Abstract
Background
Liver ischemia reperfusion injury (LIRI) is not only a common injury during liver transplantation and major hepatic surgery, but also one of the primary factors that affect the ...outcome of postoperative diseases. However, there are still no reliable ways to tackle the problem. Our study aimed to find some characteristic genes associated with immune infiltration that affect LIRI, which can provide some insights for future research in the future. Therefore, it is essential for the treatment of LIRI, the elucidation of the mechanisms of LIRI, and exploring the potential biomarkers. Efficient microarray and bioinformatics analyses can promote the understanding of the molecular mechanisms of disease occurrence and development.
Method
Data from GSE151648 were downloaded from GEO data sets, and we performed a comprehensive analysis of the differential expression, biological functions and interactions of LIRI-associated genes. Then we performed Gene ontology (GO) analysis and Kyotoencydlopedia of genes and genomes (KEGG) enrichment analysis of DEGs. At last, we performed a protein-protein interaction network to screen out hub genes.
Results
A total of 161 differentially expressed genes (DEGs) were identified. GO analysis results revealed that the changes in the modules were mostly enriched in the neutrophil degranulation, neutrophil activation involved in immune response, and neutrophil mediated immunity. KEGG enrichment analysis of DEGs demonstrated that LIRI mainly involved the cytokine-cytokine receptor interaction. Our data indicated that macrophages and neutrophils are closely related to LIRI. 9 hub genes were screened out in the protein-protein interaction network.
Conclusions
In summary, our data indicated that neutrophil degranulation, neutrophil activation involved in immune response, neutrophil mediated immunity and cytokine-cytokine receptor interaction may play a key role in LIRI, HRH1, LRP2, P2RY6, PKD1L1, SLC8A3 and TNFRSF8, which were identified as potential biomarkers in the occurrence and development of LIRI. However, further studies are needed to validate these findings and explore the molecular mechanism of these biomarkers in LIRI.
We present the first global extraction of the jet transport coefficient (qˆ) for cold nuclear matter within the framework of higher-twist expansion. The analysis takes into account the world data on ...transverse momentum broadening in semi-inclusive e-A deep inelastic scattering (DIS) and in Drell-Yan dilepton and heavy quarkonium production in p-A collisions, as well as the nuclear modification of the structure functions in DIS. The results of this work provide the first quantitative evidence for the universality and non-trivial scale dependence of the medium transport property, similar to that for nucleon structure as encoded in the standard parton distribution functions. We expect the extracted scale dependence of qˆ for cold nuclear matter can be extended to precisely identify the fundamental property of quark gluon plasma.
An extension of the van der Waals hadron resonance gas (VDWHRG) model which includes the in-medium thermal modification of hadron masses, the thermal VDWHRG (TVDWHRG) model, is considered in this ...paper. Based on the 2 + 1 flavor Polyakov linear sigma model (PLSM) and the scaling mass rule of hadrons, we obtain the temperature behavior of all hadron masses for different fixed baryon chemical potentials μB. We calculate various thermodynamic observables at μB = 0 GeV in the TVDWHRG model. An improved agreement with the lattice data from the TVDWHRG model in the crossover region ( T ∼ 0.16 – 0.19 GeV ) is observed as compared to those from the VDWHRG and ideal HRG (IHRG) models. We further discuss the effects of the in-medium modification of hadron masses and VDW interactions between (anti)baryons on the dimensionless transport coefficients, such as the shear viscosity to entropy density ratio ( η / s ) and scaled thermal ( λ / T 2 ) and electrical (σel / T) conductivities in the IHRG model at different μ B by utilizing quasiparticle kinetic theory with relaxation time approximation. We find in contrast to the IHRG model, the TVDWHRG model leads to a qualitatively and quantitatively different behavior of transport coefficients with T and μB.
The non-extensive canonical ensemble theory is reconsidered with the method of Lagrange multipliers by maximizing Tsallis entropy, with the constraint that the normalized term of Tsallis’ q−average ...of physical quantities, the sum ∑pjq, is independent of the probability pi for Tsallis parameter q. The self-referential problem in the deduced probability and thermal quantities in non-extensive statistics is thus avoided, and thermodynamical relationships are obtained in a consistent and natural way. We also extend the study to the non-extensive grand canonical ensemble theory and obtain the q-deformed Bose–Einstein distribution as well as the q-deformed Fermi-Dirac distribution. The theory is further applied to the generalized Planck law to demonstrate the distinct behaviors of the various generalized q-distribution functions discussed in literature.
•The generalized canonical ensemble theory is revisited.•The self-referential problem of Tsallis is neatly bypassed by adding an additional constraint.•The general distributions of q-BED and q-FDD, as well as its thermodynamical properties are obtained.
We calculate
ϕ
meson transverse momentum spectra in
p
+
p
collisions as well as their nuclear suppressions in central
A
+
A
collisions both at the RHIC and the LHC in LO and NLO with the QCD-improved ...parton model. We have included the parton energy loss effect in a hot/dense QCD medium with the effectively medium-modified
ϕ
fragmentation functions in the higher-twist approach of jet quenching. The nuclear modification factors of the
ϕ
meson in central
Au
+
Au
collisions at the RHIC and central
Pb
+
Pb
collisions at the LHC are provided, and nice agreement of our numerical results at NLO with the ALICE measurement is observed. Predictions of the yield ratios of neutral mesons such as
ϕ
/
π
0
,
ϕ
/
η
and
ϕ
/
ρ
0
at large
p
T
in relativistic heavy-ion collisions are also presented for the first time.
The production of the massive bosons
Z
0
and
W
±
could provide an excellent tool to study cold nuclear matter effects and the modifications of nuclear parton distribution functions (nPDFs) relative ...to the parton distribution functions (PDFs) of a free proton in high-energy nuclear reactions at the LHC as well as in heavy-ion collisions (HIC) with much higher center-of-mass energies available in the future colliders. In this paper we calculate the rapidity and transverse momentum distributions of the vector boson and their nuclear modification factors in p + Pb collisions at
s
N
N
=
63
TeV and in Pb + Pb collisions at
s
N
N
=
39
TeV in the framework of perturbative QCD by utilizing three parametrization sets of nPDFs: EPS09, DSSZ, and nCTEQ. It is found that in heavy-ion collisions at such high colliding energies, both the rapidity distribution and the transverse momentum spectrum of vector bosons are considerably suppressed in wide kinematic regions with respect to p + p reactions due to large nuclear shadowing effect. We demonstrate that the massive vector boson production processes with sea quarks in the initial state may give more contributions than those with valence quarks in the initial state; therefore in future heavy-ion collisions the isospin effect is less pronounced and the charge asymmetry of the W boson will be reduced significantly as compared to that at the LHC. A large difference between results with nCTEQ and results with EPS09 and DSSZ is observed in nuclear modifications of both rapidity and
p
T
distributions of
Z
0
and
W
in the future HIC.
Z+jet productions in heavy-ion collisions Zhang, Shan-Liang; Luo, Tan; Wang, Xin-Nian ...
Nuclear physics. A,
February 2019, 2019-02-00, Letnik:
982
Journal Article
Recenzirano
Odprti dostop
We report a systematic study of Z+jet correlation in Pb+Pb collisions at the LHC by combining the next-leading-order matrix elements calculations with matched parton shower in Sherpa for the initial ...Z+jet production, and Linear Boltzmann transport Model for jet propagation in the expanding quark-gluon-plasma. Our numerical results can well explain CMS measurements on Z+jet correlation in Pb+Pb collisions: the shift of pT imbalance xjZ=pTjet/pTZ and their mean values, the suppression of the average number of jet partners per Z boson RjZ, as well as the modification of azimuthal angle correlations ΔϕjZ. We also demonstrate that high-order corrections play a significant role in the understanding of Z+jet correlations at high energies.
An alginate lyase gene, algA, encoding a new poly β-D-mannuronate (polyM)-specific alginate lyase AlgA, was cloned from Pseudomonas sp. E03. The recombinant AlgA with (His)₆-tag, consisting of 364 ...amino acids (40.4 kDa),was purified using Ni–NTA Sepharose. The purified lyase had maximal activity (222 EU/mg) at pH 8 and 30 °C and also maintained activity between pH 7–9 and below 45 °C. It exclusively and endolytically depolymerized polyM by β-elimination into oligosaccharides with degrees of polymerization (DP) of 2–5. Due to its high substrate specificity, AlgA could be a valuable tool for production of polyM oligosaccharides with low DP and for determining the fine structure of alginate.
A series of 2-(4-phenylpiperazin-1-yl)pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized for the treatment of Alzheimer’s disease (AD). ...Their bioactivities were evaluated by the Ellman’s method, and the results showed that most of synthesized compounds displayed moderate acetylcholinesterase inhibitory activities in vitro. Among them, compound
6g
exhibited the most potent inhibitory activity against AChE with IC
50
of 0.90 μM, and poor inhibitory activity against butyrylcholinesterase (BuChE) with IC
50
of 7.53 μM, which indicated that compound
6g
was a selective AChE inhibitor, and compound
6g
as a selective AChE inhibitor was confirmed by the molecular docking studies of compound
6g
with AChE and BuChE. Furthermore, the mechanism of inhibition of compound
6g
against AChE was analyzed by the kinetic study, and the result indicated that compound
6g
was the mixed-type inhibitor of competitive inhibition and non-competitive inhibition. All the above showed that compound
6g
could be considered as a lead compound for the development of AD drugs.
Graphical abstract
Huang, Y.-G.; Yang, S.-L.; Yang, H.-F.; Wang, Y.-P.; Dai, Z.-J.; Shi, B.-W., and Wu, Q.-Y., 2021. Decadal decreases of suspended sediment concentrations within the Yangtze River Estuary: A response ...to human impacts. Journal of Coastal Research, 37(4), 852–863. Coconut Creek (Florida), ISSN 0749-0208. Changes in suspended sediment concentration (SSC) in an estuary have environmental, ecological, and social-economic implications. Under human impact, annual suspended sediment discharges into the Yangtze River Estuary (YRE) display a downward trend, greatly influencing SSCs in the YRE. In this study, statistical analysis of SSCs measured in surficial water at 10 stations in the YRE indicates variations in decadal decreases in SSC, proven to be related to dam construction and soil conservation measures in the past decades. The degree of decrease varies temporospatially, with greater reduction in the annual surficial SSCs in the inner estuary than those in the outer estuary, and with the reduction rate in the former being greater in the dry season than the flood season, primarily because of the pronounced increase in water discharge during the dry season. In the outer estuary, the reduction rate in flood seasons is greater than in dry seasons because of the greater reduction in sediment discharge during the flood season. This study finds that SSC trends can be a useful reference for related studies of the YRE.
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