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zadetkov: 70
1.
  • The Ser82 RAGE Variant Affe... The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro
    Miller, Suzanne; Henry, Amanda P; Hodge, Emily ... PloS one, 10/2016, Letnik: 11, Številka: 10
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    Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the ...
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2.
  • GSTCD and INTS12 regulation... GSTCD and INTS12 regulation and expression in the human lung
    Obeidat, Ma'en; Miller, Suzanne; Probert, Kelly ... PloS one, 09/2013, Letnik: 8, Številka: 9
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    Genome-Wide Association Study (GWAS) meta-analyses have identified a strong association signal for lung function, which maps to a region on 4q24 containing two oppositely transcribed genes: ...
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3.
  • Alternative promoter use an... Alternative promoter use and splice variation in the human histamine H1 receptor gene
    Swan, Caroline; Richards, Susan A; Duroudier, Nathalie P ... American journal of respiratory cell and molecular biology 35, Številka: 1
    Journal Article
    Recenzirano

    Upstream gene structure and mRNA expression of the human histamine H1 receptor gene was investigated in cells relevant to the pathogenesis of asthma, (primary cultured human airway smooth muscle ...
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4.
  • Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα
    Swan, Caroline; Duroudier, Nathalie P; Campbell, Eugene ... Gut, 07/2013, Letnik: 62, Številka: 7
    Journal Article
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    The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms. The authors hypothesised that polymorphisms in genes whose expression ...
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5.
  • Effects on prostate cancer ... Effects on prostate cancer cells of targeting RNA polymerase III
    Petrie, John L; Swan, Caroline; Ingram, Richard M ... Nucleic acids research, 05/2019, Letnik: 47, Številka: 8
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    Abstract RNA polymerase (pol) III occurs in two forms, containing either the POLR3G subunit or the related paralogue POLR3GL. Whereas POLR3GL is ubiquitous, POLR3G is enriched in undifferentiated ...
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6.
  • Impaired Uptake of Serotoni... Impaired Uptake of Serotonin by Platelets From Patients With Irritable Bowel Syndrome Correlates With Duodenal Immune Activation
    Foley, Stephen; Garsed, Klara; Singh, Gulzar ... Gastroenterology (New York, N.Y. 1943), 05/2011, Letnik: 140, Številka: 5
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    Background & Aims Patients with irritable bowel syndrome with diarrhea (IBS-D) have increased mucosal serotonin (5-hydroxytryptamine 5-HT) availability, possibly because immune activation reduces ...
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7.
  • Salmeterol and cytokines mo... Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus
    Smith, Natalie; Browning, Claudia A; Duroudier, Nathalie ... Respiratory research, 09/2007, Letnik: 8, Številka: 1
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    Airway hyper-responsiveness (AHR) is a key feature of asthma and a causal relationship between airway inflammation and AHR has been identified. The aim of the current study was to clarify the effect ...
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8.
  • Functional polymorphism and... Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes
    Duroudier, Nathalie P; Sayers, Ian; Castagna, Charlotte Carabott ... Cell biochemistry and biophysics, 2007, Letnik: 47, Številka: 1
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    Cysteinyl leukotrienes play an important role in the pathophysiology of many inflammatory disorders, including asthma. The aim of this study was to characterize the mechanisms underlying ...
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9.
  • Chloride intracellular channel 1 (CLIC1) contributes to modulation of cyclic AMP‐activated whole‐cell chloride currents in human bronchial epithelial cells
    Liu, Bo; Billington, Charlotte K.; Henry, Amanda P. ... Physiological reports, January 2018, Letnik: 6, Številka: 2
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    Chloride channels are known to play critical physiological roles in many cell types. Here, we describe the expression of anion channels using RNA Seq in primary cultures of human bronchial epithelial ...
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10.
  • HTR4 gene structure and alt... HTR4 gene structure and altered expression in the developing lung
    Hodge, Emily; Nelson, Carl P; Miller, Suzanne ... Respiratory research, 07/2013, Letnik: 14, Številka: 1
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    Meta-analyses of genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) spanning the 5-hydroxytryptamine receptor 4 (5-HT₄R) gene (HTR4) associated with lung ...
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