For generations, early Franciscan thought has been widely regarded as unoriginal: a mere attempt to systematize the longstanding intellectual tradition of Augustine in the face of the rising ...popularity of Aristotle. This volume brings together leading scholars in the field to undertake a major study of the sources and context of the so-called Summa Halensis (1236-45), which was collaboratively authored by the founding members of the Franciscan school at Paris, above all, Alexander of Hales, and John of La Rochelle, in an effort to lay down the Franciscan intellectual tradition or the first time. The contributions will highlight that this tradition, far from unoriginal, laid the groundwork for later Franciscan thought, which is often regarded as formative for modern thought. Furthermore, the volume shows the role this Summa played in the development of the burgeoning field of systematic theology, which has its origins in the young university of Paris. This is a crucial and groundbreaking study for those with interests in the history of western thought and theology specifically.
What do mothers want? Brown, Sheila Feig
2005., 2005, 20130513, 2013-05-13, Letnik:
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What do mothers want and need from their parenting partners, their extended families, their friends, colleagues, and communities? And what can mental health professionals do to help them meet their ...daunting responsibilities in the contemporary world? The talented contributors to What Do Mothers Want? address these questions from perspectives that encompass differences in marital status, parental status, gender, and sexual orientation. Traversing the biological, psychological, cultural, and economic dimensions of mothering, they provide a compelling brief on the perplexing choices confronting mothers in the contemporary world.
Of course, mothers most basically want their children to be safe and healthy. But to this end they want and need many things: caring partners, intergenerational and community support, a responsive workplace, public services, and opportunities to share their experiences with other mothers. And they want their feelings and actions as mothers to be understood and accepted by those around them and by society at large. The role of psychotherapy in reaching these latter goals is taken up by many of the contributors. They reflect on the special psychological challenges of pregnancy, birth, and the arrival of a newborn into a couple's (whether hetero- or homosexual) life, and they address new venues of therapeutic assistance, such as brief low-cost therapy for at-risk mothers and infants and group interventions to help couples grow into the new role of parental couples.
Lists of variations in genomic DNA and their effects have been kept for some time and have been used in diagnostics and research. Although these lists have been carefully gathered and curated, there ...has been little standardization and coordination, complicating their use. Given the myriad possible variations in the estimated 24,000 genes in the human genome, it would be useful to have standard criteria for databases of variation. Incomplete collection and ascertainment of variants demonstrates a need for a universally accessible system. These and other problems led to the World Heath Organization-cosponsored meeting on June 20-23, 2006 in Melbourne, Australia, which launched the Human Variome Project. This meeting addressed all areas of human genetics relevant to collection of information on variation and its effects. Members of each of eight sessions (the clinic and phenotype, the diagnostic laboratory, the research laboratory, curation and collection, informatics, relevance to the emerging world, integration and federation and funding and sustainability) developed a number of recommendations that were then organized into a total of 96 recommendations to act as a foundation for future work worldwide. Here we summarize the background of the project, the meeting and its recommendations.
Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack the tumour on multiple fronts. Oncolytic or "cancer-killing" viruses (OVs) represent ...up-and-coming multi-mechanistic immunotherapeutic drugs for the treatment of cancer. In this study, we perform an in-vitro screen based on virus-encoded artificial microRNAs (amiRNAs) and find that a unique amiRNA, herein termed amiR-4, confers a replicative advantage to the VSVΔ51 OV platform. Target validation of amiR-4 reveals ARID1A, a protein involved in chromatin remodelling, as an important player in resistance to OV replication. Virus-directed targeting of ARID1A coupled with small-molecule inhibition of the methyltransferase EZH2 leads to the synthetic lethal killing of both infected and uninfected tumour cells. The bystander killing of uninfected cells is mediated by intercellular transfer of extracellular vesicles carrying amiR-4 cargo. Altogether, our findings establish that OVs can serve as replicating vehicles for amiRNA therapeutics with the potential for combination with small molecule and immune checkpoint inhibitor therapy.
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