This study assessed the long-term safety and tolerability of fentanyl buccal tablet (FBT) in opioid-tolerant patients with cancer and breakthrough pain (BTP) who were either naive to FBT or had ...completed 1 of 2 previous double-blind, placebo-controlled FBT studies (rollover patients).
Patients who were FBT-naive underwent titration to find a successful FBT dose. Rollover patients used a previously identified successful dose of FBT. Patients who achieved a successful dose were eligible to enter a maintenance phase (>or=12 months). Safety assessments included adverse events (AEs), physical and neurologic examinations, and clinical laboratory tests.
Two hundred thirty-two patients were enrolled. A total of 112 entered titration; 79 identified a successful FBT dose, and 77 of these patients entered the maintenance phase along with 120 rollover patients (n = 197). AEs resulted in discontinuation of therapy for 33% of patients. The most common AEs were generally typical of opioids administered to cancer patients. All serious AEs were considered to be related to the patients' underlying conditions, except for 1 incident of FBT-related drug withdrawal syndrome. Sixty patients died after enrollment because of disease progression. Fifteen (6%) patients experienced >or=1 application-site AE, all of which were considered by investigators to be related to FBT.
FBT was generally well tolerated and had a favorable safety profile in the long-term (>or=12 months) management of patients with persistent cancer pain and BTP. No unexpected AEs occurred. Safety and tolerability was similar to that observed in short-term studies.
Adult cancer pain Swarm, Robert A; Abernethy, Amy Pickar; Anghelescu, Doralina L ...
Journal of the National Comprehensive Cancer Network,
08/2013, Letnik:
11, Številka:
8
Journal Article
Recenzirano
Odprti dostop
Pain is a common symptom associated with cancer and its treatment. Pain management is an important aspect of oncologic care, and unrelieved pain significantly comprises overall quality of life. These ...NCCN Guidelines list the principles of management and acknowledge the range of complex decisions faced in the management oncologic pain. In addition to pain assessment techniques, these guidelines provide principles of use, dosing, management of adverse effects, and safe handling procedures of pharmacologic therapies and discuss a multidisciplinary approach for the management of cancer pain.
Modern Orthodoxy is a sect of Judaism which aims to combine a high level of commitment to Jewish observance with immersion in modern society. Alumni of Modern Orthodox parochial high schools have ...varying degrees of commitment towards religion. This study was designed to better understand the factors that lead adolescents towards internalizing traditional Orthodox beliefs. Previous studies on religion in general are lacking in quality and depth, using superficial factors such as church attendance to attest to religious commitment. Studies on Modern Orthodox Jewish teens are limited in quantity, with very few studies published on this population. This study focused on 1341 students from 18 Modern Orthodox high schools in the United States using the JewBALE 2.0 to collect the data. The design evaluated the relationship between spirituality and self-esteem, spiritual struggle, religious homogeny between parents and adolescents, and gender. Factors such as mental health, positive Judaic studies experience, and relationships with Judaic studies teachers were examined as potential mediators. The data indicated that students with high levels of spirituality would also have high levels of self-esteem and religious homogeny with their parents, as well as high levels of agreement with the Orthodox communal norms. Positive relationships with teachers and experiences in Jewish studies classes mediated the otherwise negative relationship between spirituality and disagreement with communal norms. Females were more likely to have high levels of spirituality than males. This study is important for those who want to better understand the factors involved in helping students enrolled in Jewish Modern Orthodox high schools achieve high levels of spirituality.
We talk about our professional lives and our personal lives as if they can be separated. The truth is you have one life to live. The balance between work and life is a reflection of the balance ...within you. Life/work balance is a barometer for well-being: personal, professional, family, and community well-being. We stress the relationship between mind, body, and spirit and how the 12 steps lead to the B in balance. As one who has reinvented me professionally throughout my career, I am aware of the challenges of life-work balance. Regardless of the association, clinical or academic situation in which I found myself, I knew that something was missing...and that something was often at the expense of family relationships. Balancing a career or business with your personal life can be challenging, but not impossible. This article addresses the role of the radiology nurse in a life that challenges balance and sets the theme for a course of actions to build the life and career you want, need, and deserve. What better time to start that journey than now? 12 references
B is for Balance is about the individual nurse – the professional, the multi-tasker, the ‘be all things to all people’ leader. While the first edition of B is for Balance was well-received and has ...been a great resource to nurses and other professionals, the second edition has been updated to focus on 12 steps to balance, including engagement, focus, sleep deficits, fatigue, diet, re-inventing one’s career, and the need for each of us to live longer and to live well.
Adult cancer pain Swarm, Robert; Abernethy, Amy Pickar; Anghelescu, Doralina L ...
Journal of the National Comprehensive Cancer Network
8, Številka:
9
Journal Article
The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care for patients with cancer. These NCCN Guidelines Insights summarize the NCCN panel's discussions ...and guideline updates from 2013 and 2014. These include modifications/additions to palliative care screening and assessment protocols, new considerations for discussing the benefits and risks of anticancer therapy, and approaches to advance care planning. Recent updates focus on enhanced patient-centered care and seek to promote earlier integration of palliative care and advance care planning in oncology.
Palliative care Levy, Michael H; Adolph, Michael D; Back, Anthony ...
Journal of the National Comprehensive Cancer Network,
2012-Oct-01, Letnik:
10, Številka:
10
Journal Article
Recenzirano
Odprti dostop
These guidelines were developed and updated by an interdisciplinary group of experts based on clinical experience and available scientific evidence. The goal of these guidelines is to help patients ...with cancer experience the best quality of life possible throughout the illness trajectory by providing guidance for the primary oncology team for symptom screening, assessment, palliative care interventions, reassessment, and afterdeath care. Palliative care should be initiated by the primary oncology team and augmented by collaboration with an interdisciplinary team of palliative care experts.
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