AbstractObjectiveTo evaluate the relative efficacy of programmed cell death 1 (PD-1) or programmed cell death ligand 1 (PD-L1) inhibitors versus conventional drugs in patients with cancer that were ...PD-L1 positive and PD-L1 negative.DesignMeta-analysis of randomised controlled trials.Data sourcesPubMed, Embase, Cochrane database, and conference abstracts presented at the American Society of Clinical Oncology and European Society of Medical Oncology up to March 2018.Review methodsStudies of PD-1 or PD-L1 inhibitors (avelumab, atezolizumab, durvalumab, nivolumab, and pembrolizumab) that had available hazard ratios for death based on PD-L1 positivity or negativity were included. The threshold for PD-L1 positivity or negativity was that PD-L1 stained cell accounted for 1% of tumour cells, or tumour and immune cells, assayed by immunohistochemistry staining methods.Results4174 patients with advanced or metastatic cancers from eight randomised controlled trials were included in this study. Compared with conventional agents, PD-1 or PD-L1 inhibitors were associated with significantly prolonged overall survival in both patients that were PD-L1 positive (n=2254, hazard ratio 0.66, 95% confidence interval 0.59 to 0.74) and PD-L1 negative (1920, 0.80, 0.71 to 0.90). However, the efficacies of PD-1 or PD-L1 blockade treatment in patients that were PD-L1 positive and PD-L1 negative were significantly different (P=0.02 for interaction). Additionally, in both patients that were PD-L1 positive and PD-L1 negative, the long term clinical benefits from PD-1 or PD-L1 blockade were observed consistently across interventional agent, cancer histotype, method of randomisation stratification, type of immunohistochemical scoring system, drug target, type of control group, and median follow-up time.ConclusionsPD-1 or PD-L1 blockade therapy is a preferable treatment option over conventional therapy for both patients that are PD-L1 positive and PD-L1 negative. This finding suggests that PD-L1 expression status alone is insufficient in determining which patients should be offered PD-1 or PD-L1 blockade therapy.
Household air pollution generated from cooking is severe, especially for Chinese-style cooking. We measured the emission rates of multiple air pollutants including fine particles (PM2.5), ultrafine ...particles (UFPs), and volatile organic compounds (VOCs, including formaldehyde, benzene, and toluene) that were generated from typical Chinese cooking in a residential kitchen. The experiment was designed through five-factor and five-level orthogonal testing. The five key factors were cooking method, ingredient weight, type of meat, type of oil, and meat/vegetable ratio. The measured emission rates (mean value ± standard deviation) of PM2.5, UFPs, formaldehyde, total volatile organic compounds (TVOCs), benzene, and toluene were 2.056 ± 3.034 mg/min, 9.102 ± 6.909 × 1012 #/min, 1.273 ± 0.736 mg/min, 1.349 ± 1.376 mg/min, 0.074 ± 0.039 mg/min, and 0.004 ± 0.004 mg/min. Cooking method was the most influencing factor for the emission rates of PM2.5, UFPs, formaldehyde, TVOCs, and benzene but not for toluene. Meanwhile, the emission rate of PM2.5 was also significantly influenced by ingredient weight, type of meat, and meat/vegetable ratio. Exhausting the range hood decreased the emission rates by approximately 58%, with a corresponding air change rate of 21.38/h for the kitchen room.
Epidemiologic evidence indicates a relationship between outdoor particle exposure and adverse health effects, while most people spend 85–90% of their time indoors, thus understanding the relationship ...between indoor and outdoor particles is quite important. This paper aims to provide an up-to-date revision for both experiment and modeling on relationship between indoor and outdoor particles. The use of three different parameters: indoor/outdoor (I/O) ratio, infiltration factor and penetration factor, to assess the relationship between indoor and outdoor particles were reviewed. The experimental data of the three parameters measured both in real houses and laboratories were summarized and analyzed. The I/O ratios vary considerably due to the difference in size-dependent indoor particle emission rates, the geometry of the cracks in building envelopes, and the air exchange rates. Thus, it is difficult to draw uniform conclusions as detailed information, which make I/O ratio hardly helpful for understanding the indoor/outdoor relationship. Infiltration factor represents the equilibrium fraction of ambient particles that penetrates indoors and remains suspended, which avoids the mixture with indoor particle sources. Penetration factor is the most relevant parameter for the particle penetration mechanism through cracks and leaks in the building envelope. We investigate the methods used in previously published studies to both measure and model the infiltration and penetration factors. We also discuss the application of the penetration factor models and provide recommendations for improvement.
Chaos in nonlinear dynamical systems is featured with irregular appearance and with high sensitivity to initial conditions. Near-infrared light chaos based on semiconductor lasers has been ...extensively studied and has enabled various applications. Here, we report a fully-developed hyperchaos in the mid-infrared regime, which is produced from interband cascade lasers subject to the external optical feedback. Lyapunov spectrum analysis demonstrates that the chaos exhibits three positive Lyapunov exponents. Particularly, the chaotic signal covers a broad frequency range up to the GHz level, which is two to three orders of magnitude broader than existed mid-infrared chaos solutions. The interband cascade lasers produce either periodic oscillations or low-frequency fluctuations before bifurcating to hyperchaos. This hyperchaos source is valuable for developing long-reach secure optical communication links and remote chaotic Lidar systems, taking advantage of the high-transmission windows of the atmosphere in the mid-infrared regime.
Tumor-associated antigens (TAAs) have been tested in various clinical trials in cancer treatment but the patterns of specific T cell response to personalized TAA immunization remains to be fully ...understood. We report antigen-specific T cell responses in patients immunized with dendritic cell vaccines pulsed with personalized TAA panels. Tumor samples from patients were first analyzed to identify overexpressed TAAs. Autologous DCs were then transfected with pre-manufactured mRNAs encoding the full-length TAAs, overexpressed in the patients' tumors. Patients with glioblastoma multiforme (GBM) or advanced lung cancer received DC vaccines transfected with personalized TAA panels, in combination with low-dose cyclophosphamide, poly I:C, imiquimod and anti-PD-1 antibody. Antigen-specific T cell responses were measured. Safety and efficacy were evaluated. A total of ten patients were treated with DC vaccines transfected with personalized TAA panels containing 3–13 different TAAs. Among the seven patients tested for anti-TAA T cell responses, most of the TAAs induced antigen-specific CD4
+
and/or CD8
+
T cell responses, regardless of their expression levels in the tumor tissues. No Grade III/IV adverse events were observed among these patients. Furthermore, the treated patients were associated with favorable overall survival when compared to patients who received standard treatment in the same institution. Personalized TAA immunization-induced-specific CD4
+
and CD8
+
T cell responses without obvious autoimmune adverse events and was associated with favorable overall survival. These results support further studies on DC immunization with personalized TAA panels for combined immunotherapeutic regimens in solid tumor patients.
Trial registration
ClinicalTrials.gov, NCT02709616 (March, 2016), NCT02808364 (June 2016), NCT02808416 (June, 2016).
Highly crystallized ZnO–Ga2O3 core–shell heterostructure microwire is synthesized by a simple one‐step chemical vapor deposition method, and constructed into a self‐powered solar‐blind (200–280 nm) ...photodetector with a sharp cutoff wavelength at 266 nm. The device shows an ultrahigh responsivity (9.7 mA W−1) at 251 nm with a high UV/visible rejection ratio (R251 nm/R400 nm) of 6.9 × 102 under zero bias. The self‐powered device has a fast response speed with rise time shorter than 100 µs and decay time of 900 µs, respectively. The ultrahigh responsivity, high UV/visible rejection ratio, and fast response speed make it highly suitable in practical self‐powered solar‐blind detection. Additinoally, this microstructure heterojunction design method would provide a new approach to realize the high‐performance self‐powered photodetectors.
Highly crystallized ZnO–Ga2O3 heterostructure microwire is synthesized using a simple one‐step chemical vapor deposition method and the growth mechanism is discussed. A self‐powered solar‐blind photodetector based on individual ZnO–Ga2O3 heterostructures is demonstrated, and has responsivity as high as 9.7 mA W−1 at the wavelength of 251 nm without any external power source.
•A detailed introduction and analysis of radiative cooling was reviewed.•The mathematical description of radiative cooling was reviewed and discussed.•The emitters’ materials and radiative properties ...were compiled and analyzed.•The potential applications of radiative cooling were excavated.•Several recommendations on radiative cooling were presented.
As a passive, effective, and renewable way of decreasing cooling energy requirements without power input, radiative cooling has attracted considerable attention in the field of energy-saving applications. Historically, radiative cooling was limited at nighttime because radiators with strong thermal radiation lack high reflectivity in the solar radiation band. With the recent technological advancements in radiators, such as the development of photonic radiators and metamaterials, the advantages of diurnal radiative cooling has been demonstrated. In this paper, the current state of the art in passive radiative cooling technology is reviewed and updated. First, the fundamental principles of radiative cooling, which comprise different mathematical and physical descriptions, are introduced. Then, the advanced materials and structures of various radiators, which are popular topics in radiative cooling, are presented. Furthermore, application developments in radiative cooling are also summarized and its prospects are preliminarily analyzed. This study provides a detailed introduction and analysis of radiative cooling technology, thereby serving as a key reference for promoting the development of radiative cooling utilization.
Window opening behavior has a vital influence on indoor air quality, thermal comfort, and energy consumption. In residential buildings, the window opening behavior of occupants may vary considerably ...owing to different indoor and outdoor environmental parameters and personal habits. In this study, we investigated the factors influencing the window opening behavior of occupants in 19 residences in Beijing by monitoring the open/closed status of windows, and eight environmental parameters, including temperature and relative humidity of indoor and outdoor air, indoor CO2 concentration, outdoor PM2.5 concentration, and outdoor wind speed and direction. The influence of the season and time of day was also analyzed, and typical window operation schedules were determined. Predictive models of the occupants' window opening behavior were established based on multivariate linear logistic regression. The results indicated that outdoor air temperature was the most influential factor, followed by indoor CO2 concentration, indoor air temperature, outdoor and indoor relative humidity, ambient PM2.5 concentrations, and outdoor wind direction and wind speed.
•Window states were monitored in 19 residences in Beijing over 4 seasons.•Typical daily window opening and closing schedules were fitted.•The schedules provide key parameters for energy consumption and IAQ assessment.•Stochastic models of occupants' window opening behavior were established.
Dendrite growth of alkali metal anodes limited their lifetime for charge/discharge cycling. Here, we report near-perfect anodes of lithium, sodium, and potassium metals achieved by electrochemical ...polishing, which removes microscopic defects and creates ultra-smooth ultra-thin solid-electrolyte interphase layers at metal surfaces for providing a homogeneous environment. Precise characterizations by AFM force probing with corroborative in-depth XPS profile analysis reveal that the ultra-smooth ultra-thin solid-electrolyte interphase can be designed to have alternating inorganic-rich and organic-rich/mixed multi-layered structure, which offers mechanical property of coupled rigidity and elasticity. The polished metal anodes exhibit significantly enhanced cycling stability, specifically the lithium anodes can cycle for over 200 times at a real current density of 2 mA cm
with 100% depth of discharge. Our work illustrates that an ultra-smooth ultra-thin solid-electrolyte interphase may be robust enough to suppress dendrite growth and thus serve as an initial layer for further improved protection of alkali metal anodes.
Video captioning is a technique that bridges vision and language together, for which both visual information and text information are quite important. Typical approaches are based on the recurrent ...neural network (RNN), where the video caption is generated word by word, and the current word is predicted based on the visual content and previously generated words. However, in the prediction of the current word, there is much uncorrelated visual content, and some of the previously generated words provide little information, which may cause interference in generating a correct caption. Based on this point, we attempt to exploit the visual and text features that are most correlated with the caption. In this paper, a co-attention model based recurrent neural network (CAM-RNN) is proposed, where the CAM is utilized to encode the visual and text features, and the RNN works as the decoder to generate the video caption. Specifically, the CAM is composed of a visual attention module, a text attention module, and a balancing gate. During the generation procedure, the visual attention module is able to adaptively attend to the salient regions in each frame and the frames most correlated with the caption. The text attention module can automatically focus on the most relevant previously generated words or phrases. Moreover, between the two attention modules, a balancing gate is designed to regulate the influence of visual features and text features when generating the caption. In practice, the extensive experiments are conducted on four popular datasets, including MSVD, Charades, MSR-VTT, and MPII-MD, which have demonstrated the effectiveness of the proposed approach.
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