We report the recent detection by the Fermi γ-ray space telescope of high-energy γ-rays from the radio galaxy NGC 1275 that makes the observation of the very high energy (VHE: E>100 GeV) part of its ...broadband spectrum particularly interesting, especially for the understanding of active galactic nuclei with misaligned multi-structured jets. The radio galaxy NGC 1275 was recently observed by VERITAS at energies above 100 GeV for about 8 hr. No VHE γ-ray emission was detected by VERITAS from NGC 1275. Finally, a 99% confidence level upper limit of 2.1% of the Crab Nebula flux level is obtained at the decorrelation energy of approximately 340 GeV, corresponding to 19% of the power-law extrapolation of the Fermi Large Area Telescope result.
The aim of this work was to assess the level of expression of rag1 and tdt genes in mouse thymic cells in response to immunization. In general, it can be concluded that T cell progen itors respond to ...xenoantigen administration by increasing the expression of rag1 and tdt genes and that preliminary stimulation of phagocytes accelerates this process. Possibly, these results may lead to a significant correction of the notion of the process of maturation and differentiation of T cells and immunophysiology of the thymus in general.
We present the results of observations of the TeV binary LS I +61? 303 with the VERITAS telescope array between 2008 and 2010, at energies above 300 GeV. In the past, both ground-based gamma-ray ...telescopes VERITAS and MAGIC have reported detections of TeV emission near the apastron phases of the binary orbit. The observations presented here show no strong evidence for TeV emission during these orbital phases; however, during observations taken in late 2010, significant emission was detected from the source close to the phase of superior conjunction (much closer to periastron passage) at a 5.6 standard deviation (5.6 Delta *s) post-trials significance. In total, between 2008 October and 2010 December a total exposure of 64.5 hr was accumulated with VERITAS on LS I +61? 303, resulting in an excess at the 3.3 Delta *s significance level for constant emission over the entire integrated data set. The flux upper limits derived for emission during the previously reliably active TeV phases (i.e., close to apastron) are less than 5% of the Crab Nebula flux in the same energy range. This result stands in apparent contrast to previous observations by both MAGIC and VERITAS which detected the source during these phases at 10% of the Crab Nebula flux. During the two year span of observations, a large amount of X-ray data were also accrued on LS I +61? 303 by the Swift X-ray Telescope and the Rossi X-ray Timing Explorer Proportional Counter Array. We find no evidence for a correlation between emission in the X-ray and TeV regimes during 20 directly overlapping observations. We also comment on data obtained contemporaneously by the Fermi Large Area Telescope.
New esters of
N
-benzoyl-3-phenoxyphenylcarboxamide acid and
N
-benzoyl-
N
′-4-bromophenyl-3-phenoxybenzamidine were synthesized. Some of the synthesized compounds were shown to inhibit the activity ...of dipeptidyl peptidase-4 and nonenzymatic glycosylation of proteins and manifested antiplatelet and antioxidant properties. The compounds tested did not display the antagonistic effect toward angiotensin II type 1 receptor, did not influence the activity of glycogen phosphorylase and had very little ability to break cross-links of the glycated proteins. The derivatives with the biological activity of two types were found, which can serve as basic molecules in the search for new drug products.
Since 2005 September, the Whipple 10 m Gamma-ray Telescope has been operated primarily as a blazar monitor. The five northern hemisphere blazars that have already been detected at the Whipple ...Observatory, Markarian 421 (Mrk 421), H1426+428, Mrk 501, 1ES 1959+650, and 1ES 2344+514, are monitored routinely each night that they are visible. We report on the Mrk 421 observations taken from 2005 November to 2006 June in the gamma-ray, X-ray, optical, and radio bands. During this time, Mrk 421 was found to be variable at all wavelengths probed. Both the variability and the correlations among different energy regimes are studied in detail here. A tentative correlation, with large spread, was measured between the X-ray and gamma-ray bands, while no clear correlation was evident among the other energy bands. In addition to this, the well-sampled spectral energy distribution of Mrk 421 (1101+384) is presented for three different activity levels. The observations of the other blazar targets will be reported separately.
The multiwavelength observation of the nearby radio galaxy M87 provides a unique opportunity to study in detail processes occurring in active galactic nuclei from radio waves to TeV -rays. Here we ...report the detection of -ray emission above 250 GeV from M87 in spring 2007 with the VERITAS atmospheric Cerenkov telescope array and discuss its correlation with the X-ray emission. The -ray emission is measured to be pointlike with an intrinsic source radius less than 4.5 super(image ). The differential energy spectrum is fitted well by a power-law function: image m super(-2) s super(-1) TeV super(-1). We show strong evidence for a year-scale correlation between the -ray flux reported by TeV experiments and the X-ray emission measured by the ASM RXTE observatory, and discuss the possible short-timescale variability. These results imply that the -ray emission from M87 is more likely associated with the core of the galaxy than with other bright X-ray features in the jet.
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