We present the results from Suzaku observations of the Perseus Cluster, which is relatively close, the brightest in the X-ray sky, and a relaxed object with a cool core. A number of exposures of ...central regions and offset pointing with the X-ray Imaging Spectrometer cover a region within radii of 20'-30'. The central data are used to evaluate the instrumental energy-scale calibration with accuracy confirmed to within around 300 km s super(-1) by the spatial and temporal variation of the instruments. These deep and well-calibrated data are used to measure X-ray redshifts of the intracluster medium. A hint of gas bulk motion, with radial velocity of about -(150-300) km s super(-1) relative to the main system, was found at 2'-4' (45-90 kpc) west of the cluster center, where an X-ray excess and a cold front were found previously. No other velocity structure was discovered. Over spatial scales of 50-100 kpc and within 200 kpc radii of the center, the gas-radial-velocity variation is below 300 km s super(-1), while over scales of 400 kpc within 600 kpc radii, the variation is below 600 km s super(-1). These X-ray redshift distributions are compared spatially with those of optical member galaxies for the first time in galaxy clusters. Based on X-ray line widths, gas turbulent velocities within these regions are also constrained within 1000-3000 km s super(-1). These results of gas dynamics in the core and larger scales in association with cluster merger activities are discussed, and the future potential of high-energy resolution spectroscopy with ASTRO-H is considered.
The aim of the study was to evaluate the oral environment and the taste function of Japanese HIV-infected patients treated with antiretroviral therapy. Their median age of 73 patients taking anti-HIV ...drugs was 46 years. The median period of taking anti-HIV drugs was 30 months. The oral condition was evaluated by measurement of oral moisture, amount of saliva secretion, the number of oral bacteria, presence of oral candida, a taste test, and the number of missing teeth. The levels of oral moisture and secreted saliva were significantly lower in the HIV-infected group than in the healthy volunteer (control) group. The HIV-infected group showed a more robust decrease in taste sensation than the control group. The number of missing teeth was significantly higher in the HIV-infected group than in the control group. Furthermore, all of the evaluated oral conditions were worse in the HIV-infected patients whose CD4+ T lymphocyte counts were less than 500/mm
3
than in the control group. It became clear that the patients taking anti-HIV drugs, especially the CD4+ count < 500/mm3 group, had a deteriorated oral environment and dysgeusia, suggesting that the management of oral hygiene is necessary to maintain oral health, which leads to systemic health.
Overexpression of MYCN is a hallmark of neuroblastoma (NB). ALK(R1275Q), an activating mutation of ALK (anaplastic lymphoma kinase), has been found in sporadic and familial NB patients. In this ...report, we demonstrated that ALK(R1275Q) knock-in, MYCN transgenic compound mice developed NB with complete penetrance. Transcriptome analysis revealed that ALK(R1275Q) globally downregulated the expression of extracellular matrix (ECM)- and basement membrane (BM)-associated genes in both primary neuronal cells and NB tumors. Accordingly, ALK(R1275Q)/MYCN tumors exhibited reduced expression of ECM/BM-related proteins as compared with MYCN tumors. In addition, on MYCN transduction, ALK(R1275Q)-expressing neuronal cells exhibited increased migratory and invasive activities. Consistently, enhanced invasion and metastasis were demonstrated in ALK(R1275Q)/MYCN mice. These results collectively indicate that ALK(R1275Q) confers a malignant potential on neuronal cells that overexpress MYCN by impairing normal ECM/BM integrity and enhancing tumor growth and dissemination. Moreover, we found that crizotinib, an ALK inhibitor, almost completely inhibited the growth of ALK(R1275Q)/MYCN tumors in an allograft model. Our findings provided insights into the cooperative mechanism of the mutated ALK and overexpressed MYCN in the pathogenesis of NB and demonstrated the effectiveness of crizotinib on ALK(R1275Q)-positive tumors.
We performed five pointing observations with Suzaku to search for hot gases associated with the junctions of galaxy filaments where no significant diffuse X-ray sources were previously detected. We ...discovered X-ray sources successfully in all five regions including merging groups of galaxies, Suzaku J0957+2610 and Suzaku J1134+2105, and analyzed two bright sources in each field. Spectral analysis indicates that three sources originate from X-ray diffuse halos associated with optically bright galaxies or groups of galaxies with kT ~ 0.6-0.8 keV. The three other sources are possibly group- and cluster-scale X-ray halos with temperatures of ~1 keV and ~4 keV, respectively while the others are compact object origins such as active galactic nuclei. All of the three observed intracluster media within the junctions of the galaxy filaments previously found are involved in ongoing mergers. Thus, we demonstrate that deep X-ray observations at the filament junctions identified by galaxy surveys are a powerful means to explore previously undetected growing halos in a hierarchical structure.
•A threshold density for hydrodynamics between sparse and dense vegetation was found.•A secondary gyre that is generally missing in non-vegetated cavities was observed.•The mean retention time cannot ...be estimated with a single decay fit for all densities.•Vegetation further increases the macro-roughness function of lateral cavities.
Large-Eddy Simulations (LES) were used to investigate the hydrodynamics and mass transfer between the flow in the main channel and a vegetated lateral cavity. Fourteen vegetation densities (0 to 10.65 %) were tested, revealing two distinct hydrodynamic patterns. For cavities with low vegetation density (a < 3.99 %), one primary gyre in contact with the interface between main channel and cavity with high velocity was formed; the thickness of the mixing layer grew longitudinally along the interface, and regions with high vorticity and turbulence kinetic energy appeared at the interface and inside the cavity. For cavities with high vegetation density (a > 3.99 %), two gyres in contact with the interface with low velocity were formed, the thickness of the mixing layer did not grow, and the vorticity and turbulence kinetic energy were low inside the cavity. The mass transport presented the same threshold value as the hydrodynamics (a = 3.99 %). For cavities with low vegetation density, a fast mass transfer occurred through the interface between the main channel and cavity and inside the cavity, while the opposite was observed for cavities with high vegetation density. Finally, the modelled hydrodynamics was used to infer possible sediment deposition patterns and flow resistance.
The X-ray Astronomy Recovery Mission (XARM) is a recovery mission of ASTRO-H/
Hitomi
, which is expected to be launched in Japanese Fiscal Year of 2020 at the earliest. The
Resolve
instrument on XARM ...consists of an array of 6 × 6 silicon-thermistor microcalorimeters cooled down to 50 mK and a high-throughput X-ray mirror assembly with the focal length of 5.6 m.
Hitomi
was launched into orbit in February 2016 and observed several celestial objects, although the operation of
Hitomi
was terminated in April 2016. The soft X-ray spectrometer (SXS) on Hitomi demonstrated high-resolution X-ray spectroscopy of ~ 5 eV FWHM in orbit for most of the pixels. The
Resolve
instrument is planned to mostly be a copy of the Hitomi SXS and soft X-ray telescope designs, though several changes are planned based on the lessons learned from
Hitomi
. We report a brief summary of the SXS performance and the status of the Resolve instrument.
Csx/Nkx2.5 is a vertebrate homeobox gene with a sequence homology to the Drosophila tinman, which is required for the dorsal mesoderm specification. Recently, heterozygous mutations of this gene were ...found to cause human congenital heart disease (Schott, J.-J., Benson, D. W., Basson, C. T., Pease, W., Silberbach, G. M., Moak, J. P., Maron, B. J., Seidman, C. E. and Seidman, J. G. (1998) Science 281, 108-111). To investigate the functions of Csx/Nkx2.5 in cardiac and extracardiac development in the vertebrate, we have generated and analyzed mutant mice completely null for Csx/Nkx2.5. Homozygous null embryos showed arrest of cardiac development after looping and poor development of blood vessels. Moreover, there were severe defects in vascular formation and hematopoiesis in the mutant yolk sac. Interestingly, TUNEL staining and PCNA staining showed neither enhanced apoptosis nor reduced cell proliferation in the mutant myocardium. In situ hybridization studies demonstrated that, among 20 candidate genes examined, expression of ANF, BNP, MLC2V, N-myc, MEF2C, HAND1 and Msx2 was disturbed in the mutant heart. Moreover, in the heart of adult chimeric mice generated from Csx/Nkx2.5 null ES cells, there were almost no ES cell-derived cardiac myocytes, while there were substantial contributions of Csx /Nkx2.5-deficient cells in other organs. Whole-mount -gal staining of chimeric embryos showed that more than 20% contribution of Csx/Nkx2. 5-deficient cells in the heart arrested cardiac development. These results indicate that (1) the complete null mutation of Csx/Nkx2.5 did not abolish initial heart looping, (2) there was no enhanced apoptosis or defective cell cycle entry in Csx/Nkx2.5 null cardiac myocytes, (3) Csx/Nkx2.5 regulates expression of several essential transcription factors in the developing heart, (4) Csx/Nkx2.5 is required for later differentiation of cardiac myocytes, (5) Csx/Nkx2. 5 null cells exert dominant interfering effects on cardiac development, and (6) there were severe defects in yolk sac angiogenesis and hematopoiesis in the Csx/Nkx2.5 null embryos.
Aim
While deformational plagiocephaly (DP) is suspected to be associated with comorbidities, their nature and prevalence are unclear. This scoping review aims to report DP comorbidities occurring ...until the age of 2 years, their prevalence and whether they depend on the child's age and sex.
Methods
Relevant studies were identified by searching the Cochrane, MEDLINE, EMBASE, PubMed and EBSCO databases from 1992 to 30 April 2021. Data on study characteristics, comorbidities and assessment instruments were extracted and qualitatively synthesised. Risk of bias was assessed and studies with high risk of bias were excluded.
Results
Studies meeting selection criteria (n = 27) often evaluated groups from tertiary clinics, implying selection bias. Studies reported on developmental delay (n = 16), limited speech production (n = 1), auditory (n = 3), visual (n = 3), mandibular (n = 3) and neurological impairments (n = 1). The data did not allow prevalence calculation or modifying effect of sex. Due to biased data, the review provided no evidence on DP comorbidities. Weak evidence suggested that in the selective samples, DP was associated with motor and language delays in the first year.
Conclusion
Due to biased data, no evidence on comorbidity in infants with DP was available. Our study underlined the need of risk of bias assessment in scoping reviews.
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