) and SFR = \(27^{+13}_{-9}\) M\(_{\odot}\)/yr, respectively. We constrain a star formation history for COOL J1241+2219 consistent with constant star formation across \(\sim\)1 Gyr of cosmic time, and that places this galaxy on the high-mass end of the star-forming main sequence. COOL J1241+2219 is 2-4 times more luminous than a galaxy with the characteristic UV luminosity at these redshifts. The UV continuum slope \(\beta\)= -2.2\(\pm\)0.2 places this galaxy on the blue side of the observed distribution of galaxies at \(z\)=5, although the lack of Ly\(\alpha\) emission indicates dust sufficient to suppress this emission.
We report the discovery of five bright strong gravitationally lensed galaxies at \(3 < z < 4\): COOLJ0101\(+\)2055 (\(z = 3.459\)), COOLJ0104\(-\)0757 (\(z = 3.480\)), COOLJ0145\(+\)1018 (\(z = ...3.310\)), COOLJ0516\(-\)2208 (\(z = 3.549\)), and COOLJ1356\(+\)0339 (\(z = 3.753\)). These galaxies have magnitudes of \(r_{\rm AB}, z_{\rm AB} < 21.81\) mag and are lensed by galaxy clusters at \(0.26 < z < 1\). This sample nearly doubles the number of known bright lensed galaxies with extended arcs at \(3 < z < 4\). We characterize the lensed galaxies using ground-based grz/giy imaging and optical spectroscopy. We report model-based magnitudes and derive stellar masses, dust content, and star-formation rates via stellar population synthesis modeling. Building lens models based on ground-based imaging, we estimate source magnifications in the range \(\sim\)29 to \(\sim\)180. Combining these analyses, we derive demagnified stellar masses in the range \(\rm log_{10}(M_{*}/M_{\odot}) \sim 9.69 - 10.75\) and star formation rates in the youngest age bin ranging from \(\rm log_{10}(SFR/(M_{\odot}\cdot yr^{-1})) \sim 0.39 - 1.46\), placing the sample galaxies on the massive end of the star-forming main sequence in this redshift interval. In addition, three of the five galaxies have strong Ly\(\alpha\) emissions, offering unique opportunities to study Ly\(\alpha\) emitters at high redshift in future work.
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