Background Genuine Chinese medicine is produced from medicinal plant cultivated in a specific region and is of better quality and efficacy, more consistently qualified and famous than that from the ...same medicinal plant cultivated in other regions. The cultivating region of genuine medicinal plant is known as the genuine producing area. Yangchun City, which is in Guangdong Province of China, is a genuine producing area for the famous Chinese medicine Amomi Fructus (also called Sharen). Amomi Fructus is the ripe and dry fruit of the Zingiberaceae plant A. villosum Lour.. A. villosum was introduced from the Persian Gulf region and has been cultivated in China for over 1000 years. Until now there are no reports on screening for good germplasm of A. villosum. Methods The contents of volatile oil and bornyl acetate of Amomi Fructus from 14 populations were determined with GC method, and the relative contents of the main chemical components in the volatile oils were determined with GC-MS method. Evaluation and variance analysis of the comprehensive quality of the 14 samples were conducted by means of a multi-indicator entropy-weight TOPSIS model (Technique for Order Preference by Similarity to an Ideal Solution) combined with OPLS-DA (Orthogonal Partial Least Squares Discrimination Analysis) and HCA (Hierarchical Clustering Analysis). The ISSR (Inter-Simple Sequence Repeat) molecular marker technique and the UPGMA (unweighted pair-group method with arithmetic means) were employed to analyze the genetic relationship among A. villosum populations. Results The contents of volatile oil and bornyl acetate differed significantly among the different populations, but the main chemical component in the volatile oil was the same in all the samples, which was bornyl acetate. OPLS-DA results showed that 9 indicators were the main factors influencing the quality differences among the 14 populations. The entropy-weight TOPSIS results showed that there were significant differences in the comprehensive qualities of the 12 populations from the genuine producing area. The best quality of fruit was found in the genuine producing area of Chunwan Town; the qualities of 33% of genuine fruits were lower than that of non-genuine fruits. Twenty-three DNA fragments were obtained by ISSR-PCR amplification using four ISSR primers, eleven of which were polymorphic loci, which accounted for 47.8%. The similarity coefficients (GS) of different populations of A. villosum ranged from 0.6087 to 0.9565. Conclusion There are significant differences among different populations of A. villosum in terms of the kinds of major chemical components and their contents, comprehensive quality and genetic diversity. The germplasm resources of A. villosum are rich in the genuine producing area. It means superior germplasm could be selected in the area. The comprehensive quality of the fruit of A. villosum from the non-genuine producing area is better than some of that from genuine producing area, proving that the non-genuine producing area can also produce Amomi Fructus with excellent quality.
Most patients including health care workers (HCWs) survived the coronavirus disease 2019 (COVID-19), however, knowledge about the sequelae of COVID-19 after discharge remains limited.
A prospectively ...observational 3-month follow-up study evaluated symptoms, dynamic changes of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) IgG and IgM, lung function, and high resolution computed tomography (HRCT) of survivors of COVID-19 after discharge at Wuhan Union Hospital, China.
Seventy-six survivors (55 females) with a mean age of 41.3 ± 13.8 years were enrolled, and 65 (86%) were HCWs. A total of 69 (91%) patients had returned to their original work at 3-months after discharge. Most of the survivors had symptoms including fever, sputum production, fatigue, diarrhea, dyspnea, cough, chest tightness on exertion and palpitations in the three months after discharge. The serum troponin-I levels during the acute illness showed high correlation with the symptom of fatigue after hospital discharge (
= 0.782;
= 0.008) and lymphopenia was correlated with the symptoms of chest tightness and palpitations on exertion of patients after hospital discharge (
= -.285,
= 0.027;
= -.363,
= 0.004, respectively). The mean values of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC, total lung capacity and diffusion capacity were all normal (> 80% predicted) and lung HRCTs returned to normal in most of the patients (82%), however, 42% of survivors had mild pulmonary function abnormalities at 3-months after discharge. SARS-CoV-2 IgG turned negative in 11% (6 of 57 patients), 8% (4 of 52 patients) and 13% (7 of 55 patients), and SARS-CoV-2 IgM turned negative in 72% (41 of 57 patients), 85% (44 of 52 patients) and 87% (48 of 55 patients) at 1-month, 2-months and 3-months after discharge, respectively.
Infection by SARS-CoV-2 caused some mild impairments of survivors within the first three months of their discharge and the duration of SARS-CoV-2 antibody was limited, which indicates the necessity of long-term follow-up of survivors of COVID-19.
Insert gradient coils with similar imaging body shapes typically have smaller dimensions and higher spatial efficiency. This often allows the gradient coils the achievement of stronger and faster ...gradient fields. Thus, improving existing methods to make them applicable to the design of MRI gradient coils on complex surfaces has also become a challenge. This article proposes an algorithm that smooths the implicitly expressed stream function based on the intrinsic surface Laplace–Beltrami operator. This algorithm can be used to simplify the design procedure of MRI gradient coils on non-developable surfaces. The following steps are performed by the proposed algorithm: an initial design of the stream function configuration, extraction of the surface mesh, discretization of the surface smoothing operator, and a smoothing of the contour lines. To evaluate the quality of the smoothed streamline configuration, several technical parameter metrics—including magnetic field accuracy, coil power consumption, theoretical minimum wire spacing, and the maximum curvature of the contour lines—were evaluated. The proposed method was successfully validated in a design gradient coil on both developable and non-developable surfaces. All examples evolved from an initial value with a locally non-smooth and complex topological configuration to a smooth result while maintaining high magnetic field accuracy.
It is unavoidable for a soft manipulator to interact with environments during some tasks. These interactions may affect the soft manipulator and make the kinematic model different from the one in ...free space, e.g., the soft manipulator's effective length and the target positions might change. In order to apply the soft manipulator to constrained environments, an adaptive visual servo controller based on piecewise-constant curvature kinematic, without knowing the true values of the manipulator's length and the target positions, is proposed in this paper. Experimental results in the free space, constrained environment, and the gravity-influenced environment, demonstrate the convergence of the image errors under the proposed controller.
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infected over 3300 healthcare workers in early 2020 in China. Little information is known about nosocomial ...infections of healthcare workers in the initial period. We analysed data from healthcare workers with nosocomial infections in Wuhan Union Hospital (Wuhan, China) and their family members.
We collected and analysed data on exposure history, illness timelines and epidemiological characteristics from 25 healthcare workers with laboratory-confirmed coronavirus disease 2019 (COVID-19) and two healthcare workers in whom COVID-19 was highly suspected, as well as 10 of their family members with COVID-19, between 5 January and 12 February 2020. The demographics and clinical features of the 35 laboratory-confirmed cases were investigated and viral RNA of 12 cases was sequenced and analysed.
Nine clusters were found among the patients. All patients showed mild to moderate clinical manifestation and recovered without deterioration. The mean period of incubation was 4.5 days, the mean±sd clinical onset serial interval (COSI) was 5.2±3.2 days, and the median virus shedding time was 18.5 days. Complete genomic sequences of 12 different coronavirus strains demonstrated that the viral structure, with small irrelevant mutations, was stable in the transmission chains and showed remarkable traits of infectious traceability.
SARS-CoV-2 can be rapidly transmitted from person to person, regardless of whether they have symptoms, in both hospital settings and social activities, based on the short period of incubation and COSI. The public health service should take practical measures to curb the spread, including isolation of cases, tracing close contacts, and containment of severe epidemic areas. Besides this, healthcare workers should be alert during the epidemic and self-quarantine if self-suspected of infection.
Summary
Coronavirus disease 2019 (COVID‐19) can affect the haematopoietic system. Thrombocytopenia at admission was prevalent, while late‐phase or delayed‐phase thrombocytopenia (occurred 14 days ...after symptom onset) is rare. This retrospective, single‐centre study screened 450 COVID‐19 patients and enrolled 271 patients at the Union Hospital, Wuhan, China, from January 25 to March 9, 2020. COVID‐19‐associated delayed‐phase thrombocytopenia occurred in 11·8% of enrolling patients. The delayed‐phase thrombocytopenia in COVID‐19 is prone to develop in elderly patients or patients with low lymphocyte count on admission. The delayed‐phase thrombocytopenia is significantly associated with increased length of hospital stay and higher mortality rate. Delayed‐phase nadir platelet counts demonstrated a significantly negative correlation with B cell percentages. We also provided and described bone marrow aspiration pathology of three patients with delayed‐phase thrombocytopenia, showing impaired maturation of megakaryocytes. We speculated that immune‐mediated platelet destruction might account for the delayed‐phase thrombocytopenia in a group of patients. In addition, clinicians need to pay attention to the delayed‐phase thrombocytopenia especially at 3–4 weeks after symptom onset.
Saber, the only module-learning with rounding-based algorithm in NIST's third round of post-quantum cryptography (PQC) standardization process, is characterized by simplicity and flexibility. ...However, energy-efficient implementation of Saber is still under investigation since the commonly used number theoretic transform can not be utilized directly. In this manuscript, an energy-efficient configurable crypto-processor supporting multi-security-level key encapsulation mechanism of Saber, is proposed. First, an 8-level hierarchical Karatsuba framework is utilized to reduce degree-256 polynomial multiplication to the coefficient-wise multiplication. Second, a hardware-efficient Karatsuba scheduling strategy and an optimized pre-/post-processing structure is designed to reduce the area overheads of scheduling strategy. Third, a task-rescheduling-based pipeline strategy and truncated multipliers are proposed to enable fine-grained processing. Moreover, multiple parameter sets are supported in LWRpro to enable configurability among various security scenarios. Enabled by these optimizations, LWRpro requires 1066, 1456 and 1701 clock cycles for key generation, encapsulation, and decapsulation of Saber768. The post-layout version of LWRpro is implemented with TSMC 40 nm CMOS process within 0.38 mm 2 . The throughput for Saber768 is up to 275k encapsulation operations per second and the energy efficiency is 0.15 uJ/encapsulation while operating at 400 MHz, achieving nearly <inline-formula> <tex-math notation="LaTeX">50\times </tex-math></inline-formula> improvement and <inline-formula> <tex-math notation="LaTeX">31\times </tex-math></inline-formula> improvement, respectively compared with current PQC hardware solutions.
The acceleration of global urban expansion constantly occupies high-quality cropland and affects regional food security. The implementation of cropland protection policies has alleviated the pressure ...of cropland loss worldwide, and thus keeping a dynamic balance of cereal production. Such a displacement of cereal production from the lost cropland to the supplemented cropland has resulted in the massive losses of natural habitats (such as forests, grasslands, and wetlands) as well as ecosystem service values. However, the impact of cereal production displacement caused by different cropland supplement strategies has not been concerned. Therefore, taking China (mainland) as a case, this study used the LANDSCAPE model to simulate cereal production displacement caused by urban expansion and cropland supplement between 2020 and 2040, based on three scales of the Chinese administration system (i.e., the national level, the provincial level, and the municipal level). The natural habitat loss and corresponding ecosystem service value (ESV) loss were assessed. The results show that the national-scale cereal displacement will lead to a large reclamation of cropland in North China, causing the most natural habitat loss (5090 km
), and the least ESV loss (46.53 billion yuan). Cereal production displacement at the provincial and municipal scales will lead to fewer natural habitat losses (4696 km
and 4954 km
, respectively), but more ESV losses (54.16 billion yuan and 54.02 billion yuan, respectively). Based on the national food security and ecological conservation in China, this study discussed the reasons for the ecological effects of cereal production displacement, direct and indirect natural habitat loss of urban expansion, and cropland protection policies in China. We suggest that China's cropland protection policy should emphasize avoiding large-scale cropland displacement and occupation of natural habitat with high ESV for cropland supplement.
With the rapid development of urbanization and social economy, the utilization and protection of land have become one of the great social problems globally ...
A lightweight secure communication scheme, i.e., orthogonal frequency division multiplexing with index modulation using artificial noise (OFDM-IM AN), is proposed in this letter, which integrates the ...artificial noise into OFDMIM to interfere the eavesdropper (Eve) from physical layer. In the proposed scheme, ANs are generated using channel state information (CSI) of legitimate link through a differential way, so the ANs will be eliminated at the legal receiver by the differential demodulation. Since the wiretap channel is independent of the legitimate channel, Eve will be confused by AN and make wrong detection. We derive both the tight upper bound on the bit error rate (BER) and the security rate of the proposed scheme. Simulation results show that though the BER performance of OFDM-IM AN is worse than that of OFDM-IM with the same configuration, the proposed scheme can enhance the security of OFDM-IM with a low complexity.
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