Congenital hemoglobin disorders typically present as hemolytic anemia, but there are also numerous reports of thrombotic complications in these diseases, suggesting an associated hypercoagulative ...state. In hemoglobin Köln, the most common type of unstable hemoglobinopathy worldwide, there have not been many reports of such thrombotic phenomena. We herein describe the case of a patient with hemoglobin Köln demonstrating acute cerebral infarction. His father, who also had hemolytic anemia, presumably hemoglobin Köln, had a history of cerebral infarction. This case suggests that hemoglobin Köln, among other congenital hemoglobin disorders, may be a precipitating factor of thrombotic events.
Self-crack-healing by oxidation of a pre-incorporated healing agent is an essential property of high-temperature structural ceramics for components with stringent safety requirements, such as turbine ...blades in aircraft engines. Here, we report a new approach for a self-healing design containing a 3D network of a healing activator, based on insight gained by clarifying the healing mechanism. We demonstrate that addition of a small amount of an activator, typically doped MnO localised on the fracture path, selected by appropriate thermodynamic calculation significantly accelerates healing by >6,000 times and significantly lowers the required reaction temperature. The activator on the fracture path exhibits rapid fracture-gap filling by generation of mobile supercooled melts, thus enabling efficient oxygen delivery to the healing agent. Furthermore, the activator promotes crystallisation of the melts and forms a mechanically strong healing oxide. We also clarified that the healing mechanism could be divided to the initial oxidation and additional two stages. Based on bone healing, we here named these stages as inflammation, repair, and remodelling stages, respectively. Our design strategy can be applied to develop new lightweight, self-healing ceramics suitable for use in high- or low-pressure turbine blades in aircraft engines.
► A nano-hydroxyapatite collagen composite with bone morphogenetic protein was studied. ► Implanted nano-hydroxyapatite enhanced hard tissue formation on a dentin surface. ► Implanted ...nano-hydroxyapatite did not accelerate dentin resorption.
The purpose of this study was to evaluate the effects of the addition of nano-hydroxyapatite to a collagen membrane-carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) on hard tissue formation and dentin resorption on dentin surfaces in vivo.
Nano-hydroxyapatite collagen composite (nHAC) membranes or collagen (C) membranes were each immersed in either 100 or 400μg/ml rhBMP-2 and placed on dentin chips that were implanted into rat thigh muscle. The implants were analyzed at 2 or 4weeks after surgery by histological observation and histomorphometric analysis.
The percentage of the hard tissue formed by each nHAC group was significantly higher than that formed by any of the C groups, except for that formed by the group loaded with 400μg/ml rhBMP-2 at 4weeks after implantation. No significant differences were observed in the percentage of dentin resorption between the nHAC groups and C groups at any stage or at any rhBMP-2 concentration.
These findings showed that addition of nano-hydroxyapatite to a collagen membrane accelerated the formation of hard tissue induced by a low dose of rhBMP-2 on dentin surfaces at an early stage after implantation into rat thigh muscle, without increasing dentin resorption.
Background: We investigated the risk factors for recurrence in high risk stage II colorectal cancer patients over 75 years old.Methods: This study included 79 patients who underwent primary ...colorectal surgery at Minami Kyousai Hospital from January 2015 to June 2019. The inclusion criteria were as follows: (1) age over 75 years old, (2) histologically confirmed stage II colorectal adenocarcinoma after curative surgery, and (3) no other active malignancy. A Cox proportional hazards model was used to identify the risk factors for recurrence.Results: The recurrence free survival rates at 1, 2, and 3 years after surgery were 92.6%, 78.8%, and 61.9%. The risk factors for recurrence were tumor location and lymph-node dissection.Conclusion: This study revealed that left-sided colorectal cancer and under D2 dissection are risk factors for recurrence of stage II colorectal cancer in the elderly. Patients with these risk factors should be considered for adjuvant chemotherapy.
Abstract Recently, the laparoscopic approach has been used more frequently for liver resection due to the rapid development of innovative laparoscopic instruments and improvements in surgical skills. ...To control bleeding from liver parenchyma is important in laparoscopic surgical procedures. Microwave energy is a safe and effective coagulation device to achieve good hemostasis during hepatic resection with both open and laparoscopic techniques. We describe the method of laparoscopic liver resection using flexible-type needle and spatula-type electrodes of a microwave tissue coagulator. This technique is safe and bleeding can be easily controlled.
PDF
