Vitamin D is best known for its influence on skeletal health. There is growing recognition, however, that vitamin D has nonskeletal actions, which could have important implications for understanding ...the consequences of vitamin D deficiency. In epidemiologic studies, vitamin D deficiency has been consistently associated with an increased risk for cardiovascular disease and hypertension. Disruption of vitamin D signaling in animal models promotes hypertension, cardiac hypertrophy, and atherosclerosis. This evidence has led to the initiation of prospective randomized trials of vitamin D supplementation in individuals at risk for cardiovascular disease. The results of these trials should help to guide strategies for screening and management of vitamin D deficiency in the clinic and at the population level.
Recent strategies to prepare “omniphobic” surfaces have demonstrated that minimizing contact angle hysteresis (CAH) is the key criterion for effectiveness. CAH is affected by chemistry and topography ...defects at the molecular and higher levels, thus most surfaces exhibit significant CAH. Preparative methods for stable coatings on smooth substrates with negligible CAH (<2°) for a broad range of liquids have not been reported. In this work, we describe a simple and rapid procedure to prepare omniphobic surfaces that are stable under pressure and durable at elevated temperatures. Consistent with theory, they exhibit sliding angles that decrease with liquid surface tension. Slippery omniphobic covalently attached liquid (SOCAL) surfaces are obtained through acid‐catalyzed graft polycondensation of dimethyldimethoxysilane. The smooth, stable, and temperature‐resistant coatings show extremely low CAH (≤1°) and low sliding angles for liquids that span surface tensions from 78.2 to 18.4 mN m−1.
Omniphobic surfaces that are stable under pressure and durable at elevated temperatures were obtained by acid‐catalyzed graft polycondensation of dimethyldimethoxysilane. The slippery omniphobic covalently attached liquid (SOCAL) surfaces show extremely low contact angle hysteresis (≤1°) and low sliding angles for liquids with surface tensions from 78.2 to 18.4 mN m−1.
Summary On Sept 29, 2013, the Framingham Heart Study will celebrate 65 years since the examination of the first volunteer in 1948. During this period, the study has provided substantial insight into ...the epidemiology and risk factors of cardiovascular disease. The origins of the study are closely linked to the cardiovascular health of President Franklin D Roosevelt and his premature death from hypertensive heart disease and stroke in 1945. In this Review we describe the events leading to the foundation of the Framingham Heart Study, and provide a brief historical overview of selected contributions from the study.
We directly observe the hydrodynamic linear response of a unitary Fermi gas confined in a box potential and subject to a spatially periodic optical potential that is translated into the cloud at ...speeds ranging from subsonic to supersonic. We show that the time-dependent change of the density profile is sensitive to the thermal conductivity, which controls the relaxation rate of the temperature gradients and hence the responses arising from adiabatic and isothermal compression.
Transition-metal phosphides have been shown to be promising electrocatalysts in water for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). To maximize reactivity toward ...both entails limiting the catalyst size while maintaining reactivity and avoiding aggregation. Frame-like hollow nanostructures (nanoframes) provide the required open structure with sufficient channels into the interior volume. We demonstrate here the design and synthesis of CoP nanoframes (CoP NFs) by a strategy involving precipitation, chemical etching, and low-temperature phosphidation steps. It results in impressive bifunctional catalytic activities for both HER and OER and consequently enables a highly efficient water electrolyzer with a current density of 10 mA cm–2 driven by a cell voltage of only 1.65 V. The strategy has been generalized for the preparation of nanoframe Co dichalcogenides CoX2 NFs, with X = S, Se, and Te. The results of electrochemical measurements, supported by density functional theory calculations, show that HER catalytic activities for the series follow the sequence: CoP NFs > CoSe2 NFs > CoS2 NFs > CoTe2 NFs.
Hypoparathyroidism (hypoPT) is the most common complication following bilateral thyroid operations. Thyroid surgeons must employ strategies for minimizing and preventing post-thyroidectomy hypoPT. ...The objective of this American Thyroid Association Surgical Affairs Committee Statement is to provide an overview of its diagnosis, prevention, and treatment.
HypoPT occurs when a low intact parathyroid hormone (PTH) level is accompanied by hypocalcemia. Risk factors for post-thyroidectomy hypoPT include bilateral thyroid operations, autoimmune thyroid disease, central neck dissection, substernal goiter, surgeon inexperience, and malabsorptive conditions. Medical and surgical strategies to minimize perioperative hypoPT include optimizing vitamin D levels, preserving parathyroid blood supply, and autotransplanting ischemic parathyroid glands. Measurement of intraoperative or early postoperative intact PTH levels following thyroidectomy can help guide patient management. In general, a postoperative PTH level <15 pg/mL indicates increased risk for acute hypoPT. Effective management of mild to moderate potential or actual postoperative hypoPT can be achieved by administering either empiric/prophylactic oral calcium and vitamin D, selective oral calcium, and vitamin D based on rapid postoperative PTH level(s), or serial serum calcium levels as a guide. Monitoring for rebound hypercalcemia is necessary to avoid metabolic and renal complications. For more severe hypocalcemia, inpatient management may be necessary. Permanent hypoPT has long-term consequences for both objective and subjective well-being, and should be prevented whenever possible.
Photoelectrochemical (PEC) water splitting has attracted increasing attention due to its potential to mitigate energy and environmental issues. Hybrid PEC systems containing semiconductor ...photosensitizers and molecular catalysts are reported to be highly active and stable for water splitting with great potential for facilitating clean fuels production. In this review, following a showcasing of the fundamental details of hybrid PEC systems for water splitting, semiconductor/molecular catalyst interface designs are highlighted, with a focus on interfacial physicochemical interactions and binding, and interfacial energetics and dynamics for efficient charge transfer. Recent advances in hybrid system assemblies for PEC water splitting are also briefly introduced. Finally, future challenges and directions in the field of hybrid PEC water splitting for solar energy conversion are reviewed. The current review provides state‐of‐the‐art strategies for optimized interface design for creating highly active and stable PEC water splitting assemblies.
Hybrid photoelectrochemical systems combine the advantages of semiconductor light harvesting (e.g., good stability and wide light absorption), molecular complex catalysis (e.g., high atom utilization with flexible redox properties), and large “charge carrier/molecular complex” ratios. With interface design and system assembly principles demonstrated, the most recent advances of hybrid photoelectrochemical assembly for water reduction, water oxidation, and overall water splitting are highlighted.
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