The South American tomato pinworm,
Tuta absoluta
(Meyrick) (Lepidoptera: Gelechiidae), has invaded most Afro-Eurasian countries and is threatening worldwide tomato production. Various strategies have ...been developed and implemented to manage this pest. Here, we present a timely review on the up-to-date development and practical implementation of integrated pest management (IPM) programs for tomato crops across different world regions infested by
T. absoluta
. While insecticide resistance is a growing concern, biological control via releasing or conserving arthropod natural enemies and sex pheromone-based biotechnical control are the most successful management practices. Agronomic control-related research is an emerging area where the soil fertilization and/or irrigation, as well as breeding of resistant cultivars, has the potential to enhance IPM effectiveness. Grower survey responses in the native areas (i.e., South America), early-invaded areas (i.e., first report between 2006 and 2012) and newly invaded areas (i.e., first report after 2012) showed that the control programs evolved along with the areas and time since invasion. Growers in the early-invaded areas shifted more rapidly from chemical control to biological control compared to those from the native area. In all concerned regions, the pest control failure risk following chemical insecticide applications and the high cost associated with either biological or biotechnical control methods have been the greatest concerns for growers. The information gathered from the native and/or early-invaded areas may help achieve a more effective management in newly invaded areas. Lastly, researchers are expected to break the bottlenecks of some key issues that would enable lowering application cost of novel biorational alternative management options.
All-solid-state bulk-type lithium ion batteries (LIBs) are considered ultimate solutions to the safety issues associated with conventional LIBs using flammable liquid electrolyte. The development of ...bulk-type all-solid-state LIBs has been hindered by the low loading of active cathode materials, hence low specific surface capacity, and by the high interface resistance, which results in low rate and cyclic performance. In this contribution, we propose and demonstrate a synergistic all-composite approach to fabricating flexible all-solid-state LIBs. PEO-based composite cathode layers (filled with LiFePO4 particles) of ∼300 μm in thickness and composite electrolyte layers (filled with Al-LLZTO particles) are stacked layer-by-layer with lithium foils as negative layer and hot-pressed into a monolithic all-solid-state LIB. The flexible LIB delivers a high specific discharge capacity of 155 mAh/g, which corresponds to an ultrahigh surface capacity of 10.8 mAh/cm2, exhibits excellent capacity retention up to at least 10 cycles and could work properly under harsh operating conditions such as bending or being sectioned into pieces. The all-composite approach is favorable for improving both mesoscopic and microscopic interfaces inside the all-solid-state LIB and may provide a new toolbox for design and fabrication of all-solid-state LIBs.
Sorafenib (SOR) resistance remains a major obstacle in the effective treatment of hepatocellular carcinoma (HCC). A number of long noncoding RNAs (lncRNAs) are responsible for this chemoresistance. ...This study aimed to reveal the essential function of a recently defined lncRNA, lncRNA‐POIR, in the epithelial–mesenchymal transition (EMT) and SOR sensitivity of HCC cells. SOR‐induced cytotoxicity was analyzed via cell counting kit‐8 and ethynyl‐2'‐deoxyuridine incorporation assays, whereas immunoblotting and confocal immunofluorescence were used to determine the expression levels of EMT markers. Furthermore, loss‐ or gain‐of‐function approaches were used to demonstrate the role of lncRNA‐POIR/miR‐182‐5p on EMT and SOR sensitivity in HCC. The direct interaction between lncRNA‐POIR and miR‐182‐5p was verified using a luciferase reporter assay. We found that knockdown of lncRNA‐POIR sensitized HCC cells to SOR and simultaneously reversed EMT. As expected, miR‐182‐5p was confirmed as the downstream target of lncRNA‐POIR. Moreover, miR‐182‐5p overexpression clearly reversed EMT and promoted SOR‐induced cytotoxicity in representative HCC cells, whereas miR‐182‐5p downregulation played a contrasting role; miR‐182‐5p knockdown abolished the modulatory effects of lncRNA‐POIR siRNA on EMT and SOR sensitivity. Together, these pieces of data suggest that lncRNA‐POIR promotes EMT progression and suppresses SOR sensitivity simultaneously by sponging miR‐182‐5p. Thus, we proposed a compelling rationale for the use of lncRNA‐POIR as a promising predictor of SOR response and as a potential therapeutic target for HCC treatment in the future.
In this study, we verified the biological functions of lncRNA‐POIR as an aberrantly expressed lncRNA in hepatocellular carcinoma (HCC) cells. lncRNA‐POIR modulated EMT and sorafenib sensitivity of HCC cells via functioning as a competing endogenous RNA (ceRNA) of miR‐182‐5p. Our findings provide a compelling rationale for the use of lncRNA‐POIR as a predictor of SOR response and a promising therapeutic target for future HCC treatment.
•Accelerated corrosion of the longitudinal reinforcement and stirrup was carried out by the electroosmosis-constant current-dry wet cycle method.•The effects of the corrosion degree, stirrup spacing ...and cover thickness parameters on the bond performance were analyzed by pull-out tests.•A modified bond-slip constitutive model that considers the corrosion of longitudinal bars and stirrups was proposed.
The corrosion of longitudinal rebar and stirrups will cause serious degradation of the bond performance between steel bars and concrete. To investigate the impact of both longitudinal rebar and stirrup corrosion on the bond behavior, 35 reinforced concrete (RC) pull-out specimens were subjected to accelerated corrosion tests with electroosmosis/constant current/dry-wet cycling and pull-out tests. The influence laws of the degree of corrosion of the longitudinal reinforcement, degree of corrosion of the stirrups, cover thickness, stirrup spacing and longitudinal reinforcement diameter on the bond performance were also investigated. The bond behavior between corroded steel bars and concrete was analyzed from the aspects of corrosion form, failure mode and bond strength. Subsequently, based on the experimental data, a modified bond-slip constitutive model that considers the design parameters, stirrup corrosion and longitudinal rebar corrosion was built and verified. The modified bond-slip constitutive model was applied to the cohesive element to establish a finite element model of the corroded pull-out specimens, and additional parameters were analyzed.
Aim
To explore the prevalence and related factors influencing diabetes stigma among Chinese young and middle‐aged patients with type 2 diabetes.
Design
A cross‐sectional, quantitative study was ...conducted through questionnaires.
Methods
A total of 453 young and middle‐aged patients with type 2 diabetes were recruited. Questionnaire survey was conducted with convenience sampling from September 2019 to December 2020. This included demographic questionnaire, Type 2 Diabetes Stigma Assessment Scale (DSAS‐2) and Connor–Davidson Resilience Scale (CD‐RISC). The STROBE checklist was applied as the reporting guideline for this study.
Results
The scores of diabetes stigma and resilience of patients were 48.18 ± 14.52 and 66.02 ± 7.18, respectively. Diabetes stigma was negatively correlated with resilience, the correlation coefficient was −0.581. The results showed that the complications, diabetes year, monthly income and insulin treatment are important factors affecting stigma. In addition, it is resilience that was a protective factor of diabetes stigma, explaining 27.2% of the variance in diabetes stigma.
Under dehumidifying conditions, the condensed water will directly affect the heat transfer and resistance characteristics of a fin-and-tube heat exchanger. The geometrical form of condensed water on ...fin surfaces of three different fin materials (i.e., copper fin, aluminum fin, and aluminum fin with hydrophilic layer) in a fin-and-circular-tube heat exchanger was experimentally studied in this paper. The effect of the three different fin materials on heat transfer and friction performance of the heat exchanger was researched, too. The results show that the condensation state on the surface of copper fin and aluminum fin are dropwise condensation. The condensation state on the surface of the aluminum fin with the hydrophilic layer is film condensation. For the three different material fins, increasing the air velocity (ua,in) and relative humidity (RHin) of the inlet air can enhance the heat transfer of the heat exchanger. Friction factor (f) of the three different material fins decreases with the increase of ua,in, however, increases with the increase of RHin. At the same ua,in or RHin, Nusselt number (Nu) of the copper fin heat exchanger is the largest and Nu of the aluminum fin with hydrophilic layer is the smallest, f of the aluminum fin heat exchanger is the largest and f of the aluminum fin with hydrophilic layer is the smallest. Under the identical pumping power constrain, the comprehensive heat transfer performance of the copper fin heat exchanger is the best for the studied cases.
Temperature, as a critical abiotic factor, might influence the effectiveness of biological control by parasitoids in host-parasitoid systems. In this study, Neochrysocharis formosa (Westwood), a ...larval endoparasitoid, is used to investigate the efficacy of biological control on a vegetable agriculture pest, Liriomyza sativae Blanchard, reared on kidney bean (Phaseolus vulgaris L.), at four constant temperatures (26, 29, 32, and 35°C) under laboratory conditions. Our results show that high temperatures (29, 32, and 35°C) do not significantly affect lifetime host-killing events of female adults by increased daily host-killing events compared to temperature of 26°C, although their lifespans decrease with an increase in temperatures. Each life-history trait of female adults (lifespan, parasitism, stinging, or non-reproductive host-killing events) present a linear relation with temperatures and host-feeding events, respectively. Our findings contribute to a better understanding of biocontrol efficacy of parasitoid N. formosa against agromyzid leafminers at high-temperature seasons or environments.
Parasitoids are insects (usually wasps or flies) that lay eggs within or on other insects (their hosts). Host-feeding parasitoids lay eggs to parasitize the host and feed directly on the host for ...nourishment. Temperature is the most critical factor affecting insect behavioral responses. Few studies have focused on the impacts of variable temperatures across different life stages on the behaviors of host-feeding parasitoids. This study investigated the effects of temperature experienced during the preadult and adult stages on the life history traits and life table parameters of females of a host-feeding parasitoid, Eretmocerus hayati. Our results show that the temperatures experienced during the preadult and adult stages significantly change life history traits (immature development, adult longevity, host feeding and fecundity). Increasing the preadult temperature resulted in shorter development times for immature stages of the parasitoid, and decreasing the temperature during the adult stage increased reproduction and longevity. Most importantly, we found that host-feeding events changed with temperature rather than life stage. The daily host-feeding ability of the parasitoid increased with increasing temperature at all temperatures except the stress temperature (34 °C). Furthermore, switching temperatures at the immature stage and adult stage can increase the values of life table parameters, with the highest intrinsic rate of increase (r) occurring in the 30/26 °C treatment. This study provides new insight into the mass rearing of parasitic natural enemies.
GABAergic neurons in the vestibular nuclei (VN) participate in multiple vital vestibular sensory processing allowing for the maintenance and rehabilitation of vestibular functions. However, although ...the important role of GABA in the central vestibular system has been widely reported, the underlying neural circuits between VN GABAergic neurons and other brain functional regions remain elusive, which limits the further study of the underlying mechanism. Hence, it is necessary to elucidate neural connectivity based on outputs and inputs of GABAergic neurons in the VN. This study employed a modified rabies virus retrograde tracing vector and cre-dependent adeno-associated viruses (AAVs) anterograde tracing vector, combined with a transgenic VGAT-IRES-Cre mice, to map the inputs and outputs of VN GABAergic neurons in the whole brain. We found that 51 discrete brain regions received projections from VN GABAergic neurons in the whole brain, and there were 77 upstream nuclei innervating GABAergic neurons in the VN. These nuclei were mainly located in four brain regions, including the medulla, pons, midbrain, and cerebellum. Among them, VN GABAergic neurons established neural circuits with some functional nuclei in the whole brain, especially regulating balance maintenance, emotion control, pain processing, sleep and circadian rhythm regulation, and fluid homeostasis. Therefore, this study deepens a comprehensive understanding of the whole-brain neural connectivity of VN, providing the neuroanatomical information for further research on the neural mechanism of the co-morbidities with vestibular dysfunction.
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