Approximately 60% of patients with kidney renal clear cell carcinoma (KIRC) die within the first 2-3 years. The prognosis for patients with KIRC and its metastases is poor. Ferroptosis and providing ...immunity are novel treatment targets for several cancers, including KIRC. Therefore, it is important to identify suitable ferroptosis- and immune-related signatures to predict the prognosis and diagnosis of patients with KIRC.
The corresponding data of patients with KIRC were obtained from the Cancer Genome Atlas. Univariate and multivariate Cox regression analyses were used to screen candidate biomarkers in patients with KIRC.
We found that four FI-DEGs (BID, MET, LTB4R, and HMOX1) were independently associated with the overall survival of patients with KIRC. The prognosis and diagnosis model constructed using these four biomarkers could predict the outcome of KIRC, as measured by the receiver operating characteristic analyses.
We identified 4 FI-DEGs that could be used as biomarkers in patients with KIRC. The present study not only contributes to understanding the roles of ferroptosis and immunity in the development of KIRC, but also to the diagnosis and prognosis of KIRC, although it remains to be further studied.
The singly Cabibbo suppressed decay Λ + c → pη′ is measured using 4.5 fb −1 of e + e − collision data collected at center-of-mass energies between 4.600 and 4.699 GeV with the BESIII detector at ...BEPCII. Evidence for Λ + c → pη′ with a statistical significance of 3.6σ is reported with a double-tag approach. The Λ + c → pη′ absolute branching fraction is determined to be (5.62 +2.46 −2.04 ±0.26)×10 −4 , where the first and second uncertainties are statistical and systematic, respectively. Our result is consistent with the branching fraction obtained by the Belle collaboration within the uncertainty of 1σ.
The decays ψ2(3823 ) → γχc0,1,2, π+π− J/ψ, π0π0J/ψ , ηJ/ψ, and π0J/ψ are searched for using the reaction e+e− → π+π− ψ2 (3823) in a 19 fb−1 data sample collected at center-of-mass energies between ...4.1 and 4.7 GeV with the BESIII detector. The process ψ2(3823) → γχc1 is observed in a 9 fb−1 data sample in the center-of-mass energy range 4.3–4.7 GeV, which confirms a previous observation but with a higher significance of 11.8 σ , and evidence for ψ2(3823) → γχc2 is found with a significance of 3.2 σ for the first time. The branching-fraction ratio ... is determined. No significant ψ2 (3823) signals are observed for any of the other decay channels. Upper limits of branching-fraction ratios for ψ2(3823 ) → π+π− J/ψ , π0π0 J/ψ, ηJ/ψ , π0 J/ψ, γ χc0 relative to ψ2 (3823) → γχc1 are reported. The process e+e− → π0π0ψ2 (3823) is also searched for, and we find evidence for the process with a significance of 4.3 σ . The average cross-section ratio σ (e+e− → π0π0ψ2 (3823)) σ (e+e− → π+π− ψ2 (3823)) is also determined. (ProQuest: ... denotes formula omited.).
The tensile behavior of GH3535 alloy has been investigated at strain rates of 8.33 × 10−5/s−1–8.33 × 10−3/s−1, in the temperature range of 25–800 °C. The results showed that the ultimate tensile ...strength was decreased with increasing temperature and increased with rising strain rate, whereas the yield strength kept almost a constant value at the temperature range from 550 to 800 °C in all strain rates test. The formation of M12C carbides at the grain boundary during the tension process played an important role in increasing the yield strength of the alloy at elevated temperatures. But inhomogeneous deformation at 650 °C resulted in the minimum ductility of the alloy. Additionally, various types of serrations were noticed on the stress-strain curves for the alloy tested in the temperature range of 500–800 °C. Normal Portevin-Le Chatelier (PLC) effect and positive strain rate sensitivity were observed in this alloy. Type A and A + B serrations were presented to stress-strain curves at temperatures below 650 °C, whereas type C serration was noticed when the temperature rose above 650 °C. The analysis suggested that the interactions between substitutional solutes migration and mobile dislocations were the main reason for the serrated flow behavior in this alloy.
•The tensile behavior of GH3535 alloy at elevated temperature was studied.•The yield strength anomaly was observed in the temperature range from 550 to 800 °C.•The formation of M12C improves the grain boundary strength to a certain extent.•Inhomogeneous deformation at 650 °C results in the ductility loss of the alloy.•The interaction between solute atoms and dislocations results in the PLC effect.
In the case of medical implants, foreign materials are preferential sites for bacterial adhesion and microbial contamination, which can lead to the development of prosthetic infections. Commercially ...biomedical TiNi shape memory alloys are the most commonly used materials for permanent implants in contact with bone and dental, and the prevention of infections of TiNi biomedical shape memory alloys in clinical cases is therefore a crucial challenge for orthopaedic and dental surgeons. In the present study, copper has been chosen as the alloying element for design and development novel ternary biomedical Ti‒Ni‒Cu shape memory alloys with antibacterial properties. The effects of copper alloying element on the microstructure, mechanical properties, corrosion behaviors, cytocompatibility and antibacterial properties of biomedical Ti‒Ni‒Cu shape memory alloys have been systematically investigated. The results demonstrated that Ti‒Ni‒Cu alloys have good mechanical properties, and remain the excellent shape memory effects after adding copper alloying element. The corrosion behaviors of Ti‒Ni‒Cu alloys are better than the commercial biomedical Ti‒50.8Ni alloys. The Ti‒Ni‒Cu alloys exhibit excellent antibacterial properties while maintaining the good cytocompatibility, which would further guarantee the potential application of Ti‒Ni‒Cu alloys as future biomedical implants and devices without inducing bacterial infections.
Based on a sample of (1310.6±7.0)×10^{6}J/ψ events collected with the BESIII detector, we present measurements of J/ψ and η^{'} absolute branching fractions using the process J/ψ→γη^{'}. By analyzing ...events where the radiative photon converts into an e^{+}e^{-} pair, the branching fraction for J/ψ→γη^{'} is measured to be (5.27±0.03±0.05)×10^{-3}. The absolute branching fractions of the five dominant decay channels of the η^{'} are then measured for the first time and are determined to be B(η^{'}→γπ^{+}π^{-})=(29.90±0.03±0.55)%, B(η^{'}→ηπ^{+}π^{-})=(41.24±0.08±1.24)%, B(η^{'}→ηπ^{0}π^{0})=(21.36±0.10±0.92)%, B(η^{'}→γω)=(2.489±0.018±0.074)%, and B(η^{'}→γγ)=(2.331±0.012±0.035)%, where the first uncertainties are statistical and the second systematic.
Using 2.93 fb −1 of e+e− collision data taken at a center-of-mass energy of 3.773 GeV with the BESIII detector, we report the first measurements of the absolute branching fractions of 14 hadronic ...D0(+) decays to exclusive final states with an η , e.g., D0 → K−π+η , K0Sπ0η , K+K−η , K0SK0Sη, K−π+π0η , K0Sπ+π−η , K0Sπ0π0η , and π+π−π0η ; D+ → K0Sπ+η,K0SK+η, K−π+π+η, K0Sπ+π0η, π+π+π−η , and π+π0π0η. Among these decays, the D0 → K−π+η and D+→K0Sπ+η decays have the largest branching fractions, which are B (D0 → K−π+η) = ( 1.853 ± 0.02 5 stat ± 0.03 1 syst ) % and B ( D+ → K0Sπ+η ) = ( 1.309 ± 0.03 7 stat ± 0.03 1 syst ) % , respectively. The charge-parity asymmetries for the six decays with highest event yields are determined, and no statistically significant charge-parity violation is found.
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