To introduce a classification of alar retraction, and to discuss the therapeutic strategy of alar retraction with cartilage graft and the satisfaction evaluation of patients after operation.
A ...retrospective analysis was performed on 88 patients with alar retraction admitted to the Department of Plastic and Aesthetic (Burn) Surgery, the Second Xiangya Hospital of Central South University from January 2015 to December 2020, including 20 males and 68 females, aged 20 to 48 years, with an average age of 28.98 years. All patients underwent external rhinoplasty according to a series of treatment plans determined by the classification of alar retraction based on nostril exposure. Visual Analogue Scale (VAS) and Rhinoplasty Outcomes Evaluation (ROE) were used to conduct satisfaction survey before and 12 months after operation. Wilcoxon signed-rank test was used to analyze patient satisfaction.
A total of 88 patients were included in this study. According to the classification of alar retraction based on nostril expos
To analyze the epidemiological characteristics of mumps in 2012 and 2014, and to explore the preventive effect of the second dose of mumps-containing vaccine (MuCV) in mumps in Shandong province.
On ...the basis of certain model assumptions, a Space State model was formulated. Iterated Filter was applied to the epidemic model to estimate the parameters.
The basic reproduction number (
(0)) for children in schools was 4.49 (95
: 4.30-4.67) and 2.50 (95
: 2.38-2.61) respectively for the year of 2012 and 2014.
Space State model seems suitable for mumps prevalence description. The policy of 2-dose MuCV can effectively reduce the number of total patients. Children in schools are the key to reduce the mumps.
A new strategy has been put forward that small complexes with several linear-aligned metal cations can provide precursors for the growth of metal oxide nanowires, if they can be linearly connected ...with each other by bridging anions with rodlike micelles confined. As an example, Cu2O monocrystalline nanowires were prepared via a novel complex-precursor surfactant-assisted (CPSA) route, in which linear alignment of copper cations in Cu3(dmg)2Cl4 as precursors provided orientation for the growth of Cu2O nanowires while rodlike SDS micelles drove the linear units of Cu3(dmg)2Cl4 to connect with each other by Cl anions to form Cu3(dmg)2Cl2 n 2 n + and confined the diameter of nanowires. The infrared absorption spectra and laser light scattering show our strategy is reasonable and successful. The band gap of Cu2O nanowires was determined to 2.34 eV by UV−vis absorption spectrum, showing its promising application for the reversible conversion between solar energy and electrical or chemical energy. This method can be easily controlled and is expected to extend to fabricate other metal oxide or chalcogenide 1D nanomaterials.
Epitaxial anatase TiO2 films with thickness of around 300nm were deposited on SrTiO3 and irradiated with 250keV Ne ions at room temperature. X-ray diffraction, Rutherford backscattering spectrometry, ...and transmission electron microscopy were used to characterize the microstructural changes under irradiation. Two primary features are observed in the irradiated material: a damaged layer with a high density of nano-sized defects including dislocation loops was observed in the TiO2 film and, near the TiO2/SrTiO3 interface, a defect denuded zone formed on the TiO2 side while an amorphous layer formed on the SrTiO3 side. Atomistic calculations attribute the formation of both the defect-denuded zone and the interfacial amorphous layer not to the interaction between the irradiation induced defects and the TiO2/SrTiO3 hetero-interface but rather differences in chemical potential and mobilities for defects in each of the two phases.
Transgenic plants offer advantages for biomolecule production because plants can be grown on a large scale and the recombinant macromolecules can be easily harvested and extracted. We introduced an ...Aspergillus phytase gene into canola (Brassica napus) (line 9412 with low erucic acid and low glucosinolates) by Agrobacterium-mediated transformation. Phytase expression in transgenic plant was enhanced with a synthetic phytase gene according to the Brassica codon usage and an endoplasmic reticulum (ER) retention signal KDEL that confers an ER accumulation of the recombinant phytase. Secretion of the phytase to the extracellular fluid was also established by the use of the tobacco PR-S signal peptide. Phytase accumulation in mature seed accounted for 2.6% of the total soluble proteins. The enzyme can be glycosylated in the seeds of transgenic plants and retain a high stability during storage. These results suggest a commercial feasibility of producing a stable recombinant phytase in canola at a high level for animal feed supplement and for reducing phosphorus eutrophication problems.
To explore the clinical features of patients with synchronous lymphoma and carcinoma.
The clinical data of 17 patients with Synchronous lymphoma and carcinoma from February 2012 to October 2017 were ...analyzed retrospectively.
Among 17 patients of lymphoma, 1 case HL, 2 cases B-NHL, 6 cases MZBL, 3 cases DLBCL, 1 case mantle cell lymphoma (MCL) , 3 cases NK/T- cell lymphoma, 1 case anaplastic large cell lymphoma(ALCL). In terms of 17 patients with carcinoma, 3 cases esophageal carcinoma, 3 cases gastric carcinoma, 2 cases colorectal carcinoma, 7 cases thyroid carcinoma, 1 case hepatocellular carcinoma and lung cancer. Up to 15 patients received operation, and some of them combined with chemotherapy, radiotherapy and autologous transplant. Follow-up analysis showed that 3 cases was undergoing treatment, 2 cases lost follow-up, 4 cases died, 3 cases achieved CR, 3 cases remained to be at SD, and 2 cases assessed for progression or recurrence.
The relationship between lymphoma and carcinoma was under discussion, p
The reactions of 3,5‐dinitrotyrosine (H2DNTY) with Nd(NO3)3⋅6 H2O, Mn(ClO4)2⋅6 H2O, and Pb(OAc)2 afforded three homochiral compounds: discrete Nd(Hdnty)2(NO3)(H2O)5⋅3 H2O (1) and two‐ and ...three‐dimensional coordination polymers, Mn(Hdnty)2 (2) and Pb(dnty)(0.5 H2O) (3), respectively. The Nd atom in 1 displays a tricapped trigonal prism and supramolecular weak interactions, such as π–π stacking and H‐bonds, between amino and nitro groups result in the formation of a three‐dimensional network through these interactions. 2 has a two‐dimensional square‐grid topological net while 3 has the first three‐dimensional homochiral ThSi2 net. To the best of our knowledge, these are the first metal coordination compounds with 3,5‐dinitrotyrosine. Preliminary second harmonic generation (SHG) investigations indicated that 1 and 2 are SHG active with estimated responses 5 and 6 times larger than that of urea, respectively, while 3 is SHG non‐active (obeying the Klainman symmetry requirement). Strong enhancement of their SHG efficiency, compared with H2DNTY, may be due to 1) the addition of a good donor–π–acceptor organic chromophore into the compound resulting in superior qualities of both inorganic and organic materials and 2) the H‐bonds that persist in them. Crystal data: 1: C18H32N7O25Nd, Mr=890.75 g mol−1, monoclinic, P21, a=7.0179(7), b=27.060(3), c=8.3097(8) Å, α=γ=90.00, β=95.646(2)°, V=1570.4(3) Å3, Z=2, ρcalcd=1.884 Mg m−3, R1=0.0489, wR2=0.1223, μ=17.67 mm−1, S=0.811, Flack value=0.003(13); 2: C18H16N6O14Mn, Mr=595.31 g mol−1, orthorhombic, P21212, a=8.4381(14), b=13.639(2), c=19.697(3) Å, α=β=γ=90.00°, V=2266.9(6) Å3, Z=4, ρcalcd=1.744 Mg m−3, R1=0.0866, wR2=0.2030, μ=6.72 mm−1, S=1.095, Flack value=0.02(6); 3: C9H8N3O7.5Pb, Mr=485.37 g mol−1, tetragonal, P41212, a=12.8136(12), b=12.8136(12), c=14.931(2), α=β=γ=90.00°, V=2451.5(5) Å3, Z=8, ρcalcd=1.885 Mg m−3, R1=0.0564, wR2=0.1323, μ=6.942 mm−1, S=0.878, Flack value=0.03(2). For space group P43212: R1=0.0672, wR2=0.1656, S=1.034, Flack value=1.02(3); this suggests the chosen space group P41212 is correct.
Homochiral nets: The reactions of 3,5‐dinitrotyrosine (H2DNTY) with Nd(NO3)3⋅6 H2O, Mn(ClO4)2⋅6 H2O, and Pb(OAc)2 afforded three homochiral coordination compounds, Nd(Hdnty)2(NO3)(H2O)⋅3 H2O (1), Mn(Hdnty)2 (2), and Pb(dnty)(0.5 H2O) (3), respectively. Compound 1 is a discrete molecule but has a three‐dimensional network through supramolecular interactions, 2 has a two‐dimensional square‐grid topological net, while 3 is the first three‐dimensional homochiral ThSi2 net (see scheme).
A novel amperometric sensor for glucose was constructed by entrapping glucose oxidase (GOD) in a new chitosan composite doped with ferrocene monocarboxylic acid-modified 3-(aminopropyl) ...triethoxysilane enwrapping multiwalled carbon nanotubes (FMC-AMWNTs). The approach was very simple, timesaving and effectively prevented the leakage of the ferrocene monocarboxylic acid mediator during measurements. The entrapped FMC-AMWNTs composite performed excellent redox electrochemistry and acted as an electron transfer mediator. This matrix showed a biocompatible microenvironment for retaining the native activity of the entrapped GOD and a very low mass transport barrier to the substrate. Under optimal conditions, this biosensor was able to detect glucose in the linear range of 0.01–4.2
mM with a detection limit of 3.4
μM (S/N
=
3), the value of
K
M
app
was 6.3
mM. This immobilization approach effectively improved the stability of the electron transfer mediator and is promising for construction of biosensor and bioelectronic devices.
Virulence factor expression is integral to pathogenicity of Staphylococcus aureus. We previously demonstrated that aspirin, through its major metabolite, salicylic acid (SAL), modulates S. aureus ...virulence phenotypes in vitro and in vivo. We compared salicylate metabolites and a structural analogue for their ability to modulate S. aureus virulence factor expression and phenotypes: (i) acetylsalicylic acid (ASA, aspirin); (ii) ASA metabolites, salicylic acid (SAL), gentisic acid (GTA) and salicyluric acid (SUA); or (iii) diflunisal (DIF), a SAL structural analogue. None of these compounds altered the growth rate of any strain tested. ASA and its metabolites SAL, GTA and SUA moderately impaired hemolysis and proteolysis phenotypes in multiple S. aureus strain backgrounds and their respective deletion mutants. Only DIF significantly inhibited these virulence phenotypes in all strains. The kinetic profiles of ASA, SAL or DIF on expression of hla (alpha hemolysin), sspA (V8 protease) and their regulators (sigB, sarA, agr (RNAIII)) were assessed in two prototypic strain backgrounds: SH1000 (methicillin-sensitive S. aureus; MSSA) and LAC-USA300 (methicillin-resistant S. aureus; MRSA). DIF induced sigB expression which is coincident with the significant inhibition of RNAIII expression in both strains and precedes significant reductions in hla and sspA expression. The inhibited expression of these genes within 2 h resulted in the durable suppression of hemolysis and proteolysis phenotypes. These results indicate that DIF modulates the expression of key virulence factors in S. aureus via a coordinated impact on their relevant regulons and target effector genes. This strategy may hold opportunities to develop novel antivirulence strategies to address the ongoing challenge of antibiotic-resistant S. aureus.
To evaluate the efficiency of a recombinase-aided amplification (RAA) assay for the detection of
infections in
snails.
A group test was employed. Fifty
snails were collected as a detection sample. ...The detection samples without infected snails were designated as negative specimens, while the detection samples that contained different numbers of infected snails were designated as positive specimens. A total of 10 negative specimens, 10 positive specimens containing 1 infected snail, 20 positive specimens containing 2 infected snails and 10 positive specimens containing 3 infected snails were assigned. Following random grouping, 40 specimens were subject to the florescent RAA assay using a blind method. The miradium shedding method served as a gold standard, and the sensitivity, specificity, Youden's index and coincidence rate of the florescent RAA assay were estimated. In addition, 20 samples consisted of 5 negative specimens and 15 positive specimens with 1, 2 and 3 infected snails respectively were grouped ra
