3D printing offers enormous flexibility in fabrication of polymer objects with complex geometries. However, it is not suitable for fabricating large polymer structures with geometrical features at ...the sub-micrometer scale. Porous structure at the sub-micrometer scale can render macroscopic objects with unique properties, including similarities with biological interfaces, permeability and extremely large surface area, imperative inter alia for adsorption, separation, sensing or biomedical applications. Here, we introduce a method combining advantages of 3D printing via digital light processing and polymerization-induced phase separation, which enables formation of 3D polymer structures of digitally defined macroscopic geometry with controllable inherent porosity at the sub-micrometer scale. We demonstrate the possibility to create 3D polymer structures of highly complex geometries and spatially controlled pore sizes from 10 nm to 1000 µm. Produced hierarchical polymers combining nanoporosity with micrometer-sized pores demonstrate improved adsorption performance due to better pore accessibility and favored cell adhesion and growth for 3D cell culture due to surface porosity. This method extends the scope of applications of 3D printing to hierarchical inherently porous 3D objects combining structural features ranging from 10 nm up to cm, making them available for a wide variety of applications.
Pancreatic cancer (PC) is one of the most lethal malignancies. Recent studies indicate that patients with incidentally diagnosed PC have better prognosis than those with symptoms and that there is a ...sufficient window for early detection. However, effective early diagnosis remains difficult and depends mainly on imaging modalities and the development of screening methodologies with highly sensitive and specific biomarkers. This review summarizes recent advances in effective screening for early diagnosis of PC using imaging modalities and novel molecular biomarkers discovered from various “omics” studies including genomics, epigenomics, non‐coding RNA, metabonomics, liquid biopsy (CTC, ctDNA and exosomes) and microbiomes, and their use in body fluids (feces, urine and saliva). Although many biomarkers for early detection of PC have been discovered through various methods, larger scale and rigorous validation is required before their application in the clinic. In addition, more effective and specific biomarkers of PC are urgently needed.
Topology in quench dynamics gives rise to intriguing dynamic topological phenomena, which are intimately connected to the topology of static Hamiltonians yet challenging to probe experimentally. Here ...we theoretically characterize and experimentally detect momentum-time skyrmions in parity-time Formula: see text-symmetric non-unitary quench dynamics in single-photon discrete-time quantum walks. The emergent skyrmion structures are protected by dynamic Chern numbers defined for the emergent two-dimensional momentum-time submanifolds, and are revealed through our experimental scheme enabling the construction of time-dependent non-Hermitian density matrices via direct measurements in position space. Our work experimentally reveals the interplay of Formula: see text symmetry and quench dynamics in inducing emergent topological structures, and highlights the application of discrete-time quantum walks for the study of dynamic topological phenomena.
We experimentally simulate nonunitary quantum dynamics using a single-photon interferometric network and study the information flow between a parity-time- (PT-)symmetric non-Hermitian system and its ...environment. We observe oscillations of quantum-state distinguishability and complete information retrieval in the PT-symmetry-unbroken regime. We then characterize in detail critical phenomena of the information flow near the exceptional point separating the PT-unbroken and PT-broken regimes, and demonstrate power-law behavior in key quantities such as the distinguishability and the recurrence time. We also reveal how the critical phenomena are affected by symmetry and initial conditions. Finally, introducing an ancilla as an environment and probing quantum entanglement between the system and the environment, we confirm that the observed information retrieval is induced by a finite-dimensional entanglement partner in the environment. Our work constitutes the first experimental characterization of critical phenomena in PT-symmetric nonunitary quantum dynamics.
We report the experimental detection of bulk topological invariants in nonunitary discrete-time quantum walks with single photons. The nonunitarity of the quantum dynamics is enforced by periodically ...performing partial measurements on the polarization of the walker photon, which effectively introduces loss to the dynamics. The topological invariant of the nonunitary quantum walk is manifested in the quantized average displacement of the walker, which is probed by monitoring the photon loss. We confirm the topological properties of the system by observing localized edge states at the boundary of regions with different topological invariants. We further demonstrate the robustness of both the topological properties and the measurement scheme of the topological invariants against disorder.
Abstract
Contextuality is a striking feature of our nature predicted by quantum theory and tested by various experiments. In a qubit system, testing contextuality requires scenarios distinct from ...traditional ones for systems with dimension of three or greater. In this paper, we consider the noncontextuality inequality developed by Liang-Spekkens-Wiseman and Yu-Oh, and investigate the set of three qubit measurements that can be used to test and violate this inequality. Our numerical results show that two of the three measurements can be almost arbitrary. Moreover, we have singled out several extremely interesting sets of measurements, e.g. one measurements can be white noise while the other two are arbitrarily close to white noise. These sets fulfill our knowledge about contextuality in this minimum quantum system.
Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the ...immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and the tumor microenvironment are being investigated. Some of these approaches, such as checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and BiTE antibodies, have achieved exciting outcomes in preclinical and clinical trials. The current review describes the roles of immune cells and the immunosuppressive microenvironment in the development of pancreatic cancer, as well as the preclinical and clinical outcomes and benefits of recent immunotherapeutic approaches, which may help us further disclose the mechanisms of pancreatic cancer progression and the dialectical views of feasibility and effectiveness of immunotherapy in treatment of pancreatic cancer.
•The recent advances regarding immunotherapy in pancreatic cancer are reviewed.•The roles of immune cells and the immunosuppressive microenvironment in pancreatic cancer are described.•The preclinical and clinical outcomes and benefits of immunotherapy for pancreatic cancer are illustrated.Some approaches, such as checkpoint inhibitors, chimeric antigen receptor T-cell therapy, showed exciting outcomes.
OLIG2 is a transcription factor that activates the expression of myelin-associated genes in the oligodendrocyte-lineage cells. However, the mechanisms of myelin gene inactivation are unclear. Here, ...we uncover a non-canonical function of OLIG2 in transcriptional repression to modulate myelinogenesis by functionally interacting with tri-methyltransferase SETDB1. Immunoprecipitation and chromatin-immunoprecipitation assays show that OLIG2 recruits SETDB1 for H3K9me3 modification on the Sox11 gene, which leads to the inhibition of Sox11 expression during the differentiation of oligodendrocytes progenitor cells (OPCs) into immature oligodendrocytes (iOLs). Tissue-specific depletion of Setdb1 in mice results in the hypomyelination during development and remyelination defects in the injured rodents. Knockdown of Sox11 by siRNA in rat primary OPCs or depletion of Sox11 in the oligodendrocyte lineage in mice could rescue the hypomyelination phenotype caused by the loss of OLIG2. In summary, our work demonstrates that the OLIG2-SETDB1 complex can mediate transcriptional repression in OPCs, affecting myelination.
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