Transition-region explosive events (EEs) are characterized by non-Gaussian line profiles with enhanced wings at Doppler velocities of 50-150 km s super( -1). They are believed to be the signature of ...solar phenomena that are one of the main contributors to coronal heating. The aim of this study is to investigate the link of EEs to dynamic phenomena in the transition region and chromosphere in an active region. We analyse observations simultaneously taken by the Interface Region Imaging Spectrograph (IRIS) in the Si IV 1394 A line and the slit-jaw (SJ) 1400 A images, and the Swedish 1-m Solar Telescope in the Ha line. In total 24 events were found. They are associated with small-scale loop brightenings in SJ 1400 A images. Only four events show a counterpart in the Ha-35 km s super( -1) and Ha+35 km s super( -1) images. Two of them represent brightenings in the conjunction region of several loops that are also related to a bright region (granular lane) in the Ha-35 km s super( -1) and Ha+35 km s super( -1) images. 16 are general loop brightenings that do not show any discernible response in the Ha images. Six EEs appear as propagating loop brightenings, from which two are associated with dark jet-like features clearly seen in the Ha-35 km s super( -1) images. We found that chromospheric events with jet-like appearance seen in the wings of the Ha line can trigger EEs in the transition region and in this case the IRIS Si IV 1394 A line profiles are seeded with absorption components resulting from Fe II and Ni II. Our study indicates that EEs occurring in active regions have mostly upper-chromosphere/transition-region origin. We suggest that magnetic reconnection resulting from the braidings of small-scale transition region loops is one of the possible mechanisms of energy release that are responsible for the EEs reported in this paper.
A consequent tendency toward high-performance quantum information processing is to develop the fully integrated photonic chip. Here, we report the on-chip generation and manipulation of entangled ...photons based on reconfigurable lithium-niobate waveguide circuits. By introducing a periodically poled structure into the waveguide circuits, two individual photon-pair sources with a controllable electro-optic phase shift are produced within a Hong-Ou-Mandel interferometer, resulting in a deterministically separated identical photon pair. The state is characterized by 92.9±0.9% visibility Hong-Ou-Mandel interference. The photon flux reaches ∼1.4×10(7) pairs nm-1 mW-1. The whole chip is designed to contain nine similar units to produce identical photon pairs spanning the telecom C and L band by the flexible engineering of nonlinearity. Our work presents a scenario for on-chip engineering of different photon sources and paves the way to fully integrated quantum technologies.
This review assesses storm studies over the North Atlantic and northwestern Europe regarding the occurrence of potential long‐term trends. Based on a systematic review of available articles, trends ...are classified according to different geographical regions, datasets, and time periods. Articles that used measurement and proxy data, reanalyses, regional and global climate model data on past and future trends are evaluated for changes in storm climate. The most important result is that trends in storm activity depend critically on the time period analysed. An increase in storm numbers is evident for the reanalyses period for the most recent decades, whereas most long‐term studies show merely decadal variability for the last 100–150 years.
Storm trends derived from reanalyses data and climate model data for the past are mostly limited to the last four to six decades. The majority of these studies find increasing storm activity north of about 55–60° N over the North Atlantic with a negative tendency southward. This increase from about the 1970s until the mid‐1990s is also mirrored by long‐term proxies and the North Atlantic Oscillation and constitutes a part of their decadal variability. Studies based on proxy and measurement data or model studies over the North Atlantic for the past which cover more than 100 years show large decadal variations and either no trend or a decrease in storm numbers. Future scenarios until about the year 2100 indicate mostly an increase in winter storm intensity over the North Atlantic and western Europe. However, future trends in total storm numbers are quite heterogeneous and depend on the model generation used.
Summary
Classical swine fever (CSF) is a devastating infectious disease of pigs caused by classical swine fever virus (CSFV). In China, CSF has been under control owing to extensive vaccination with ...the lapinized attenuated vaccine (C‐strain) since 1950s, despite sporadic or endemic in many regions. However, recently, CSF outbreaks occurred in a large number of swine herds in China. Here, we isolated 15 CSFV strains from diverse C‐strain‐vaccinated pig farms in China and characterized the genetic variations and antigenicity of the new isolates. The new strains showed unique variations in the E2 protein and were clustered to the subgenotype 2.1d of CSFV recently emerging in China in the phylogenetic tree. Cross‐neutralization test showed that the neutralizing titres of porcine anti‐C‐strain sera against the new isolates were substantially lower than those against both the highly virulent Shimen strain and the subgenotype 2.1b strains that were isolated in China in 2006 and 2009, respectively. In addition, experimental animal infection showed that the HLJZZ2014 strain‐infected pigs displayed lower mortality and less severe clinical signs and pathological changes compared with the Shimen strain‐infected pigs. The HLJZZ2014 strain was defined to be moderately virulent based on a previously established assessment system for CSFV virulence evaluation, and the virus shedding and the viral load in various tissues of the CSFV HLJZZ2014 strain‐infected pigs were significantly lower than those of the Shimen strain‐infected pigs. Taken together, the subgenotype 2.1d isolate of CSFV is a moderately virulent strain with molecular variations and antigenic alterations.
The c-Jun NH2-terminal kinase (JNK) pathway represents one subgroup of MAP kinases that are activated primarily by cytokines and exposure to environmental stress. Autophagy is a protein-degradation ...system characterized by the formation of double-membrane vacuoles termed autophagosomes. Autophagy-related gene beclin 1 plays a key role in autophagosome formation. However, the relationships between activation of JNK pathway, autophagy induction and Beclin 1 expression remain elusive. In this study, we used human cancer cell lines CNE2 and Hep3B to investigate the role of JNK-mediated Beclin 1 expression in ceramide-induced autophagic cell death. Ceramide-treated cells exhibited the characteristics of autophagy (that is, acidic vesicular organelle formation and the LC3-II generation). JNK was activated in these two cell lines exposed to ceramide and the phosphorylation of c-Jun also increased. In the meantime, we found that ceramide upregulated Beclin 1 expression in cancer cells. The upregulation of Beclin 1 expression could be blocked by SP600125 (a specific inhibitor of JNK) or a small interfering RNA (siRNA) directed against JNK1/2 or c-Jun. Chromatin immunoprecipitation and luciferase reporter analysis revealed that c-Jun was involved in the regulation of beclin 1 transcription in response to ceramide treatment. In addition, inhibition of JNK activity by SP600125 could inhibit autophagy induction by ceramide. Furthermore, Beclin 1 knockdown by siRNA also inhibited ceramide-mediated autophagic cell death. JNK-mediated Beclin 1 expression was also observed in topotecan-induced autophagy. These data suggest that activation of JNK pathway can mediate Beclin 1 expression, which plays a key role in autophagic cell death in cancer cells.
•Extension of phase field to interface damage is extended to saturated porous media.•The fluid can flow within both bulk cracks and interfacial cracks.•The formulation is adapted to voxel-based ...models of realistic heterogeneous media.•3D simulations of hydraulic fracture with interfacial damage induced by the fluid.
In this work, we propose an extension of the phase field model for the modeling of hydraulic fracturing or cracking in heterogeneous saturated porous media. The involved extensions comprise: (a) taking into account interfacial damage between the inclusions and the matrix; (b) modeling fluid flow within both matrix cracks and interfacial cracks; (c) the possibility to handle geometries of the heterogeneous media in the form of regular grids of voxels e.g. as obtained from experimental imaging techniques. The developed numerical framework is based on the phase field method with a regularized description of both bulk and interface discontinuities, extended to a fully coupled hydro-mechanical framework. Both 2D and 3D examples are presented for hydro-mechanical microcracking initiation and propagation in voxel-based models of complex heterogeneous media with interfacial damage between the inclusions and the matrix.
SARS-CoV-2 can spread by close contact through large droplet spray and indirect contact via contaminated objects. There is mounting evidence that it can also be transmitted by inhalation of infected ...saliva aerosol particles. These particles are generated when breathing, talking, laughing, coughing or sneezing. It can be assumed that aerosol particle concentrations should be kept low in order to minimize the potential risk of airborne virus transmission. This paper presents measurements of aerosol particle concentrations in a gym, where saliva aerosol production is pronounced. 35 test persons performed physical exercise and aerosol particle concentrations, CO2 concentrations, air temperature and relative humidity were obtained in the room of 886 m³. A separate test was used to discriminate between human endogenous and exogenous aerosol particles. Aerosol particle removal by mechanical ventilation and mobile air cleaning units was measured. The gym test showed that ventilation with air-change rate ACH = 2.2 h−1, i.e. 4.5 times the minimum of the Dutch Building Code, was insufficient to stop the significant aerosol concentration rise over 30 min. Air cleaning alone with ACH = 1.39 h−1 had a similar effect as ventilation alone. Simplified mathematical models were engaged to provide further insight into ventilation, air cleaning and deposition. It was shown that combining the above-mentioned ventilation and air cleaning can reduce aerosol particle concentrations with 80 to 90% , depending on aerosol size. This combination of existing ventilation supplemented with air cleaning is energy efficient and can also be applied for other indoor environments.
•Aerosol particle concentration measurements in a gym with 35 exercising persons.•Assessment of deposition, ventilation and air cleaning (AC) for aerosol reduction.•Gym ventilation with ACH = 2.2 h−1 has similar effect as air cleaning with ACH = 1.39 h−1.•Application of simplified mathematical models to predict other scenarios.•Combining ventilation & AC gives reduction factors 2.3 up to 3.7 depending on aerosol size.
To investigate how to use polymyxin B rationally in order to produce the best efficacy and safety in patients with carbapenem-resistant gram-negative organisms (CRO) infection. The clinical ...characteristics and microbiological results of 181 patients caused by CRO infection treated with polymyxin B in the First Affiliated Hospital from July 2018 to May 2020 were retrospectively analyzed. The bacterial clearance rate, clinical efficacy, adverse drug reactions and 28 days mortality were evaluated. The overall effective rate of 181 patients was 49.72%, the total bacterial clearance rate was 42.0%, and the 28 day all-cause mortality rate was 59.1%. The effective rate and bacterial clearance rate in the group of less than 24 h from the isolation of CRO to the use of polymyxin B were significantly higher than those in the group of more than 24 h. Logistics multivariate regression analysis showed that the predictive factors for effective treatment of CRO with polymyxin B were APACHEII score, duration of polymyxin B treatment, combination of polymyxin B and other antibiotics, and bacterial clearance. 17 cases (9.36%) of acute kidney injury were considered as polymyxin B nephrotoxicity and 4 cases (23.5%) recovered after polymyxin B withdrawal. After 14 days of polymyxin B use, 3 cases of polymyxin B resistance appeared, and there were 2 cases of polymyxin B resistance in the daily dose 1.5 mg/kg/day group. For CRO infection, the treatment of polymyxin B should be early, combined, optimal dose and duration of treatment, which can achieve better clinical efficacy and microbial reactions, and reduce the adverse reactions and drug resistance.
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