A foldable organic light‐emitting diode display integrating a touch sensor is fabricated. The touch sensor has an in‐cell structure where metal‐mesh sensor electrodes are formed in a counter ...substrate. It is demonstrated that touch on the entire panel surface, including a bent portion, is detected and that the touch panel operates correctly after 100,000 folding operations with a radius of curvature of 5 mm.
A foldable organic light‐emitting diode display integrating a touch sensor is fabricated. The touch sensor has an in‐cell structure where metal‐mesh sensor electrodes are formed in a counter substrate. It is demonstrated that touch on the entire panel surface, including a bent portion, is detected and that the touch panel operates correctly after 100,000 folding operations with a radius of curvature of 5 mm.
Semaphorin-3A (Sema3A), a member of class 3 semaphorins, regulates axon and dendrite guidance in the nervous system. How Sema3A and its receptors plexin-As and neuropilins regulate neuronal guidance ...is unknown. We observed that in
fyn- and
cdk5-deficient mice, Sema3A-induced growth cone collapse responses were attenuated compared to their heterologous controls. Cdk5 is associated with plexin-A2 through the active state of Fyn. Sema3A promotes Cdk5 activity through phosphorylation of Tyr15, a phosphorylation site with Fyn. A Cdk5 mutant (Tyr15 to Ala) shows a dominant-negative effect on the Sema3A-induced collapse response. The
sema3A gene shows strong interaction with
fyn for apical dendrite guidance in the cerebral cortex. We propose a signal transduction pathway in which Fyn and Cdk5 mediate neuronal guidance regulated by Sema3A.
Cerebral cavernous malformations (CCM) are irregularly shaped and enlarged capillaries in the brain that are prone to hemorrhage, resulting in headaches, seizures, strokes and even death in patients. ...The disease affects up to 0.5% of the population and the inherited form has been linked to mutations in one of three genetic loci, CCM1, CCM2 and CCM3. To understand the pathophysiology underlying the vascular lesions in CCM, it is critical to develop a reproducible mouse genetic model of this disease. Here, we report that limited conditional ablation of Ccm2 in young adult mice induces observable neurological dysfunction and reproducibly results in brain hemorrhages whose appearance is highly reminiscent of the lesions observed in human CCM patients. We first demonstrate that conventional or endothelial-specific deletion of Ccm2 leads to fatal cardiovascular defects during embryogenesis, including insufficient vascular lumen formation as well as defective arteriogenesis and heart malformation. These findings confirm and extend prior studies. We then demonstrate that the inducible deletion of Ccm2 in adult mice recapitulates the CCM-like brain lesions in humans; the lesions display disrupted vascular lumens, enlarged capillary cavities, loss of proper neuro-vascular associations and an inflammatory reaction. The CCM lesions also exhibit damaged neuronal architecture, the likely cause of neurologic defects, such as ataxia and seizure. These mice represent the first CCM2 animal model for CCM and should provide the means to elucidate disease mechanisms and evaluate therapeutic strategies for human CCM.
Single-cell RNA-seq analysis has been widely used for revealing heterogeneity of cells in various tissues and conditions. The goal of our research is to elucidate a variety of responses of individual ...leukocytes in inflammatory stimulation by analyzing their transcriptomic heterogeneity. In this research, we present an analysis of single-cell transcriptome data of mouse leukocytes in several inflammatory stimulations.
The result of analyses of an arcade flare on 1999 July 19, observed by the Satellite TRACE, is reported, and the significance of the following findings is stressed. It is clearly seen that four ...magnetic regions of alternating polarities named A(
$+$
), B(
$-$
), C(
$+$
), and D(
$-$
) from the East in the flaring region are involved in this arcade flare event in an essential way. The high structure covering the triangular region between A and the northern part of D disappears when the dark filament lying between B and C erupts. The X-ray arcade is formed only between B and C. The overlying structure connecting regions A and the northern part of D disappears and the entire region is involved in the flare. Low-lying loops connect the inner sources to the outer sources. The field lines from regions B to A and C to D are not much affected by the eruption of the dark filament, itself, but the loops near the upper surfaces of the closed loop regions are clearly seen to move toward each other (from both sides to the central line) as the arcade flare progresses between the inner pair, B and C; some of them appear to be converted into a flare arcade. The observed behavior can best be understood in terms of the quadruple magnetic source model advocated by one of the authors (YU). The long-conceived “reclosing of once opened bipolar magnetic arcade” models by the rising dark filament (called CSHKP model) find it difficult to explain this.
We fabricated a hybrid display with low power consumption and high visibility in any environment by combining organic light‐emitting diodes (OLEDs) and reflective liquid crystal (LC) elements. This ...display, which has improved pixel structures of OLEDs and reflective LC elements, achieves high resolution and low power consumption.
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