Consolidating the results of poverty alleviation and achieving carbon neutrality are serious challenges for global sustainable development, and it is essential to explore the relationship between ...these goals, and then offer scientific responses. Based on the panel data of 30 provinces in China from 2010 to 2019, this paper conducted the 2SLS model by compromising the merits of the Regression Discontinuity principle with the STIRPAT model to study the interaction between poverty alleviation and carbon reduction. The study found that: (1) the implementation of poverty alleviation aggravates the problem of carbon emissions, and the main mechanism is that poverty alleviation promotes consumption and production by increasing the wealth of farmers, thereby increasing carbon emissions. (2) Carbon reduction weakens the achievement of poverty alleviation significantly, but the mitigation effect presents an “inverted U”-shaped curve, which first increases and then wanes. (3) Farmers' income and the development of rural transportation play a role in acting on the negative effects of carbon reduction. By integrating poverty theory and energy management, this article reveals the complex relationship between two important policies in China and offers relevant policy recommendations, which will not only promote the advancement of rural revitalization but also promote global sustainable development.
•A distribution network restoration model based on multi-source collaboration is proposed.•The risk of transportation route is considered in the dispatching process of mobile power sources.•A new ...multi-objective optimization method, ripple diffusion algorithm, is used.
With the frequent occurrence of sudden natural disasters, there are more and more disaster events in distribution network, so the research on improving the resilience of distribution network after disaster has attracted increasing interest. Considering the diversity of emergency recovery resources in post-disaster distribution networks, this paper proposes a power grid resilience enhancement model based on multi-source coordination strategy, which comprehensively considers the synergistic effects of distribution line topology, distributed generator(DG) equipment and mobile power sources(MPS). In order to solve the problem that the scheduling strategy is difficult to implement due to the influence of transportation roads, this paper considers the risk problem of transportation lines on the basis of transportation distance factors, and uses ripple spreading algorithm(RSA) to calculate the Pareto front of transportation routes, which is used as an alternative set of transportation routes for MPS equipment. Finally, the IEEE 33-node model is used to verify the effectiveness of the proposed model, the importance of considering transport road risk for actual resource scheduling, and the advantages of RSA in terms of speed and accuracy. The results show that the model can effectively solve the optimal scheduling strategy according to the decision maker's risk preference.
It has been demonstrated that large numbers of tumor-specific T cells for adoptive cell transfer (ACT) can be manufactured by retroviral genetic engineering of autologous peripheral blood lymphocytes ...and expanding them over several weeks. In mouse models, this therapy is optimized when administered with dendritic cell (DC) vaccination. We developed a short 1-week manufacture protocol to determine the feasibility, safety, and antitumor efficacy of this double cell therapy.
A clinical trial (NCT00910650) adoptively transferring MART-1 T-cell receptor (TCR) transgenic lymphocytes together with MART-1 peptide-pulsed DC vaccination in HLA-A2.1 patients with metastatic melanoma. Autologous TCR transgenic cells were manufactured in 6 to 7 days using retroviral vector gene transfer, and reinfused with (n = 10) or without (n = 3) prior cryopreservation.
A total of 14 patients with metastatic melanoma were enrolled and 9 of 13 treated patients (69%) showed evidence of tumor regression. Peripheral blood reconstitution with MART-1-specific T cells peaked within 2 weeks of ACT, indicating rapid in vivo expansion. Administration of freshly manufactured TCR transgenic T cells resulted in a higher persistence of MART-1-specific T cells in the blood as compared with cryopreserved. Evidence that DC vaccination could cause further in vivo expansion was only observed with ACT using noncryopreserved T cells.
Double cell therapy with ACT of TCR-engineered T cells with a very short ex vivo manipulation and DC vaccines is feasible and results in antitumor activity, but improvements are needed to maintain tumor responses.
The highly effective phosphate-solubilizing microorganisms are significant for making full use of the potential phosphorus resources in the soil and alleviating the shortage of phosphorus resources. ...In this study, a phosphate-solubilizing fungus was isolated from wheat and cotton rhizosphere soils in the lower reaches of the Yellow River in China and was identified as
by morphological and ITS sequencing analysis. In order to obtain a fungus with more efficient phosphorus solubilization ability, we tested three positive mutant strains (P1, P2, and P3) and three negative mutant strains (N1, N2, and N3) through low-energy nitrogen ion implantation mutagenesis. Compared with the parental strain, the phosphate-solubilizing capacity of P1, P2, and P3 was enhanced by 56.88%, 42.26%, and 32.15%, respectively, and that of N1, N2, and N3 was weakened by 47.53%, 35.27%, and 30.86%, respectively. Compared with the parental strain, the total amount of organic acids secreted significantly increased in the three positive mutant strains and decreased in the negative mutant strains; the pH of culture medium was significantly lower in the positive mutant strains and higher in the negative mutant strains. The capacity of phosphate-solubilizing fungus to secrete organic acids and reduce the growth-medium pH was closely related to its phosphate-solubilizing ability. The changes in the amount of organic acids secreted by mutants can alter their acidification and phosphate-solubilizing capacity. In conclusion, this study offers a theoretical basis and strain materials for the exploration and application of phosphate-solubilizing fungi.
Specular highlight detection and removal is a fundamental problem in computer vision and image processing. In this paper, we present an efficient end-to-end deep learning model for automatically ...detecting and removing specular highlights in a single image. In particular, an encoder—decoder network is utilized to detect specular highlights, and then a novel Unet-Transformer network performs highlight removal; we append transformer modules instead of feature maps in the Unet architecture. We also introduce a highlight detection module as a mask to guide the removal task. Thus, these two networks can be jointly trained in an effective manner. Thanks to the hierarchical and global properties of the transformer mechanism, our framework is able to establish relationships between continuous self-attention layers, making it possible to directly model the mapping between the diffuse area and the specular highlight area, and reduce indeterminacy within areas containing strong specular highlight reflection. Experiments on public benchmark and real-world images demonstrate that our approach outperforms state-of-the-art methods for both highlight detection and removal tasks.
Abstract Mice deficient in classical major histocompatibility complex class I (MHCI) have aberrations in neurodevelopment. The consequences of upregulated neuronal MHCI expression have not been ...examined. We found that transgenic C57Bl/6 mice that are engineered to express higher levels of self-Db on their CNS neurons have alterations in their hippocampal morphology and retinogeniculate projections, as well as impaired neurorepair responses. Thus, enhanced neuronal classical MHCI expression can lead to aberrations in neural circuitry and neurorepair. These findings complement a growing body of knowledge concerning the neurobiological activities of MHCI and may have potential clinical relevance.
PDF
