We are in an era of precision measurements at the Large Hadron Collider. The precision that can be achieved on some of those is limited however due to large systematic uncertainties. This paper ...introduces a new technique to reduce the total systematic uncertainty by quantifying the systematic impact of single events and correlating it with event observables to identify classes of events that are more sensitive to systematic effects. A proof of concept is presented by means of a simplified top quark mass estimator applied on simulated events. Even without a thorough optimization, it is shown that the total systematic uncertainty can be reduced by at least 30%.
Top quark properties Petra Van Mulders; on behalf of the ATLAS; Collaborations, CMS
arXiv.org,
12/2018
Paper, Journal Article
Odprti dostop
The multi-purpose experiments at CERN's Large Hadron Collider have a very rich programme in top quark physics. The large amount of data allows for measuring the top quark properties with an ...unprecedented precision. This document presents some of the properties that have been measured using top quark pair events produced in proton-proton collisions with a centre-of-mass energy of 13 TeV. The focus lies on the measurements of the colour flow, the charge asymmetry and spin correlations in top quark pair events.
Strawberry cultivation is notoriously unpredictable due to inherent fluctuating yields. The possibility for yield prediction has useful and important operational and logistical advantages. One ...possible indicator for yield prediction is the number of blooming flowers. Counting flowers however is very labor intensive and difficult to extrapolate over larger areas due to local variations. In this paper we present an automated predictive strategy for counting strawberry flowers in agricultural settings by image processing of drone imagery. The counting algorithm is based upon density prediction with a convolutional neural network (CNN). Furthermore, we present the data collection, annotation and augmentation, and focus on several practical issues that can have a large effect on the performance of this technique. The automated counts are assessed against manually annotated results which differ by less than 10%, and is comparable to the variation in annotation among different observers.
CMS analysis operations Andreeva, J; Calloni, M; Colling, D ...
Journal of physics. Conference series,
04/2010, Letnik:
219, Številka:
7
Journal Article
Recenzirano
Odprti dostop
During normal data taking CMS expects to support potentially as many as 2000 analysis users. Since the beginning of 2008 there have been more than 800 individuals who submitted a remote analysis job ...to the CMS computing infrastructure. The bulk of these users will be supported at the over 40 CMS Tier-2 centres. Supporting a globally distributed community of users on a globally distributed set of computing clusters is a task that requires reconsidering the normal methods of user support for Analysis Operations. In 2008 CMS formed an Analysis Support Task Force in preparation for large-scale physics analysis activities. The charge of the task force was to evaluate the available support tools, the user support techniques, and the direct feedback of users with the goal of improving the success rate and user experience when utilizing the distributed computing environment. The task force determined the tools needed to assess and reduce the number of non-zero exit code applications submitted through the grid interfaces and worked with the CMS experiment dashboard developers to obtain the necessary information to quickly and proactively identify issues with user jobs and data sets hosted at various sites. Results of the analysis group surveys were compiled. Reference platforms for testing and debugging problems were established in various geographic regions. The task force also assessed the resources needed to make the transition to a permanent Analysis Operations task. In this presentation the results of the task force will be discussed as well as the CMS Analysis Operations plans for the start of data taking.
The high center-of-mass energy at the LHC provides the opportunity to test the predictions of some of the beyond the standard model theories. We provide an overview of a selected number of searches ...for new fermions and new bosons with the ATLAS and CMS experiments. No evidence for the existence of new particles was found and therefore limits are obtained on the parameters of the models under consideration.
Myotonic dystrophy type 1 (DM1) is caused by toxicity of an expanded, noncoding (CUG)n tract in DM protein kinase (DMPK) transcripts. According to current evidence the long (CUG)n segment is involved ...in entrapment of muscleblind (Mbnl) proteins in ribonuclear aggregates and stabilized expression of CUG binding protein 1 (CUGBP1), causing aberrant premRNA splicing and associated pathogenesis in DM1 patients. Here, we report on the use of antisense oligonucleotides (AONs) in a therapeutic strategy for reversal of RNA-gain-of-function toxicity. Using a previously undescribed mouse DM1 myoblast-myotube cell model and DM1 patient cells as screening tools, we have identified a fully 2'-O-methyl-phosphorothioate-modified (CAG)7 AON that silences mutant DMPK RNA expression and reduces the number of ribonuclear aggregates in a selective and (CUG)n-length-dependent manner. Direct administration of this AON in muscle of DM1 mouse models in vivo caused a significant reduction in the level of toxic (CUG)n RNA and a normalizing effect on aberrant premRNA splicing. Our data demonstrate proof of principle for therapeutic use of simple sequence AONs in DM1 and potentially other unstable microsatellite diseases.
Deficiency of adenosine deaminase-2 (DADA2) is an autosomal recessive autoinflammatory disease with an extremely variable disease presentation. This paper provides a comprehensive overview of the ...Dutch DADA2 cohort. We performed a retrospective cohort study in 29 ADA2-deficient patients from 23 families with a median age at inclusion of 26 years. All patients had biallelic pathogenic variants in the
ADA2
gene. The most common clinical findings included cutaneous involvement (79.3%), (hepato)splenomegaly (70.8%) and recurrent infections (58.6%). Stroke was observed in 41.4% of the patients. The main laboratory abnormalities were hypogammaglobulinemia and various cytopenias. Patients presented most often with a mixed phenotype involving vasculopathy, immunodeficiency and hematologic manifestations (62.1%). In this cohort, malignancies were reported in eight patients (27.6%), of whom five presented with a hematologic malignancy and two with a basal cell carcinoma. Four patients developed hemophagocytic lymphohistiocytosis (HLH) or an HLH-like episode, of whom three passed away during or shortly after the occurrence of HLH. TNF-inhibitors (TNFi) were effective in treating vasculopathy-associated symptoms and preventing stroke, but were hardly effective in the treatment of hematologic manifestations. Three patients underwent hematopoietic cell transplantation and two of them are doing well with complete resolution of DADA2-related symptoms. The overall mortality in this cohort was 17.2%. In conclusion, this cohort describes the clinical, genetic and laboratory findings of 29 Dutch DADA2 patients. We describe the occurrence of HLH as a life-threatening disease complication and report a relatively high incidence of malignancies and mortality.
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