Previous research has demonstrated the positive effects of congruent personal and environmental characteristics on creativity. None of them, however, has tested the formal theory of ...person-environment fit for predicting creativity in the context of multicultural experiences. This study examined the effects of two versions of person-environment fit (Demands-abilities fit and Needs-supplies fit) on employee creativity in China, taking into account the moderating role of multicultural experiences. The results, based on the data of East Asian Social Survey in the Chinese General Social Survey (CGSS) in 2015, showed employees with demands-abilities fit have lower creativity than those with demands-abilities misfit; nevertheless, the demands-abilities fit creates a growing impact on employee creativity with increasing multicultural experience. Additionally, the higher the needs-supplies fit, the stronger the employee creativity; and, the needs-supplies fit creates a growing impact on employee creativity with increasing multicultural experience. It shows that different versions of person-environment fit have different effects on employee creativity and multicultural experience moderated the effects of person-environment fit on employee creativity. Implications for research and practice are discussed.
As the most promising alternative to traditional indium tin oxide (ITO), silver nanowire (AgNW) composite transparent electrodes with improved stabilities compared with that of the pristine AgNWs ...networks have been demonstrated in various devices. However, a stable AgNW/polymer composite as the bottom electrode for perovskite solar cells has not yet been reported. Here, a long-term stable, smooth AgNW composite with an antioxidant-modified chitosan polymer was developed. The modified polymer can effectively protect pristine AgNWs from side reactions with perovskite, whereas it does not block the carrier drift through the interface of the insulating polymer. The as-prepared AgNW/polymer composite electrode exhibited a root mean square roughness below 10 nm at a scan size of 50 μm × 50 μm, and its original sheet resistance did not change obviously after aging at 85 °C for 40 days in air. As a result, the perovskite solar cell employing the composite as the bottom electrode yielded a power conversion efficiency of 7.9%, which corresponds to nearly 75% of that of the reference device with an ITO electrode.
In this work, a composite silver nanowire (AgNW) transparent electrode that is large-area ultrasmooth without conductivity or transmittance scarifice, removable but with good resistance to both water ...and organic solvent, is reported. Via a simple low-temperature solution process without complicated transfer steps or additional pressure pressing, a new kind of AgNWs composite with biocompatible and patternable chitosan polymer complex demonstrates a quite low root-mean-square roughness ∼7 nm at a largest reported scan size of 50 μm × 50 μm, which is among the best flat surface. After long-term exposure to both water and organic solvent, it still shows strong adhesion, unchanged transparency, and no obvious conductivity reduction, suggesting a good stability staying on the substrate. Meanwhile, the polymer and silver nanowire in the composite electrode can be damaged via the same process through concentrated acid or base etching to leave off the substrate, allowing a simple patterning technology. Besides, the imported insulating polymer does not lower down the opto-electrical performance, and a high figure of merit close to 300 is obtained for the composite electrode, significantly outperforming the optoelectronic performance of indium-tin oxide (ITO) coated plastics (∼100) and comparable to ITO-coated glass. It shows great advantage to replace ITO as a promising transparent electrode.
Silver nanowire (AgNW) network has been employed into many electronic devices as transparent electrode. However, the poor electrical stability under current shock has been seriously holding its ...practical application, and we still lack a long-term electrically stable AgNW system to study the underlying fundamentals of electrical failure. In this work, the electrical stability performance and failure mechanism of chitosan–ascorbic acid (Chi-AsA)/AgNW composite under current stress were thoroughly studied. The composite electrode maintained stable above 24,000 h under high current density of 100 mA cm
−1
. The main failure in AgNW composite is found to be a wave break perpendicular to the current instead of traditional uniform degradation across the entire AgNW networks. More interestingly, the AgNWs in failed composite electrode maintained their original smooth morphology excepting the crack region, while the AgNWs in pristine networks degraded to nanoparticles or became disconnected everywhere. The patterned AgNW composite in microscale exhibits long lifetime in resisting current stress as well. The effect of over-coating location, electrical stress, temperature, and over-coating materials on the electrical stability were studied. The over-coating layer of Chi-AsA is proven to suppress the silver atoms from electromigration, reduce the concentrated Joule heating at junctions, and inhibit the corrosion. The Chi-AsA/AgNW composite enables electrically stable transparent conductor for long-serving optoelectronics, and the mechanism investigation deepens the comprehension of preparing electrically stable AgNW system.
Abstract
Background
Gastric cancer patients harboring a
TP53
mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, efforts to identify the vulnerabilities to overcome these ...aggressive malignancies have made minimal progress in recent years. Therefore, there is an urgent need to explore the novel therapeutic strategies for this subclass. Histone methylation modulators are critical epigenetic targets for cancer therapies that help maintain the malignancies of cancers harboring
TP53
mutations and senescence evasion. Triggering senescence is now considered to benefit multiple cancer therapies. Furthermore, senescence-based “one-two punch” therapy was validated in clinical trials. Therefore, we hypothesized that screening epigenetic modulators might help identify a novel vulnerability to trigger senescence in gastric cancer harboring
TP53
mutations.
Results
We developed a novel efficient approach to identify senescence inducers by sequentially treating cells with drug candidates and senolytic agents. Based on this, we demonstrated that QC6352 (a selective KDM4C inhibitor) efficiently triggered cellular senescence in gastric cancer harboring
TP53
mutations. More importantly, the “one-two punch’ therapy consisting of QC6352 and SSK1 eliminates tumor cells harboring
TP53
mutations. This finding highlights a potential therapeutic strategy for the aggressive subgroup of gastric cancer. Besides, the functions of QC6352 were totally unknown. We demonstrated that QC6352 might possess far more powerful anti-tumor capacities compared to the traditional genotoxic drugs, 5-Fu and Oxaliplatin.
Conclusions
This initial investigation to identify a senescence inducer revealed that QC6352 triggers senescence in gastric cancer cells harboring
TP53
mutations by regulating the SP1/CDK2 axis through suppressing KDM4C. QC6352 and senolytic agent-SSK1 represent a novel ‘one-two punch’ therapeutic strategy for the more malignant gastric cancer subtypes.
The Ti-4Al-2V (wt. %) titanium alloy has garnered widespread applications across diverse fields due to its exceptional strength-to-weight ratio, high toughness, specific strength, and corrosion ...resistance. The welding of Ti-4Al-2V titanium alloy components is often necessary in manufacturing processes, where the reliability of a welded joint critically influences the overall service life of these components. Consequently, a comprehensive understanding of the welded joint’s microstructure and mechanical properties is imperative. In this study, Ti-4Al-2V titanium alloy was welded using multi-layer and multi-pass TIG welding techniques, and a detailed examination was conducted to analyze the microstructure and grain morphology of each microzone of the welded joint. The results revealed the presence of an initial α phase and a secondary lamellar α phase in the heat affected zone (HAZ). Meanwhile, the fusion zone (FZ) primarily comprised a coarse secondary α phase and a small amount of an acicular martensitic α’ phase. Both the recrystallization zone and the superheated zone exhibited a distinct preferred orientation, with grains smaller than 10 μm accounting for 65.9% and 55.1%, respectively. To assess the mechanical properties of the various microzones and the typical microstructure within the welded joint, nanoindentation tests were performed. The results indicated that the recrystallization zone possessed a higher nanohardness (3.753 GPa) than the incomplete recrystallization zone (3.563 GPa) and the superheated zone (3.48 GPa). Among all the microzones, the FZ exhibited the lowest average nanohardness (3.058 GPa). Notably, the basket-weave microstructure demonstrated the highest average nanohardness, reaching 3.93 GPa. This was followed by the fine-grain microstructure, which possessed a slightly lower nanohardness. The Widmanstätten microstructure, on the other hand, exhibited the lowest nanohardness among the three microstructures within the HAZ. Therefore, the basket-weave microstructure stands out as the most desirable microstructure to achieve in the welded joint. In summary, this study provides a comprehensive characterization and analysis of the microstructure and properties of Ti-4Al-2V titanium alloy TIG welds, aiming to contribute to the optimization of the TIG welding process for Ti-4Al-2V titanium alloy.
By using miniature SENB specimens, the fracture properties of the materials in the region of welded metal, 321 stainless steel heat affected zone, 690 alloy heat affected zone of 321/690 dissimilar ...metal girth welded joints were tested. Both the J-resistance curves and critical fracture toughness of the three different materials are affected by the crack size because of the effect of crack tip constraint. Groups of constraint corrected J-resistance curves of the three materials are obtained according to J-Q-M approach. The welded metals exhibit the best fracture resistance but the worst fracture resistance is observed in the material of 690 alloy heat affected zone.
Real-time phase measurement is of great value to study the evolution of optical vortex. However, it cannot be recorded in real time due to the limitation of the exposure time of the recording device ...in the experiment. Therefore, based on the temporal and spatial evolution correlation of the optical phase, a real-time phase measurement method of optical vortex generated by an acoustically induced fiber grating is proposed based on digital holographic reconstruction algorithm. First, a series of holograms are continuously recorded using a low frame rate CCD. Then, the evolution of optical vortex over time is translated into changes in transmission distance. Furthermore, the unrecorded vortex phase distributions are calculated using diffraction theory. By serializing these phase maps over time, the propagation and evolution of spiral phase structure of the vortex beam can be demonstrated in real time.
Silver nanowires (AgNWs) have been employed in various optoelectronic devices as transparent electrodes. However, it remains a great challenge to facilely pattern silver nanowires to realize ...desirable soft skin devices. Here, we develop an intact transfer method via a double-layered adhesion regulator of graphene oxide (GO) enabling complete transfer of a silver nanowire pattern from a tough substrate onto soft polydimethylsiloxane (PDMS) and flexible polyethylene (PE). We achieve positive and negative patterns simultaneously when selectively transferring silver nanowire patterns. The resulting patterned AgNW electrodes have uniform conductivity and long-term stability. The underlying mechanism of the clean transfer is thoroughly investigated via transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). GO plays a role in reducing the adhesion of AgNW to the donor tough substrate and enhancing adhesion of AgNW to the target soft substrate simultaneously. Finally, we demonstrate the utility of the patterned electrodes as transparent sensors detecting body motion. This work offers an effective solution to the challenging patterning problem of silver nanowires on a hydrophobic soft substrate, which is compatible with the soft component in emerging smart skin or wearable electronics.
Gastric cancer (GC) is a common form of cancer and the leading cause of cancer-related deaths worldwide. Chemotherapy is the primary treatment for patients with unresectable or partially resectable ...GC. However, its adverse effects and chemoresistance greatly restrict its applicability and efficacy. Although HER2-targeted therapy and immunotherapy have been successfully used for GC treatment, their beneficial population is limited. To expand the range of cancer treatments, drug repurposing has emerged as a promising strategy. In this study, we evaluated the potential of Metformin, an oral anti-hyperglycemic agent, to suppress GC progression both in vivo and in vitro. Functional investigations showed that Metformin significantly inhibits GC proliferation and migration. Furthermore, we discovered that Metformin bound and disrupted STAT1 phosphorylation, inhibiting PRMT1 expression and consequently GC progression. In conclusion, our study not only provides further evidence for the anti-GC role of Metformin but also identifies the direct target mediating the tumor-inhibitory effects of Metformin in GC.
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