Structural rearrangements within single molecules occur on ultrafast time scales. Many aspects of molecular dynamics, such as the energy flow through excited states, have been studied using ...spectroscopic techniques, yet the goal to watch molecules evolve their geometrical structure in real time remains challenging. By mapping nuclear motions using femtosecond x-ray pulses, we have created real-space representations of the evolving dynamics during a well-known chemical reaction and show a series of time-sorted structural snapshots produced by ultrafast time-resolved hard x-ray scattering. A computational analysis optimally matches the series of scattering patterns produced by the x rays to a multitude of potential reaction paths. In so doing, we have made a critical step toward the goal of viewing chemical reactions on femtosecond time scales, opening a new direction in studies of ultrafast chemical reactions in the gas phase.
A simple analytical method is developed to compare the combinations of stator and rotor pole numbers in flux-switching permanent magnet (PM) machines in terms of back electromotive force (EMF) and ...electromagnetic torque. The winding connections and winding factors of machines having all poles and alternate poles wound, and different numbers of phases, from two to six, are determined by the coil-EMF vectors. Their differences from analyzing the conventional fractional-slot PM machines with concentrated nonoverlapping windings are highlighted. The general conditions are established for balanced symmetrical back-EMF waveform. It shows that the optimized rotor pole number should be close to the number of stator poles, whereas larger torque can be obtained by the machine with relatively higher rotor pole number. The analysis is validated by finite-element analyses and experiment.
This paper overviews the recent development and new topologies of flux-switching (FS) machines, with particularly emphasis on the permanent magnet (PM) type. Specific design issues, including winding ...configurations, combinations of stator and rotor pole numbers, rotor pole width, split ratio, etc., are investigated, while the torque capability of selected FSPM machines is also compared.
Abstract
We present the first data release of the James Clerk Maxwell Telescope Plane Survey (JPS), the JPS Public Release 1. JPS is an 850-μm continuum survey of six fields in the northern inner ...Galactic plane in a longitude range of ℓ = 7°–63°, made with the Submillimetre Common-User Bolometer Array 2. This first data release consists of emission maps of the six JPS regions with an average pixel-to-pixel noise of 7.19 mJy beam−1, when smoothed over the beam, and a compact source catalogue containing 7813 sources. The 95 per cent completeness limits of the catalogue are estimated at 0.04 Jy beam−1 and 0.3 Jy for the peak and integrated flux densities, respectively. The emission contained in the compact source catalogue is 42 ± 5 per cent of the total and, apart from the large-scale (greater than 8 arcmin) emission, there is excellent correspondence with features in the 500-μm Herschel maps. We find that, with two-dimensional matching, 98 ± 2 per cent of sources within the fields centred at ℓ = 20°, 30°, 40° and 50° are associated with molecular clouds, with 91 ± 3 per cent of the ℓ = 30° and 40° sources associated with dense molecular clumps. Matching the JPS catalogue to Herschel 70-μm sources, we find that 38 ± 1 per cent of sources show evidence of ongoing star formation. The JPS Public Release 1 images and catalogue will be a valuable resource for studies of star formation in the Galaxy and the role of environment and spiral arms in the star formation process.
The molecular mechanism underlying gastric cancer (GC) invasion and metastasis is still poorly understood. In this study, we tried to investigate the roles of CXCR4 and CXCR2 signalings in gastric ...cancer metastasis. A highly invasive gastric cancer cell model was established. Chemokines receptors were profiled to search for the accountable ones. Then the underlying molecular mechanism was investigated using both in vitro and in vivo techniques, and the clinical relevance of CXCR4 and CXCR2 expression was studied in gastric cancer samples. CXCR4 and CXCR2 were highly expressed in a high invasive gastric cancer cell model and in gastric cancer tissues. Overexpression of CXCR4 and CXCR2 was associated with more advanced tumor stage and poorer survival for GC patients. CXCR4 and CXCR2 expression strongly correlated with each other in the way that CXCR2 expression changed accordingly with the activity of CXCR4 signaling and CXCR4 expression also changed in agreement with CXCR2 activity. Further studies demonstrated CXCR4 and CXCR2 can both activated NF-κB and STAT3 signaling, while NF-κBp65 can then transcriptionally activate CXCR4 and STAT3 can activate CXCR2 expression. This crosstalk between CXCR4 and CXCR2 contributed to EMT, migration and invasion of gastric cancer. Finally, Co-inhibition of CXCR4 and CXCR2 is more effective in reducing gastric cancer metastasis. Our results demonstrated that CXCR4 and CXCR2 cross-activate each other to promote the metastasis of gastric cancer.
A simple method for generating single-spike hard x-ray pulses in free-electron lasers (FELs) has been developed at the Linac Coherent Light Source (LCLS). This is realized by nonlinear bunch ...compression using 20-pC bunch charge, demonstrated in the hard x-ray regime at 5.6 and 9 keV, respectively. Measurements show about half of the FEL shots containing a single-spike spectrum. At 5.6-keV photon energy, the single-spike shots have a mean pulse energy of about 10 μJ with 70% intensity fluctuation and the pulse full width at half maximum is evaluated to be at 200-as level.
ABSTRACT
Observations in the local universe show a tight correlation between the masses of supermassive black holes (SMBHs; MBH) and host-galaxy bulges (Mbulge), suggesting a strong connection ...between SMBH and bulge growth. However, direct evidence for such a connection in the distant universe remains elusive. We have studied sample-averaged SMBH accretion rate ($\overline{\rm BHAR}$) for bulge-dominated galaxies at z = 0.5–3. While previous observations found $\overline{\rm BHAR}$ is strongly related to host-galaxy stellar mass (M⋆) for the overall galaxy population, our analyses show that, for the bulge-dominated population, $\overline{\rm BHAR}$ is mainly related to SFR rather than M⋆. This ${\overline{\rm BHAR}}$–SFR relation is highly significant, e.g. 9.0σ (Pearson statistic) at z = 0.5–1.5. Such a $\overline{\rm BHAR}$–SFR connection does not exist among our comparison sample of galaxies that are not bulge dominated, for which M⋆ appears to be the main determinant of SMBH accretion. This difference between the bulge-dominated and comparison samples indicates that SMBHs only coevolve with bulges rather than the entire galaxies, explaining the tightness of the local MBH−Mbulge correlation. Our best-fitting ${\overline{\rm BHAR}}$–SFR relation for the bulge-dominated sample is ${\log \overline{\rm BHAR}= \log \mathrm{SFR} - (2.48\pm 0.05)}$ (solar units). The best-fitting $\overline{\rm BHAR}/\mathrm{SFR}$ ratio (10−2.48) for bulge-dominated galaxies is similar to the observed MBH/Mbulge values in the local universe. Our results reveal that SMBH and bulge growth are in lockstep, and thus non-causal scenarios of merger averaging are unlikely the origin of the MBH−Mbulge correlation. This lockstep growth also predicts that the MBH−Mbulge relation should not have strong redshift dependence.
Permanent-magnet vernier machine (PMVM) is a relatively new type of PM machines. An analytical subdomain model accounting for tooth-tips and flux modulation poles is developed to accurately predict ...on-load field distributions in PMVMs. Based on two-dimensional (2-D) polar coordinate and magnetic vector potential, this method solves the Maxwell's equations in slot, air-gap, flux modulation pole slot (FMPS), and PM regions. Consequently, the electromagnetic performance such as cogging torque, back-electromotive force (EMF), electromagnetic torque, power factor, and magnet loss are calculated. In addition, the model can also be used for the evaluation of demagnetization withstand capability. The finite-element analysis (FEA) and experimental results validate the accuracy of the developed analytical model.
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