The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently ...been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut-lung axis. Although the gut-lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.
A detailed processing cost breakdown is given for lithium-ion battery (LIB) electrodes, which focuses on: 1) elimination of toxic, costly N-methylpyrrolidone (NMP) dispersion chemistry; 2) doubling ...the thicknesses of the anode and cathode to raise energy density; and 3) reduction of the anode electrolyte wetting and SEI-layer formation time. These processing cost reduction technologies generically adaptable to any anode or cathode cell chemistry and are being implemented at ORNL. This paper shows step by step how these cost savings can be realized in existing or new LIB manufacturing plants using a baseline case of thin (power) electrodes produced with NMP processing and a standard 10–14-day wetting and formation process. In particular, it is shown that aqueous electrode processing can cut the electrode processing cost and energy consumption by an order of magnitude. Doubling the thickness of the electrodes allows for using half of the inactive current collectors and separators, contributing even further to the processing cost savings. Finally wetting and SEI-layer formation cost savings are discussed in the context of a protocol with significantly reduced time. These three benefits collectively offer the possibility of reducing LIB pack cost from $502.8 kW h−1-usable to $370.3 kW h−1-usable, a savings of $132.5/kWh (or 26.4%).
Display omitted
•A comprehensive cost study on lithium-ion electrode processing is reported.•Advanced electrode processing can save up to $111/kWh-usable.•Reduced SEI-layer formation time can save an additional $22/kWh-usable.•These processing technologies are amenable to any anode or cathode chemistry.•Capital cost savings realized and cell processing bottlenecks addressed.
An in-depth historical and current review is presented on the science of lithium-ion battery (LIB) solid electrolyte interphase (SEI) formation on the graphite anode, including structure, morphology, ...composition, electrochemistry, and formation mechanism. During initial LIB operation, the SEI layer forms on the graphite surfaces, the most common anode material. The SEI is essential to the long-term performance of LIBs, and it also has an impact on its initial capacity loss, self-discharge characteristics, rate capability, and safety. While the presence of the anode SEI is vital, it is difficult to control its formation and growth, as they depend on several factors. These factors include the type of graphite, electrolyte composition, electrochemical conditions, and temperature. Thus, SEI formation and electrochemical stability over long-term operation should be a primary topic of future investigation in the LIB development. This article covers the progression of knowledge regarding the SEI, from its discovery in 1979 to the current state of understanding, and covers differences in the chemical and structural makeup when cell materials and components are varied. It also discusses the relationship of the SEI layer to the LIB formation step, involving both electrolyte wetting and subsequent slow charge–discharge cycles to grow the SEI.
Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death globally, and manifests as a progressive inflammatory lung disease with no curative treatment. The lung microbiome ...contributes to COPD progression, but the function of the gut microbiome remains unclear. Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species differing between the two groups. Several species, including Streptococcus sp000187445, Streptococcus vestibularis and multiple members of the family Lachnospiraceae, also correlate with reduced lung function. Untargeted metabolomics identifies a COPD signature comprising 46% lipid, 20% xenobiotic and 20% amino acid related metabolites. Furthermore, we describe a disease-associated network connecting Streptococcus parasanguinis_B with COPD-associated metabolites, including N-acetylglutamate and its analogue N-carbamoylglutamate. While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of healthy individuals, and may thus aid in the search for biomarkers for COPD.
It is critical to develop a low-cost and environmentally friendly system to manufacture and recycle lithium-ion batteries (LIBs) as the demand on LIBs keeps increasing dramatically. Conventional LIB ...cathodes are manufactured using N-methyl-2-pyrrolidone as the solvent, which is expensive, highly toxic, flammable, and energy intensive to produce and recover. Ideally, a close-loop industrial supply chain should be built, in which the batteries are manufactured, market harvested, and recycled with minimal external toxic solvent through the whole system. This work demonstrates a green and more sustainable manufacturing method for LIBs where no hazardous organic solvent is used during electrode manufacturing and recycling. The electrodes fabricated via water-based processing demonstrate comparable rate performance and cycle life to the ones from conventional solvent-based processing. Utilization of a water-soluble binder enables recovering the cathode compound from spent electrodes using water, which is successfully regenerated to deliver comparable electrochemical performance to the pristine one.
Display omitted
•Aqueous processed NCM523 cathodes show performance comparable with the NMP processed one•The spent NCM523 compound was separated from other cathode components in water•The spent NCM523 was successfully relithiated, restored and showed performance comparable with the pristine•This provides a potential path toward green and sustainable battery manufacturing
Electrochemical Energy Storage; Energy Sustainability; Manufacturing
This paper considers the effect of wake expansion on the finite blade functions in blade element/momentum theory for horizontal-axis wind turbines. For any velocity component, the function is the ...ratio of the streamtube average to that at the blade elements. In most cases, the functions are set by the trailing vorticity only and Prandtl’s tip loss factor can be a reasonable approximation to the axial and circumferential functions at sufficiently high tip speed ratio. Nevertheless, important cases like coned or swept rotors or shrouded turbines involve more complex blade functions than provided by the tip loss factor or its recent modifications. Even in the presence of significant wake expansion, the functions derived from the exact solution for the flow due to constant pitch and radius helical vortices provide accurate estimates for the axial and circumferential blade functions. Modifying the vortex pitch in response to the expansion improves the accuracy of the latter. The modified functions are more accurate than the tip loss factor for the test cases at high tip speed ratio that are studied here. The radial velocity is important for expanding flow as it has the magnitude of the induced axial velocity near the edge of the rotor. It is shown that the resulting angle of the flow to the axial direction is small even with significant expansion, as long is the tip speed ratio is high. This means that blade element theory does not have account for the effective blade sweep due to the radial velocity. Further, the circumferential variation of the radial velocity is lower than of the other components.
Engineered purification tags can facilitate very efficient purification of recombinant proteins, resulting in high yields and purities in a few standard steps. Over the years, many different ...purification tags have been developed, including short peptides, epitopes, folded protein domains, non-chromatographic tags and more recently, compound multifunctional tags with optimized capabilities. Although classic proteases are still primarily used to remove the tags from target proteins, new self-cleaving methods are gaining traction as a highly convenient alternative. In this review, we discuss some of these emerging trends, and examine their potential impacts and remaining challenges in recombinant protein research.
Ischaemic heart disease has a multifactorial aetiology and can be prevented from developing in populations primordially, and in individuals at high risk by primary prevention. The primordial approach ...focuses on social determinants of health in populations: political, economic, and social factors, principally unplanned urbanisation, illiteracy, poverty, and working and living conditions. Implementation of the UN Sustainable Development Goals can lead to major improvements in cardiovascular health, and adequate health-care financing and universal health care are important for achieving these goals. Population-level interventions should focus on tobacco control, promotion of healthy foods (fruits, vegetables, legumes, and nuts), curbing unhealthy foods (saturated fats, trans fats, refined carbohydrates, excessive salt, and alcohol), promotion of physical activity in everyday living, and control of ambient and indoor pollution. At the individual level, identification of people at high multifactorial risk and guideline-driven management of hypertension, LDL cholesterol, and diabetes is required. Strategies to improve adherence to healthy lifestyles and drug therapies are essential and can be implemented at health system, health care, and patient levels with use of education, technology, and personalised approaches. Improving quality of medical education with a focus on ischaemic heart disease prevention for physicians, nurses, allied health workers, and the public is required.
Enabling fast charging capability of high energy density Li-ion cells could dramatically increase the widespread adoption of battery electric vehicles. However, fast charging is limited by Li ion ...depletion in the electrolyte and increasing Li ion transport from cathode to anode is essential. By evaluating different Li salts in the electrolyte, we find lithium bis(fluorosulfonyl)imide (LFSI) has both higher conductivity and higher Li ion transference number compared to the traditional LiPF6 salt. In a 12-minute charge, the electrolyte with LiPF6 salt reaches the cut-off voltage rapidly while the one with LiFSI exhibits a longer constant current charge with more capacity achieved. The LiFSI electrolyte also shows better cycling performance and less Li plating after repeated fast charging cycles.
•LiFSI has higher conductivity and higher transference number than LiPF6.•LiFSI electrolyte shows 13% capacity improvement under 12-minute fast charging.•The cell using LiFSI shows much less severe Li plating after 500 cycles.
PDF
