Background: As COVID-19 occurs suddenly and is highly contagious, this will inevitably cause people anxiety, depression, etc. The study on the public psychological states and its related factors ...during the COVID-19 outbreak is of practical significance.
Methods: 600 valid questionnaires were received. The Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) were used.
Results: Females' anxiety risk was 3.01 times compared to males (95% CI 1.39-6.52). Compared with people below 40 years old, the anxiety risk of people above 40 years old was 0.40 times (95% CI 0.16-0.99). SDS results indicated that the difference between education level and occupation was statistically significant (p = 0.024, 0.005). Compared to people with a master's degree or above, those with a bachelor's degree group had a depression risk of 0.39 times (95% CI 0.17-0.87). Compared with professionals, industrial service workers and other staff had a depression risk of 0.31 times (95% CI 0.15-0.65) and 0.38 times (95% CI 0.15-0.93).
Conclusions: 600 questionnaire participants were psychologically stable. Non-anxiety and non-depression rates were 93.67% and 82.83%, respectively. There were anxiety in 6.33% and depression in 17.17%. Therefore, we should pay attention to the psychological states of the public.
Solution‐processable highly conductive polymers are of great interest in emerging electronic applications. For p‐doped polymers, conductivities as high a nearly 105 S cm−1 have been reported. In the ...case of n‐doped polymers, they often fall well short of the high values noted above, which might be achievable, if much higher charge‐carrier mobilities determined could be realized in combination with high charge‐carrier densities. This is in part due to inefficient doping and dopant ions disturbing the ordering of polymers, limiting efficient charge transport and ultimately the achievable conductivities. Here, n‐doped polymers that achieve a high conductivity of more than 90 S cm−1 by a simple solution‐based co‐deposition method are reported. Two conjugated polymers with rigid planar backbones, but with disordered crystalline structures, exhibit surprising structural tolerance to, and excellent miscibility with, commonly used n‐dopants. These properties allow both high concentrations and high mobility of the charge carriers to be realized simultaneously in n‐doped polymers, resulting in excellent electrical conductivity and thermoelectric performance.
Two conjugated polymers with rigid planar backbones, but with disordered crystalline structures, exhibit surprising structural tolerance to commonly used n‐dopants. These properties allow both high concentrations and high mobility of the charge carriers to be realized simultaneously in n‐doped polymers, resulting in excellent electrical conductivity of over 90 S cm−1 and thermoelectric performance up to 106 µW m−1 K−2.
Taking into account the impact of time factors on emission reductions and brand reputation, the reference carbon emission effect and dual-channel supply chain are incorporated into a unified analysis ...framework. We applied differential game theory to build models under centralized decision-making and decentralized decision-making. The aim of the research is to explore the strategies of a single manufacturer and a single retailer on product pricing, low-carbon production, and advertising. The research analyses the impact of reference carbon emission effects, cost coefficients, and interchannel substitutable coefficients on profits. In order to alleviate the double marginal effect brought about by decentralized decision-making, a cost-compensation coordination mechanism is proposed. The conclusions are as follows. First, centralized decision-making is the optimal decision-making mode, but further consultation is required to implement it voluntarily by both parties. Second, a cost-recovery contract occurs when the fixed fee that the retailer gives the manufacturer meets certain conditions. The contract can make the retailer’s advertising investment reach the level of centralized decision-making and improve the member’s profit under the decentralized decision-making. The coordination mechanism is effective. Third, the reference carbon emission effect can bring about an increase in the manufacturer’s low-carbon production input and profits. The retailer’s advertising investment is not affected by the reference carbon emission effect. Fourth, wholesale prices and online or offline retail prices are all positively correlated with the market share of the channel. The price-substitution coefficient between channels is positively correlated with both low-carbon inputs and profits.
Immunotherapies based on T cells have gained significant success in the treatment of diverse cancers, however, several limitations also exist, including low response, acquired resistance and severe ...side effects, which lead to unfavorable outcomes. Recent studies found that traditional therapies, radiotherapy and/or chemotherapy may affect the immune condition in situ and cause abscopal effect, which may improve the response of immunotherapies, enhance the efficiency, and reduce the untoward effect. Here, we review the mechanisms uncovering the cancer immunotherapy and immunogenic effects of radiotherapy and chemotherapy, aiming to highlight the principles underlying the therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy and ultimately guide better designs for future synergistic cancer therapies.
•Limitations of current immunotherapies including low response, acquired resistance, severe side effects lead to unfavorable outcomes•Radiotherapy and chemotherapy improve the efficiency of immunotherapies through modifying immune condition in situ and cause abscopal effect.•Strategies combining immunotherapy and radiotherapy/chemotherapy can synergistically improve the outcome of cancer treatment.
Conformation Control of Conjugated Polymers Yu, Zi‐Di; Lu, Yang; Wang, Jie‐Yu ...
Chemistry : a European journal,
December 9, 2020, Letnik:
26, Številka:
69
Journal Article
Recenzirano
In the past few decades, conjugated polymers have aroused extensive interest in organic electronic applications. The electrical performance of conjugated polymers has a close relationship with their ...backbone conformation. The conformation of the polymer backbone strongly affects the πelectron delocalization along polymer chains, the energy band gap, interchain interactions, and further affects charge transport properties. To realize a rigid coplanar backbone that usually possesses efficient intrachain charge transport properties and enhanced π–π stackings, such conformation control becomes a useful strategy to achieve high‐performance (semi)conducting polymers. This minireview summarizes the most important polymer structures through conformation control at the molecular level, and then divides these rigid coplanar conjugated polymers into three categories: 1) noncovalent interactions locked conjugated polymers; 2) double‐bond linked conjugated polymers; 3) ladder conjugated polymers. The effect of the conformation control on physical nature, optoelectronic properties, and their device performance is also discussed, as well as the challenges of chemical synthesis and structural characterization.
Under control: Conformation control strategies from the molecular level for conjugated polymers in the past several decades are summarized, with a focus on their influence on device performance and challenges in synthesis, characterization and subsequent processing.
Low n‐doping efficiency and inferior stability restrict the thermoelectric performance of n‐type conjugated polymers, making their performance lag far behind of their p‐type counterparts. Reported ...here are two rigid coplanar poly(p‐phenylene vinylene) (PPV) derivatives, LPPV‐1 and LPPV‐2, which show nearly torsion‐free backbones. The fused electron‐deficient rigid structures endow the derivatives with less conformational disorder and low‐lying lowest unoccupied molecular orbital (LUMO) levels, down to −4.49 eV. After doping, two polymers exhibited high n‐doping efficiency and significantly improved air stability. LPPV‐1 exhibited a high conductivity of up to 1.1 S cm−1 and a power factor as high as 1.96 μW m−1 K−2. Importantly, the power factor of the doped LPPV‐1 thick film degraded only 2 % after 7 day exposure to air. This work demonstrates a new strategy for designing conjugated polymers, with planar backbones and low LUMO levels, towards high‐performance and potentially air‐stable n‐type polymer thermoelectrics.
Stability: A new rigid coplanar poly(p‐phenylene vinylene) (PPV) derivative, LPPV‐1, is synthesized with a rigid planar backbone and low‐lying LUMO, which lead to reduced conformational disorder and high n‐type doping efficiency. The conductivity of LPPV‐1 is up to 1.1 S cm−1, and the power factor is only 2 % after a 7 day exposure to air. This work represents an effective strategy towards high‐performance and potentially air‐stable n‐type polymer thermoelectrics.
Display omitted
•An eco-friendly, flexible chitosan@starch composite film was prepared.•Highly transparent CS-F/TENG possessed excellent outputs and pressure sensitivity.•Application potential for ...monitoring human/vehicle movements.
Natural biomaterials based triboelectric nanogenerator (TENG) is crucial for sustainable self-powered devices that achieves high outputs, biocompatibility, and reduces the environment impact. Meanwhile, transparent TENG can integrate with commercial optoelectronic devices to simultaneously realize the self-powering sensing and visual transmission of information. Herein, we prepared an eco-friendly, flexible, transparent chitosan@starch composite film by drop casting process, which reveals high transmittance exceed 88% in the visible light range. A transparent TENG was designed by pairing the chitosan@starch composite film with the fluorinated ethylene propylene (FEP) film, and transparent PET/ITO electrodes. The optimized chitosan@starch-FEP based TENG (CS-F/TENG) exhibits the open-circuit voltage of ∼1080 V, short-circuit current of ∼16.9 mA m−2 and the maximum power density of ∼5.07 W m−2. Ultrahigh sensitivity of 46.03 V kPa−1 in the pressure range of 1.25–6.25 kPa is achieved by the CS-F/TENG as a self-powered force sensor, and its potential applications in monitoring human motion and vehicles’ speed are also demonstrated. Our work provides novel insights in the utilization of sustainable chitosan@starch composite film for transparent wearable TENG with decent output performance, and also facilitates the potential applications of this device in monitoring human motion and vehicle movement.
Long noncoding RNAs in cancer‐immunity cycle Yu, Wei‐Di; Wang, Huanhuan; He, Qi‐Feng ...
Journal of cellular physiology,
September 2018, Letnik:
233, Številka:
9
Journal Article
Recenzirano
The imbalance of immune status in cancer microenvironment plays an important role in the development and progression of cancer. Immunotherapy based on this has become an important field of cancer ...research in recent years. Many studies on long noncoding RNA (lncRNA) in cancer have focus on its regulation in cancer development and metastasis. Recent studies have suggested that lncRNAs play crucial roles in different phases of cancer immunity, including antigen releasing, antigen presentation, immune activation, immune cells migration, infiltrating into cancer tissues, and killing cancer cells. The functional studies of lncRNAs in cancer immuntity revealed the complicated molecular mechanisms in cancer immunity from a new point of view, which may provide novel potential targets for cancer immunotherapies. Based on the classical cancer‐immunity cycle theory, we review the recent studies on the functions and mechanisms of immune‐related lncRNAs in different stages of cancer immunity, to summarize the relationship between lncRNAs, and cancer immunity and to provide a framework for further research.
The functional studies of lncRNAs in cancer immuntity revealed the complicated molecular mechanisms in cancer immunity from a new point of view, which may provide novel potential targets for cancer immunotherapies. Based on the classical cancer‐immunity cycle theory, we review therecent studies on the functions and mechanisms of immune‐related lncRNAs in different stages of cancer immunity, to summarize the relationship between lncRNAs, and cancer immunity and to provide a framework for further research.
The role of solution aggregates on the charge transport process of conjugated polymers in electronic devices has gained increasing attention; however, the correlation of the charge carrier mobilities ...between the solution aggregates and the solid‐state films remains elusive. Herein, three polymers, FBDOPV‐2T, FBDOPV‐2F2T, and FBDOPV‐4F2T, are designed and synthesized with distinct aggregation behavior in solution. By combining contact‐free ultrafast terahertz (THz) spectroscopy and field‐effect transistor measurements, we track the charge carrier mobility of the aggregates of these polymers from the solution to the thin‐film state. Remarkably, the mobility of these three polymers is found to follow nearly the same trend (FBDOPV‐2T>FBDOPV‐2F2T≫FBDOPV‐4F2T) in both solutions and thin‐film states. The quantitative mobility correlation indicates that the charge transport properties of solution aggregates play a critical role in determining the thin‐film charge transport properties and final device performance. Our results highlight the importance of investigating and controlling solution aggregation structures towards efficient organic electronic devices.
Different aggregation structures of three BDOPV‐based polymers in solution were obtained via subtle adjustment of the molecular structures. By employing contact‐free ultrafast terahertz (THz) spectroscopy, we directly reveal that the correlation of the charge carrier mobilities between the solution aggregates and the solid‐state films remains highly consistent.
Bladder cancer was a malignant disease in patients, our research aimed at discovering the possible biomarkers for the diseases.
The gene chip GSE31684, including 93samples, was downloaded from the ...GEO datasets and co-expression network was constructed by the data. Molecular complex detection(MCODE) was used to identify hub genes. The most significant cluster including 16 genes:
,
,
,
,
,
,
,
,
,
,
,
,
,
,
, and
was identified. After annotated by BiNGO, they were suggested associated with collagen fibril organization and blood vessel development. In addition, the Kaplan Meier curves were obtained by UALCAN. The high expression of
,
,
,
,
,
,
,
,
,
, and
indicated poor prognosis of the patients(
< 0.05). Finally, we examined genes' expression between low and high tumor stage by the Wilcoxon test(P < 0.05),
was excluded.
associated with the tumor stage as well as tumor patients' prognosis
(
< 0.01) may serve as therapeutic targets for the disease.
PDF
