Summary
The China Health and Nutrition Survey (CHNS) began in 1989 with the goal of creating a multilevel method of data collection from individuals and households and their communities to understand ...how the wide‐ranging social and economic changes in China affect a wide array of nutrition and health‐related outcomes. Initiated with a partial sample in 1989, the full survey runs from 1991 to 2011, and this issue documents the CHNS history. The CHNS cohort includes new household formation and replacement communities and households; all household members are studied. Furthermore, in‐depth community data are collected. The sample began with eight provinces and added a ninth, Heilongjiang, in 1997 and three autonomous cities, Beijing, Shanghai, and Chongqing, in 2011. The in‐depth community contextual measures have allowed us to create a unique measure of urbanicity that captures major dimensions of modernization across all 288 communities currently in the CHNS sample. The standardized, validated urbanicity measure captures the changes in 12 dimensions: population density; economic activity; traditional markets; modern markets; transportation infrastructure; sanitation; communications; housing; education; diversity; health infrastructure; and social services. Each is based on numerous measures applicable to each dimension. They are used jointly and separately in hundreds of studies.
Summary
China's food consumption patterns and eating and cooking behaviours changed dramatically between 1991 and 2011. Macronutrient composition has shifted towards fats, and protein and sodium ...intakes remain high and potassium intake low. The rapid decline in intake of coarse grains and, later, of refined grains and increases in intake of edible oils and animal‐source foods accompanied by major eating and cooking behaviour shifts are leading to what might be characterized as an unhealthy Western type of diet, often based on traditional recipes with major additions and changes. The most popular animal‐source food is pork, and consumption of poultry and eggs is increasing. The changes in cooking and eating styles include a decrease in the proportion of food steamed, baked, or boiled, and an increase in snacking and eating away from home. Prior to the last decade, there was essentially no snacking in China except for hot water or green tea. Most recently, the intake of foods high in added sugar has increased. The dietary shifts are affected greatly by the country's urbanization. The future, as exemplified by the diet of the three mega cities, promises major growth in consumption of processed foods and beverages.
A new project, high intensity heavy ion accelerator facility (HIAF), is currently under design and construction in China. The HIAF front end, composed of electron cyclotron resonance (ECR) ion ...sources, low energy beam transport (LEBT) and radio frequency quadrupole (RFQ), will produce and provide beams of ions with a mass up to uranium at a beam energy of0.5MeV/u. The typical beam intensity is designed up to 2 emA for the uranium beam with a charge state of35+. This paper presents an overall design of the front end for HIAF and discusses several key issues in the design. By modeling the beam extraction from the ECR source, we got a reliable starting beam condition to perform the design. Transverse coupling of the beam from the source was elaborated. To relieve the coupling we implanted two solenoids after the source. Space charge effect in the charge state selection of the ion source was evaluated. An overall space charge compensation degree of no less than 70% was predicted. A beam dynamics simulation was performed by using the initial particle distribution obtained from the extraction modeling. The simulation resulted in development of a beam collimation system in the LEBT to confine the transverse emittance. The RFQ design will follow the development of LEAF-RFQ at Institute of Modern Physics, which has successfully commissioned with several beams and demonstrated as an excellent design. Recent beam commissioning results of LEAF-RFQ will also be presented in this paper.
Magnetic field effects have been a successful tool for studying carrier dynamics in organic semiconductors as the weak spin-orbit coupling in these materials gives rise to long spin relaxation times. ...As the spin-orbit coupling is strong in organic-inorganic hybrid perovskites, which are promising materials for photovoltaic and light-emitting applications, magnetic field effects are expected to be negligible in these optoelectronic devices. We measured significant magneto-photocurrent, magneto-electroluminescence and magneto-photoluminescence responses in hybrid perovskite devices and thin films, where the amplitude and shape are correlated to each other through the electron-hole lifetime, which depends on the perovskite film morphology. We attribute these responses to magnetic-field-induced spin-mixing of the photogenerated electron-hole pairs with different g-factors--the Δg model. We validate this model by measuring large Δg (~ 0.65) using field-induced circularly polarized photoluminescence, and electron-hole pair lifetime using picosecond pump-probe spectroscopy.
Abstract Mesenchymal stem cells (MSCs) are being recognized as a viable cell source for cartilage repair and members of the transforming growth factor-beta (TGF-β) superfamily are a key mediator of ...MSC chondrogenesis. While TGF-β mediated MSC chondrogenesis is well established in in vitro pellet or hydrogel cultures, clinical translation will require effective delivery of TGF-βs in vivo . Here, we investigated the co-encapsulation of TGF-β3 containing alginate microspheres with human MSCs in hyaluronic acid (HA) hydrogels towards the development of implantable constructs for cartilage repair. TGF-β3 encapsulated in alginate microspheres with nanofilm coatings showed significantly reduced initial burst release compared to uncoated microspheres, with release times extending up to 6 days. HA hydrogel constructs seeded with MSCs and TGF-β3 containing microspheres developed comparable mechanical properties and cartilage matrix content compared to constructs supplemented with TGF-β3 continuously in culture media, whereas constructs with TGF-β3 directly encapsulated in the gels without microspheres had inferior properties. When implanted subcutaneously in nude mice, constructs containing TGF-β3 microspheres resulted in superior cartilage matrix formation when compared to groups without TGF-β3 or with TGF-β3 added directly to the gel. However, calcification was observed in implanted constructs after 8 weeks of subcutaneous implantation. To prevent this, the co-delivery of parathyroid hormone-related protein (PTHrP) with TGF-β3 in alginate microspheres was pursued, resulting in partially reduced calcification. This study demonstrates that the controlled local delivery of TGF-β3 is essential to neocartilage formation by MSCs and that further optimization is needed to avert the differentiation of chondrogenically induced MSCs towards a hypertrophic phenotype.
In the recent 30 years, Shanghai experienced fast urbanization which landscape shows various types of conflicts among the modern forms and the traditional forms. The insertion of new typologies in ...the traditional district introduces new urban characteristics and dynamics, which are not typically associated with the traditionally framed cities. The constructions of substantial industrial and commercial projects have caused the demolition of traditional urban forms. Urban designers aspire to revitalize the traditional neighborhood by combining urban fabrics without destroying the structure of the historic neighborhood. This paper attempts to exam the effectiveness of the urban network, the continuity of public structures and operational interactions between new projects and the local context through the study of a "failed" regeneration project in Shanghai, China. Consequently, this paper raised rules in reconnecting the city fabrics towards differential urbanism.
Liver kinase B1 (LKB1) is mutationally inactivated in Peutz-Jeghers syndrome and in a variety of cancers including human papillomavirus (HPV)-caused cervical cancer. However, the significance of LKB1 ...mutations in cervical cancer initiation and progress has not been examined. Herein, we demonstrated that, in mouse embryonic fibroblasts, loss of LKB1 and transduction of HPV16 E6/E7 had an additive effect on constraining cell senescence while promoting cell proliferation and increasing glucose consumption, lactate production and ATP generation. Knockdown of LKB1 increased and ectopic expression of LKB1 decreased glycolysis, anchorage-independent cell growth, and cell migration and invasion in HPV-transformed cells. In the tumorigenesis and lung metastasis model in syngeneic mice, depletion of LKB1 markedly increased tumor metastatic colonies in lungs without affecting subcutaneous tumor growth. We showed that HPV16 E6/E7 enhanced the expression of hexokinase-ll (HK-II) in the glycolytic pathway through elevated c-MYC. Ectopic LKB1 reduced HK-II along with glycolysis. The inverse relationship between HK-II and LKB1 was also observed in normal and HPV-associated cervical lesions. We propose that LKB1 acts as a safeguard against HPV-stimulated aerobic glycolysis and tumor progression. These findings may eventually aid in the development of therapeutic strategy for HPV-associated malignancies by targeting cell metabolism.
Although the roles of the metabolic stress in organ ischemia‐reperfusion injury (IRI) have been well recognized, the question of whether and how these stress responses regulate innate immune ...activation against IR remains unclear. In a murine liver partial warm ischemia mode, we showed that prolonged ischemia triggered endoplasmic reticulum (ER) stress response, particularly, the activating transcription factor 6 (ATF6) branch, in liver Kupffer cells (KCs) and altered their responsiveness against Toll‐like receptor (TLR) stimulation. Ischemia‐primed cells increased pro‐, but decreased anti‐, inflammatory cytokine productions. Alleviation of ER stress in vivo by small chemical chaperon 4‐phenylbutyrate or ATF6 small interfering RNA (siRNA) diminished the pro‐inflammatory priming effect of ischemia in KCs, leading to the inhibition of liver immune response against IR and protection of livers from IRI. In vitro, ATF6 siRNA abrogated the ER stress‐mediated pro‐inflammatory enhancement of macrophage TLR4 response, by restricting NF‐κB and restoring Akt activations. Thus, ischemia primes liver innate immune cells by ATF6‐mediated ER stress response. The IR‐induced metabolic stress and TLR activation function in synergy to activate tissue inflammatory immune response.
This study demonstrates that ischemia promotes pro‐inflammatory innate immune activation by activating ATF6 signaling pathways in murine liver ischemia and reperfusion injury.
This study numerically investigates performance analysis of three types of microchannels and the results obtained are compared with the open literature. The results show that the effect of different ...types of ribs on the overall performance is evident. The thermal enhancement factor η of the microchannels F–R (with rectangular ribs) is always the lowest, depending on the range of Reynolds number. Furthermore, different comprehensive performance criteria, based on the first and second law of thermodynamics, are proposed to assess the relative merit of each microchannel. The microchannel F-Trp (with trapezoidal ribs) is appeared to be the most promising configuration when Re<300, while the microchannel F–C (with circular ribs) has the best performance when Re>300. According to field synergy principle, the heat transfer enhancement can be attributed to the good synergy between velocity vector and temperature gradient. Moreover, thermal boundary is disturbed after adding ribs and temperature different between the channel wall and fluid is small, thus the corresponding of irreversibility (entropy generation) reduces and heat transfer rate improves. The present study aims to provide alternative ways to evaluate the heat transfer performance of microchannels.
In the present study, fluid flow and heat transfer in microchannel heat sinks with different inlet/outlet locations (I, C and Z-type), header shapes (triangular, trapezoidal and rectangular) and ...microchannel cross-section shapes (the conventional rectangular microchannel, the microchannel with offset fan-shaped reentrant cavities and the microchannel with triangular reentrant cavities) are numerically studied with computational domain including the entire microchannel heat sink. Detailed three-dimensional numerical simulations are useful in identifying the optimal geometric parameters that provide better heat transfer and flow distribution in a microchannel heat sink. Results highlight that flow velocity uniformity is comparatively better for I-type and poor for Z-type. The flow distribution is found to be symmetrical for I-type. It is seen from the header shapes analysis that the rectangular header shapes provides better flow velocity uniformity than the trapezoidal and triangular headers. The fluid flow mechanism can be attributed to the interaction of the branching of fluid and the friction offered by the walls of the header. Effects of microchannel cross-section shapes emphasize that the microchannel with offset fan-shaped reentrant cavities and the microchannel with triangular reentrant cavities of the heat sinks enhance the heat transfer compared to the conventional rectangular microchannel. The heat transfer mechanism can be attributed to the jetting and throttling effect, the additional flow disturbance near the wall of the reentrant cavities and the form drag of the reentrant cavities. The heat sink C has better heat transfer characteristic for qv=150ml/min and is able to prolong the life of the microelectronic devices.
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