Background
The overproduction of IgE plays a critical role in the pathogenesis of allergy; the mechanism is unclear. Histone‐acetyltransferase (HAT) activities are required in gene transcription of a ...large number of molecules in the immune system of the body.
Objectives
This study tests a hypothesis that HAT Tat‐interactive protein 60 (Tip60) plays an important role in the initiation of IgE‐mediated allergy.
Methods
The effects of Tip60 on regulating IgE expression were assessed with B cells. An intestinal allergy mouse model was developed to assess the role of Tip60 in the induction of IgE‐mediated allergic inflammation.
Results
High levels of Tip60 were observed in the peripheral B cells of patients with FA. Tat‐interactive protein 60 (Tip60) was required in the expression of IgE and IgG1 in B cells by inducing the chromatin remolding at the gene locus, in which histone acetylation, signal transducer and activator of transcription 6 (STAT6), and nuclear factor‐κB at the locus of Iε promoter were markedly increased. Blocking Tip60 significantly attenuated the allergic inflammation in the mouse intestinal mucosa.
Conclusions
Tat‐interactive protein 60 (Tip60) plays an important role in the induction of IgE in B cells. Blocking Tip60 inhibits the allergic inflammation in the intestine, suggesting Tip60 inhibitor may be a potential anti‐allergy drug.
We describe here a comprehensive study on the effect of cellular structure and melt pool boundary (MPB) condition on the mechanical properties, deformation and failure behavior of AlSi10Mg alloy ...processed by selective laser melting (SLM). The morphology of melt pool (MP) on the load bearing face of tensile samples was significantly different with build directions. It resulted in different mechanical properties of the samples with different build directions. Furthermore, the microstructure analysis revealed that the MP in the SLM AlSi10Mg alloy mainly consisted of columnar α-Al grains which were made of ultra-fine elongated cellular structure. Electron back-scatter diffraction (EBSD) analysis revealed that the long axis of cellular structure and columnar grains were parallel to < 100 >, which resulted in < 100 > fiber texture in SLM AlSi10Mg alloy. However, Schmid factor calculation demonstrated that the anisotropy of mechanical properties of the SLM AlSi10Mg alloy built with different direction was mainly dependent on the distribution of MPB on the load bearing face, and not texture. The defects including pores, residual stress and heat affected zone (HAZ) located at MPB made it the weakest part in the SLM AlSi10Mg. The sample built along horizontal direction exhibited good combination of strength and plasticity and is attributed to the lowest fraction of MPBs that withstand load during tensile. MPB had strong influence on the mechanical properties and failure behavior of SLM AlSi10Mg built with different directions.
NiTiHf alloys exhibit remarkable shape memory and pseudoelastic properties that are of fundamental interest to a growing number of industries. In this study, differential scanning calorimetry and ...isothermal compression tests have revealed that the 51Ni–29Ti–20Hf alloy has useful shape memory properties that include a wide range of transformation temperatures as well as highly stable pseudoelastic behavior. These properties are governed by short-term aging conditions, which may be tailored to control transformation temperatures while giving rise to exceptionally high austenite yield strengths which aid transformation stability. The yield strength of the austenite phase can reach 2.1 GPa by aging for 3 h at 500 °C, while aging for 3 h at 700 °C produced an alloy with an austenite finish temperature (A f) of 146 °C. High-resolution scanning transmission electron microscopy has revealed a new precipitate phase, H′-phase, under the homogenized and extruded conditions and under the 500 °C-3-h-aged condition, but only the previously identified H-phase precipitate was observed after aging at temperatures of 600 and 700 °C for 3 h. Finally, dislocation analysis indicated that plastic deformation of the austenite phase occurred by 〈100〉 type slip, similar to that observed in binary NiTi.
A novel concept for integrating visible light communications (VLC) with three‐dimensional indoor positioning is presented. A VLC link based on transmitter and receiver characteristics using ...experimental measurements was modelled. Proposed is a three‐dimensional positioning algorithm using received signal strength indication, which changes based on the angle and distance of the location based service. To reduce inter‐cell interference, the transmitter's location code was sent using different subcarriers. A demonstration shows that the proposed algorithm can obtain a user's position, including height, accurately and without inter‐cell interference.
The most intensively star-forming galaxies are extremely luminous at far-infrared (FIR) wavelengths, highly obscured at optical and ultraviolet wavelengths, and lie at z ≥ 1-3. We present a programme ...of FIR spectroscopic observations with the SPIRE FTS, as well as photometric observations with PACS, both on board Herschel, towards a sample of 45 gravitationally lensed, dusty starbursts across z ∼ 1-3.6. In total, we detected 27 individual lines down to 3 σ, including nine C II 158 μm lines with confirmed spectroscopic redshifts, five possible C II lines consistent with their FIR photometric redshifts, and in some individual sources a few O III 88 μm, O III 52 μm, O I 145 μm, O I 63 μm, N II 122 μm and OH 119 μm (in absorption) lines. To derive the typical physical properties of the gas in the sample, we stack all spectra weighted by their intrinsic luminosity and by their 500μm flux densities, with the spectra scaled to a common redshift. In the stacked spectra, we detect emission lines of C II 158 μm, N II 122 μm, O III 88 μm, O III 52 μm, O I 63 μm and the absorption doublet of OH at 119 μm, at high fidelity. We find that the average electron densities traced by the N II and O III lines are higher than the average values in local star-forming galaxies and ULIRGs, using the same tracers. From the N II/C II and O I/C II ratios, we find that the C II emission is likely dominated by the photodominated regions (PDR), instead of by ionized gas or large-scale shocks.
Thermodynamic behavior has been extensively used to evaluate the stability of materials and predict the direction of the chemical reaction at different pH values, temperatures, potentials, and ion ...concentrations. Although researching efforts on Sn species in an aqueous solution system (Sn/H2O) of acid, alkali, and salt have been reported, scattered data leads to the inefficiency of a thermodynamic method in the practical application. This article provides a brief review on the potentialpH diagram for Sn/H2O system, which reflects the thermodynamic behavior of Sn species in an aqueous solution and extracts thermodynamic data for the practical application of Sn species. Firstly, the relationship of the thermodynamic behavior, potential-pH diagram, and equilibrium relations of Sn species for Sn/H2O system was overviewed. Additionally, the potential-pH diagram of Sn/H2O system at different temperatures (298 K, 373 K, and 550 K), dissolved Sn activities (1, 10?1, 10?3, and 10?6), and the potential-pH diagram of the Sn species in a chloridion aqueous solution (Sn/H2O-Cl) was summarized. Finally, the application prospect of the potential-pH diagram for Sn/H2O system was investigated in the intelligent simulation of Sn metallurgy and the practical application of Sn materials.
ABSTRACT
We present the results of a systematic search for new rapidly oscillating Ap (roAp) stars using the 2-min cadence data collected by the Transiting Exoplanet Survey Satellite (TESS) during ...its Cycle 1 observations. We identify 12 new roAp stars. Amongst these stars we discover the roAp star with the longest pulsation period, another with the shortest rotation period, and six with multiperiodic variability. In addition to these new roAp stars, we present an analysis of 44 known roAp stars observed by TESS during Cycle 1, providing the first high-precision and homogeneous sample of a significant fraction of the known roAp stars. The TESS observations have shown that almost 60 per cent (33) of our sample of stars are multiperiodic, providing excellent cases to test models of roAp pulsations, and from which the most rewarding asteroseismic results can be gleaned. We report four cases of the occurrence of rotationally split frequency multiplets that imply different mode geometries for the same degree modes in the same star. This provides a conundrum in applying the oblique pulsator model to the roAp stars. Finally, we report the discovery of non-linear mode interactions in α Cir (TIC 402546736, HD 128898) around the harmonic of the principal mode – this is only the second case of such a phenomenon.
The wide application of magnesium alloys as biodegradable implant materials is limited because of their fast degradation rate. Hydroxyapatite (HA) coating can reduce the degradation rate of Mg alloys ...and improve the biological activity of Mg alloys, and has the ability of bone induction and bone conduction. The preparation of HA coating on the surface of degradable Mg alloys can improve the existing problems, to a certain extent. This paper reviewed different preparation methods of HA coatings on biodegradable Mg alloys, and their effects on magnesium alloys’ degradation, biocompatibility, and osteogenic properties. However, no coating prepared can meet the above requirements. There was a lack of systematic research on the degradation of coating samples in vivo, and the osteogenic performance. Therefore, future research can focus on combining existing coating preparation technology and complementary advantages to develop new coating preparation techniques, to obtain more balanced coatings. Second, further study on the metabolic mechanism of HA-coated Mg alloys in vivo can help to predict its degradation behavior, and finally achieve controllable degradation, and further promote the study of the osteogenic effect of HA-coated Mg alloys in vivo.
In strongly correlated systems the strength of Coulomb interactions between electrons, relative to their kinetic energy, plays a central role in determining their emergent quantum mechanical phases. ...We perform resonant x-ray scattering on Bi
Sr
CaCu
O
, a prototypical cuprate superconductor, to probe electronic correlations within the CuO
plane. We discover a dynamic quasi-circular pattern in the x-y scattering plane with a radius that matches the wave vector magnitude of the well-known static charge order. Along with doping- and temperature-dependent measurements, our experiments reveal a picture of charge order competing with superconductivity where short-range domains along x and y can dynamically rotate into any other in-plane direction. This quasi-circular spectrum, a hallmark of Brazovskii-type fluctuations, has immediate consequences to our understanding of rotational and translational symmetry breaking in the cuprates. We discuss how the combination of short- and long-range Coulomb interactions results in an effective non-monotonic potential that may determine the quasi-circular pattern.
PDF
