We discover a new contribution to the pressure (or stress) exerted by a suspension of self-propelled bodies. Through their self-motion, all active matter systems generate a unique swim pressure that ...is entirely athermal in origin. The origin of the swim pressure is based upon the notion that an active body would swim away in space unless confined by boundaries-this confinement pressure is precisely the swim pressure. Here we give the micromechanical basis for the swim stress and use this new perspective to study self-assembly and phase separation in active soft matter. The swim pressure gives rise to a nonequilibrium equation of state for active matter with pressure-volume phase diagrams that resemble a van der Waals loop from equilibrium gas-liquid coexistence. Theoretical predictions are corroborated by Brownian dynamics simulations. Our new swim stress perspective can help analyze and exploit a wide class of active soft matter, from swimming bacteria to catalytic nanobots to molecular motors that activate the cellular cytoskeleton.
The current understanding is that the non-Newtonian rheology of active matter suspensions is governed by fluid-mediated hydrodynamic interactions associated with active self-propulsion. Here we ...discover an additional contribution to the suspension shear stress that predicts both thickening and thinning behavior, even when there is no nematic ordering of the microswimmers with the imposed flow. A simple micromechanical model of active Brownian particles in homogeneous shear flow reveals the existence of off-diagonal shear components in the swim stress tensor, which are independent of hydrodynamic interactions and fluid disturbances. Theoretical predictions from our model are consistent with existing experimental measurements of the shear viscosity of active suspensions, but also suggest new behavior not predicted by conventional models.
We report an improved measurement of the cosmic microwave background B-mode polarization power spectrum with the Polarbear experiment at 150 GHz. By adding new data collected during the second season ...of observations (2013-2014) to re-analyzed data from the first season (2012-2013), we have reduced twofold the band-power uncertainties. The band powers are reported over angular multipoles , where the dominant B-mode signal is expected to be due to the gravitational lensing of E-modes. We reject the null hypothesis of no B-mode polarization at a confidence of 3.1 including both statistical and systematic uncertainties. We test the consistency of the measured B-modes with the Λ Cold Dark Matter (ΛCDM) framework by fitting for a single lensing amplitude parameter AL relative to the Planck 2015 best-fit model prediction. We obtain 0.14(foreground) 0.04(multi), where is the fiducial ΛCDM value.
Towards a thermodynamics of active matter Takatori, S C; Brady, J F
Physical review. E, Statistical, nonlinear, and soft matter physics
91, Številka:
3
Journal Article
Odprti dostop
Self-propulsion allows living systems to display self-organization and unusual phase behavior. Unlike passive systems in thermal equilibrium, active matter systems are not constrained by conventional ...thermodynamic laws. A question arises, however, as to what extent, if any, can concepts from classical thermodynamics be applied to nonequilibrium systems like active matter. Here we use the new swim pressure perspective to develop a simple theory for predicting phase separation in active matter. Using purely mechanical arguments we generate a phase diagram with a spinodal and critical point, and define a nonequilibrium chemical potential to interpret the "binodal." We provide a generalization of thermodynamic concepts like the free energy and temperature for nonequilibrium active systems. Our theory agrees with existing simulation data both qualitatively and quantitatively and may provide a framework for understanding and predicting the behavior of nonequilibrium active systems.
We present the first measurement of cross-correlation between the lensing potential, reconstructed from cosmic microwave background (CMB) polarization data, and the cosmic shear field from galaxy ...shapes. This measurement is made using data from the Polarbear CMB experiment and the Subaru Hyper Suprime-Cam (HSC) survey. By analyzing an 11 deg2 overlapping region, we reject the null hypothesis at 3.5 and constrain the amplitude of the cross-spectrum to , where is the amplitude normalized with respect to the Planck 2018 prediction, based on the flat Λ cold dark matter cosmology. The first measurement of this cross-spectrum without relying on CMB temperature measurements is possible owing to the deep Polarbear map with a noise level of ∼6 K arcmin, as well as the deep HSC data with a high galaxy number density of . We present a detailed study of the systematics budget to show that residual systematics in our results are negligibly small, which demonstrates the future potential of this cross-correlation technique.
Several lines of evidence suggest that aberrant Notch signaling contributes to the development of several types of cancer. Activation of Notch receptor is executed through intramembrane proteolysis ...by γ-secretase, which is a multimeric membrane-embedded protease comprised of presenilin, nicastrin (NCT), anterior pharynx defective 1 and PEN-2. In this study, we report the neutralization of the γ-secretase activity by a novel monoclonal antibody A5226A against the extracellular domain of NCT, generated by using a recombinant budded baculovirus as an immunogen. This antibody recognized fully glycosylated mature NCT in the active γ-secretase complex on the cell surface, and inhibited the γ-secretase activity by competing with the substrate binding in vitro. Moreover, A5226A abolished the γ-secretase activity-dependent growth of cancer cells in a xenograft model. Our data provide compelling evidence that NCT is a molecular target for the mechanism-based inhibition of γ-secretase, and that targeting NCT might be a novel therapeutic strategy against cancer caused by aberrant γ-secretase activity and Notch signaling.
POLARBEAR-2b (PB-2b) is the second of three cryogenic receivers of the Simons Array cosmic microwave background polarization experiment. PB-2b contains over 7500 transition-edge sensor (TES) ...bolometers cooled to 250 mK and read out using digital frequency-division multiplexing (DfMux). Stray impedance in the DfMux circuit obscures TES characterization and affects TES dynamic behavior. In order to accurately characterize TESs, it is necessary to account for stray impedance in the bias circuit. We define a stray impedance model, and we describe the technique used to measure model parameters in situ and to remove their effects on TES characterization. We use the same model to predict TES dynamic behavior and show good agreement between data and the model.
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