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zadetkov: 586
1.
  • Tumor-Treating Fields: A Fo... Tumor-Treating Fields: A Fourth Modality in Cancer Treatment
    Mun, Elijah J; Babiker, Hani M; Weinberg, Uri ... Clinical cancer research, 01/2018, Letnik: 24, Številka: 2
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    Despite major advances in therapy, cancer continues to be a leading cause of mortality. In addition, toxicities of traditional therapies pose a significant challenge to tolerability and adherence. ...
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2.
  • Enzymatic Targeting of the ... Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
    Provenzano, Paolo P.; Cuevas, Carlos; Chang, Amy E. ... Cancer cell, 03/2012, Letnik: 21, Številka: 3
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    Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates inordinately high interstitial fluid ...
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3.
  • Blocking Nerve Growth Facto... Blocking Nerve Growth Factor Signaling Reduces the Neural Invasion Potential of Pancreatic Cancer Cells
    Bapat, Aditi A; Munoz, Ruben M; Von Hoff, Daniel D ... PloS one, 10/2016, Letnik: 11, Številka: 10
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    Perineural invasion (PNI) is thought to be one of the factors responsible for the high rate of tumor recurrence after surgery and the pain generation associated with pancreatic cancer. Signaling via ...
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4.
  • Inhibition of ROCK1 kinase ... Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer
    Whatcott, Clifford J; Ng, Serina; Barrett, Michael T ... PloS one, 08/2017, Letnik: 12, Številka: 8
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    ROCK, or Rho-associated coiled coil-containing protein kinase, is a member of the AGC kinase family and has been shown to play a role in cell migration, ECM synthesis, stress-fiber assembly, and cell ...
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5.
  • Desmoplasia in Primary Tumo... Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer
    Whatcott, Clifford J; Diep, Caroline H; Jiang, Ping ... Clinical cancer research, 08/2015, Letnik: 21, Številka: 15
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    Pancreatic ductal adenocarcinoma (PDAC) is characterized by high levels of fibrosis, termed desmoplasia, which is thought to hamper the efficacy of therapeutics treating PDAC. Our primary focus was ...
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6.
  • NAPOLI-1 phase 3 study of l... NAPOLI-1 phase 3 study of liposomal irinotecan in metastatic pancreatic cancer: Final overall survival analysis and characteristics of long-term survivors
    Wang-Gillam, Andrea; Hubner, Richard A.; Siveke, Jens T. ... European journal of cancer (1990), February 2019, 2019-02-00, 20190201, Letnik: 108
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    Liposomal irinotecan (nal-IRI) plus 5-fluorouracil and leucovorin (5-FU/LV) is approved for patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based ...
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7.
  • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    Von Hoff, Daniel D; Ervin, Thomas; Arena, Francis P ... The New England journal of medicine, 10/2013, Letnik: 369, Številka: 18
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    In a phase 1-2 trial of albumin-bound paclitaxel (nab-paclitaxel) plus gemcitabine, substantial clinical activity was noted in patients with advanced pancreatic cancer. We conducted a phase 3 study ...
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8.
  • BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial
    Bockorny, Bruno; Semenisty, Valerya; Macarulla, Teresa ... Nature medicine, 06/2020, Letnik: 26, Številka: 6
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    Programmed cell death 1 (PD-1) inhibitors have limited effect in pancreatic ductal adenocarcinoma (PDAC), underscoring the need to co-target alternative pathways. CXC chemokine receptor 4 (CXCR4) ...
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9.
  • Triptolide and Its Derivati... Triptolide and Its Derivatives as Cancer Therapies
    Noel, Pawan; Von Hoff, Daniel D.; Saluja, Ashok K. ... Trends in pharmacological sciences (Regular ed.), 20/May , Letnik: 40, Številka: 5
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    Triptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor, immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor solubility, ...
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10.
  • nab-Paclitaxel plus gemcita... nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial
    Goldstein, David; El-Maraghi, Robert Hassan; Hammel, Pascal ... JNCI : Journal of the National Cancer Institute, 02/2015, Letnik: 107, Številka: 2
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    Positive findings from the phase III MPACT trial led to the regulatory approval of nab-paclitaxel plus gemcitabine as a treatment option for patients with metastatic pancreatic cancer. This report is ...
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zadetkov: 586

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