Currently, there are no confident prognostic markers in patients with coronary artery disease (CAD) undergoing angioplasty. The present study aimed to explore whether basal coronary circulating ...Mononuclear Progenitor Cells (MPCs) and vascular injury biomarkers were related to development of major adverse cardiovascular events (MACEs) and may impact clinical prognosis.
Methods
The number of MPCs and soluble mediators such as IL‐1β, sICAM‐1, MMP‐9, malondialdehyde, superoxide dismutase and nitric oxide were determined in coronary and peripheral circulation. Prognostic ability for MACEs occurring at 6 months follow up was assessed by time‐to‐event and event free survival estimations.
Results
Lower coronary circulating MPCs subpopulations CD45+CD34+, CD45+CD34+CD133+CD184+, lower MMP‐9 and higher sICAM‐1 significantly associated with MACEs presentation and showed prognostic ability; while peripheral blood increase in malondialdehyde and decreased superoxide dismutase were observed in patients with MACEs.
Conclusion
Coronary concentration of biomarkers related with vascular repair, such as MPCs subpopulations and adhesion molecules, may predict MACEs and impact prognosis in patients with CAD undergoing angioplasty; whereas peripheral pro‐oxidative condition may be also associated.
•Elimination of vegetative cells of yeast, molds and bacteria by UHPH in must.•Strong inactivation of oxidative enzymes: PPO.•Absence of thermal degradation markers. No detection of HMF.•Higher ...antioxidant activity in UHPH processed must.•UHPH is a powerful tool to reduce SO2 in white wines.
The use of UHPH sterilization in the absence of SO2 has been used to eliminate wild microorganisms and inactivate oxidative enzymes. A white must of the Muscat of Alexandria grape variety was continuously processed by UHPH at 300 MPa (inlet temperature: 23–25 °C). The initial microbial load of the settled must was 4-log CFU/mL for both yeast and moulds, and slightly lower for bacteria. After UHPH processing, no microorganisms were detected in 1 mL. UHPH musts remain without fermentative activity for more than 60 days. Concentrations of the thermal markers indicated the absence of thermal damage in the UHPH-treated musts, since 5-hydroxymethylfurfural was not detected. In addition, the must treated by UHPH keeps terpene concentrations similar to those of the untreated controls. A strong inactivation of the oxidative enzymes was observed, with no browning at room temperature for more than 3 days. The antioxidant value of the UHPH-treated must was 156% higher than the control.
Manual tests in clinical investigation must be supported by anatomical and physiological findings in order to obtain an objective information. The application of different mandibular positions in ...children obtains a variation in the ‘hip rotators test’ (p < 0.001). The possible relationships behind the muscle tone of the external rotators of the hips and the stomatognathic system are exposed, with special attention on the fascial tissue and its morphological characteristics. Despite these anatomical and physiological connections, there is no further evidence of a strong cause-effect relationship in this test.
Objective
The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, ...which are potentially associated with clinical reproductive abnormalities causing infertility in couples.
Methods
Thirty-seven couples who were attending an infertility clinic were enrolled. Detection of genital mycoplasmas was performed in cervicovaginal samples or male urethral swabs. Microbiological culture and biochemical and antimicrobial profiles were characterized using a Mycoplasma kit. The results were associated with reproductive abnormalities, as assessed by medical specialists from the infertility clinic.
Results
Up to 28.3% of all biological samples (n = 74) showed positive cultures. Bacterial isolates were Ureaplasma urealyticum (71.4%), Mycoplasma hominis (9.5%), or coinfections (19%). Most Mollicutes showed significant resistance to fluoroquinolones, macrolides, and tetracycline; and showed susceptibility to doxycycline, josamycin, and pristinamycin. The presence of resistant strains to any antibiotic was significantly associated with genital abnormalities (χ2 test, relative risk = 11.38 95% confidence interval: 5.8–22.9), particularly in women. The highest statistical association was found for macrolide-resistant strains.
Conclusion
The microbiological antibiotic resistance profile is epidemiologically associated with abnormalities of the reproductive system in couples attending an infertility clinic.
Indirect free kicks are relatively common in soccer and have the potential to change the outcome of a match. The aim of this study was to determine the effectiveness of these kicks, to identify ...variables associated with success, and propose a model for optimal execution. We analyzed and coded 506 indirect free kicks taken in 64 matches during the FIFA 2014 World Cup in Brazil and conducted univariate, bivariate (chi-square), and multivariate (binary logistic regression) analyses. Our results show very low success rates in terms of shots, shots between the posts, and goals. Nevertheless, 89% of goals scored from indirect free kicks led to the teams gaining valuable points. Determinants of success included a dynamic attack based on the creation and occupation of spaces and the intervention of up to four attackers. Our findings offer an interesting starting point for trainers to build on tactical strategies designed to improve free-kick performance.
The physical-chemical composition, sensory characteristics, and nutritional value of the grape juice can provide sports drink (isotonic beverage) with antioxidant compounds that complement the ...beneficial effect of these drinks to the rehydration and replacement of minerals and carbohydrates, during physical activity. Grape juice contains mainly water, sugars, organic acids, and phenolic compounds. By diluting the sugar content of the must to 40-50 g/L, it will allow us to obtain a drink with beneficial properties for health, avoiding the addition of sweeteners. Phenolic compounds play an important role in the prevention of various diseases through their biological activities related to antioxidant, anti-inflammatory, anticancer, anti-aging, antimicrobial and cardioprotective properties. Several studies have shown that grape juice allows to improve the performance of the activity, protect against oxidative damage, and reduce inflammation during, sports activities. The polyphenolic substances present in grape musts provide sensory characteristics of interest, mainly color and aroma, important indicators for consumers when choosing this type of beverage. The anthocyanin content of musts from red varieties, gives the drink a more natural and attractive character for the consumer without the use of synthetic dyes. It is important to recognize the demand of consumers for new innovative, and healthy products, so we focus on the development of a natural, functional drink using red grape musts as a base (concentrated or treated with UHPH) as a source of polyphenols and sugars, showing interesting organoleptic properties without chemical additives, and that allows to replenish electrolytes and energy.
The use of unconventional yeasts, also called non-
Saccharomyces
yeasts, is a hot topic in current enology due to the improvement that can be produced in the sensory profile during fermentation. ...However, the use of these yeasts have problems due to difficulties in the implantation and competition with wild
Saccharomyces
yeasts. Ultra-High Pressure Homogenization (UHPH) has demonstrated to be a powerful tool to eliminate microorganisms in grape must, specially yeast and bacteria even at low in-valve temperatures. UHPH can be considered a non-thermal technology with protective effect on sensitive molecules as terpenes and anthocyanins. The preprocessing of must by UHPH leaves it free of yeast with an optimal sensory quality, being this a perfect situation to inoculate non-
Saccharomyces
yeasts. We have fermented UHPH musts and controls with several non-
Saccharomyces
species (
Lachancea thermotolerans
,
Metschnikowia pulcherrima
,
Torulaspora delbrueckii
,
Hanseniaspora vineae
), reaching in most of the UHPH treatments better implantations of the inoculated yeasts and a complete elimination of wild yeasts. The impact of the UHPH treatment is a better expression of the metabolic and enzymatic activities of the non-
Saccharomyces
yeasts. That effect enhances the sensory quality and facilitates the use of non-
Saccharomyces
yeasts at industrial scale.
The implementation of collaborative approaches in supply chains is an objective of many companies. The proposal of this work is to present a model that favors horizontal integration at the ...tactical-operational level of the supply chain. The model is based in the principles of logistics flow management; and in the balance of demand, supplies, capacities and stocks. The main contribution of the research is the practical application of collaborative planning as a daily tool for integration between all supply chain echelons. The results obtained in the case studies show that this type of approach improve the efficiency and effectiveness of the logistics system.
Freshness, although it is a concept difficult to define in wines, can be understood as a combination of different circumstances. Organolepticwise, bluish red, floral and fruity, more acidic and ...full-bodied wines, are perceived as younger and fresher by consumers. In traditional winemaking processes, these attributes are hard to boost if no other technology or biotechnology is involved. In this regard, the right selection of yeast strains plays an important role in meeting these parameters and obtaining wines with fresher profiles. Another approach in getting fresh wines is through the use of novel non-thermal technologies during winemaking. Herein, the contributions of non-
yeasts and emerging technologies to these parameters are reviewed and discussed.
PDF
