Aim: In this study we examined the effect of oral application of garlic form garlic oil (GO) on rats after renal ischemia-reperfusion (I R) injury. Materials and methods: Forty male Wistar albino ...rats were divided into four groups: control, sham-operated, I R, and I R + GO. GO was diluted in water and administered by oral intubation three times each week for 6 weeks. All rats except sham-operated underwent 45 min of bilateral renal ischemia followed by 6 hr of reperfusion. Blood samples and kidney tissues were harvested from the rats, and then rats were killed. Serum urea, creatinine, and cystatin C levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxidant status (TOS), oxidative stress index (OSI), myeloperoxidase (MPO), nitrite oxide (NO), and protein carbonyl (PC) levels in kidney tissue and blood were measured. In addition, kidney tissue histopathology was evaluated. Results: The serum urea, creatinine, and cystatin C levels were significantly higher in I R group compared to I R + GO group (p < 0.01). The serum and tissue antioxidant markers (TAC, CAT) were significantly lower in I R group than I R + GO group (p < 0.01). The serum oxidant markers (TOS, MPO, NO, and PC) were significantly higher in I R group than I R + GO group (p < 0.01). Also oral application of GO was effective in decreasing of tubular necrosis score. Conclusion: Based on the present data, we conclude that increased antioxidants and decreased oxidants modulated by oral application of GO attenuated the renal I R injury.
Introduction and Aim: Primary mediastinal B-cell lymphomas (PMBL) are aggressive B- cell lymphomas. Although the initial treatment models vary in PMBL, appropriate treatment methods are not known. We ...aim to show real-life data on health outcomes in adult patients with PMBL who received various type of chemoimmunotherapies in Turkey.
Method: We analyzed the data of 61 patients who received treatments for PMBL from 2010 to 2020. The overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) of the patients were evaluated.
Results: 61 patients were observed in this study. The mean age of the study group was 38.4 ± 13.5 years. From among them, 49.2% of the patients were female (n = 30). For first-line therapy, 33 of them had received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen (54%). Twenty-five patients had received rituximab, etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH-R) regimen. The ORR was 77%. The median OS and PFS were as follows: 25 months (95% CI: 20.4-29.4) and 13 months (95% CI: 8.6-17.3), respectively. The OS and PFS at 12 months were 91.3% and 50%, respectively. The OS and PFS at five years were 64.9% and 36.7%, respectively. Median follow-up time period was 20 months (IQR 8.5-38.5).
Conclusion: R-CHOP and DA-EPOCH-R showed good results in PMBL. These remain one of the best determined systemic treatment options for first-line therapy. Also, the treatment was associated with good efficacy and tolerability.
Biyotinidaz eksikliği, nadir görülen otozomal çekinik olarak kalıtılan bir hastalıktır. Erken yenidoğan döneminde tedavi edilmezse ciddi nörolojik kusurlara, metabolik bozukluklara, komaya ve ölüme ...neden olabilir. Yenidoğanlarda biyotinidaz eksikliği taraması ve biyotin takviyesi ile erken tedavi, semptomların çoğunun ortaya çıkması engellenebilir. Biyotinidaz enzimi, BTD geni tarafından kodlanır. BTD geninde 165'ten fazla mutasyon tanımlanmıştır. Bu olgu bildiriminde Ulusal Yenidoğan Tarama programında tespit edilen, BTD geninde homozigot çift mutasyon saptanan nadir bir tablo sunulmuş olup yeni bir allelik varyant ve genotip bildirilmiştir. Özellikle akraba evliliklerinin sık rastlanıldığı toplumlarda; yaygın görülen mutasyonlar haricinde farklı genetik tabloların da görülebileceği akılda tutulmalıdır.
Biotinidase deficiency is a rare autosomal recessive inherited metabolic disorder. If not treated in the early neonatal period, it can cause serious neurological defects, metabolic abnormalities, coma and death. Screening for biotinidase deficiency in newborns and early treatment with free biotin supplementation can prevent all symptoms from occurring. The biotinidase enzyme is encoded by the BTD gene. More than 165 mutations have been identified in the BTD gene. In this case report; a rare case with homozygous double mutation in the BTD gene is presented; and a new allelic variant and genotype is defined. Especially in societies where consanguineous marriages are common; it should be kept in mind that apart from common mutations, different genetic variants may also be seen.
Purpose: To compare the effects of vitamin E and 1% methylen blue solutions on prevention of experimentally induced adhesions in rats. Methods: Thirty seven female Spraque Dawley rats were randomized ...into four groups. First group was kept as sham operated group. An adhesion model was constituted on the left uterine horn of the other groups. The lesion areas of rats from the second, the third and the fourth groups were coated with 2 ml 0.9 % saline solution (C group), 10 mg vitamin E (VE group) and 1% methylen blue solutions (MB group), respectively. Results: Histopathologically, adhesion scores, mononuclear cell infiltration, oedema and fibrosis were more prominent in the MB group compared with C and VE groups. There were no significant differences between the groups in tissue glutathione peroxidase (GPx), catalase (CAT) activities and glutation (GSH) level, these parameters were slightly increased in group with VE supplementation though. The administration of VE and MB significantly decreased NO (P<0.01) levels when compared to the C group. The level of malondialdehyde (MDA) in the VE group was significantly lower (P<0.05) than those of the Sh and C groups. Conclusion: Intraperitoneal methylen blue solutions treatments were more effective according to vitamin E in preventing the formation of intra-abdominal adhesion in a rat uterine horn model.Objetivo: Comparar os efeitos da vitamina E e 1% da solução de azul de metileno na prevenção de aderências induzidas em ratos. Métodos: Trinta e sete ratos fêmeas Spraque Dawley foram distribuídos em quatro grupos. O primeiro grupo foi mantido como grupo sham. O modelo de aderência foi realizado no corno uterino esquerdo nos outros grupos. As áreas da lesão dos ratos do segundo, terceiro e quarto grupos foram revestidas com 2 ml de solução salina 0,9% (Grupo C), 10 mg de vitamina E (Grupo VE) e solução de azul de metileno 1% (Grupo MB), respectivamente. Resultados: Histopatologicamente, o escore das aderências, infiltração celular mononuclear, edema e fibrose foram mais proeminentes no grupo MB em comparação aos grupos C e VE. Não houve diferença significante entre os grupos na peroxidase da glutatione do tecido (GPx), atividade da catalase (CAT) e o nível de glutation (GSH). Estes parâmetros foram ligeiramente aumentados no grupo com suplemento da VE. A administração da VE e do MB diminuiu significantemente os níveis quando quando comparada ao Grupo C. O nível de malondialdeído no grupo VE foi significantemente mais baixo do que nos grupos sham e C. Conclusão: A administração intraperitoneal da solução de azul de metileno foi mais eficaz de acordo com a vitamina E na prevenção de aderências intra-abdominais no corno uterino de ratos.
To investigate mean platelet volume (MPV) levels in patients with coronary slow flow (CSF).
465 stable angina pectoris cases with angiographically normal coronary arteries were recruited coronary ...slow flow group (n=76), control group (n=389) in the observational retrospective cohort study. Clinical, biochemical and demographic variables including MPV were noted and coronary blood flow was assessed with TIMI frame count (TFC).
Gender, smoking, height, serum creatinine, uric acid levels, hemoglobin, waist/hip ratio, systolic blood pressure but not MPV were significantly different among groups. Independent predictors of CSF were height (p=.029) and serum uric acid level (p=.045). Gender, height, weight, hip circumference, systolic blood pressure, fasting blood glucose, serum urea, creatinine, uric acid levels, hemoglobin and platelet count were associated with mean TFC whereas independent predictors of mean TIMI frame count were height (p=.010) and serum uric acid level (p=.041).
Height and serum uric acid level but not MPV were independent predictors of both CSF and mean TFC.
This prospective study investigated radiation dose and volume changes during breathing cycle. Ten patients with left breast carcinoma receiving radiotherapy were included. Treatment planning images ...were obtained as three different sets of series taken: without breath control (F), deep inspiration (I), and end of expiration (E), with 3-mm intervals. As such, whole breath cycle was simulated. CT images taken during I and E were registered to F, according to DICOM coordinates. Each patient's target and organ at risk volumes were contoured by the primary radiation oncologist except heart components which were contoured by radiologist on F, I and E series. Radiotherapy planning was done on F series, then planning and beam data were transferred from F to I and E image series. Target and organs at risk (OAR) dose distributions for E and I image series were obtained. Dose changes between F, E, and I phases for whole heart and components, namely, left ventricle (LV), right ventricle (RV), left auricle (LA), right auricle (RA), and left anterior descendent artery (LAD) were examined. Furthermore, the issue of any compartment representing the maximum heart dose was investigated. Volume and dose variations for heart, LV, RV, LA, RA, and LAD were observed during breath cycle. Exposured dose was more than defined tolerance level for LV, RV, and LAD in some patients. However, dose differences between F-I and F-E were not statistically significant. Radiotherapy planning without breath control is not capable of compensating for whole intra-fraction heart and its components' volumes and dose changes.
Objective: Nutritional status assessment, dysphagia evaluation and enteral feeding decision are important determinants of prognosis in acute neurovascular diseases. Materials and Methods: NöroTek is ...a point prevalence study conducted with the participation of 87 hospitals spread across all health sub regions of Turkey conducted on 10-May-2018 (World Stroke Awareness Day). A total of 972 hospitalized neurovascular patients female: 53%, age: 69+-14; acute ischemic stroke in 845; intracerebral hematoma (ICH) in 119 and post-resuscitation encephalopathy (PRE) in 8 with complete data were included in this sub-study. Results: Gastrostomy was inserted in 10.7% of the patients with ischemic stroke, 10.1% of the patients with ICH and in 50% of the patients with PRE. Independent predictors of percutaneous endoscopic gastrostomy (PEG) administration were The National Institutes of Health Stroke Scale score at admission exp (β): 1.09 95% confidence interval (CI): 1.05-1.14, per point in ischemic stroke; and mechanical ventilation in ischemic exp (β): 6.18 (95% CI: 3.16-12.09) and hemorrhagic strokes exp (β): 26.48 (95% CI: 1.36-515.8). PEG was found to be a significant negative indicator of favorable (modified Rankin's scale score 0-2) functional outcome exp (β): 0.032 (95% CI: 0.004-0.251) but not of in-hospital mortality exp (β): 1.731 (95% CI: 0.785-3.829). Nutritional and swallowing assessments were performed in approximately two-thirds of patients. Of the nutritional assessments 69% and 76% of dysphagia assessments were completed within the first 2 days. Tube feeding was performed in 39% of the patients. In 83.5% of them, tube was inserted in the first 2 days; 28% of the patients with feeding tube had PEG later. Conclusion: The NöroTek study provided the first reliable and large-scale data on key quality metrics of nutrition practice in acute stroke in Turkey. In terms of being economical and accurate it makes sense to use the point prevalence method.
Normal tissue injury may lead to severe late side effects after therapeutic use of irradiation. Radiation myelopathy (RM) is an uncommon complication of therapeutic irradiation whenever the spinal ...cord is included within the radiation treatment field. Several factors such as radiation dose, fractination, linear energy transfer, chemotherapy, modify its occurrence and severity. Herein, we report a 43-year-old male patient with nasopharyngeal cancer who developed RM after concomitant chemoradiotherapy and discussed the literature. Key words: Myelopathy; radiation; spinal cord. Radyoterapinin terapotik kullaniminda normal dokunun zarar gormesi ciddi yan etkiler ortaya cikarabilir. Radyoterapi sonrasi gorulen, radyasyon miyelopatisi (RM), nadir bir komplikasyon olup genellikle spinal kordun beyaz cevher hasari ile gelisir. RM gelisimini ve siddetini radyoterapi alani, dozu, uygulama suresi, kemoterapinin birlikte veya ardisik uygulanmasi, lineer enerji transferi gibi faktorler etkilemektedir. Bu yazida, nazofarenks kanseri tanisiyla kemoradyoterapi uygulanan 43 yasindaki erkek hastada 14 ay sonra gelisen sag hemiparalizi sunuldu. Anahtar sozcukler: Miyelopati; radyoterapi; spinal kord.
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