This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries, examined and described. In addition to extensive morphological ...descriptions and appropriate asexual and sexual connections, DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ranks. Wherever new species or combinations are proposed, we apply an integrative approach using morphological and molecular data as well as ecological features wherever applicable. Notes on 112 fungal taxa are compiled in this paper including
Biatriosporaceae
and
Roussoellaceae
,
Didysimulans
gen. nov., 81 new species, 18 new host records and new country records, five reference specimens, two new combinations, and three sexual and asexual morph reports. The new species are
Amanita cornelii
,
A
.
emodotrygon
,
Angustimassarina alni
,
A
.
arezzoensis
,
A
.
italica
,
A
.
lonicerae
,
A
.
premilcurensis
,
Ascochyta italica
,
A
.
rosae
,
Austroboletus appendiculatus
,
Barriopsis thailandica
,
Berkleasmium ariense
,
Calophoma petasitis
,
Camarosporium laburnicola
,
C
.
moricola
,
C
.
grisea
,
C
.
ossea
,
C
.
paraincrustata
,
Colletotrichum sambucicola
,
Coprinopsis cerkezii
,
Cytospora gelida
,
Dacrymyces chiangraiensis
,
Didysimulans italica
,
D
.
mezzanensis
,
Entodesmium italica
,
Entoloma magnum
,
Evlachovaea indica
,
Exophiala italica
,
Favolus gracilisporus
,
Femsjonia monospora
,
Fomitopsis flabellata
,
F
.
roseoalba
,
Gongronella brasiliensis
,
Helvella crispoides
,
Hermatomyces chiangmaiensis
,
H
.
chromolaenae
,
Hysterium centramurum
,
Inflatispora caryotae
,
Inocybe brunneosquamulosa
,
I
.
luteobrunnea
,
I
.
rubrobrunnea
,
Keissleriella cirsii
,
Lepiota cylindrocystidia
,
L
.
flavocarpa
,
L
.
maerimensis
,
Lophiotrema guttulata
,
Marasmius luculentus
,
Morenoina calamicola
,
Moelleriella thanathonensis
,
Mucor stercorarius
,
Myrmecridium fluviae
,
Myrothecium septentrionale
,
Neosetophoma garethjonesii
,
Nigrograna cangshanensis
,
Nodulosphaeria guttulatum
,
N
.
multiseptata
,
N
.
sambuci
,
Panus subfasciatus
,
Paraleptosphaeria padi
,
Paraphaeosphaeria viciae
,
Parathyridaria robiniae
,
Penicillium punicae
,
Phaeosphaeria calamicola
,
Phaeosphaeriopsis yuccae
,
Pleurophoma italica
,
Polyporus brevibasidiosus
,
P
.
koreanus
,
P
.
orientivarius
,
P
.
parvovarius
,
P
.
subdictyopus
,
P
.
ulleungus
,
Pseudoasteromassaria spadicea
,
Rosellinia mearnsii
,
Rubroboletus demonensis
,
Russula yanheensis
,
Sigarispora muriformis
,
Sillia italica
,
Stagonosporopsis ailanthicola
,
Strobilomyces longistipitatus
,
Subplenodomus galicola
and
Wolfiporia pseudococos
. The new combinations are
Melanomma populina
and
Rubroboletus eastwoodiae
. The reference specimens are
Cookeina tricholoma
,
Gnomoniopsis sanguisorbae
,
Helvella costifera
,
Polythrincium trifolii
and
Russula virescens
. The new host records and country records are
Ascochyta medicaginicola
,
Boletellus emodensis
,
Cyptotrama asprata
,
Cytospora ceratosperma
,
Favolaschia auriscalpium
,
F
.
manipularis
,
Hysterobrevium mori
,
Lentinus sajor
-
caju
,
L
.
squarrosulus
,
L
.
velutinus
,
Leucocoprinus cretaceus
,
Lophiotrema vagabundum
,
Nothophoma quercina
,
Platystomum rosae
,
Pseudodidymosphaeria phlei
,
Tremella fuciformis
,
Truncatella spartii
and
Vaginatispora appendiculata
and three sexual and asexual morphs are
Aposphaeria corallinolutea
,
Dothiora buxi
and
Hypocrella calendulina
.
Alagille syndrome (ALGS) is characterized by chronic cholestasis with associated pruritus and extrahepatic anomalies. Maralixibat, an ileal bile acid transporter inhibitor, is an approved ...pharmacologic therapy for cholestatic pruritus in ALGS. Since long-term placebo-controlled studies are not feasible or ethical in children with rare diseases, a novel approach was taken comparing 6-year outcomes from maralixibat trials with an aligned and harmonized natural history cohort from the G lobal AL agille A lliance (GALA) study.
Maralixibat trials comprise 84 patients with ALGS with up to 6 years of treatment. GALA contains retrospective data from 1438 participants. GALA was filtered to align with key maralixibat eligibility criteria, yielding 469 participants. Serum bile acids could not be included in the GALA filtering criteria as these are not routinely performed in clinical practice. Index time was determined through maximum likelihood estimation in an effort to align the disease severity between the two cohorts with the initiation of maralixibat. Event-free survival, defined as the time to first event of manifestations of portal hypertension (variceal bleeding, ascites requiring therapy), surgical biliary diversion, liver transplant, or death, was analyzed by Cox proportional hazards methods. Sensitivity analyses and adjustments for covariates were applied. Age, total bilirubin, gamma-glutamyl transferase, and alanine aminotransferase were balanced between groups with no statistical differences. Event-free survival in the maralixibat cohort was significantly better than the GALA cohort (HR, 0.305; 95% CI, 0.189-0.491; p <0.0001). Multiple sensitivity and subgroup analyses (including serum bile acid availability) showed similar findings.
This study demonstrates a novel application of a robust statistical method to evaluate outcomes in long-term intervention studies where placebo comparisons are not feasible, providing wide application for rare diseases. This comparison with real-world natural history data suggests that maralixibat improves event-free survival in patients with ALGS.
Abstract Background Adherence to evidence-based medications after myocardial infarction is associated with improved outcomes. However, long-term data on factors affecting medication adherence after ...myocardial infarction are lacking. Methods Olmsted County residents hospitalized with myocardial infarction from 1997-2006 were identified. Adherence to HMG-CoA reductase inhibitors (statins), beta blockers, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, were examined. Cox proportional hazard regression was used to determine the factors associated with medication adherence over time. Results Among 292 subjects with incident myocardial infarction (63% men, mean age 65 years), patients were followed for an average of 52 ± 31 months. Adherence to guideline-recommended medications decreased over time, with 3-year medication continuation rates of 44%, 48%, and 43% for statins, beta-blockers, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, respectively. Enrollment in a cardiac rehabilitation program was associated with an improved likelihood of continuing medications, with adjusted hazard ratio (95% confidence interval) for discontinuation of statins and beta-blockers among cardiac rehabilitation participants of 0.66 (0.45-0.92) and 0.70 (0.49-0.98), respectively. Smoking at the time of myocardial infarction was associated with a decreased likelihood of continuing medications, although results did not reach statistical significance. There were no observed associations between demographic characteristics, clinical characteristics of the myocardial infarction, and medication adherence. Conclusions After myocardial infarction, a large proportion of patients discontinue use of medications over time. Enrollment in cardiac rehabilitation after myocardial infarction is associated with improved medication adherence.
The Transiting Exoplanet Survey Satellite, TESS, is currently carrying out an all-sky search for small planets transiting bright stars. In the first year of the TESS survey, a steady progress was ...made in achieving the mission’s primary science goal of establishing bulk densities for 50 planets smaller than Neptune. During that year, the TESS’s observations were focused on the southern ecliptic hemisphere, resulting in the discovery of three mini-Neptunes orbiting the star TOI-125, a V = 11.0 K0 dwarf. We present intensive HARPS radial velocity observations, yielding precise mass measurements for TOI-125b, TOI-125c, and TOI-125d. TOI-125b has an orbital period of 4.65 d, a radius of 2.726 ± 0.075 R(E), a mass of 9.50 ± 0.88 M(E), and is near the 2:1 mean motion resonance with TOI-125c at 9.15 d. TOI-125c has a similar radius of 2.759 ± 0.10 R(E) and a mass of 6.63 ± 0.99 M(E), being the puffiest of the three planets. TOI-125d has an orbital period of 19.98 d and a radius of 2.93 ± 0.17 R(E) and mass 13.6 ± 1.2 M(E). For TOI-125b and d, we find unusual high eccentricities of 0.19 ± 0.04 and 0.17(sup +0.08, sub −0.06), respectively. Our analysis also provides upper mass limits for the two low-SNR planet candidates in the system; for TOI-125.04 (R(P) = 1.36 R(E), P = 0.53 d), we find a 2σ upper mass limit of 1.6 M(E), whereas TOI-125.05 (R(P) = 4.2(sup +2.4, sub −1.4 R(E), P = 13.28 d) is unlikely a viable planet candidate with an upper mass limit of 2.7 M(E). We discuss the internal structure of the three confirmed planets, as well as dynamical stability and system architecture for this intriguing exoplanet system.
Background and Aims
Mutations in ATPase phospholipid transporting 8B1 (ATP8B1) can lead to familial intrahepatic cholestasis type 1 (FIC1) deficiency, or progressive familial intrahepatic cholestasis ...type 1. The rarity of FIC1 deficiency has largely prevented a detailed analysis of its natural history, effects of predicted protein truncating mutations (PPTMs), and possible associations of serum bile acid (sBA) concentrations and surgical biliary diversion (SBD) with long‐term outcome. We aimed to provide insights by using the largest genetically defined cohort of patients with FIC1 deficiency to date.
Approach and Results
This multicenter, combined retrospective and prospective study included 130 patients with compound heterozygous or homozygous predicted pathogenic ATP8B1 variants. Patients were categorized according to the number of PPTMs (i.e., splice site, frameshift due to deletion or insertion, nonsense, duplication), FIC1‐A (n = 67; no PPTMs), FIC1‐B (n = 29; one PPTM), or FIC1‐C (n = 34; two PPTMs). Survival analysis showed an overall native liver survival (NLS) of 44% at age 18 years. NLS was comparable among FIC1‐A, FIC1‐B, and FIC1‐C (% NLS at age 10 years: 67%, 41%, and 59%, respectively; P = 0.12), despite FIC1‐C undergoing SBD less often (% SBD at age 10 years: 65%, 57%, and 45%, respectively; P = 0.03). sBAs at presentation were negatively associated with NLS (NLS at age 10 years, sBAs < 194 µmol/L: 49% vs. sBAs ≥ 194 µmol/L: 15%; P = 0.03). SBD decreased sBAs (230 125‐282 to 74 11‐177 μmol/L; P = 0.005). SBD (HR 0.55, 95% CI 0.28‐1.03, P = 0.06) and post‐SBD sBA concentrations < 65 μmol/L (P = 0.05) tended to be associated with improved NLS.
Conclusions
Less than half of patients with FIC1 deficiency reach adulthood with native liver. The number of PPTMs did not associate with the natural history or prognosis of FIC1 deficiency. sBA concentrations at initial presentation and after SBD provide limited prognostic information on long‐term NLS.
We report the discovery of a multiplanetary system transiting the M0 V dwarf HD 260655 (GJ 239, TOI-4599). The system consists of at least two transiting planets, namely HD 260655 b, with a period of ...2.77 d, a radius of
R
b
= 1.240 ± 0.023
R
⊕
, a mass of
M
b
= 2.14 ± 0.34
M
⊕
, and a bulk density of
ρ
b
= 6.2 ± 1.0 g cm
−3
, and HD 260655 c, with a period of 5.71 d, a radius of ${R_c} = 1.533_{ - 0.046}^{ + 0.051}{R_ \oplus }$, a mass of
M
c
= 3.09 ± 0.48
M
⊕
, and a bulk density of ${\rho _c} = 4.7_{ - 0.8}^{ + 0.9}{\rm{g}}$ g cm
−3
. The planets have been detected in transit by the Transiting Exoplanet Survey Satellite (TESS) mission and confirmed independently with archival and new precise radial velocities obtained with the HIRES and CARMENES instruments since 1998 and 2016, respectively. At a distance of 10 pc, HD 260655 has become the fourth closest known multitransiting planet system after HD 219134, LTT 1445 A, and AU Mic. Due to the apparent brightness of the host star (
J
= 6.7 mag), both planets are among the most suitable rocky worlds known today for atmospheric studies with the
James Webb
Space Telescope, both in transmission and emission.
Three short-period Jupiters from TESS Nielsen, L. D.; Brahm, R.; Bouchy, F. ...
Astronomy and astrophysics (Berlin),
07/2020, Letnik:
639
Journal Article, Web Resource
Recenzirano
Odprti dostop
We report the confirmation and mass determination of three hot Jupiters discovered by the Transiting Exoplanet Survey Satellite (TESS) mission: HIP 65Ab (TOI-129, TIC-201248411) is an ...ultra-short-period Jupiter orbiting a bright (
V
= 11.1 mag) K4-dwarf every 0.98 days. It is a massive 3.213 ± 0.078
M
J
planet in a grazing transit configuration with an impact parameter of
b
= 1.17
−0.08
+0.10
. As a result the radius is poorly constrained, 2.03
−0.49
+0.61
R
J
. The planet’s distance to its host star is less than twice the separation at which it would be destroyed by Roche lobe overflow. It is expected to spiral into HIP 65A on a timescale ranging from 80 Myr to a few gigayears, assuming a reduced tidal dissipation quality factor of
Q
s
′
= 10
7
− 10
9
. We performed a full phase-curve analysis of the TESS data and detected both illumination- and ellipsoidal variations as well as Doppler boosting. HIP 65A is part of a binary stellar system, with HIP 65B separated by 269 AU (3.95 arcsec on sky). TOI-157b (TIC 140691463) is a typical hot Jupiter with a mass of 1.18 ± 0.13
M
J
and a radius of 1.29 ± 0.02
R
J
. It has a period of 2.08 days, which corresponds to a separation of just 0.03 AU. This makes TOI-157 an interesting system, as the host star is an evolved G9 sub-giant star (
V
= 12.7). TOI-169b (TIC 183120439) is a bloated Jupiter orbiting a
V
= 12.4 G-type star. It has a mass of 0.79 ±0.06
M
J
and a radius of 1.09
−0.05
+0.08
R
J
. Despite having the longest orbital period (
P
= 2.26 days) of the three planets, TOI-169b receives the most irradiation and is situated on the edge of the Neptune desert. All three host stars are metal rich with Fe / H ranging from 0.18 to0.24.
The simultaneous maturation of multiple digital and telecommunications technologies in 2020 has created an unprecedented opportunity for ophthalmology to adapt to new models of care using tele-health ...supported by digital innovations. These digital innovations include artificial intelligence (AI), 5th generation (5G) telecommunication networks and the Internet of Things (IoT), creating an inter-dependent ecosystem offering opportunities to develop new models of eye care addressing the challenges of COVID-19 and beyond. Ophthalmology has thrived in some of these areas partly due to its many image-based investigations. Tele-health and AI provide synchronous solutions to challenges facing ophthalmologists and healthcare providers worldwide. This article reviews how countries across the world have utilised these digital innovations to tackle diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, glaucoma, refractive error correction, cataract and other anterior segment disorders. The review summarises the digital strategies that countries are developing and discusses technologies that may increasingly enter the clinical workflow and processes of ophthalmologists. Furthermore as countries around the world have initiated a series of escalating containment and mitigation measures during the COVID-19 pandemic, the delivery of eye care services globally has been significantly impacted. As ophthalmic services adapt and form a “new normal”, the rapid adoption of some of telehealth and digital innovation during the pandemic is also discussed. Finally, challenges for validation and clinical implementation are considered, as well as recommendations on future directions.
A dual-peak long period fiber grating (DP-LPFG) sensor functionalized by polypyrrole-chitosan composite was proposed for sensitive detection of Cu
ions in aqueous solution. The nitrogen atom on the ...polypyrrole ring and the amino group on the chitosan chain in the complex matrix can chelate the Cu
ions. Thus, the refractive index of the overlay changed and further modulated the transmission spectrum of DP-LPFG. After special design, the double peaks can move in opposite directions with the increase of Cu
ion concentration, thereby greatly improving detection sensitivity. The linear sensitivity of the fabricated sensor was measured to be 9.12 and 2.14 nm/ppm (0.61 and 0.14 nm/µM) for concentrations of 0.1-0.5 (1.5 µM-7.5 µM) and 0.5-2 ppm (7.5 µM-30 µM), respectively. In addition, the Langmuir isothermal model was used to evaluate the overall response of the sensor to Cu
ions quantitatively, and the detection limit was determined to be 0.05 ppb (0.75 nM). This ingenious sensor offers a new solution for sensitive detection of heavy metal ions in environmental water.
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