Combination of chemotherapy and gene therapy provides an effective strategy for cancer treatment. However, the lack of suitable codelivery systems with efficient endo/lysosomal escape and ...controllable drug release/gene unpacking is the major bottleneck for maximizing the combinational therapeutic efficacy. In this work, we developed a photoactivatable Pt(IV) prodrug-backboned polymeric nanoparticle system (CNPPtCP/si(c‑fos)) for light-controlled si(c-fos) delivery and synergistic photoactivated chemotherapy (PACT) and RNA interference (RNAi) on platinum-resistant ovarian cancer (PROC). Upon blue-light irradiation (430 nm), CNPPtCP/si(c‑fos) generates oxygen-independent N3 • with mild oxidation energy for efficient endo/lysosomal escape through N3 •-assisted photochemical internalization with less gene deactivation. Thereafter, along with Pt(IV) prodrug activation, CNPPtCP/si(c‑fos) dissociates to release active Pt(II) and unpack si(c-fos) simultaneously. Both in vitro and in vivo results demonstrated that CNPPtCP/si(c‑fos) displayed excellent synergistic therapeutic efficacy on PROC with low toxicity. This PACT prodrug-backboned polymeric nanoplatform may provide a promising gene/drug codelivery tactic for treatment of various hard-to-tackle cancers.
Intraoperative bleeding is an essential factor leading to the earliest recurrence and tumor metastasis frequently seen after resection of solid tumors. Local drug delivery implants show the unique ...advantages on postoperative cancer therapy. Herein, a sandwich‐like cisplatin‐loaded fibers/sponge composite (CFSC) combining chemotherapy and hemostasis is constructed. The obtained implantable CFSC is able to simultaneously stop bleeding and absorb disseminated tumor cells after tumor resection. More importantly, sustained released cisplatin can kill local residual tumor cells as well as those concentrated in the CFSC, which significantly inhibits local tumor recurrence and distant tumor metastasis on the subcutaneous postoperative recurrence model and metastasis models. This dual functional implant strategy with low toxicity to healthy organs may inspire new aspects for efficient postoperative cancer therapy.
A sandwich‐like fibers/sponge composite combining chemotherapy and hemostasis is constructed as a postoperative supplement. The implantable cisplatin‐loaded fibers/sponge composite (CFSC) is able to simultaneously stop bleeding and absorb disseminated cancer cells after tumor resection. More importantly, sustained released cisplatin can kill residual tumor cells as well as those concentrated in the CFSC, which significantly enhances the antirecurrence and antimetastasis efficiency with low toxicity.
In this paper, a single‐layer substrate‐integrated waveguide (SIW) filtering antenna with three independently controllable radiation nulls is presented. The antenna consists of a single‐layer SIW ...loaded with two radiation gaps, four metallization columns, and folded‐type slots etched on the chip. The back‐cavity double slots are responsible for extending the bandwidth and realizing the radiation function. Three radiation nulls are generated by analyzing the current distribution of the radiation chip, radiation gap, and folded slots. By adjusting the radiation gap distance, the length of the radiation gap, and the folded slot, three broadside radiation nulls are independently controlled without influence on each other. Therefore, flexible out‐of‐band suppression characteristic is obtained. For demonstration, a prototype is fabricated and tested. The measurements match the simulation results better. The filtering antenna operates at 3.70 GHz with a bandwidth of 5.68% (3.59–3.80 GHz), achieving an average realized gain of 5.10 dBi in a flat passband. The out‐of‐band rejection level exceeds 20 dB.
Three radiation nulls are independently controlled by adjusting the radiation gap position, the length of the radiation gap, and the folded slot separately. The single‐layer SIW filtering antenna satisfies the design requirements of integration and miniaturization, while providing filtering performance.
To improve the accuracy of the current vision-based linear displacement measurement in a large range, a new type of linear displacement sensing system, namely, image grating, is proposed in this ...paper. The proposed system included a patterned glass plate attached to the moving object and an ultra-low distortion lens for high-accuracy image matching. A DFT local up-sampling phase correlation method was adopted to obtain the sub-pixel translation of the patterns onto the target plate. Multiple sets of stripe patterns with different designs were located on the glass plate to expand the measurement range, based on the principle of phase correlation. In order to improve the measurement accuracy, the main errors of the image grating system were analyzed, and the nonlinear error compensation was completed based on the dynamic calibration of the pixel equivalent. The measurement results, after the error compensation, showed that the total error of the proposed system was less than 2.5 μm in the range of 60 mm, and the repeatability was within 0.16 μm, as quantified by standard deviation.
In this paper, we demonstrate a strategy of covalently bonding bioactive molecules onto inorganic hydroxyapatite (HAp) to improve the compatibility between organic and inorganic components and endow ...the bone composites with sustainable bioactivity. Bone morphogenetic protein-2 (BMP-2) peptide covalently immobilized nano-hydroxyapatite (nHAp-BMP-2) is developed to preserve the bioactivity and slow the release of the BMP-2 peptide. Then nHAp-BMP-2 was further incorporated into an ultraviolet-curable mixture of gelatin methacrylamide (GelMA) and four-armed PEG methacrylamide (four-armed PEGMA) to form a Gel/(nHAp-BMP-2) composite. The hydrogen bonding between gelatin and BMP-2 on nHAp-BMP-2 enhanced the compatibility between inorganic and organic components. The Gel/(nHAp-BMP-2) composite exhibited superior biocompatibility caused by gelatin and nHAp-BMP-2, except in a two-dimensional cell culture, the hydrogel was also capable of a three-dimensional cell culture. In addition, the introduction of nHAp-BMP-2 had a positive influence on bone marrow mesenchymal stem cell proliferation, differentiation, and the subsequent calcification on the composite. After treatment of a rat calvarial defect model for 12 weeks, the Gel/(nHAp-BMP-2) group showed the largest new bone volume and the highest ratio of new bone (50.54 ± 13.51 mm3 and 64.38 ± 17.22%, respectively) compared to those of the other groups. These results demonstrate that this way of controlling BMP-2 release is effective and the Gel/(nHAp-BMP-2) composite has great potential in bone regeneration therapy.
In this paper, a novel design of polarization selective surface (PSS) is proposed for co‐channel interference (CCI) suppression. By establishing a switchable doublet topology, two types of ...second‐order filtering responses with two transmission zeros are generated under TE and TM polarizations. The PSS element is composed of a combined dual‐mode resonant cavity. Meanwhile, the coupling matrix provides guidelines for PSS design. Moreover, detailed analyses of polarization angles account for CCI suppression. Finally, to verify the design, the PSS prototype is fabricated and tested. Measured results are in good agreement with simulations. The CCI suppression is demonstrated at two frequency bands with the highest suppression level up to 42.6 dB.
In this paper, a novel design of high roll‐off frequency selective surface (FSS) is proposed based on a single‐layer substrate integrated waveguide (SIW) cavity. Fully canonical filtering responses ...with three transmission poles (TPs) and three transmission zeros (TZs) are obtained by employing transversal signal‐interference techniques (TSITs). The FSS unit cell can be regarded as a combined triple‐mode cavity consisting of one cross‐slot resonator and two SIW cavities. By using the filtering coupling matrix, the FSS can be well designed and analysed. Accordingly, to verify the design concept, a prototype is fabricated and experimented. Measured and simulated results are in good agreement, showing high performances in terms of high roll‐off and low profile.
A non-degenerate dual-mode resonator derived from circular substrate integrated waveguide is proposed, and two pseudoelliptic bandpass filters with non-resonant mode based on the dual-mode resonators ...are presented. Two resonant modes (higher order modes) are employed to degenerate a passband, while a non-resonant mode (fundamental mode) is designed to provide a direct input-to-output coupling. Owning to an additional path provided by non-resonant mode, the filters have good selectivity and very compact size. The presented simulation and measurement results are in good agreement.
The resonant characteristic of rectangular strip patch resonator (RSPR) is studied in detail, and a new dual-mode resonator based on TM 100 and TM 020 modes is proposed to design bandpass filters ...(BPFs). A two-pole BPF with two finite transmission zeros (FTZs) based on one nondegenerate dual-mode RSPR is presented and analyzed. And then, a four-pole BPF with four FTZs based on two cascaded nondegenerate dual-mode RSPRs is proposed. The two dual-mode RSPRs are connected directly by a quarter wavelength strip-line. Finally, a four-pole BPF with the center frequency of 5.8 GHz is designed, fabricated, and measured. The measured insertion loss in center frequency, 1-dB bandwidth, and return loss are 1.45 dB, 206 MHz, and 12.85 dB, respectively. Measured <inline-formula> <tex-math notation="LaTeX">Q </tex-math></inline-formula>-factor is about 315.
Carborane-conjugated amphiphilic copolymer nanoparticles were designed to deliver anticancer drugs for the combination of chemotherapy and boron neutron capture therapy (BNCT). Poly(ethylene ...glycol)-b-poly(L-lactide-co-2-methyl-2(2-dicarba-closo-dodecarborane)propyloxycarbonyl-propyne carbonate) (PLMB) was synthesized via the versatile reaction between decaborane and side alkynyl groups, and self-assembled with doxorubicin (DOX) to form drug-loaded nanoparticles. These DOX@PLMB nanoparticles could not only suppress the leakage of the boron compounds into the bloodstream due to the covalent bonds between carborane and polymer main chains, but also protect DOX from initial burst release at physiological conditions because of the dihydrogen bonds between DOX and carborane. It was demonstrated that DOX@PLMB nanoparticles could selectively deliver boron atoms and DOX to the tumor site simultaneously in vivo. Under the combination of chemotherapy and BNCT, the highest tumor suppression efficiency without reduction of body weight was achieved. This polymeric nanoparticles delivery system could be very useful in future chemoradiotherapy to obtain improved therapeutic effect with reduced systemic toxicity.
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