Relative brain size has long been considered a reflection of cognitive capacities and has played a fundamental role in developing core theories in the life sciences. Yet, the notion that relative ...brain size validly represents selection on brain size relies on the untested assumptions that brain-body allometry is restrained to a stable scaling relationship across species and that any deviation from this slope is due to selection on brain size. Using the largest fossil and extant dataset yet assembled, we find that shifts in allometric slope underpin major transitions in mammalian evolution and are often primarily characterized by marked changes in body size. Our results reveal that the largest-brained mammals achieved large relative brain sizes by highly divergent paths. These findings prompt a reevaluation of the traditional paradigm of relative brain size and open new opportunities to improve our understanding of the genetic and developmental mechanisms that influence brain size.
The Asteroid Terrestrial-impact Last Alert System (ATLAS) carries out its primary planetary defense mission by surveying about 13,000 deg2 at least four times per night. The resulting data set is ...useful for the discovery of variable stars to a magnitude limit fainter than r ∼ 18, with amplitudes down to 0.02 mag for bright objects. Here, we present a Data Release One catalog of variable stars based on analyzing the light curves of 142 million stars that were measured at least 100 times in the first two years of ATLAS operations. Using a Lomb-Scargle periodogram and other variability metrics, we identify 4.7 million candidate variables. Through the Space Telescope Science Institute, we publicly release light curves for all of them, together with a vector of 169 classification features for each star. We do this at the level of unconfirmed candidate variables in order to provide the community with a large set of homogeneously analyzed photometry and to avoid pre-judging which types of objects others may find most interesting. We use machine learning to classify the candidates into 15 different broad categories based on light-curve morphology. About 10% (427,000 stars) pass extensive tests designed to screen out spurious variability detections: we label these as "probable" variables. Of these, 214,000 receive specific classifications as eclipsing binaries, pulsating, Mira-type, or sinusoidal variables: these are the "classified" variables. New discoveries among the probable variables number 315,000, while 141,000 of the classified variables are new, including about 10,400 pulsating variables, 2060 Mira stars, and 74,700 eclipsing binaries.
New estimates of measurement and sampling uncertainties of gridded in situ sea surface temperature anomalies are calculated for 1850 to 2006. The measurement uncertainties account for correlations ...between errors in observations made by the same ship or buoy due, for example, to miscalibration of the thermometer. Correlations between the errors increase the estimated uncertainties on grid box averages. In grid boxes where there are many observations from only a few ships or drifting buoys, this increase can be large. The correlations also increase uncertainties of regional, hemispheric, and global averages above and beyond the increase arising solely from the inflation of the grid box uncertainties. This is due to correlations in the errors between grid boxes visited by the same ship or drifting buoy. At times when reliable estimates can be made, the uncertainties in global average, Southern Hemisphere, and tropical sea surface temperature anomalies are between 2 and 3 times as large as when calculated assuming the errors are uncorrelated. Uncertainties of Northern Hemisphere averages are approximately double. A new estimate is also made of sampling uncertainties. They are largest in regions of high sea surface temperature variability such as the western boundary currents and along the northern boundary of the Southern Ocean. The sampling uncertainties are generally smaller in the tropics and in the ocean gyres.
Key Points
Errors in SST measurements are correlated
Errors in SST measurements have previously been underestimated
New error estimates in SST data have been made which account for these
The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant ...CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of intrathymic ectopic lipid. CR-induced transcriptional reprogramming in adipose tissue implicated pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity. Expression of the gene
encoding platelet activating factor acetyl hydrolase (PLA2G7) is inhibited in humans undergoing CR. Deletion of Pla2g7 in mice showed decreased thymic lipoatrophy, protection against age-related inflammation, lowered NLRP3 inflammasome activation, and improved metabolic health. Therefore, the reduction of PLA2G7 may mediate the immunometabolic effects of CR and could potentially be harnessed to lower inflammation and extend the health span.
Introduction and objectivesSurgical site infections (SSIs) represent a common and serious complication of all surgical interventions. Microorganisms are able to colonise sutures that are implanted in ...the skin, which is a causative factor of SSIs. Triclosan-coated sutures are antibacterial sutures aimed at reducing SSIs. Our objective is to update the existing literature by systematically reviewing available evidence to assess the effectiveness of triclosan-coated sutures in the prevention of SSIs.MethodsA systematic review of EMBASE, MEDLINE, AMED (Allied and complementary medicine database) and CENTRAL was performed to identify full text randomised controlled trials (RCTs) on 31 May 2019.InterventionTriclosan-coated sutures versus non-triclosan-coated sutures.Primary outcomeOur primary outcome was the development of SSIs at 30 days postoperatively. A meta-analysis was performed using a fixed-effects model.ResultsTwenty-five RCTs were included involving 11 957 participants. Triclosan-coated sutures were used in 6008 participants and non triclosan-coated sutures were used in 5949. Triclosan-coated sutures significantly reduced the risk of SSIs at 30 days (relative risk 0.73, 95% CI 0.65 to 0.82). Further sensitivity analysis demonstrated that triclosan-coated sutures significantly reduced the risk of SSIs in both clean and contaminated surgery.ConclusionTriclosan-coated sutures have been shown to significantly reduced the risk of SSIs when compared with standard sutures. This is in agreement with previous work in this area. This study represented the largest review to date in this area. This moderate quality evidence recommends the use of triclosan-coated sutures in order to reduce the risk of SSIs particularly in clean and contaminated surgical procedures.PROSPERO registration numberCRD42014014856
PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small ...biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.
We present infrared observations of 66 starburst galaxies over the full range of oxygen abundances observed in local star-forming galaxies, from image to 8.9. The data include imaging and ...spectroscopy from the Spitzer Space Telescope, supplemented by ground-based near-infrared imaging. We confirm a strong correlation of aromatic emission with metallicity, with a threshold at image. We show that the far-infrared color temperature of the large dust grains increases toward lower metallicity, peaking at a metallicity of 8 before turning over. We compute dust masses and compare them to H i masses from the literature to derive the ratio of atomic gas to dust, which increases by nearly 3 orders of magnitude between solar metallicity and a metallicity of 8, below which it flattens out. The abrupt change in aromatic emission at mid-infrared wavelengths thus appears to be reflected in the far-infrared properties, indicating that metallicity changes affect the composition of the full range of dust grain sizes that dominate the infrared emission. Although the great majority of galaxies show similar patterns of behavior as described above, there are three exceptions, SBS 0335-052E, Haro 11, and SHOC 391. Their infrared SEDs are dominated energetically by the mid- IR near 24 mum rather than by the 60-200 mum region. In addition, they have very weak near-infrared outputs and their SEDs are dominated by emission by dust at wavelengths as short as 1.8 mum. The latter behavior indicates that the dominant star-forming episodes in them are extremely young. The component of the ISM responsible for the usual far-infrared emission appears to be either missing or inefficiently heated in these three galaxies.
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