This study investigated the relationship between recall of real‐life pretrial publicity (PTP) in a high‐profile fraud case and subsequent reasoning about the trial evidence and verdict decisions. ...Tracking the reasoning and verdict judgments of 50 mock jurors during a video simulation of the trial material, the effect of factual recall of PTP was compared with recall indicating an affective or evaluative response from the PTP. Affective/evaluative recall, but not factual recall, was significantly associated with anti‐defendant reasoning and confidence in guilt. This effect was partially mediated by reasoning developed during the course of evidence presentation. The potentially prejudicial effect of affective/evaluative recall of PTP is discussed in terms of it activating an explanatory structure that frames evidence interpretation.
A thorough reconstruction of historical processes is essential for a comprehensive understanding of the mechanisms shaping patterns of genetic diversity. Indeed, past and current conditions ...influencing effective population size have important evolutionary implications for the efficacy of selection, increased accumulation of deleterious mutations, and loss of adaptive potential. Here, we gather extensive genome-wide data that represent the extant diversity of the Coho salmon (Oncorhynchus kisutch) to address two objectives. We demonstrate that a single glacial refugium is the source of most of the present-day genetic diversity, with detectable inputs from a putative secondary micro-refugium. We found statistical support for a scenario whereby ancestral populations located south of the ice sheets expanded recently, swamping out most of the diversity from other putative micro-refugia. Demographic inferences revealed that genetic diversity was also affected by linked selection in large parts of the genome. Moreover, we demonstrate that the recent demographic history of this species generated regional differences in the load of deleterious mutations among populations, a finding that mirrors recent results from human populations and provides increased support for models of expansion load. We propose that insights from these historical inferences should be better integrated in conservation planning of wild organisms, which currently focuses largely on neutral genetic diversity and local adaptation, with the role of potentially maladaptive variation being generally ignored.
High-fidelity two-qubit gates at scale are a key requirement to realize the full promise of quantum computation and simulation. The advent and use of coupler elements to tunably control two-qubit ...interactions has improved operational fidelity in many-qubit systems by reducing parasitic coupling and frequency crowding issues. Nonetheless, two-qubit gate errors still limit the capability of near-term quantum applications. The reason, in part, is that the existing framework for tunable couplers based on the dispersive approximation does not fully incorporate three-body multilevel dynamics, which is essential for addressing coherent leakage to the coupler and parasitic longitudinal (ZZ) interactions during two-qubit gates. Here, we present a systematic approach that goes beyond the dispersive approximation to exploit the engineered level structure of the coupler and optimize its control. Using this approach, we experimentally demonstrate CZ andZZ-free iSWAP gates with two-qubit interaction fidelities of99.76±0.07%and99.87±0.23%, respectively, which are close to theirT1limits.
The flow cytometric crossmatch is a technique that is increasingly being used by clinical transplant laboratories. In this multicenter study by the British Society for Histocompatibility and ...Immunogenetics Flow Cytometry Group, a series of crossmatches were carried out to determine whether different centers obtained same results when performing the same crossmatch. There was greater than 80% agreement among participating laboratories on the results of 35/54 tests. There was no clear agreement in the remaining 20 cases. Quantitative analysis, estimating the number of cell-bound fluorescein molecules, demonstrated that differences in the criteria used by each center to define a positive crossmatch were responsible for some discordant results. When applied, definition of positivity based on the molecules of fluorescein increased concordance from 57.5% to 81.4%.l. These results suggest that a criterion for the interpretation of results based on quantitative analysis of bound antibody may be more reliable than methods in current routine use.
This report describes and discusses the history, clinical, pathologic, epidemiologic, and human health aspects of an outbreak of Mycobacterium bovis infection in domestic wapiti in Alberta between ...1990 and 1993, shortly after legislative changes allowing game farming. The extent and seriousness of the outbreak of M. bovis in wapiti in Alberta was not fully known at its onset. The clinical findings in the first recognized infected wapiti are presented and the postmortem records for the herd in which the animal resided are summarized. Epidemiologic findings from the subsequent field investigation are reviewed, the results of recognition and investigation of human exposure are updated, and recommendations for reduction of human exposure are presented.
Which are the studies, special reports and commentaries that have been most influential in shaping the health promotion profession? This editorial poses that question to many of America’s most ...accomplished researchers. Each was asked to name one or two ‘must read’ studies from other scholars as well as to feature one of their own research projects that has had the greatest reach. This review of seminal studies focuses on community health, patient education and behavior change research and a future editorial will focus on workplace based health promotion research. Readers are challenged to review the four decades of research represented by this list and consider whether trends can be identified with respect to the relative attention researchers are giving to individual, interpersonal, community and societal factors influencing health behavior. How clear is the evidence that the choices we make are determined by the choices we have?
Summary
There are many ways to categorize work‐related stressors, and in recent years, a common distinction in occupational health psychology is between stressors viewed as challenges versus ...hindrances. Is this a useful conceptualization that provides practical and theoretical implications for IO psychologists? As Kurt Lewin famously prescribed, “there is nothing so practical as a good theory,” and we discuss the challenge–hindrance framework as a developing theory that can be useful for researchers and practitioners. We note that some of the early thinking and development of the challenge–hindrance distinction relied on both resource and appraisal theories of stress. Overall, we find that the challenge–hindrance distinction can be viewed as a framework that is useful by producing interesting, valuable, and innovative research. Simply striving to find meaningful and useful categorizations of stressors can lead us to discover new insights into the occupational stress domain, and the challenge–hindrance categories have already spurred a great deal of research.
Cytokines have been detected by ELISA in a variety of body fluids. Recycling immunoaffinity chromatography (RIC) coupled with laser-induced fluorescence detection is a highly sensitive and specific ...method, which allows simultaneous measurements of many analytes in small volumes of biological fluids. This method has been applied to plasma, cervical secretions and other body fluids, but has not previously been applied to sweat. The aim of this study was to validate the RIC methodology in sweat for measurements of IL-1α, IL-1β, IL-6, TNF-α, IL-8 and TGF-β. Two sweat patches were applied for 24 h on the torso, and blood was collected at one time point during this period in nine healthy women. Cytokines were measured in paired samples of plasma and sweat. Cytokines were detected in sweat in similar concentrations to plasma. Linear regression analysis confirmed that sweat levels of these cytokines accounted for a large percentages of variance in plasma levels: IL-1α (
R
2
=
0.70,
p
=
0.005), IL-1β (
R
2
=
0.79,
p
=
0.003), IL-6 (
R
2
=
0.52,
p
=
0.03), TNF-α (
R
2
=
0.95,
p
<
0.0001), IL-8 (
R
2
=
0.81,
p
=
0.001) and TGF-β (
R
2
=
0.94,
p
=
0.0003). These findings indicate that cytokine levels measured in sweat are informative of circulating levels and that sweat patches combined with RIC represents a viable non-invasive method to measure cytokines in ambulatory settings over time. This method is unobtrusive and requires minimal active compliance on the part of the subjects being studied, without pain or stress. This approach can open a new generation of studies to address the effects of environmental factors on immune responses in a wide range of different settings.
The COVID-19 pandemic presents clinicians a unique set of challenges in managing breast cancer (BC) patients. As hospital resources and staff become more limited during the COVID-19 pandemic, it ...becomes critically important to define which BC patients require more urgent care and which patients can wait for treatment until the pandemic is over. In this Special Communication, we use expert opinion of representatives from multiple cancer care organizations to categorize BC patients into priority levels (A, B, C) for urgency of care across all specialties. Additionally, we provide treatment recommendations for each of these patient scenarios. Priority A patients have conditions that are immediately life threatening or symptomatic requiring urgent treatment. Priority B patients have conditions that do not require immediate treatment but should start treatment before the pandemic is over. Priority C patients have conditions that can be safely deferred until the pandemic is over. The implementation of these recommendations for patient triage, which are based on the highest level available evidence, must be adapted to current availability of hospital resources and severity of the COVID-19 pandemic in each region of the country. Additionally, the risk of disease progression and worse outcomes for patients need to be weighed against the risk of patient and staff exposure to SARS CoV-2 (virus associated with the COVID-19 pandemic). Physicians should use these recommendations to prioritize care for their BC patients and adapt treatment recommendations to the local context at their hospital.
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