Herein, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) coated Cu x Se y (PC-Cu x Se y ) nanowires are prepared by a wet-chemical method, and PEDOT:PSS/Cu x Se y nanocomposite ...films on flexible nylon membrane are fabricated by vacuum assisted filtration and then cold-pressing. XRD analysis reveals that the Cu x Se y with different compositions can be obtained by adjusting the nominal Cu/Se molar ratios of their sources. For the composite film starting from a Cu/Se nominal molar ratio of 3, an optimized power factor of ∼270.3 μW/mK2 is obtained at 300 K. Moreover, the film exhibits a superior flexibility with 85% of the original power factor retention after bending for 1000 cycles around a rod with a diameter of 5 mm. TEM and STEM observations of the focused ion beam (FIB) prepared sample reveal that it is mainly attributed to a synergetic effect of the nylon membrane and the composite film with nanoporous structure formed by the intertwined nanowires, besides the intrinsic flexibility of nylon. Finally, a thermoelectric prototype composed of nine legs of the optimized hybrid film generates a voltage and a maximum power of 15 mV and 320 nW, respectively, at a temperature gradient of 30 K. This work offers an effective approach for high TE performance inorganic/polymer composite film for flexible TE devices.
With the development of Internet of Things technology, Channel State Information (CSI) based human activity recognition (HAR) plays an important role in Human-Computer Interaction and achieves ...considerable advancements over recent years. However, when the trained model is applied to recognize new activity categories or recognizing new users in new scenarios, the recognition performance of general methods will dramatically decline. And re-collecting adequate new activity categories' samples to train the HAR model to adapt to the new situation will consume a lot of time and human effort. To overcome this challenge, we propose a framework, Augment Few Shot Learning-based Human Activity Recognition (AFSL-HAR), which can achieve significant performance in recognizing new categories through a small amount of samples to fine-tune the model parameters and avoid retraining the network from scratch again. And besides, in order to improve the robustness of AFSL-HAR, we design a Feature Wasserstein Generative Adversarial Network (FWGAN) module, which can synthesize diverse samples to help the recognition model learn more sharper classification boundaries. Specifically, the FWGAN module incorporates a feature extractor to realize converging with a fewer number of training samples, and takes an improved discriminator to enhance system performance. The experimental results demonstrate that AFSL-HAR can achieve accuracy of 98.9% and 94.7% when recognizing new activities using few samples for each category on the public data set and self-made data set, respectively.
An artificial “closed‐loop” system that mimics the glucose‐responsive insulin secretion of pancreas β‐cells can potentially improve the treatment efficacy for diabetes. Herein, a lipid bilayer‐coated ...polymeric nanoparticle (NP) with “core–shell” structure is designed. As far as it is known, it is the first and only intravenous nanoplatform utilizing enzymatic‐oxidation scheme to achieve glucose‐responsive insulin delivery so far. Ethoxy acetal–derivatized dextran nanoparticles (Ace‐DEX NPs) are constructed as “inner core” loaded with insulin, and coloading glucose oxidase (GOx) and catalase (CAT) endow the “inner core” excellent glucose‐sensitive ability. Red blood cell membrane (RBCm)‐derived coating is adopted as “outer shell.” It collectively provides a closed microenvironment for GOx‐based enzymatic‐oxidation scheme and camouflages it from elimination. Above all, the anchored glucose transporters (GLUTs) on the “outer shell” are able to sense blood glucose levels and facilitate the transport of outer blood glucose getting inside. Under a hyperglycemic condition, the internalized glucose is catalytically converted into gluconic acid with the aid of the GOx and subsequently triggers acid degradation of the “inner core” to secrete insulin. By governing the blood glucose levels on an automatic and continuous basis, the RBCm‐Ace‐DEX NPs can effectively respond to hyperglycemia and turn to resting conditions under normoglycemia.
Ethoxy acetal derivatized dextran nanoparticles (Ace‐DEX NPs) are constructed as “inner core” and red blood cell membrane (RBCm)‐derived coating is adopted as “outer shell”. This glucose‐responsive nanoplatform can steadily circulate in the blood at normalglycemia. While under hyperglycemic condition, the glucose internalized by the anchored GLUTs is catalytically converted into gluconic acid with the aid of GOx and CAT and subsequently triggers acid degradation of RBCm‐Ace‐DEX NPs to secrete insulin.
We investigated the frictional properties of carbonate‐rich gouge layers at a slip rate of 1.3 m/s, under dry and water‐saturated conditions, while monitoring temperature at different locations on ...one of the gouge‐host rock interfaces. All experiments showed a peak frictional strength of 0.4–0.7, followed by strong slip weakening to steady state values of 0.1–0.3. Experiments which used a pore fluid with a constant drainage path to the atmosphere showed the development of a temperature plateau beyond 100°C, contemporaneous with the dynamic slip weakening and consistent with thermodynamic considerations of ongoing vaporization of pore water. Upon pore fluid vaporization, the pore pressure increases, while the temperature is buffered endothermically, such that the pore water moves along the liquid‐vapor transition curve in a pressure‐temperature phase diagram. Pore fluid phase transitions of this kind are expected to occur in natural earthquakes at relatively shallow crustal levels, enhancing fluid pressurization while impeding the achievement of high temperatures. Therefore, the operation of vaporization may help explain the low downhole temperature anomalies obtained shortly after large earthquakes.
Key Points
Water vaporization was “observed” in high‐velocity friction experiments
Water vaporization promotes fluid pressurization during coseismic slip
Water vaporization limits the temperature rise during coseismic slip
In the 1840s F. M. Dostoevsky became famous in literary circles thanks to his story Poor Folk, but was widely criticized by the Slavophiles, namely by the Aksakov brothers for his creative approach ...and political ideology. In the 1860s heated disputes between Vremenya and Den’ confirmed Dostoevsky’s ideological disagreements with the Slavophiles. In the 1880s, as the author of the article shows, begins a convergence of Dostoevsky’s position, his artistic ideas and the views of the Aksakov brothers, which is especially noticeable in Dostoevsky’s speech at the Pushkin holiday. The article comprehends the main ideological differences and points of contact between pochvennichestvo and Slavophilism, traces the difficult relationship between Dostoevsky and the Aksakov brothers, which lasted more than 40 years. Numerous disagreements in the beliefs of these contemporaries concerned the issue of creative style, the purpose of literature and ideological currents. Dostoevsky believed in Slavophile thought, but was more progressive; he developed and deepened the ideals of fundamentalism in the second half of the 19th century.
The first catalytic enantioselective aromatic Claisen rearrangement of allyl 2-naphthyl ethers using 5-10 mol% of π-copper(
ii
) complexes is reported. A Cu(OTf)
2
complex with an
l
-α-homoalanine ...amide ligand gave (
S
)-products in up to 92% ee. Conversely, a Cu(OSO
2
C
4
F
9
)
2
complex with an
l
-
tert
-leucine amide ligand gave (
R
)-products in up to 76% ee. Density-functional-theory (DFT) calculations suggest that these Claisen rearrangements proceed stepwise
via
tight-ion-pair intermediates, and that (
S
)- and (
R
)-products are enantioselectively obtained
via
the staggered transition states for the cleavage of the C-O bond, which is the rate-determining step.
The first catalytic enantioselective aromatic Claisen rearrangement of allyl 2-naphthyl ethers using 5-10 mol% of π-copper(
ii
) complexes is reported.
Catalytic enantioselective halocyclization of 2-alkenylphenols and enamides have been achieved through the use of chiral amidophosphate catalysts and halo-Lewis acids. Density functional theory ...calculations suggested that the Lewis basicity of the catalyst played an important role in the reactivity and enantioselectivity. The resulting chiral halogenated chromans can be transformed to α-Tocopherol, α-Tocotrienol, Daedalin A and Englitazone in short steps. Furthermore, a halogenated product with an unsaturated side chain may provide polycyclic adducts under radical cyclization conditions.
Silica based nanoparticles have emerged as a promising vaccine delivery system for cancer immunotherapy, but their bio-degradability, adjuvanticity and the resultant antitumor activity remain to be ...largely improved. In this study, we report biodegradable glutathione-depletion dendritic mesoporous organosilica nanoparticles (GDMON) with a tetrasulfide-incorporated framework as a novel co-delivery platform in cancer immunotherapy. Functionalized GDMON are capable of co-delivering an antigen protein (ovalbumin) and a toll-like receptor 9 (TLR9) agonist into antigen presenting cells (APCs) and inducing endosome escape. Moreover, decreasing the intracellular glutathione (GSH) level through the -S-S-/GSH redox chemistry increases the ROS generation level both in vitro and in vivo, facilitating cytotoxic T lymphocyte (CTL) proliferation and reducing tumour growth in an aggressive B16-OVA melanoma tumour model. Our results have shown the potential of GDMON as a novel self-adjuvant and co-delivery nanocarrier for cancer vaccine.
Large N limit of complex multi-matrix model Wang, Lu-Yao; Zhu, Yu-Sen; Yao, Shao-Kui ...
Nuclear physics. B,
January 2024, 2024-01-00, 2024-01-01, Letnik:
998
Journal Article
Recenzirano
Odprti dostop
We construct the complex multi-matrix model with W-representation and calculate the correlators. We establish the correspondence between the connected correlators and length-2n q-colored Dyck walks ...in Fredkin spin chain and discuss the entanglement entropy. Moreover, we analyze the free energy of this multi-matrix model. For the leading coefficient of the free energy, it relates to the connected correlators in large N limit.
The prevalence of mutations in cancer susceptibility genes such as
and
and other cancer susceptibility genes and their clinical relevance are largely unknown among a large series of unselected breast ...cancer patients in the Chinese population.
A total of 8,085 consecutive unselected Chinese breast cancer patients were enrolled. Germline mutations in 46 cancer susceptibility genes were detected using a 62-gene panel.
Pathogenic mutations were identified in 9.2% of patients among the 8,085 unselected breast cancer patients. Of these, 5.3% of patients carried a
or
mutation (1.8% in
and 3.5% in
), 2.9% carried other breast cancer susceptibility genes (BOCG) and 1.0% carried another cancer susceptibility genes. Triple-negative breast cancers had the highest prevalence of
mutations (11.2%) and other BOCG mutations (3.8%) among the four molecular subgroups, whereas ER
/PR
HER2
breast cancers had the lowest mutations in
(1.8%) and BOCG (1.6%). In addition,
mutation carriers had a significant worse disease-free survival unadjusted hazard ratio (HR) 1.60; 95% confidence interval (CI) 1.10-2.34;
= 0.014 and disease-specific survival (unadjusted HR 1.96; 95% CI, 1.03-3.65;
= 0.040) than did non-carriers, whereas no significant difference in survival was found between
mutation carriers and non-carriers.
9.2% of breast cancer patients carry a pathogenic mutation in cancer susceptibility genes in this large unselected series. Triple-negative breast cancers have the highest prevalence of mutations in
and other breast cancer susceptibility genes among the four molecular subgroups, whereas ER
/PR
HER2
breast cancers had the lowest mutations in these genes.
.
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