Accurate and generalized collaborative prediction of multi-cluster renewable energy power generation is both an inevitable trend and urgent demand as the growth of multi-region interconnected power ...grids with wind and photovoltaic (PV) power. In this paper, a novel heterogeneous spatiotemporal graph convolution network (HSTGCN) is proposed for ultra-short-term multi-modal prediction oriented to wind-PV power, which sufficiently considers spatiotemporal correlations in tens of wind farms or PV stations of each neighboring region and effectively coordinates the heterogeneities of different power generation types in different regions. This approach first designs a dynamical heterogeneous graph structure including modes, nodes, and edges to give a unified framework evolving over time for different interdependencies in the multi-cluster wind and PV sites, and then develops a hierarchical spatiotemporal learning mechanism to enhance representation power for multi-cluster prior information from temporal and spatial dimensions, integrating 2-D CNN with different sizes of filters and GCN embedded a specially designed lightweight graph convolution attention module (GCAM). Experiments including 57 operating wind farms and PV stations from 4 regions distributed over a broad spatial scale demonstrate the generalization and interpretation of HSTGCN compared with other commonly considered benchmarks.
Cyclin-dependent kinase 9 (CDK9) plays a critical role in transcription initiation and is essential for maintaining gene silencing at heterochromatic loci. Inhibition of CDK9 increases sensitivity to ...immunotherapy, but the underlying mechanism remains unclear. We now report that RNF20 stabilizes LSD1 via K29-mediated ubiquitination, which is dependent on CDK9-mediated phosphorylation. This CDK9- and RNF20-dependent LSD1 stabilization is necessary for the demethylation of histone H3K4, then subsequent repression of endogenous retrovirus, and an interferon response, leading to epigenetic immunosuppression. Moreover, we found that loss of RNF20 sensitizes cancer cells to the immune checkpoint inhibitor anti-PD-1 in vivo and that this effect can be rescued by the expression of ectopic LSD1. Our findings are supported by the observation that RNF20 levels correlate with LSD1 levels in human breast cancer specimens. This study sheds light on the role of RNF20 in CDK9-dependent LSD1 stabilization, which is crucial for epigenetic silencing and immunosuppression. Our findings explore the potential importance of targeting the CDK9-RNF20-LSD1 axis in the development of new cancer therapies.
In recent years, with the rapid development of mobile social networks and services, the research of mobile malicious webpage detection has become a hot topic. Most of the existing malicious webpage ...detection systems are deployed on desktop systems and servers. Due to the limitation of network transmission delay and computing resources, these existing solutions fail to provide the real‐time and lightweight properties for mobile webpage detection. In this paper, we propose an advanced mobile malicious webpage detection framework based on deep learning and edge cloud. Inspired by the idea of edge computing, a multidevice load optimization approach is first introduced to improve detection efficiency. Second, an automatic extraction approach based on deep learning model features is presented to enhance detection accuracy. Furthermore, detection systems can be flexibly deployed on edge nodes and servers, thus providing the properties of resource optimization deployment and real‐time detection. Finally, comparative analysis and performance evaluation are presented to show the detection efficiency and accuracy of the proposed framework.
Using alternating diene metathesis (ALTMET) polycondensation and acyclic diene metathesis (ADMET) polymerization, two kinds of alternating and random copolymers from electron-deficient azobenzene ...(azo)-functionalized α,ω-diene monomers that are photoresponsive molecules and comonomers such as electron-rich carbazole or fluorene-functionalized diene or diacrylate monomers were synthesized. All of these copolymers were tailored to explore the effects of alternating and random monomer sequences and electron transfer capability on the self-assembly morphology and photoresponsive properties. As expected, the distinct absorption features from azo units in these copolymers are observed in their optical spectra, which cannot be achieved by traditional azo-containing homo- and copolymers. Because of the presence of stiff and electron-rich carbazole or fluorene motifs, the ability and efficiency of photoisomerization was depressed to some extent according to the sequential differences of two monomers and the electron effect in the copolymer chain. Moreover, the sizes and morphologies of alternating copolymers can be modulated through the methylene spacer and sequence of rigid conjugated motifs generating diverse nanostructures leading to a different chain mobility, which ultimately exhibited the unique photoisomerization behaviors. These interesting findings not only demonstrate a facile and efficient method for constructing azo-carbazole and azo-fluorene metathesis copolymers but also expand the optical properties of azo-containing polymers.
•The astringency is primarily concentrated in the seed coat rather than the seed kernel.•NaHCO3 treatment promotes postharvest de-astringency of Torreya grandis nuts.•Differential metabolites ...analysis showed condensed tannins account for astringency.•EGC, GC, catechin, procyanidin (B1-3, C1) are potential components to astringency.
Astringency removal is important for the quality of Torreya grandis nut and occurs after harvest. Here, we evaluated the effect of NaHCO3 treatment on astringency removal and compared the differential metabolites of the seed coat and kernel using a UHPLC QQQ-MS-based metabolomics approach. The result revealed the nut astringency was primarily enriched in the seed coat with more soluble tannins. The NaHCO3 treatment greatly shortened the de-astringency process, as indicated by a faster conversion of soluble tannins to insoluble tannins and more acetaldehyde production. Besides, a total of 293 metabolites, including 92 phenolic acids and 37 flavonoids, were tentatively characterized in the seed coat. A further comparative analysis of the metabolomics indicated epigallocatechin, gallocatechin, catechin, procyanidin B1, B2, B3 and C1 to be the major metabolites influenced by the NaHCO3 treatment. This study provides new insights regarding the metabolite differences of Torreya grandis nuts processed with different de-astringent treatments.
With the development of Internet finance, the real estate financial credentials have been extensively utilized in capital and trading markets. The extensive use of these private credentials, e.g., ...exchange, circulation or sharing on public clouds, can cause severe security and privacy problems. Existing security solutions for financial credentials may either introduce undesired overhead or fail to provide traceability and anonymity for data sharing. In this paper, we propose an enhanced blockchain-based secure sharing scheme for real estate financial credentials, providing the following three properties: credential confidentiality, anonymous authentication, identity tracking and transaction auditing. A comprehensive evaluation, including security analysis, efficiency analysis and simulation evaluation, is presented to show the security and feasibility of the proposed scheme.
•The chemical vapor deposition method realizes the controllable preparation of uniform γ-In2Se3 nanosheets.•Growing γ-In2Se3 nanosheets on SiO2/Si substrates can avoid potential contamination and ...damage during the transfer process.•The prepared γ-In2Se3 based photodetector has a stable broadband optical response.
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Two-dimensional (2D) In2Se3 with excellent optical and electrical properties has great application potential for flexible devices, photodetectors, and phase change memories. Here, we report the successes of growing In2Se3 nanosheets on SiO2/Si substrates by chemical vapor deposition (CVD) and fabricating broadband photodetector based on In2Se3. The Raman spectroscopy and transmission electron microscopy studies indicate that our 2D In2Se3 is in γ-phase. Our 2D γ-In2Se3 photodetector shows a broadband response range from near ultraviolet (350 nm) to infrared (1000 nm). The stable broadband response provides opportunities for the application of 2D γ-In2Se3-based devices and also a reference for the preparation and application of other 2D materials.
•Terpenes were the predominant aromatic compounds in harvested raw T. grandis nuts.•High humidity treatments enhanced terpene formation.•High humidity treatments promoted terpenes by stimulating ...d-limonene synthesis.
The postharvest ripening stage is necessary for Torreya grandis (T. grandis) nuts to complete aromatic synthesis, which requires appropriate temperature and relative humidity (RH). Currently, scarce information is available regarding the changes in aroma profiles in T. grandis nuts and the relationship with their response to different environmental conditions. Therefore, the interaction of temperature (20 °C or 30 °C) and relative humidity (70% RH or 90% RH) was investigated on aromatic substances after harvest. The results showed that 56 aromatic components were detected by a gas chromatography-mass spectrometer (GC–MS) and mainly divided into five categories, among which terpenes were the most abundant (56.2–86.7%). Principal component analysis (PCA) showed that both temperature and humidity can affect the aroma composition, and terpenes were mainly influenced by humidity. Specifically, d-limonene occupied the largest proportion of terpenes (63.0–90.8%) and was significantly upregulated by high humidity.
Abstract
Terpenes are volatile compounds responsible for aroma and the postharvest quality of commercially important xiangfei (Torreya grandis) nuts, and there is interest in understanding the ...regulation of their biosynthesis. Here, a transcriptomics analysis of xiangfei nuts after harvest identified 156 genes associated with the terpenoid metabolic pathway. A geranyl diphosphate (GPP) synthase (TgGPPS) involved in production of the monoterpene precursor GPP was targeted for functional characterization, and its transcript levels positively correlated with terpene levels. Furthermore, transient overexpression of TgGPPS in tobacco (Nicotiana tabacum) leaves or tomato (Solanum lycopersicum) fruit led to monoterpene accumulation. Analysis of differentially expressed transcription factors identified one basic helix-loop-helix protein (TgbHLH95) and one basic leucine zipper protein (TgbZIP44) as potential TgGPPS regulators. TgbHLH95 showed significant transactivation of the TgGPPS promoter, and its transient overexpression in tobacco leaves led to monoterpene accumulation, whereas TgbZIP44 directly bound to an ACGT-containing element in the TgGPPS promoter, as determined by yeast 1-hybrid test and electrophoretic mobility shift assay. Bimolecular fluorescence complementation, firefly luciferase complementation imaging, co-immunoprecipitation, and GST pull-down assays confirmed a direct protein–protein interaction between TgbHLH95 and TgbZIP44 in vivo and in vitro, and in combination these proteins induced the TgGPPS promoter up to 4.7-fold in transactivation assays. These results indicate that a TgbHLH95/TgbZIP44 complex activates the TgGPPS promoter and upregulates terpene biosynthesis in xiangfei nuts after harvest, thereby contributing to its aroma.
A bHLH-bZIP transcription complex regulates terpene biosynthesis by activating TgGPPS expression in Torreya grandis nuts during the postharvest ripening stage
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