The ANAIS (Annual modulation with NaI(Tl) Scintillators) experiment aims at the confirmation or refutation of the DAMA/LIBRA positive annual modulation signal in the low energy detection rate, using ...the same target and technique, at the Canfranc Underground Laboratory (LSC) in Spain. ANAIS-112, consisting of nine 12.5 kg NaI(Tl) modules produced by Alpha Spectra Inc. in a
3
×
3
matrix configuration, is taking data smoothly in “dark matter search” mode since August, 2017, after a commissioning phase and operation of the first detectors during the last years in various set-ups. A large effort has been carried out within ANAIS to characterize the background of sodium iodide detectors, before unblinding the data and performing the first annual modulation analysis. Here, the background models developed for all the nine ANAIS-112 detectors are presented. Measured spectra from threshold to high energy in different conditions are well described by the models based on quantified activities independently estimated following several approaches. In the region from 1 to
6
keV
ee
the measured, efficiency corrected background level is
3.58
±
0.02
keV
-
1
kg
-
1
day
-
1
; NaI crystal bulk contamination is the dominant background source being
210
Pb
,
40
K
,
22
Na
and
3
H
contributions the most relevant ones. This background level, added to the achieved
1
keV
ee
analysis threshold (thanks to the outstanding light collection and robust filtering procedures developed), allow ANAIS-112 to be sensitive to the modulation amplitude measured by DAMA/LIBRA, and able to explore at three sigma level in 5 years the WIMP parameter region singled out by this experiment.
ANAIS is a direct detection dark matter experiment aiming at the study of the annual modulation expected in the interaction rate. It uses same target and technique as the DAMA/LIBRA experiment, which ...reported a highly significant positive modulation compatible with that expected for dark matter particles distributed in the galactic halo. However, other very sensitive experiments do not find any hint of particles with the required properties, although comparison is model dependent. In 2017, ANAIS-112 experiment was installed at the Canfranc Underground Laboratory (LSC), in Spain, and after the commissioning run for calibration and general assessment, ANAIS-112 started data taking in dark matter mode on August 3rd, 2017. It consists of nine NaI(Tl) modules, amounting 112.5 kg of mass in total. Here we report on the experimental apparatus and detector performance after the first year of data taking. Total live time available amounts to 341.72 days, being the corresponding exposure 105.32 kg
×
year. ANAIS-112 has achieved an analysis energy threshold of 1 keVee and an average background in the region of interest, from 1 to 6 keVee, of 3.6 counts/keVee/kg/day after correcting by the event selection efficiencies. In these conditions, ANAIS-112 will be able to test the DAMA/LIBRA result at three sigma level in five years of data taking.
The largest galaxies in the universe reside in galaxy clusters. Using sensitive observations of carbon monoxide, we show that the Spiderweb galaxy—a massive galaxy in a distant protocluster—is ...forming from a large reservoir of molecular gas. Most of this molecular gas lies between the protocluster galaxies and has low velocity dispersion, indicating that it is part of an enriched intergalactic medium. This may constitute the reservoir of gas that fuels the widespread star formation seen in earlier ultraviolet observations of the Spiderweb galaxy. Our results support the notion that giant galaxies in clusters formed from extended regions of recycled gas at high redshift.
We report the discovery of rising X-ray emission from the binary neutron star merger event GW170817. This is the first detection of X-ray emission from a gravitational-wave (GW) source. Observations ...acquired with the Chandra X-ray Observatory (CXO) at t 2.3 days post-merger reveal no significant emission, with L x 3.2 × 10 38 erg s − 1 (isotropic-equivalent). Continued monitoring revealed the presence of an X-ray source that brightened with time, reaching L x 9 × 10 38 erg s − 1 at 15.1 days post-merger. We interpret these findings in the context of isotropic and collimated relativistic outflows (both on- and off-axis). We find that the broadband X-ray to radio observations are consistent with emission from a relativistic jet with kinetic energy E k ∼ 10 49 − 50 erg , viewed off-axis with θ obs ∼ 20 ° - 40 ° . Our models favor a circumbinary density n ∼ 10 − 4 - 10 − 2 cm − 3 , depending on the value of the microphysical parameter ϵ B = 10 − 4 - 10 − 2 . A central-engine origin of the X-ray emission is unlikely. Future X-ray observations at t 100 days, when the target will be observable again with the CXO, will provide additional constraints to solve the model degeneracies and test our predictions. Our inferences on θ obs are testable with GW information on GW170817 from advanced LIGO/Virgo on the binary inclination.
ANAIS is a direct detection dark matter experiment aiming at the testing of the DAMA/LIBRA annual modulation result, which, for about two decades, has neither been confirmed nor ruled out by any ...other experiment in a model independent way. ANAIS-112, consisting of 112.5 kg of sodium iodide crystals, has been taking data at the Canfranc Underground Laboratory, Spain, since August 2017. This Letter presents the annual modulation analysis of 1.5 years of data, amounting to 157.55 kg yr. We focus on the model independent analysis searching for modulation and the validation of our sensitivity prospects. ANAIS-112 data are consistent with the null hypothesis (p values of 0.67 and 0.18 for 2-6 and 1-6 keV energy regions, respectively). The best fits for the modulation hypothesis are consistent with the absence of modulation (S_{m}=-0.0044±0.0058 cpd/kg/keV and -0.0015±0.0063 cpd/kg/keV, respectively). They are in agreement with our estimated sensitivity for the accumulated exposure, which supports our projected goal of reaching a 3σ sensitivity to the DAMA/LIBRA result in five years of data taking.
We describe the simulated data sample for the Photometric Large Synoptic Survey Telescope (LSST) Astronomical Time Series Classification Challenge (PLAsTiCC), a publicly available challenge to ...classify transient and variable events that will be observed by the LSST, a new facility expected to start in the early 2020s. The challenge was hosted by Kaggle, ran from 2018 September 28 to December 17, and included 1094 teams competing for prizes. Here we provide details of the 18 transient and variable source models, which were not revealed until after the challenge, and release the model libraries at https://doi.org/10.5281/zenodo.2612896. We describe the LSST Operations Simulator used to predict realistic observing conditions, and we describe the publicly available SNANA simulation code used to transform the models into observed fluxes and uncertainties in the LSST passbands (ugrizy). Although PLAsTiCC has finished, the publicly available models and simulation tools are being used within the astronomy community to further improve classification, and to study contamination in photometrically identified samples of SN Ia used to measure properties of dark energy. Our simulation framework will continue serving as a platform to improve the PLAsTiCC models, and to develop new models.
► Valorisation of biodiesel industry by-products for PHA production. ► Replacement of commercial carbon sources and nutrient supplements. ► Replacement of precursors for co-polymer production. ► ...Influence of salt impurities concentration on PHA production. ► Analysis of thermophysical properties of the produced PHAs.
Utilization of by-products from oilseed-based biodiesel production (crude glycerol, rapeseed meal hydrolysates) for microbial polyhydroxyalkanoate (PHA) production could lead to the replacement of expensive carbon sources, nutrient supplements and precursors for co-polymer production. Batch fermentations in shake flasks with varying amounts of free amino nitrogen led to the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (P(3HB-co-3HV)) with a 2.8–8% 3HV content. Fed-batch fermentations in shake flasks led to the production of 10.9g/L P(3HB-co-3HV) and a 55.6% P(3HB-co-3HV) content. NaCl concentrations between 2 and 6g/L gradually became inhibitory to bacterial growth and PHA formation, whereas in the case of K2SO4, the inhibitory effect was observed only at concentrations higher than 20g/L. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and nuclear magnetic resonance (13C NMR) demonstrated that the incorporation of 3HV into the obtained P(3HB-co-3HV) lowered glass transition temperature, crystallinity and melting point as compared to polyhydroxybutyrate. Integrating PHA production in existing oilseed-based biodiesel plants could enhance the viability and sustainability of this first generation biorefinery.
To enhance risk stratification for Wilms tumour (WT) in a pre-operative chemotherapy setting, we explored the prognostic significance and optimal age cutoffs in patients treated according to ...International Society of Paediatric Oncology Renal Tumour Study Group (SIOP-RTSG) protocols.
Patients(6 months-18 years) with unilateral WT were selected from prospective SIOP 93-01 and 2001 studies(1993-2016). Martingale residual analysis was used to explore optimal age cutoffs. Outcome according to age was analyzed by uni- and multivariable analysis, adjusted for sex, biopsy(yes/no), stage, histology and tumour volume at surgery.
5631 patients were included; median age was 3.4 years(IQR: 2-5.1). Estimated 5-year event-free survival (EFS) and overall survival (OS) were 85%(95%CI 83.5-85.5) and 93%(95%CI 92.0-93.4). Martingale residual plots detected no optimal age cutoffs. Multivariable analysis showed lower EFS with increasing age(linear trend P<0.001). Using previously described age categories, EFS was lower for patients aged 2-4(HR 1.34, P = 0.02), 4-10(HR 1.83, P<0.0001) and 10-18 years(HR 1.74, P = 0.01) as compared to patients aged 6 months-2 years. OS was lower for patients 4-10 years(HR 1.67, P = 0.01) and 10-18 years(HR 1.87, P = 0.04), but not for 2-4 years(HR 1.29, P = 0.23). Higher stage, histological risk group and tumour volume were independent adverse prognostic factors.
Although optimal age cutoffs could not be identified, we demonstrated the prognostic significance of age as well as previously described cutoffs for EFS (2 and 4 years) and OS (4 years) in children with WT treated with pre-operative chemotherapy. These findings encourage the consideration of age in the design of future SIOP-RTSG protocols.
Abstract
The joint detection of gravitational waves (GWs) and electromagnetic radiation from the binary neutron star (BNS) merger GW170817 has provided unprecedented insight into a wide range of ...physical processes: heavy element synthesis via the
r
-process; the production of relativistic ejecta; the equation of state of neutron stars and the nature of the merger remnant; the binary coalescence timescale; and a measurement of the Hubble constant via the “standard siren” technique. In detail, all of these results depend on the distance to the host galaxy of the merger event, NGC 4993. In this Letter we measure the surface brightness fluctuation (SBF) distance to NGC 4993 in the F110W and F160W passbands of the Wide Field Camera 3 Infrared Channel (WFC3/IR) on the
Hubble Space Telescope
(
HST
). For the preferred F110W passband we derive a distance modulus of
(
m
−
M
)
=
33.05
±
0.08
±
0.10
mag, or a linear distance
d
= 40.7 ± 1.4 ± 1.9 Mpc (random and systematic errors, respectively); a virtually identical result is obtained from the F160W data. This is the most precise distance to NGC 4993 available to date. Combining our distance measurement with the corrected recession velocity of NGC 4993 implies a Hubble constant
H
0
= 71.9 ± 7.1 km s
−1
Mpc
−1
. A comparison of our result to the GW-inferred value of
H
0
indicates a binary orbital inclination of
i
≳ 137°. The SBF technique can be applied to early-type host galaxies of BNS mergers to ∼100 Mpc with
HST
and possibly as far as ∼300 Mpc with the
James Webb Space Telescope
, thereby helping to break the inherent distance-inclination degeneracy of the GW data at distances where many future BNS mergers are likely to be detected.
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