Mature civil engineering software and platforms can provide a dynamic correlated situation of the road design, generate a quick and accurate grading design in terrain model making, and, most ...importantly, improve the design efficiency and calculation accuracy and reduce the workload of designers in the construction project. However, the application of existing platforms in complex site engineering for the design of ski tracks has not been well developed. The design process of ski tracks requires consideration of elaborate requirements in complex environmental conditions. In this study, we aim to simplify digital elevation model (DEM) data, optimize ski track contour lines, and localize the design expression of the ski track designs based on the experience of the construction of the National Alpine Ski Center in the Yanqing Competition Zone for the Beijing 2022 Winter Olympic Games. This study examines the feasibility of the optimal digital approach combining mathematics and computer science based on the case study of the warm-up and training ski track of the south area in the Yanqing Competition Zone. This study will contribute to the optimal design of skiing tracks in construction projects and help to improve designers’ workload efficiency for the design and construction of ski tracks in the future.
Obesity, metabolic changes, and intestinal microbiota disruption significantly affect tumorigenesis and metastasis in colorectal cancer (CRC). However, the relationships among these factors remain ...poorly understood. In this study, we found that a high-fat diet (HFD) promoted gut barrier dysfunction and inflammation in the colorectum and liver. We further investigated gut microbiota changes through 16S rRNA sequencing of faecal samples from HFD-fed rats and CRC hepatic metastasis patients and found an abundance of
(DSV). DSV could also induce barrier dysfunction in the colorectum and inflammation in the colorectum and liver, suggesting that it contributes to the formation of a microenvironment conducive to CRC tumorigenesis and metastasis. These findings highlight that HFD-induced microbiota dysbiosis, especially DSV abundance, could promote CRC initiation and metastasis.
is the most well-known risk factor for gastric cancer. Antibiotic resistance is the main reason for the failure of
eradication, and understanding the antibiotic resistance before treatment may be the ...main determinant of successful eradication of
. This study aims to evaluate the efficacy and safety of quadruple therapy based on faecal molecular antimicrobial susceptibility tests for the first-line eradication of
infection.
This is a single-centre, single-blind, randomised controlled trial, enrolling 855 patients with
infection. Patients are randomised to three groups for a 14-day treatment: group A: amoxicillin- and clarithromycin-based bismuth-containing quadruple therapy (BQT) (rabeprazole 10 mg, amoxicillin 1 g, clarithromycin 500 mg and colloidal bismuth 200 mg two times per day); group B: clarithromycin medication history-based BQT (rabeprazole 10 mg, amoxicillin 1 g, furazolidone 100 mg (with clarithromycin medication history)/clarithromycin 500 mg (without clarithromycin medication history) and colloidal bismuth 200 mg two times per day); group C: antimicrobial susceptibility test-based BQT (rabeprazole 10 mg, amoxicillin 1 g, clarithromycin 500 mg (clarithromycin-sensitive)/furazolidone 100 mg (clarithromycin resistant) and colloidal bismuth 200 mg two times per day). The primary end point is the eradication rate. The secondary end points are the incidence of adverse events and compliance.
This study was approved by the Ethics Committee of Second Affiliated Hospital, School of Medicine, Zhejiang University (Number 20230103). The results will be published in the appropriate peer-reviewed journal.
NCT05718609.
ObjectivesTo explore the outcomes of Helicobacter pylori infection treatments for naïve patients in the real-world settings.DesignA retrospective observational study.SettingSingle tertiary level ...academic hospital in China.ParticipantsWe identified patients initially receiving quadruple therapy for H. pylori infection from 2017 to 2020 in whom eradication was confirmed (n=23 470).Primary outcomeEfficacy of different initial H. pylori infection treatments.Secondary outcomeResults of urea breath test (UBT) after H. pylori eradication.ResultsAmong 23 470 patients who received initial H. pylori treatment, 21 285 (90.7%) were treated with amoxicillin-based regimens. The median age of the patients decreased from 2017 to 2020 (45.0 vs 39.0, p<0.0001). The main treatments were therapies containing amoxicillin and furazolidone, which had an eradication rate of 87.6% (14 707/16 784); those containing amoxicillin and clarithromycin had an eradication rate of 85.5% (3577/4182). The date of treatment, age, antibiotic regimen and duration of treatment showed correlations with the failure of H. pylori eradication in a multivariable logistic regression analysis. Finally, positive UBT results after eradication clustered around the cut-off value, in both the 13C-UBT and 14C-UBT.ConclusionsThe major H. pylori infection treatments for naïve patients were those containing amoxicillin and furazolidone, which offered the highest eradication rate. The date of treatment, age, antibiotic regimen and duration of treatment were risk factors for the failure of H. pylori eradication. Additionally, positive UBT results after eradication clustered around the cut-off value.
As a critical part of flexible electronics, flexible circuits inevitably work in a dynamic state, which causes electrical deterioration of brittle conductive materials (i.e., Cu, Ag, ITO). Recently, ...gallium‐based liquid metal particles (LMPs) with electrical stability and self‐repairing have been studied to replace brittle materials owing to their low modulus and excellent conductivity. However, LMP‐coated Ga2O3 needs to activate by external sintering, which makes it more complicated to fabricate and gives it a larger short‐circuit risk. Core–shell structural particles (Ag@LMPs) that exhibit excellent initial conductivity(8.0 Ω sq−1) without extra sintering are successfully prepared by coating nanosilver on the surface of LMPs through in situ chemical reduction. The critical stress at which rigid Ag shells rupture can be controlled by adjusting the Ag shell thickness so that LM cores with low moduli can release, achieving real‐time self‐repairing (within 200 ms) under external destruction. Furthermore, a flexible circuit utilizing Ag@LMPs is fabricated by screen printing, and exhibits outstanding stability and durability (R/R0 < 1.65 after 10 000 bending cycles in a radius of 0.5 mm) because of the functional core–shell structure. The self‐repairable Ag@LMPs prepared in this study are a candidate filler for flexible circuit design through multiple processing methods.
A novel core–shell conductive particle based on liquid metal (Ag@LMPs) is developed. This particle exhibits excellent conductivity without external sintering, while simultaneously exhibiting long‐term durability and real‐time self‐repairing in flexible circuits owing to the release of the liquid metal core. These Ag@LMPs are a candidate filler for self‐repairing flexible circuit design.
The aim of this study was to investigate the roles of connective tissue growth factor (CTGF) in the development of anastomotic strictures after surgical repair of the esophagus.
Tissues collected ...from the patients were divided into three groups based on the results of endoscopy and clinical grading. Patients without dysphagia after esophagectomy were used as the control population. The protein levels of CTGF, TGF-β1, Smad2, and Smad4 were determined by immunohistochemistry (IHC) and western blot analyses, while the mRNA levels of the two growth factors were evaluated by real-time polymerase chain reaction.
Compared with the control group, significantly increased (p < 0.01) levels of CTGF and TGF-β1 protein were observed in the anastomotic stenosis (AS) group, and levels of the two proteins detected by the IHC and western blot analyses were also significantly increased with the increasing severity of stenosis (p < 0.05). The mRNA levels of CTGF and TGF-β1 in the tissues collected from the patients with stenosis were significantly up-regulated (p < 0.05) as compared with those from the control group. In addition, the levels of Smad2 and Smad4 protein were also significantly increased (p < 0.05) with the increasing severity of stenosis, and the protein levels were positively correlated with the levels of CTGF (r = 0.59, p < 0.05) and TGF-β1 (r = 0.63, p < 0.05).
Inhibition of CTGF protein or mRNA expression may be a distinctive and effective therapy for the treatment of postoperative anastomotic strictures.
Network on chip emerged as the prime candidate to meet the requirement of increasing communication bandwidth in multi-core systems. But the scaling deep sub-micron technology exacerbated the ...reliability issues. However, not all the packets have the equal reliability degree. From this view, we proposed a method to maintain reliability based on divided data flow. Namely, the configurable CRC unit serves parts of the virtual channels on demand. The simulation results show our method can achieve a better tradeoff among reliability, cost, and performance as predicted.
To benefit of both regular topology and partially customized structure, we adopt application specified link removal strategy to minimize NoC (Network on Chip) area consumption with partial regularity ...twist and guaranteed performance. Our link removal for single application mainly includes iterative link removal selection algorithm based on low link utilization for topology optimization and turn model based deadlock free routing algorithm for irregular 2D Mesh with reduced links. In addition, we also consider multiapplication from realistic requirement and try to define various execution modes. The seamless combination of multiapplications and link removal method is achieved via corresponding interoperation of removed link set. Taking typical media applications VOPD and MWD for example, the simulation results verify proposed multi-application specified NoC link removal strategy valid for area cost optimization and acceptable performance degradation.
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