The number of cases identified with autism spectrum disorder (ASD) is showing a rapid upward trend. while ASD may accompany sufferers for a lifetime, it does not mean that they cannot live a normal ...life, let alone that they have lost the possibility of holistic development. A social organization named Golden Wings that, based on the idea of holistic development, adopts a specific approach to support the development of a group of children for a long period of time. At this point in time, these children identified with ASD have shown their wonderful lives. This is a 13-year exploration, and it is still ongoing. By tracing and exploring their growth histories, the study aims to identify key elements supporting their realization of personal traits and attempt to establish a theoretical path for supporting systems needed for the development of autistic children. This study has randomly selected 10 members and their parents from the painting classes at Golden Wings, a rehabilitation center for disabled children
In the Internet age, social needs have become more diverse. The private sector has achieved great success in integrating resources to provide services to customers thanks to technological ...breakthroughs such as mobile Internet and big data, while the public sector has become even more dwarfed. The public sector urgently needs new theoretical support to integrate administrative resources more effectively, so as to provide the public with one-stop, holistic and seamless services as a whole. The “holistic governance” theory effectively responded to the abovementioned problems and gradually condensed the consensus of the academic and practical circles and became the most influential theory. The method of mathematical modeling is used to combine the improved wavelet domain Wiener filter and the comprehensive model of partial differential equations. This paper proposes an image recognition algorithm based on partial differential equations and wavelet transform. The algorithm uses weight coefficients to organically combine high-order partial differential equation models, retains the advantages of the second- and fourth-order partial differential recognition models, effectively improves the ability to maintain image edge detail information, and achieves better recognition results. This article starts with the description of the fragmentation of a street’s grassroots governance and sorts out the process of implementing overall governance with the “big linkage mechanism” as the main carrier. Due to the limitations of research ability and objective conditions, this article intercepts the “cross-section” of the big linkage mechanism in a certain street to demonstrate it and analyzes this “cross-section” more thoroughly. The experimental results of the data show that the image recognition algorithm based on partial differential equations and wavelet transform is effective and practical in the intelligent linkage system of the government urban public management.
Abstract
Intrinsic van der Waals materials layered magnets have attracted much attention, especially the air-stable semiconductor CrSBr. Herein, we carry out a comprehensive investigation of both ...bulk and monolayer CrSBr using the first-principles linear-response method. Through the calculation of the magnetic exchange interactions, it is confirmed that the ground state of bulk CrSBr is A-type antiferromagnetic, while there are five sizable large intralayer exchange interactions with small magnetic frustration, which results in a relatively high magnetic transition temperature of both bulk and monolayer CrSBr. Moreover, the significant electron doping effect and strain effect are demonstrated, with further increased Curie temperature for monolayer CrSBr, as well as an antiferromagnetic to ferromagnetic phase transition for bulk CrSBr. We also calculate the magnon spectra using linear spin-wave theory. These features of CrSBr can be helpful to clarify the microscopic magnetic mechanism and promote the application in spintronics.
Amines are fundamental motifs in bioactive natural products and pharmaceuticals. Using simple toluene derivatives, a one-pot aminobenzylation of aldehydes is introduced that provides rapid access to ...amines. Simply combining benzaldehydes, toluenes, NaN(SiMe
)
, and additive Cs(O
CCF
) (0.35 equiv.) generates a diverse array of 1,2-diarylethylamine derivatives (36 examples, 56-98% yield). Furthermore, suitably functionalized 1,2-diarylethylamines were transformed into 2-aryl-substituted indoline derivatives via Buchwald-Hartwig amination. It is proposed that the successful deprotonation of toluene by MN(SiMe
)
is facilitated by cation-π interactions between the arene and the group(I) cation that acidify the benzylic C-Hs.
Particle filters can become quite inefficient when being applied to a high-dimensional state space since a prohibitively large number of samples may be required to approximate the underlying density ...functions with desired accuracy. In this paper, by proposing an adaptive Rao-Blackwellized particle filter for tracking in surveillance, we show how to exploit the analytical relationship among state variables to improve the efficiency and accuracy of a regular particle filter. Essentially, the distributions of the linear variables are updated analytically using a Kalman filter which is associated with each particle in a particle filtering framework. Experiments and detailed performance analysis using both simulated data and real video sequences reveal that the proposed method results in more accurate tracking than a regular particle filter
Indoles are essential heterocycles in medicinal chemistry, and therefore, novel and efficient approaches to their synthesis are in high demand. Among indoles, 2‐aryl indoles have been described as ...privileged scaffolds. Advanced herein is a straightforward, practical, and transition‐metal‐free assembly of 2‐aryl indoles. Simply combining readily available 2‐fluorotoluenes, nitriles, LiN(SiMe3)2, and CsF enables the generation of a diverse array of indoles (38 examples, 48–92 % yield). A range of substituents can be introduced into each position of the indole backbone (C4 to C7, and aryl groups at C2), providing handles for further elaboration.
Indoles galore: A remarkably easy synthesis of indoles is introduced. Simply combining 2‐fluorotoluenes, benzonitriles, base, and CsF followed by heating results in the formation of 2‐aryl indoles with diverse substitution patterns.
This study takes environmental factors and individual factors as variables to explore the deep internal mechanism of the impact of a comprehensive environment on higher education physical education ...(PE) teachers' job burnout. Little research has been done on how environmental factors affect the internal mechanism of college and university PE teachers' job burnout through individual factors (e.g., professional pressure and teaching efficacy). In this study, the participants were 231 PE teachers from seven comprehensive universities, and four questionnaires were administered to measure the participants' job burnout, perceived overall environment, teaching efficacy, and occupational stress. Research has found that environmental factors have a significant negative impact on occupational stress, and occupational stress plays an important mediating role between environment and occupational burnout. Research has shown that differences in external environments lead to varying levels of personal stress among college physical education teachers, which in turn affects their level of occupational burnout. The study concludes that a good social, working, and living environment helps to reduce the work pressure on PE teachers, improves their sense of teaching efficacy, and inhibits the occurrence of teachers' job burnout.
Global geophysical networks provide powerful databases to infer globally coherent signals, and array processing techniques are useful for inferring them. In this study, we comprehensively analyze ...seven spherical harmonic-based array processing techniques: spherical harmonic stacking (SHS) as well as its gridded form (SHS_GT) and grid-interval weighted forms (SHS_GK1, SHS_GK2); matrix SHS (MSHS); multi-station experiment (MSE); and optimal sequence estimation (OSE). We first use more specific synthetic tests to evaluate the pros and cons of these techniques, and estimate bias in solutions caused by the station distributions. These methods are applied to four global observation networks, the Global Geodynamics Project (GGP) Network, the Global Seismographic Network (GSN), the Global Geomagnetic (GGM) Network and the Global GNSS Network. For the first time, we restored a much cleaner sequence for one singlet of the 0S2 mode based on the GGP network, and restored similar result for one singlet of the 3S1 mode based on the GSN network. We further isolate different Ylm-related tidal signals from the GGM network for the first time. Moreover, based on global GNSS observations, we estimate the Love number h21 = 0.6243(±7e−4) − 0.01(±6e−3)i at the Chandler Wobble (CW) frequency with OSE/MSHS (The accuracy of the estimate is an order of magnitude higher than the previous results), and further obtain the corresponding lower-mantle anelasticity (fr(ω) = −29.5 ± 0.9, fi(ω) = 12.0 ± 7.2). Our findings confirm that OSE and MSHS methods can more accurately obtain the complex amplitude of any Ylm-related signal, which is not possible with other methods (and we do obtain more precise results than previous studies upon using them); besides, we also confirm that OSE and MSHS methods can greatly reduce the interference of other signals to the target signals. Hence, we believe the results obtained from the OSE/MSHS will helpful for obtaining reasonable geophysical explanations.
•We perform comprehensive analysis of seven different array processing techniques.•The pros and cons of those methods are clearly demonstrated for the first time.•Typical cases confirm optimal sequence estimation/matrix-SHS is the preferred method.•Different Ylm related geomagnetic tides are isolated for the first time.•The lower mantle anelasticity is more robustly estimated.
Beta adrenergic receptors (βARs) mediate physiologic responses to the catecholamines epinephrine and norepinephrine released by the sympathetic nervous system. While the hormone epinephrine binds ...β1AR and β2AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately tenfold selective for the β1AR. To understand the structural basis for this physiologically important selectivity, we solved the crystal structures of the human β1AR bound to an antagonist carazolol and different agonists including norepinephrine, epinephrine and BI-167107. Structural comparison revealed that the catecholamine-binding pockets are identical between β1AR and β2AR, but the extracellular vestibules have different shapes and electrostatic properties. Metadynamics simulations and mutagenesis studies revealed that these differences influence the path norepinephrine takes to the orthosteric pocket and contribute to the different association rates and thus different affinities.
The misuse and abuse of antibiotics in livestock and poultry seriously endanger both human health and the continuously healthy development of the livestock and poultry breeding industry. ...Plant-derived bioactive compounds (curcumin, capsaicin, quercetin, resveratrol, catechin, lignans, etc.) have been widely studied in recent years, due to their extensive pharmacological functions and biological activities, such as anti-inflammatory, antioxidant, antistress, antitumor, antiviral, lowering blood glucose and lipids, and improving insulin sensitivity. Numerous studies have demonstrated that plant-derived bioactive compounds are able to enhance the host's ability to resist or diminish diseases by regulating the abundance of its gut microbiota, achieving great potential as a substitute for antibiotics. Recent developments in both humans and animals have also highlighted the major contribution of gut microbiota to the host's nutrition, metabolism, immunity, and neurological functions. Changes in gut microbiota composition are closely related to the development of obesity and can lead to numerous metabolic diseases. Mounting evidence has also demonstrated that plant-derived bioactive compounds, especially curcumin, can improve intestinal barrier function by regulating intestinal flora. Furthermore, bioactive constituents can be also directly metabolized by intestinal flora and further produce bioactive metabolites by the interaction between the host and intestinal flora. This largely enhances the protective effect of bioactive compounds on the host intestinal and whole body health, indicating that the bidirectional regulation between bioactive compounds and intestinal flora has great application potential in maintaining the host's intestinal health and preventing or treating various diseases. This review mainly summarizes the latest research progress in the bioregulation between gut microbiota and plant-derived bioactive compounds, together with its application potential in humans and animals, so as to provide theoretical support for the application of plant-derived bioactive compounds as new feed additives and potential substitutes for antibiotics in the livestock and poultry breeding industry. Overall, based on this review, it can be concluded that plant-derived bioactive compounds, by modulating gut microbiota, hold great promise toward the healthy development of both humans and animal husbandry.
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