The germination of uredospores appears to be controlled by simple molecules. Few of these compounds have been isolated or characterized, and their mode of action is even more obscure. Recent results ...show that uredospores can serve as excellent models for basic studies of regulatory mechanisms involved in the transition from the resting spore to active growth. The literature on germination inhibitors, stimulators and differentiation factors is reviewed, principally in rust fungi, to provide an example of the scope and direction that the work is taking among higher fungi.