Depression is a major contributor to poor global health and disability, with a recently increasing incidence. Although drug therapy is commonly used to treat depression, conventional antidepressant ...drugs have several disadvantages, including slow onset, low response rates and severe adverse effects. Therefore, developing effective therapies for depression remains challenging. Although various aetiological theories of depression exist, the underlying mechanisms of depression are complex, and further research is crucial. Moreover, oxidative stress (OS)-induced lipid peroxidation has been demonstrated to trigger ferroptosis. Both OS and ferroptosis are pivotal mechanisms implicated in the pathogenesis of neurological disorders, and investigation of the mediators involved in these processes has emerged as a prominent and active research direction. One previous study revealed that regulatory proteins involved in ferroptosis are implicated in the pathogenesis of depression, and antidepressant drugs could reverse depressive symptoms by inhibiting ferroptosis in vivo, suggesting an important role of ferroptosis in the pathogenesis of depression. Hence, our current comprehensive review offers an up-to-date perspective on the intricate mechanisms involved, specifically concerning ferroptosis and OS in the context of depression, along with promising prospects for using molecular mediators to target ferroptosis. We delineate the key targets of molecular mediators involved in OS and ferroptosis implicated in depression, most notably reactive oxygen species and iron overload. Considering the pivotal role of OS-induced ferroptosis in the pathogenesis of neurological disorders, delving deeper into the underlying subsequent mechanisms will contribute significantly to the identification of novel therapeutic targets for depression.
The low response rate to immunosuppressant is mainly due to the lack of adequate knowledge about the tumor microenvironment (TME) and screening biomarkers for gliomas. We aimed to identify the ...promising immune biomarkers and new immune classification of glioma. In this study, multiple‐immune algorithms were used to calculate immune‐infiltration scores. Unsupervised and supervised machine learning methods were used to perform the classification. We observed that OLFML3 overexpression was indicated in gliomas and linked to poor prognosis. OLFML3 knockdown inhibited proliferation, invasion and increased the sensitivity of glioma cells to temozolomide. OLFML3 expression could also reflect the aberrant immune status. Based on the immune‐related signature, patients were divided into three immune subtypes via consensus clustering. Patients with C2 subtype presented poorer prognosis and shorter progression free survival than patients with other two subtypes. The TME patterns among subtypes were different. C2 and C3 subtypes are the immune‐inflamed and immune‐desert tumors, respectively. Additionally, compared with C3 subtype, patients with C1/C2 subtypes were more likely to respond to immunotherapy. The pRRophetic algorithm indicated patients with C1/C2 subtypes were more resistant to temozolomide, but sensitive to paclitaxel and cisplatin. To conclude, OLFML3 overexpression affects glioma cell proliferation, invasion, and TMZ sensitivity and has been proved to be an independent prognostic‐ and immune‐related biomarker. Additionally, the novel immune subtype's classification could provide the prognostic and predictive predictors for glioma patients and may guide physicians in selecting potential responders.
OLFML3 might be served as a novel prognostic biomarker and potential therapeutic target in gliomas. The OLFML3 expression can also reflect aberrant immune status of glioma‐immune microenvironment.
Three-dimensional flower-like BiOI/BiOX (X = Br or Cl) hybrids were synthesized via a facile one-pot solvothermal approach. With systematic characterizations by X-ray diffraction (XRD), scanning ...electron microscopy (SEM), Transmission electron microscopy (TEM), the Brunauer-Emmett-Teller (BET)specific surface area, X-ray photoelectron spectroscopy (XPS), and the UV-Vis diffuse reflectance spectra (DRS), the BiOI/BiOCl composites showed a fluffy and porous 3-D architecture with a large specific surface area (SSA) and high capability for light absorption. Among all the BiOX (X = Cl, Br, I) and BiOI/BiOX (X = Cl or Br) composites, BiOI/BiOCl stands out as the most efficient photocatalyst under both visible and UV light irradiations for methyl orange (MO) oxidation. The reaction rate of MO degradation on BiOI/BiOCl was 2.1 times higher than that on pure BiOI under visible light. Moreover, BiOI/BiOCl exhibited enhanced water oxidation efficiency for O₂ evolution which was 1.5 times higher than BiOI. The enhancement of photocatalytic activity could be attributed to the formation of a heterojunction between BiOI and BiOCl, with a nanoporous structure, a larger SSA, and a stronger light absorbance capacity especially in the visible-light region. The in situ electron paramagnetic resonance (EPR) revealed that BiOI/BiOCl composites could effectively evolve superoxide radicals and hydroxyl radicals for photodegradation, and the superoxide radicals are the dominant reactive species. The superb photocatalytic activity of BiOI/BiOCl could be utilized for the degradation of various industrial dyes under natural sunlight irradiation which is of high significance for the remediation of industrial wastewater in the future.
With the rapid development of industries, the issue of pollution on Earth has become increasingly severe. This has led to the deterioration of various surfaces, rendering them ineffective for their ...intended purposes. Examples of such surfaces include oil rigs, seawater intakes, and more. A variety of functional surface techniques have been created to address these issues, including superwetting surfaces, antifouling coatings, nano-polymer composite materials, etc. They primarily exploit the membrane's surface properties and hydration layer to improve the antifouling property. In recent years, biomimetic superwetting surfaces with non-toxic and environmental characteristics have garnered massive attention, greatly aiding in solving the problem of pollution. In this work, a detailed presentation of antifouling superwetting materials was made, including superhydrophobic surface, superhydrophilic surface, and superhydrophilic/underwater superoleophobic surface, along with the antifouling mechanisms. Then, the applications of the superwetting antifouling materials in antifouling domain were addressed in depth.
This review concentrated on recent developments of antifouling mechanism and application in biomimetic superwetting surfaces based on green antifouling. Display omitted
•The latest advances of bio-inspired antifouling superwetting surfaces were reviewed.•Typical antifouling superwetting surfaces including SHB, SHL and SHL/USOB surfaces were covered.•The antifouling mechanism of bio-inspired antifouling superwetting surfaces were provided.•The applications of bio-inspired antifouling superwetting surfaces in antifouling field were reviewed.
This article studies the problem of dissipative control for singular Takagi-Sugeno fuzzy systems with time delay. In order to reduce the conservatism brought by the time delay, we choose a proper ...augmented Lyapunov-Krasovskii functional and the auxiliary-function-based integral inequality to analyze the admissibility and dissipativity of the system. The singularity of the derivative matrix of the system leads to the matrix coupling terms, which are difficult to handle in the controller design by using the common controller design methods, so we propose an iterative algorithm to solve the controller parameters. The sufficient conditions of ensuring that the closed-loop system is admissible and dissipative are presented. Finally, three persuasive examples are given to demonstrate the effectiveness of the proposed method.
This paper investigates the problems of state and static output feedback control for a class of singular Takagi–Sugeno fuzzy systems with time-varying delay. Two kinds of controllers are considered: ...one is the proportional plus derivative state feedback controller, the other is the proportional plus derivative static output feedback controller. The augmented Lyapunov–Krasovskii functional is chosen to analyze the stabilization of the considered system and the sufficient conditions are proposed based on the Lyapunov stability theory. In order to solve the controller gains, two iterative algorithms are built. Two persuasive examples are given to show the effectiveness of our methods.
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•Magnetic Ni-Co alloy encapsulated N-doped carbon nanotubes were prepared.•The materials were used in peroxymonosulfate activation for organic degradation.•Catalytic membrane ...configuration was employed for the operation.•The membrane catalysis exhibits high performance and stability.
Nitrogen-doped carbon nanotubes encapsulated with Ni-Co alloy nanoparticles (NiCo@NCNTs) were readily synthesized by annealing Ni/Co salts with dicyandiamide. The magnetic nanocarbons were assembled as a flat membrane for heterogeneous degradation of organic toxins. The synergistic effect of nitrogen doping and metal alloy encapsulation significantly enhanced the catalytic activity and stability of NCNTs in catalytic activation of peroxymonosulfate (PMS) for purification of an emerging pollutant, ibuprofen. The hybrid catalyst yielded a fast reaction rate of 0.31 min−1, which was 23.4 and 5.8 times higher than that of pristine CNTs and monometallic (Ni or Co) encased CNTs, respectively. The robust membrane catalysis was further confirmed by degrading other organic aqueous pollutants, such as naproxen, sulfachloropyridazine, phenol, methylene blue, and methyl orange. Mechanistic investigation was performed using electron paramagnetic resonance and competitive radical screening tests, which indicated that radical (OH and SO4−) oxidation and nonradical pathway co-existed and played critical roles for catalytic degradation. The study provides a novel advanced oxidation system with catalytic membrane for wastewater remediation.
Among various advanced oxidation processes, coupled photocatalysis and heterogeneous Fenton‐like catalysis (known as photo‐Fenton‐like catalysis) to generate highly reactive species for environmental ...remediation has attracted wide interests. As an emerging metal‐free photocatalyst, graphitic carbon nitride (g‐C3N4, CN) has been recently recognized as a promising candidate to catalyze robustly heterogeneous photo‐Fenton‐like reactions for wastewater remediation. This review summarizes recent progress in fabricating various types of CN‐based catalysts for the photo‐Fenton‐like reaction process. Innovative engineering strategies on the CN matrix are outlined, ranging from morphology control, defect engineering, nonmetal atom doping, organic molecule doping to modification by metal‐containing species. The photo‐Fenton‐like catalytic activities of CN loaded with auxiliary sub‐nanoscale (e.g., quantum dots, organometallic molecules, metal cations, and single atom metals) and nanoscale metal‐based materials are critically evaluated. Hybridization of CN with bandgap‐matching semiconductors for the construction of type‐II and Z‐scheme heterojunctions are also examined. The critical factors (e.g., morphology, dimensionality, light absorption, charge excitation/migration, catalytic sites, H2O2 generation and activation) that determine the performance of CN‐based photocatalysts in Fenton‐like catalysis are systematically discussed. After examining the structure–activity relationship, research perspectives are proposed for further development of CN‐based photocatalysts toward more efficient photo‐Fenton‐like reactions and their application in practical water treatment.
A systematic review on graphitic carbon nitride based photocatalysts for coupled photocatalysis and Fenton‐like reaction in environmental remediation is presented. Strategies for engineering carbon nitride for more efficient photocatalysis are evaluated and the structure–activity correlation is discussed. Moreover, perspectives and future research directions are proposed.
Porous carbon serves as a green material for efficient wastewater purification by adsorption and advanced oxidation processes. However, a clear understanding of the simultaneous removal of multiple ...pollutants in water is still ambiguous. Herein, the synergistic effect of adsorption and peroxydisulfate (PS) activation on kinetics and mechanism of removing single and binary antibiotic pollutants, sulfamethoxazole (SMX) and ibuprofen (IBP), from water by biomass-derived N-doped porous carbon was investigated. Our findings suggest that adsorption contributed to efficient removals of SMX/IBP. Comparative quenching experiments and electrochemical analysis demonstrated that hydroxyl (•OH) and sulfate (SO4•−) radicals, as well as singlet oxygen (1O2) led to the catalytic degradation of SMX, while only 1O2 reacted for IBP oxidation. Superoxide ion (O2•−) radicals were not related to SMX/IBP degradation. Electron transfer pathway accounted for PS activation but was not involved in direct SMX/IBP oxidation. Only slight differences were found between the degradation kinetics of SMX and IBP in the binary and single SMX or IBP solutions. This arose from the non-selective effect of adsorption and 1O2 attack for SMX/IBP removal, and the weak selective oxidation process of SMX by •OH and SO4•−. This study provides a new viewpoint on the role of adsorption in catalysis and enriches the mechanistic study of multi-component antibiotic degradation.
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•N-biochar/persulfate for removals of single/binary antibiotics in water was studied.•The roles of adsorption and degradation by radicals, and non-radicals were unveiled.•Adsorption contributed to effective removal of sulfamethoxazole(SMX)/ibuprofen(IBP).••OH, SO4•−, and 1O2 led to SMX degradation, while 1O2 reacted for IBP oxidation.•Similar kinetics of SMX and IBP removals in binary and single solutions were observed.
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