Abstract
The Encyclopedia of DNA Elements (ENCODE) Data Coordinating Center has developed the ENCODE Portal database and website as the source for the data and metadata generated by the ENCODE ...Consortium. Two principles have motivated the design. First, experimental protocols, analytical procedures and the data themselves should be made publicly accessible through a coherent, web-based search and download interface. Second, the same interface should serve carefully curated metadata that record the provenance of the data and justify its interpretation in biological terms. Since its initial release in 2013 and in response to recommendations from consortium members and the wider community of scientists who use the Portal to access ENCODE data, the Portal has been regularly updated to better reflect these design principles. Here we report on these updates, including results from new experiments, uniformly-processed data from other projects, new visualization tools and more comprehensive metadata to describe experiments and analyses. Additionally, the Portal is now home to meta(data) from related projects including Genomics of Gene Regulation, Roadmap Epigenome Project, Model organism ENCODE (modENCODE) and modERN. The Portal now makes available over 13000 datasets and their accompanying metadata and can be accessed at: https://www.encodeproject.org/.
Pulsating auroras (PsAs) are thought to be generated by precipitating electrons scattered by lower‐band chorus (LBC) waves near the magnetic equator. One‐to‐one correlation between the LBC intensity ...and the PsA intensity has been reported. Electrostatic electron cyclotron harmonic (ECH) waves can also scatter electrons. However, direct correlation between ECH and PsA has not been reported yet. In this study, using a coordinated Exploration of energization and Radiation in Geospace (Arase) satellite and ground‐based imager observation, we report that not only LBC but also ECH have correlation with PsA. We estimated the precipitating electron energy by assuming that the time lag when the cross‐correlation coefficient became the highest was travel time of electrons from the modulation region. We found that the estimated energies show reasonable values as the cyclotron resonance energy of each wave.
Plain Language Summary
Pulsating auroras (PsAs), which have quasiperiodic on‐off switching emission, are caused by the intermittent electron precipitation from the magnetosphere. Such electrons are precipitated by wave‐particle interactions. The candidate waves to interact with electrons are lower‐band chorus (LBC) and electrostatic electron cyclotron harmonic (ECH) waves. One‐to‐one correspondence between the LBC wave intensity and the PsA intensity has been reported by previous studies. However, the correlation between ECH and PsA has not been reported yet. In this study, using a coordinated Exploration of energization and Radiation in Geospace (Arase) satellite and ground‐based all‐sky imager observation, we report that not only LBC but also ECH waves have correlation with PsAs.
Key Points
The lower‐band chorus and electrostatic electron cyclotron harmonic wave intensities had correlation with the pulsating auroral intensity
Taking advantage of high sampling rate of the imager, we estimated the energy of precipitating electrons
The energy of precipitating electrons was reasonable compared with the cyclotron resonance energy of each wave
Abstract
The Encyclopedia of DNA Elements (ENCODE) is an ongoing collaborative research project aimed at identifying all the functional elements in the human and mouse genomes. Data generated by the ...ENCODE consortium are freely accessible at the ENCODE portal (https://www.encodeproject.org/), which is developed and maintained by the ENCODE Data Coordinating Center (DCC). Since the initial portal release in 2013, the ENCODE DCC has updated the portal to make ENCODE data more findable, accessible, interoperable and reusable. Here, we report on recent updates, including new ENCODE data and assays, ENCODE uniform data processing pipelines, new visualization tools, a dataset cart feature, unrestricted public access to ENCODE data on the cloud (Amazon Web Services open data registry, https://registry.opendata.aws/encode-project/) and more comprehensive tutorials and documentation.
Pancreatic cancer is known for its dismal prognosis despite efforts to improve therapeutic outcome. Recently, cancer nanomedicine, application of nanotechnology to cancer diagnosis and treatment, has ...gained interest for treatment of pancreatic cancer. The enhanced permeability and retention (EPR) effect that promotes selective accumulation of nanometer‐sized molecules within tumors is the theoretical rationale of treatment. However, it is clear that EPR may be insufficient in pancreatic cancer as a result of stromal barriers within the tumor microenvironment (TME). These limit intratumoral accumulation of macromolecules. The TME and stromal barriers inside it consist of various stromal cell types which interact both with each other and with tumor cells. We are only beginning to understand the complexities of the stromal barriers within the TME and its functional consequences for nanomedicine. Understanding the complex crosstalk between barrier stromal cells is challenging because of the difficulty of modeling pancreatic cancer TME. Here we provide an overview of stromal barriers within the TME. We also describe the preclinical models, both in vivo and in vitro, developed to study them. We furthermore discuss the critical gaps in our understanding, and how we might formulate a better strategy for using nanomedicine against pancreatic cancer.
The use of nanomedicine has gained much interest for the treatment of pancreatic cancer, but biological and physical obstacles exist within the tumor microenvironment which limit penetration of the tumor by nanomedicine. These stromal barriers must be better understood and overcome to formulate an efficacious treatment of pancreatic cancer. This review therefore provides an overview of the stromal barriers within the pancreatic tumor microenvironment and the experimental models being developed to study them.
Shape-memory alloys, such as Ni-Ti and Cu-Zn-Al, show a large reversible strain of more than several percent due to superelasticity. In particular, the Ni-Ti-based alloy, which exhibits some ...ductility and excellent superelastic strain, is the only superelastic material available for practical applications at present. We herein describe a ferrous polycrystalline, high-strength, shape-memory alloy exhibiting a superelastic strain of more than 13%, with a tensile strength above 1 gigapascal, which is almost twice the maximum superelastic strain obtained in the Ni-Ti alloys. Furthermore, this ferrous alloy has a very large damping capacity and exhibits a large reversible change in magnetization during loading and unloading. This ferrous shape-memory alloy has great potential as a high-damping and sensor material.
A topological insulator is an unusual quantum state of matter, characterized by the appearance, at its edges or on its surface, of a gapless metallic state that is protected by time-reversal ...symmetry. The discovery of topological insulators has stimulated the search for other topological states protected by other symmetries, such as the recently predicted topological crystalline insulator (TCI) in which the metallic surface states are protected by the mirror symmetry of the crystal. Here we present experimental evidence for the TCI phase in tin telluride (SnTe), which has been predicted to be a TCI (ref. ). Our angle-resolved photoemission spectra show the signature of a metallic Dirac-cone surface band, with its Dirac point slightly away from the edge of the surface Brillouin zone in SnTe. Such a gapless surface state is absent in a cousin material, lead telluride, in line with the theoretical prediction. PUBLICATION ABSTRACT
Achieving high directionality of scattered light in combination with high flexibility of the direction using plasmonic nanoparticles is desirable for future optical nanocircuits and on-chip optical ...links. The plasmonic characteristics of nanoparticles strongly depend on their geometry. Here, we studied directional light scattering by a single-element triangular plasmonic nanoparticle. Our experimental and simulation results demonstrated that the triangular nanoparticle spatially sorted the incoming photons into three different scattering directions according to their polarization direction, including circular polarization, despite its compact overall volume of ∼λ3/300. The broken mirror symmetry and rotational symmetry of the triangular nanoparticle enabled such passive tridirectional polarization routing through the constructive and destructive interference of different plasmon modes. Our findings should markedly broaden the versatility of triangular plasmonic nanodevices, extending their possible practical applications in photon couplers and sorters and chemo-/biosensors.
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