As mentioned above, the following comments address missing details, erroneous quantitative conclusions, and incorrect mathematical expressions in the study. Consequently, this investigation compares ...and corrects the publication "Mixed convective flow in a multiple port ventilation square cavity with insulated baffle." Case Studies in Thermal Engineering 30 (2022) 101785.
Introduction. A variety of musculoskeletal disorders (MS) have been associated with diabetes mellitus (DM). This study aimed at assessing the prevalence and associated factors of MS disorders in ...Moroccan diabetic patients. Methods. A cross-sectional study enrolled consecutive patients with DM. We recorded demographic features of patients and characteristics of DM. MS disorders and vascular complications were assessed by clinical examinations and investigations. Associated factors of MS disorders were assessed by univariate and multivariate analyses. Result. 376 subjects were included; 84.6% had type 2 DM. The participants’ median age was 54 years 45–62; 41% had one or more vascular complications. 34.4% had one or more MS disorders. Osteoarthritis was present in 19.4% of patients. Hand disorders were seen in 14.4%. Shoulder capsulitis was present in 12.5%. Long duration of diabetes and dyslipidemia were associated with increased prevalence of hand abnormalities (P=0.017; P=0.019, respectively). Age and dyslipidemia were associated with shoulder capsulitis (P=0.019; P=0.047, respectively). Female gender, overweight, and nephropathy were associated with increased odds of osteoarthritis (P=0.009, P=0.004, and P=0.032, respectively). Conclusion. MS disorders are frequent in this population and associated with various factors. HbA1c level does not appear to be associated with development of MS disorders.
Summary
Several studies have reported changes in body composition in rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Our study showed that body composition measurements obtained by ...absorptiometry were highly reproducible in patients suffering from these diseases. This study justifies the use of absorptiometry measurements in longitudinal studies in this population.
Purpose
Our study aimed to assess the reproducibility of total and regional body composition in patients with rheumatoid arthritis (RA) and with ankylosing spondylitis (AS) and to compare them to healthy subjects.
Methods
The study enrolled 80 subjects including 32 healthy subjects, 31 RA patients, and 17 AS patients. Each subject had two scans in one day under the same standard conditions and none ate nor drunk before being repositioned on the table. The reproducibility was assessed through the coefficient of variation (CV), the least significant change (LSC), the intraclass correlation (ICC), and the smallest significant difference (SDD).
Results
Total body composition measurements obtained by dual-energy X-ray absorptiometry (DXA) were highly reproducible, and there was no statistically significant difference between reproducibility in healthy subjects, patients with RA, and patients with AS. For total body fat mass (FM), lean mass (LM), and bone mineral content (BMC) in the total population, CV values were 1.71%, 1.25%, and 1.74%, respectively; ICC values were 0.998, 0.996, and 0.993, respectively; LSC values were 4.88%, 3.7%, and 5.2%, respectively; and SDD values were ± 1.23 Kg, ± 1.47 Kg, and ± 126.0 g, respectively. For regional body FM, LM, and BMC in the total population, CV values in the arms were 8.46%, 4.17%, and 3.79%, respectively; in the legs 6.24%, 3.59%, and 2.04%, respectively, and in the trunk 5.02%, 2.92%, and 5.24%, respectively.
Conclusion
Total body tissue mass, FM percentage, FM, LM, and BMC measurements obtained by DXA are highly reproducible in RA and AS.
In this study, we investigated the structure-activity relationships of a series of β-carboline alkaloid derivatives using the 2D-QSAR and molecular docking, in order to identify the mode of ...interaction between β-carboline derivatives and the PLK1 kinase, and determine their key substituents responsible for the cytotoxic activity. The obtained QSAR models using multiple linear regression (MLR) and partial least squares (PLS) methods showed a high correlation between the experimental activity and the predicted one by PLS (
R
2
PLS
= 0.82,
q
2
= 0.72) and MLR (
R
2
MLR
= 0.82,
q
2
= 0.72). An external dataset was used to test the extrapolation power of the models which resulted in an
R
2
PLS
(EV) = 0.76; RMSE = 0.39. The 2D-QSAR analysis reveals that lipophilicity plays an important role in the cytotoxic activity of this group of β-carboline derivatives. Indeed, the molecular docking study into the active site of the polo-like kinase (PLK1) revealed that the most active ligand 57 shows higher binding energy and interacts, especially by H-bonds and hydrophobic interactions, with the active site of the PLK1 kinase. Consequently, the results obtained from the 2D-QSAR and docking studies provided a useful tool to design new and potent β-carboline derivatives as cytotoxic agents.
Despite of the availability of several effective bDMARDs, a significant proportion of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients discontinued bDMARDs. The aims of this study ...were to analyze causes of bDMARDs discontinuation in RA and AS included in the Moroccan registry RBSMR. A historical prospective multicenter cohort study based on the RBSMR database at 12 months of follow-up, which included 225 RA and 170 AS. Using T student, Mann–Whitney U, chi-squared or Fischer exact tests, baseline demographic and clinical features were compared between patients discontinuing bDMARDs and patients remaining on initiated bDMARDs or switching bDMARDs. Logistic regression models were used to identify factors associated with drugs discontinuation. 61 RA discontinued bDMARDs and 47 AS interrupted anti-TNF. The most common reasons for drugs discontinuation were adverse events (7.5%) in RA patients and social security reimbursement problems (16.8%) in AS. RA patients discontinuing bDMARDs were more frequently first-line biological drugs users, more frequently female and had more comorbidities and lower DAS28 CRP than RA patients remaining on initiated bDMARDs or switching bDMARDs (
p
< 0.001,
p
= 0.01,
p
< 0.001 and
p
< 0.001 respectively). Female sex and comorbidities were the significant predictors of bDMARDs discontinuation in RA patients. Higher baseline BASDAI had a protective role on anti-TNF interruption in AS patients. Adverse events and social security reimbursement problems were the main reasons for drugs discontinuation in RA and AS patients respectively. Female sex and comorbidities in RA patients, baseline BASDAI in AS patients impacted bDMARDs discontinuation in real-life settings.
The following comments address an inappropriate implementation of a theoretical relationship and some incorrect qualitative and quantitative findings in the paper, as mentioned above. Therefore, this ...analysis clarifies the article “Numerical study on the conjugate effect of joule heating and magneto-hydrodynamics mixed convection in an obstructed lid-driven square cavity.” International Communications in Heat and Mass Transfer 37 (2010), 524–534.
For an efficient electron transfer from donor to acceptor unit, the heterocycles units play a crucial role as π-bridges in the Donor-π-Acceptor (D-π-A) organic sensitizers for dye-sensitized solar ...cells (DSSCs). A series of organic D-π-A dyes, based on triphenylamine donor (D), cyanoacrylic acid acceptor (A)and bridged by different π-conjugated spacer systems, are studied by density functional theory (DFT) and time-dependent DFT (TD-DFT) with the Becke 3-Parameter-Lee-Yang-Parr (B3LYP) functional and the 6-31G (d, p) basis set. Generally, the fundamental parameters, such as the HOMO and LUMO energies, of studying dyes have been discussed. The calculated results show that the narrow energy gaps (1.98 to 2.48 eV) and the large visible absorption bands (from 556.72 to 707.10 nm), suggest the studied compounds as promising light harvesters materials for organic solar cell applications. Furthermore, our theoretical results demonstrate that sensitizer D5 with the benzothiadiazole spacer has a broader absorption (707.10 nm) and the lower energy gap (1.98 eV) compare to other dyes; this opens a new way to design new efficient organic sensitizers for dye sensitized solar cells (DSSCs).
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