At the end of 2013, China reported a countrywide outbreak of measles. From January to May 2014, we investigated the clinical and immunological features of the cases of the outbreak admitted to our ...hospital. In this study, all 112 inpatients with clinically diagnosed measles were recruited from the 302 Military Hospital of China. The virus was isolated from throat swabs from these patients, and cytokine profiles were examined. By detecting the measles virus of 30 of the 112 patients, we found that this measles outbreak was of the H1 genotype, which is the major strain in China. The rates of complications, specifically pneumonia and liver injury, differed significantly in patients aged <8 months, 8 months to 18 years, and >18 years: pneumonia was more common in children, while liver injury was more common in adults. Pneumonia was a significant independent risk factor affecting measles duration. Compared to healthy subjects, measles patients had fewer CD4⁺IL-17⁺, CD4⁺IFN-𝛾⁺, and CD8⁺IFN-𝛾⁺ cells in both the acute and recovery phases. In contrast, measles patients in the acute phase had more CD8+IL-22+ cells than those in recovery or healthy subjects. We recommend that future studies focus on the agerelated distribution of pneumonia and liver injury as measles-related complications as well as the association between immunological markers and measles prognosis.
A
bstract
Based on
e
+
e
−
collision samples corresponding to an integrated luminosity of 4.4 fb
−
1
collected with the BESIII detector at center-of-mass energies between 4
.
6 GeV and 4
.
7 GeV, a ...partial wave analysis of the charmed baryon hadronic decay
Λ
c
+
→
Λ
π
+
π
0
is performed, and the decays
Λ
c
+
→
Λ
ρ
(770)
+
and
Λ
c
+
→
Σ(1385)
π
are studied for the first time. Making use of the world-average branching fraction
B
Λ
c
+
→
Λ
π
+
π
0
, their branching fractions are determined to be
B
Λ
c
+
→
Λ
ρ
770
+
=
4.06
±
0.30
±
0.35
±
0.23
×
10
−
2
,
B
Λ
c
+
→
Σ
1385
+
π
0
=
5.86
±
0.49
±
0.52
±
0.35
×
10
−
3
,
B
Λ
c
+
→
Σ
1385
0
π
+
=
6.47
±
0.59
±
0.66
±
0.38
×
10
−
3
,
where the first uncertainties are statistical, the second are systematic, and the third are from the uncertainties of the branching fractions
B
Λ
c
+
→
Λ
π
+
π
0
and
B
Σ
1385
→
Λ
π
. In addition, the decay asymmetry parameters are measured to be
α
Λ
ρ
(770)+
= − 0.763 ± 0.053 ± 0.045,
α
Σ
1385
+
π
0
=
−
0.917
±
0.069
±
0.056
, and
α
Σ
1385
0
π
+
=
−
0.789
±
0.098
±
0.056
.
Uniform silver (Ag) nanowires with an average length of 6
μm and diameter of 70
nm have been synthesized via PVP-assisted (polyvinylpyrrolidone, PVP-K30) polyol reduction. The structure of ...thus-obtained Ag nanowires has been investigated thoroughly through scanning electron microscopy (SEM), transmission electron microscopy (TEM) and selected area electron diffraction (SAED). Combined with the previous results, it is concluded that the Ag nanowires possess five-fold twinned crystal structure with 1
1
0 growth direction, bounded by five 1
0
0 planes and capped by ten 1
1
1 planes. The SAED of the pentagonal cross-section gives direct evidence of the five-fold symmetry of the Ag nanowires. The high-resolution TEM image clearly shows the five twinning boundaries with various defects. UV–visible absorption spectra, which are related to the well-defined structure of the Ag nanowires, exhibit unique transversal modes of the Ag nanowries. IR spectra of the Ag nanowires, compared with the pure PVP, indicate that the Ag atoms on the surface of the Ag nanowires are coordinated with oxygen atoms in the carbonyl group of the PVP. It has been proposed that the PVP main chain might lie on the surface of the Ag nanowires with the pyrrolidone ring tilted on them.
Apurinic/apyrimidinic endonuclease (APE1), a bifunctional AP endonuclease/redox factor, is important in DNA repair and redox signaling, may be associated with radioresistance. Here we investigate ...whether targeted inhibition of APE1 can sensitize tumor cells to irradiation in vitro and in vivo. We first constructed chimeric adenoviral vector Ad5/F35 carrying human APE1 siRNA (Ad5/F35-APE1 siRNA). The infectivity of chimeric Ad5/F35 to LOVO colon cancer cells was greater than that of Ad5. APE1 was strongly expressed and nuclear factor kappaB (NF-kappaB), a downstream molecule of APE1, known as a radioresistance factor, was constitutively active in LOVO cells. Infection of LOVO cells with Ad5/F35-APE1 siRNA resulted in a dose-dependent decrease of APE1 protein and AP endonuclease activity in vitro. Ad5/F35-APE1 siRNA significantly enhanced sensitivity of LOVO cells to irradiation in clonogenic survival assays, associated with increased cell apoptosis. The APE1 expression in LOVO cells was induced by irradiation in a dose-dependent manner, accompanied with the enhancement of DNA-binding activity of NF-kappaB and Ad5/F35-APE1 siRNA effectively inhibited constitutive and irradiation-induced APE1 expression and NF-kappaB activation. In a subcutaneous nude mouse colon cancer model, Ad5/F35-APE1 siRNA (5 x 10(8) IU, intratumoral injection) inhibited the expression of APE1 protein in LOVO xenografts, and significantly enhanced inhibition of tumor growth by irradiation. In conclusion, APE1 may be involved as one of the radioresistance factors, and targeted inhibition of APE1 shows an effective means of enhancing tumor sensitivity to radiotherapy.
A
bstract
Using data samples with an integrated luminosity of 6
.
4 fb
−
1
collected by the BESIII detector operating at the BEPCII storage ring, the process of
e
+
e
−
→
γϕJ/ψ
is studied. The ...processes of
e
+
e
−
→
ϕχ
c
1
,
c
2
,
χ
c
1
,
c
2
→
γJ/ψ
are observed with a significance of more than 10
σ
. The
s
-dependent cross section of
e
+
e
−
→
ϕχ
c
1
,
c
2
is measured between 4.600 and 4.951 GeV, and evidence of a resonance structure is found for the first time in the
ϕχ
c
2
process. We also search for the processes of
e
+
e
−
→
γX
(4140),
γX
(4274) and
γX
(4500) via the
γϕJ/ψ
final state, but no obvious structures are found. The upper limits on the production cross section times the branching fraction for these processes at the 90% confidence level are reported.
An acute gastroenteritis (AGE) outbreak caused by a norovirus occurred at a hospital in Shanghai, China, was studied for molecular epidemiology, host susceptibility and serological roles. Rectal and ...environmental swabs, paired serum samples and saliva specimens were collected. Pathogens were detected by real-time polymerase chain reaction and DNA sequencing. Histo-blood group antigens (HBGA) phenotypes of saliva samples and their binding to norovirus protruding proteins were determined by enzyme-linked immunosorbent assay. The HBGA-binding interfaces and the surrounding region were analysed by the MegAlign program of DNAstar 7.1. Twenty-seven individuals in two care units were attacked with AGE at attack rates of 9.02 and 11.68%. Eighteen (78.2%) symptomatic and five (38.4%) asymptomatic individuals were GII.6/b norovirus positive. Saliva-based HBGA phenotyping showed that all symptomatic and asymptomatic cases belonged to A, B, AB or O secretors. Only four (16.7%) out of the 24 tested serum samples showed low blockade activity against HBGA-norovirus binding at the acute phase, whereas 11 (45.8%) samples at the convalescence stage showed seroconversion of such blockade. Specific blockade antibody in the population played an essential role in this norovirus epidemic. A wide HBGA-binding spectrum of GII.6 supports a need for continuous health attention and surveillance in different settings.
Observation of e+e−→ π0π0ψ2(3823) Bai, X. H.; Balossino, I.; Bettoni, D. ...
The journal of high energy physics,
16/2, Letnik:
2023, Številka:
2
Journal Article
Recenzirano
Odprti dostop
A
bstract
Using a data sample corresponding to an integrated luminosity of 11.3 fb
−
1
collected at center-of-mass energies from 4.23 to 4.70 GeV with the BESIII detector, we observe the process
e
+
...e
−
→ π
0
π
0
ψ
2
(3823) for the first time with a statistical significance of 6
.
0 standard deviations. The ratio of average cross sections for
e
+
e
−
→ π
0
π
0
ψ
2
(3823) and
π
+
π
−
ψ
2
(3823) is determined to be
R
=
σ
e
+
e
−
→
π
0
π
0
ψ
2
3823
σ
e
+
e
−
→
π
+
π
−
ψ
2
3823
=
0.57
±
0.14
±
0.05
, which is consistent with expectations from isospin symmetry. Here and below, the first uncertainties are statistical and the second are systematic. The mass of the
ψ
2
(3823) is measured to be
M
ψ
2
(3823) = 3824
.
5
±
2
.
4
±
1
.
0 MeV/
c
2
. Due to the limited data sample, an upper limit of 18.8 MeV at 90% confidence level is set on the intrinsic width of
ψ
2
(3823).
Here the transcriptome and differential gene expression in the adult brain and gonads of the Chinese sea perch Lateolabrax maculatus were reported. A total of 78 256 909 clean reads were generated ...from the adult brain, ovary and testis by using the Illumina HiSeq2000 platform and assembled into 274 909 contigs. A total of 31 683 unigenes were annotated based on sequence similarity and 20 702 unigenes were found to exhibit 8237 gene ontology terms and 3888 signal pathways. Transcripts of 26 623 unigenes were present in all of the tissues, whereas pairwise comparisons revealed that 671/367, 496/315 and 1668/580 unigenes were up–down regulated by at least two‐fold between the brain and ovary, ovary and testis and brain and testis, respectively. Homology search led to the identification of reproduction‐associated genes of the brain‐gonad axis, including those involved in sex differentiation and maintenance. The data provided an integrated and comprehensive transcriptome resource for L. maculatus, which could be used for further research on hypothalamus‐pituitary‐gonad axis gene function, reproduction regulation and sex‐biased gene expression.
A
bstract
The singly Cabibbo-suppressed decay
D
s
+
→
K
+
π
+
π
−
π
0
is observed by using a data set corresponding to an integrated luminosity of 6.32 fb
−
1
recorded by the BESIII detector at the ...centre-of-mass energies between 4.178 and 4.226 GeV. The first amplitude analysis of
D
s
+
→
K
+
π
+
π
−
π
0
reveals the sub-structures in this decay and determines the fractions and relative phases of different intermediate processes. The dominant intermediate process is
D
s
+
→
K
*0
ρ
+
, with a fit fraction of (40
.
5 ± 2
.
8
stat
.
± 1
.
5
syst
.
)%. With the detection efficiency based on our amplitude analysis, the absolute branching fraction for
D
s
+
→
K
+
π
+
π
−
π
0
is measured to be (9
.
75
±
0
.
54
stat
.
±
0
.
17
syst
.
)
×
10
−
3
.
The cross section of the process e+e−→K+K− is measured at a number of center-of-mass energies s from 2.00 to 3.08 GeV with the BESIII detector at the Beijing Electron Positron Collider (BEPCII). The ...results provide the best precision achieved so far. A resonant structure around 2.2 GeV is observed in the cross section line shape. A Breit-Wigner fit yields a mass of M=2239.2±7.1±11.3 MeV/c2 and a width of Γ=139.8±12.3±20.6 MeV, where the first uncertainties are statistical and the second ones are systematic. In addition, the timelike electromagnetic form factor of the kaon is determined at the individual center-of-mass energy points.
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