Objective: To explore the survival status and prognostic factors of patients with pancreatic cancer in Hainan.
Methods: Clinical data of patients who were diagnosed as pancreatic cancer and visited ...the First and Second Affiliated Hospital of Hainan Medical University and Haikou People's Hospital from 2013 to 2017 were collected based on electronic medical records. Basic information was collected by a self-designed questionnaire. Data about admission examinations including blood routine examination, blood biochemistry tests, tumour markers tests, imaging examination and other clinical tests were also collected. The date of follow-up via telephone was 30 June 2018. The survival rate was analyzed by the Kaplan-Meier method and the logrank test. Univariate and multivariate analyses were performed with COX regression model.
Results: A total of 198 patients were included in the study. Kaplan-Meier results showed that the overall survival (OS) in 6 months and 1, 2, 3 and 5 years was 47.4%, 26.8%, 16.4%, 13.2%, and 8.7%, respectively. The median OS was 5.8 months. Log-rank test analysis found that there were significant differences in OS among patients with different age, surgery status, distant metastasis or absolute number of neutrophils, percentage of neutrophils, absolute number of lymphocytes, neutrophil-to-lymphocyte ratio (NLR), CA199 and carcino-embryonic antigen (P<0.1). COX multivariate analysis showed that age, surgical presence, presence or absence of distant metastasis and NLR were significantly associated OS (P<0.05).
Conclusions: Older age, higher NLR and liver or lung metastasis are independent risk factors, while surgical treatment is an independent protective factor for patients with pancreatic cancer.
Abstract
Under hydrothermal conditions, two families of new Cu
II
‐substituted sandwich‐type germanotungstates (GTs): Cu
6
‐GTs (enH
2
)
2
Cu(en)
2
2
Cu
6
(en)
2
(H
2
O)
2
(B‐α‐GeW
9
O
34
)
2
⋅4H
2
...O (
1
), H
4
Cu(deta)(H
2
O)
2
Cu
6
(en)
2
(H
2
O)
2
(B‐GeW
9
O
34
)
2
⋅8H
2
O (
2
), Cu(en)(H
2
O)
2
2
Cu(en)
2
2
Cu
6
(en)
2
(H
2
O)
2
(B‐α‐GeW
9
O
34
)
2
⋅8H
2
O (
3
) (en=ethylenediamine, deta=diethylenetriamine) and Cu
4
‐GTs H
4
Cu(H
2
O)
4
2
Cu(H
2
O)
5
2
Cu
4
(H
2
O)
2
(B‐α‐GeW
9
O
34
)
2
⋅8H
2
O (
4
), H
10
Cu(H
2
O)
3
(Cl)
2
Cu
4
(B‐α‐GeW
9
O
34
)
2
⋅8H
2
O (
5
), H
8
Na(H
2
O)
4
2
Cu(H
2
O)
3
(Cl)
2
Cu
4
(B‐α‐GeW
9
O
34
)
2
⋅8H
2
O (
6
) have been made and characterized. Single‐crystal structural analyses indicate that
1–3
contain a belt‐like hexa‐Cu
II
substituted sandwich‐type Cu
6
(en)
2
(H
2
O)
2
(B‐α‐GeW
9
O
34
)
2
8+
unit. Notably,
1–3
are rare organic‐inorganic hybrid polyoxometalates with Cu
6
(en)
2
(H
2
O)
2
(B‐α‐GeW
9
O
34
)
2
8−
subunits, displaying the assembly from 1‐D chain to 3‐D framework by the Cu(en)
2
2+
or Cu(deta)
2
(H
2
O)
2+
linkers.
4–6
contain rhomb‐like tetra‐Cu
II
substituted sandwich‐type Cu
4
(H
2
O)
n
(B‐α‐GeW
9
O
34
)
2
12−
(n=2, 0) units linked by Cu(H
2
O)
4
2+
or Cu
2
(H
2
O)
6
Cl
2
+
clusters to from 1‐D chain. Magnetic measurements performed on
3
indicate the occurrence of ferromagnetic interactions within the copper ions. Furthermore, the electrochemical and electro‐catalysis properties of
3
have been studied in 0.02 M H
2
SO
4
+ 0.5 M Na
2
SO
4
solution, and show good electro‐catalytic activity to the reduction of nitrite.
The effects of sintering temperature and Bi2O3 content on the microstructure and magnetic properties of lithium-zinc (LiZn) ferrites prepared by a conventional ceramic method were investigated. The ...results show that the densification behavior and grain growth rate were greatly improved by the addition of Bi2O3, because a liquid phase sintering occurred during the sintering process at high temperature due to the low-melting point of Bi2O3 (825 deg C). X-ray diffraction (XRD) patterns of the slightly doped samples did not reveal the appearance of any phase other than spinel LiZn ferrite. However, the secondary phase of perovskite BiFeO3 was detected for Bi2O3 content of more than 0.25wt%. The studies further show that Bi oxide was present at grain boundary, and promoted the grain growth as reaction center at lower temperature. A high saturation magnetization, squareness ratio, minimum ferromagnetic resonance linewidth and low coercive force were obtained for the sample with 1.00wt% Bi2O additive at lower sintering temperature (1100 deg C).
We present a study of a transition metal oxide composite modified n-Si photoanode for efficient and stable water oxidation. This sputter-coated composite functions as a protective coating to prevent ...Si from photodecomposition, a Schottky heterojunction, a hole conducting layer for efficient charge separation and transportation, and an electrocatalyst to reduce the reaction overpotential. The formation of mixed-valence oxides composed of Ni and Ru effectively modifies the optical, electrical, and catalytic properties of the coating material, as well as the interfaces with Si. The successful application of this oxide composite on nanotextured Si demonstrates improved conversion efficiency due to enhanced catalytic activity, minimized reflection, and increased surface reaction sites. Although the coated nanotextured Si shows a noticeable degradation from 500 cycles of operation, the oxide composite provides a simple method to enable unstable photoanode materials for solar fuel conversion.
Objective
To investigate the antidepressant-like effects of Chaihu Shugan Powder (CSP, 柴胡疏肝散) and to explore its underlying mechanisms.
Methods
Thirty-two Sprague-Dawley rats were randomly divided ...into control (CON), chronic unpredictable mild stress (CUMS), fluoxetine (FLU), and CSP groups, 8 rats in each group. All of the rats except for those in the control group were subjected to 3 consecutive weeks of CUMS to establish the depression model. The open field test (OFT), forced swimming test (FST), and sucrose preference test were used to assess the anti-anxiety and antidepressant effects of CSP. Terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling was used to determine the apoptosis rate in the hippocampal tissues. The mRNA and protein levels of glucose-regulated protein (GRP) 78, spliced X-box-binding protein (XBP)-1, CCAAT/enhancer-binding protein homologous protein (CHOP), caspase-12, and
c
-Jun N-terminal kinase (JNK) in the hippocampus of rats were evaluated by real-time PCR and Western blot analysis, respectively.
Results
Administration of CSP alleviated anxiety and depression-like behavior in CUMS rats, as revealed by enhanced time and distance in the center of the OFT (
P
<0.05), an increased preference for sucrose, and longer swimming time and shorter immobility time during the FST (all
P
<0.05). In addition, CSP treatment significantly reduced the rate of apoptosis in rat hippocampal neurons
(P
<0.05). The mRNA and protein expression levels of GRP78, spliced XBP-1, and CHOP were down-regulated along with the expression of caspase-12 and cleaved caspase-12 proteins (all
P
<0.05), whereas total and phosphorylated JNK1 protein levels did not differ significantly between control and CSP-treated rats.
Conclusion
CSP can improve depression-like behavior in rats exposed to CUMS, possibly by suppressing CHOP and caspase-12 mediated apoptosis in the rat hippocampus.
Sparse data injection attacks are data injection attacks that target a limited number of sensors in the smart grid paradigm. In this paper, sparse attack construction strategy is proposed for the ...information-theoretic stealth attacks, in which the attacker minimizes the amount of information acquired by the operator about the power system from the observations and the probability of being detected simultaneously. For Gaussian distributed state variables, closed-form expression is proposed for the optimal Gaussian sparse attacks when the attacker targets deterministic observations and gets access to the full system information. Based on that, two target observation selection strategies are introduced to find the vulnerable observations in the system, in which the algorithms take different tradeoff strategies between performance and computational time. Furthermore, a locally perfect stealthy attack construction strategy is proposed for the case in which the attacker only has partial system information but gets access to real-time realizations of the local state variables. The optimality of Gaussian sparse attacks and the performance of the selection strategies are validated on the IEEE 30 Bus and 118 Bus test systems.
This work demonstrates the dependence between magnetic properties and the thickness of NiFe thin films. More importantly, a quantitative study of the surface composition of NiFe thin film exposed to ...atmospheric conditions has been carried out employing angle-resolved X-ray photoelectron spectroscopy (ARXPS). In this study, we fabricated Ni81Fe19 (NiFe) thin films on Si (100) substrate using electron beam evaporation and investigated their surface morphologies, magnetic properties, and the thickness of the surface oxide layer. The coexistence of metallic and oxidized species on the surface are suggested by the depth profile of ARXPS spectra. The thickness of the oxidized species, including NiO, Ni(OH)2, Fe2O3, and Fe3O4, are also estimated based on the ARXPS results. This work provides an effective approach to clarify the surface composition, as well as the thickness of the oxide layer of the thin films.
The relationship between the progression of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and the gut microbiota is poorly understood, and an HBV-ACLF-related microbiome has yet ...to be identified. In this study alterations in the fecal microbiome of 91 patients with HBV-ACLF (109 stool samples), including a cohort of nine patients at different stages of HBV-ACLF, were determined by high-throughput 16S rDNA sequencing. The operational taxonomic units and Shannon indexes indicated that the diversity and abundance of the gut microbiome significantly decreased with the progression of HBV-ACLF (p <0.05). The relative abundance of the
phylum in the microbiome was significantly reduced, whereas the abundance of potentially pathogenic bacteria, such as
,
,
, and
, was highly enriched in the HBV-ACLF group compared with the healthy control group. The abundance of
was negatively correlated with the level of serum alpha fetoprotein, and the abundance of
was positively correlated with serum total bilirubin (TBIL). Furthermore, the abundance of
was significantly negatively correlated with the level of serum TBIL and the international normalized ratio and positively correlated with prothrombin time activity. Our findings suggest that the gut microbiota plays an important role in the development of HBV-ACLF.
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