Gene mutations were found in acute myeloid leukemia (AML) and their importance has been noted. To clarify the importance and stability of mutations, we examined gene mutations in paired samples at ...diagnosis and relapse of 34 adult AML patients. Five acquired gene mutations were detected at relapse. Of the 45 gene mutations at diagnosis, 11 of them were lost at relapse. The acquired mutations at relapse were all class I mutations as Fms-like tyrosine kinase 3 (FLT3) and rat sarcoma viral oncogene homolog (RAS) mutations. The disappeared mutations at relapse were 3 of 11 internal tandem duplications of FLT3 (FLT3-ITD) (27.3%), 3 of 3 FLT3 tyrosine kinase domain (FLT3-TKD) (100%), 3 of 13 Nucleophosmin 1 (23.1%) and 2 of 5 CCAAT/enhancer-binding protein-α (40%) mutations. However, epigenetics-modifying gene (DNMT3a, TET2 and IDH1/2) mutations had no change between diagnosis and relapse samples, and may become minimal residual disease marker. The frequency of FLT3-ITD at relapse in patients with DNMT3a mutation at diagnosis is significantly higher than those in patients without them (P=0.001). Moreover, the high frequency of FLT3-ITD at relapse is also seen in AML cases that initially present with any epigenetics-modifying gene mutations (P<0.001). Our results indicate that epigenetics-modifying gene mutations may cause genetic instability and induce FLT3-ITD, leading to resistance to therapy and relapse.
Purpose: The objective of this study was to determine the benefits of adjuvant radiotherapy after radical resection of locally advanced main hepatic duct carcinoma (Klatskin tumor).
Methods and ...Materials: We conducted a retrospective review of 63 patients who underwent surgical resection of Stage IVA Klatskin tumor. Of the 63 patients, 47 had microscopic tumor residue (RT1). Twenty-eight of the 47 patients with RT1 were treated by adjuvant radiotherapy and the remaining 19 patients were treated exclusively by surgical resection. Seventeen of the 28 patients with RT1 were treated by both intraoperative radiotherapy (IORT) and postoperative radiotherapy (PORT); of the remaining 11 patients with RT1, 6 underwent resection and IORT, and 5 underwent resection and PORT.
Results: The major complication and 30-day operative death rates were significantly lower in the radiation group (9.5% and 0.0%, respectively) than in the resection alone group (28.5% and 9.5%, respectively). Of the eight 5-year survivors with RT1, 6 had adjuvant radiotherapy and the remaining 2 had resection alone. Adjuvant radiotherapy for patients with RT1 yielded significantly (p = 0.0141) higher 5-year survival rates (33.9%) than in the resection alone group (13.5%). The best 5-year survival rate (39.2%) was found in patients who underwent a combination of IORT and PORT after resection. The local-regional control rate was significantly higher in the adjuvant radiation group than in the resection alone group (79.2% vs. 31.2%).
Conclusion: Our data clearly suggest the improved prognosis of patients with locally advanced Klatskin tumor by integrated adjuvant radiotherapy with IORT and PORT to complete gross tumor resection with acceptable treatment mortality and morbidity.
A reaction plane detector for PHENIX at RHIC Richardson, E.; Akiba, Y.; Anderson, N. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2011, Letnik:
636, Številka:
1
Journal Article
Recenzirano
Odprti dostop
A plastic scintillator paddle detector with embedded fiber light guides and photomultiplier tube readout, referred to as the Reaction Plane Detector (RXNP), was designed and installed in the PHENIX ...experiment prior to the 2007 run of the Relativistic Heavy Ion Collider (RHIC). The RXNP's design is optimized to accurately measure the reaction plane (RP) angle of heavy-ion collisions, where, for mid-central sNN=200GeV Au+Au collisions, it achieved a 2nd harmonic RP resolution of ∼0.75, which is a factor of ∼2 greater than PHENIX's previous capabilities. This improvement was accomplished by locating the RXNP in the central region of the PHENIX experiment, where, due to its large coverage in pseudorapidity (1.0<|η|<2.8) and ϕ(2π), it is exposed to the high particle multiplicities needed for an accurate RP measurement. To enhance the observed signal, a 2-cm Pb converter is located between the nominal collision region and the scintillator paddles, allowing neutral particles produced in the heavy-ion collisions to contribute to the signal through conversion electrons. This paper discusses the design, operation and performance of the RXNP during the 2007 RHIC run.
Measurements of two particle azimuthal correlations in relativistic heavy ion collisions are useful tools to dissect the interplay between hard-scattered partons and hot dense medium. Correlations ...with trigger particle selection relative to second order event plane are sensitive to the path-length dependence of parton energy loss and to the influence of the medium on jet for high and intermediate transverse momenta pairs, respectively. To study the parton-medium coupling, it is also crucial to obtain correlations with rejection of contributions from higher harmonic flow. We present current results of second order event plane dependent correlations as well as correlations in which contributions from higher harmonic flow have been excluded in Au+Au collisions at sNN=200GeV measured by PHENIX.
Surgery is the only curative treatment for gallbladder cancer. However, because of frequent local-regional and distant recurrences, radical surgery during advanced stages of the disease is often ...unsuccessful. Despite potential improvements in patient survival and quality of life, alternatives such as chemotherapeutic regimens have not been fully developed for treatment of gallbladder cancer. The present paper reviews current publications that deal exclusively with the use of chemotherapy for treatment of gallbladder cancer, with particular attention to adjuvant chemotherapy including postoperative and preoperative systemic or regional hepatic arterial infusion chemotherapy. Treatment outcomes, including response rate, adverse effects, and survival are summarized.
Significant excesses of J/ yield at very low transverse momentum (pT < 0:3 GeV/c) were observed by the ALICE and STAR collaborations in peripheral hadronic A+A collisions. This is a Sign of coherent ...photoproduction of J/ψ in violent hadronic interactions. Theoretically, the photoproduction of J= in hadronic collisions raises questions about how spectator and non-spectator nucleons participate in the coherent reaction. We argue that the strong interactions in the overlapping region of incoming nuclei may disturb the coherent production, leaving room for different coupling assumptions. The destructive interference between photoproduction on ions moving in opposite directions also needs to be included. This letter presents calculations of J/ψ production from coherent photon-nucleus (γ+A → J/ψ +A) interactions in hadronic A+A collisions at RHIC and LHC energies with both nucleus and spectator coupling hypotheses. The integrated yield of coherent J/ψ as a function of centrality is found to be significantly different, especially towards central collisions, for different coupling scenarios. Differential distributions as a function of transverse momentum, azimuthal angle and rapidity in different centrality bins are also shown, and found to be more sensitive to the Pomeron coupling than to the photon coupling. Lastly, these predictions call for future experimental measurements to help better understand the coherent interaction in hadronic heavy-ion collisions.
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